scholarly journals The Method and Results of a Treatment Targeting SARS-CoV-2-Activated Inflammasomes

2021 ◽  
Author(s):  
Badar Kanwar ◽  
Asif Khattak ◽  
Chul Joong Lee ◽  
Jenny Balentine ◽  
R. E. Kast ◽  
...  
Keyword(s):  
Medical Center ◽  
Response To Treatment ◽  
Entire Study ◽  
Significant Difference ◽  
Regional Medical ◽  
Regional Medical Center ◽  
Chemically Reacting ◽  
Second Period ◽  
The Brain ◽  
Onset Group

Abstract In COVID-19 patients, clinicians should consider an increase in the oxygen requirement from 6 l/min to as high as 100% with a high-flow nasal cannula, as well as dapsone administration. A COVID-19 committee at Hunt Regional Medical Center reviewed the use of dapsone as an off-label medication in the first period. The hospital then revalidated its effectiveness by reporting the findings of 44 (22 cases/22 controls) patients with ARDS treated with dapsone in the second period. In ARDS-onset patients treated with dapsone, there was a decrease in FIO2 requirements in 7 patients and no worsening in 1 patient. In aggravated ARDS patients treated with dapsone, there was a decrease in FIO2 requirements in 6 patients and no worsening in 3 patients. In patients with severe ARDS treated with dapsone, no response to treatment was observed in 2 patients. In the ARDS-onset group not treated with dapsone, eight of twenty patients died, but in the ARDS-onset group treated with dapsone, no one of seventeen patients died throughout the entire study period. There was a significant difference in dapsone treatment results in the ARDS-onset group. We clinically diagnosed transient bulbar palsy of medulla oblongata in the brain associated with SARS-CoV-2 infection in the ARDS-onset group. We confirmed that dapsone clinically treated the onset of ARDS by targeting SARS-CoV-2-activated inflammasomes. Like chemically reacting substances, inflammasome and dapsone are competing, proving that it is only effective in treating early ARDS.

scholarly journals SARS-CoV-2 Seroprevalence among Health Care Workers—A Voluntary Screening Study in a Regional Medical Center in Southern Germany

2021 ◽  
Vol 18 (8) ◽  
pp. 3910
Author(s):  
Katharina Müller ◽  
Philipp Girl ◽  
Michaela Ruhnke ◽  
Mareike Spranger ◽  
Klaus Kaier ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Close Contact ◽  
Medical Center ◽  
Limited Information ◽  
Specific Antibodies ◽  
Care Workers ◽  
Significant Difference ◽  
Regional Medical ◽  
Regional Medical Center

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is associated with a potentially severe clinical manifestation, coronavirus disease 2019 (COVID-19), and currently poses a worldwide challenge. Health care workers (HCWs) are at the forefront of any health care system and thus especially at risk for SARS-CoV-2 infection due to their potentially frequent and close contact with patients suffering from COVID-19. Serum samples from 198 HCWs with direct patient contact of a regional medical center and several outpatient facilities were collected during the early phase of the pandemic (April 2020) and tested for SARS-CoV-2-specific antibodies. Commercially available IgA- and IgG-specific ELISAs were used as screening technique, followed by an in-house neutralization assay for confirmation. Neutralizing SARS-CoV-2-specific antibodies were detected in seven of 198 (3.5%) tested HCWs. There was no significant difference in seroprevalence between the regional medical center (3.4%) and the outpatient institution (5%). The overall seroprevalence of neutralizing SARS-CoV-2-specific antibodies in HCWs in both a large regional medical center and a small outpatient institution was low (3.5%) at the beginning of April 2020. The findings may indicate that the timely implemented preventive measures (strict hygiene protocols, personal protective equipment) were effective to protect from transmission of an airborne virus when only limited information on the pathogen was available.

Rewards and Challenges of Nursing Wounded Warriors at Landstuhl Regional Medical Center, Germany

2010 ◽  
Vol 45 (2) ◽  
pp. 205-218 ◽  
Author(s):  
Nancy M. Steele ◽  
Ann Kobiela Ketz ◽  
Kathleen D. Martin ◽  
Dawn M. Garcia ◽  
Shannon Womble ◽  
...  
Keyword(s):  
Medical Center ◽  
Regional Medical ◽  
Regional Medical Center ◽  
Wounded Warriors

scholarly journals An Examination of Individualism within Employee Help-Seeking Networks

2018 ◽  
Vol 8 (4) ◽  
pp. 1
Author(s):  
Randall P. Settoon ◽  
Sang H. Lee
Keyword(s):  
Help Seeking ◽  
Medical Center ◽  
Future Research ◽  
Dense Networks ◽  
Helping Others ◽  
Regional Medical ◽  
Regional Medical Center ◽  
The Impact ◽  
The Relationship

Prior research focusing on the impact of individualistic orientations on the performance of cooperative behaviors has produced mixed results. Researchers have concluded that the self-focused orientation of individualists will lead them to be less cooperative than others. On the other hand, some scholars have argued that helping others is core to individualists’ self-concept and that competently assuming the role of help-giver is a source of intrinsic satisfaction. In this study, we test this proposition by examining individualistic orientations within employee help-seeking networks. Results from a sample of 107 employees within a regional medical center indicate that the level of individualism in helping-seeking networks is positively associated with help-seekers’ perceptions of support. Further, the results suggest that the relationship is stronger in dense networks. Implications of this work and directions for future research are discussed.

Anastomotic Outcomes in Military Exploratory Laparotomies in the Modern Combat Era

2022 ◽  
pp. 000313482110502
Author(s):  
Patrick F. Walker ◽  
Joseph D. Bozzay ◽  
David W. Schechtman ◽  
Faraz Shaikh ◽  
Laveta Stewart ◽  
...  
Keyword(s):  
Medical Center ◽  
Damage Control ◽  
Surgical Site Infections ◽  
Trauma Patients ◽  
Intestinal Anastomoses ◽  
Military Hospitals ◽  
Anastomotic Failure ◽  
Significant Difference ◽  
Regional Medical Center ◽  
Outcome Differences

Background Intestinal anastomoses in military settings are performed in severely injured patients who often undergo damage control laparotomy in austere environments. We describe anastomotic outcomes of patients from recent wars. Methods Military personnel with combat-related intra-abdominal injuries (June 2009-December 2014) requiring laparotomy with resection and anastomosis were analyzed. Patients were evacuated from Iraq or Afghanistan to Landstuhl Regional Medical Center (Germany) before being transferred to participating U.S. military hospitals. Results Among 341 patients who underwent 1053 laparotomies, 87 (25.5%) required ≥1 anastomosis. Stapled anastomosis only was performed in 57.5% of patients, while hand-sewn only was performed in 14.9%, and 9.2% had both stapled and hand-sewn techniques (type unknown for 18.4%). Anastomotic failure occurred in 15% of patients. Those with anastomotic failure required more anastomoses (median 2 anastomoses, interquartile range [IQR] 1-3 vs. 1 anastomosis, IQR 1-2, P = .03) and more total laparotomies (median 5 laparotomies, IQR 3-12 vs. 3, IQR 2-4, P = .01). There were no leaks in patients that had only hand-sewn anastomoses, though a significant difference was not seen with those who had stapled anastomoses. While there was an increasing trend regarding surgical site infections (SSIs) with anastomotic failure after excluding superficial SSIs, it was not significant. There was no difference in mortality. Discussion Military trauma patients have a similar anastomotic failure rate to civilian trauma patients. Patients with anastomotic failure were more likely to have had more anastomoses and more total laparotomies. No definitive conclusions can be drawn about anastomotic outcome differences between hand-sewn and stapled techniques.

An Evaluation of Snake Bites and Antivenin Use at a Regional Medical Center

2010 ◽  
Vol 76 (7) ◽  
pp. 755-758
Author(s):  
Larry I. Watson ◽  
Christy Spivey ◽  
Cen Rema Menon ◽  
Cyrus A. Kotwall ◽  
Thomas V. Clancy ◽  
...  
Keyword(s):  
Medical Center ◽  
Length Of Hospital Stay ◽  
Clinical Information ◽  
P Value ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Snake Bites ◽  
Regional Medical ◽  
Regional Medical Center ◽  
Physical Findings

Snake bites are a rare but challenging problem for surgeons. The purpose of our study was to evaluate our experience with snake bites at a regional medical center. We reviewed patients treated for snake bites from 2004 to July 2008. Demographics, clinical information, and outcomes were documented. Descriptive statistics were used, and χ2, t test, and Fisher exact test were used to compare patients based on antivenin use. A P value < 0.05 was considered significant. Over the study period, 126 patients presented to the emergency department with 44 (35%) requiring hospital admission. The average age was 38 years (range, 2 to 76 years); 66 per cent were male and 95 per cent white. Bites most commonly occurred in the summer and fall months with none from December through March. Copperhead bites accounted for 50 per cent of bites. An average of 4.8 vials of antivenin was given to 61 per cent of admitted patients with 93 per cent receiving the drug within 6 hours. Minor reactions to antivenin occurred in three patients (11%). Two patients required surgery (5%), and the readmission rate was 7 per cent. There was no known morbidity or mortality. When comparing patients who received antivenin with patients who did not, the only significant clinical variables were an increased prothrombin time (12.1 vs 11.7, respectively; P = 0.048) and a longer length of hospital stay (3 vs 1.8 days, P = 0.0006) in patients receiving antivenin. The majority of patients with snake bites can be treated with supportive care and antivenin when indicated. Antivenin use at our institution is largely based on physical findings and not related to laboratory values.

Sign in / Sign up

Export Citation Format

Share Document