scholarly journals Associations Between I/ D polymorphism in the ACE gene and lung cancer: an updated systematic review and a meta-analysis

2020 ◽  
Author(s):  
Junjian Chen ◽  
Mao Sun ◽  
Min Zhou ◽  
Renfu Lu
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Cancer Risks ◽  
Funnel Plot ◽  
Random Ratio ◽  
Regression Test

Abstract BackgroundThis study has evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by constructing a meta-analysis.MethodsThe heterogeneity in the study was tested by the Q-test and I2, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI), to estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. We have performed Sensitivity analysis. Using funnel plot and Begger’s regression test investigated the publication bias. All data Statistical analyses were performed using Stata 12.0 and Revman 5.3.ResultsA total of 4307 participants (2181 patients; 2126 controls) were included in twelve case-control studies selected. No significant association was found between the ACE I/D polymorphism and lung cancer risks (II vs ID + DD: OR = 1.22, 95% CI = 0.89–1.68; II + ID vs DD: OR = 1.21, 95% CI = 0.90–1.63; I vs D: OR =1.15, 95% CI = 0.95–1.39). In the subgroup analysis by ethnicity, no significant association between this polymorphism and lung cancer risks was also found among Asia and Caucasian populations for the comparison of II vs ID + DD, II + ID vs DD and I vs D genetic models.ConclusionOur study indicated that the ACE I/ D polymorphism was not associated with the risk of lung cancer.

scholarly journals Associations Between I/ D polymorphism in the ACE gene and lung cancer: an updated systematic review and a meta-analysis

2021 ◽  
Author(s):  
Junjian Chen ◽  
Mao Sun ◽  
Min Zhou ◽  
Renfu Lu
Keyword(s):  
Lung Cancer ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Rank Test ◽  
Case Control Studies ◽  
Cancer Risks ◽  
Funnel Plot ◽  
Random Ratio ◽  
Q Statistic

Abstract Background: This study has evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by constructing a meta-analysis.Methods: The heterogeneity in the study was tested by the Cochran c2-based Q statistic test and I2 test, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI), to estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. We have performed Sensitivity analysis. Using funnel plot and Begg's rank test investigated the publication bias. All data Statistical analyses were performed using Stata 12.0 and Revman 5.3.Results: A total of 4307 participants (2181 patients; 2126 controls) were included in twelve case-control studies selected. No significant association was found between the ACE I/D polymorphism and lung cancer risks (II vs ID + DD: OR = 1.22, 95% CI = 0.89–1.68; II + ID vs DD: OR = 1.21, 95% CI = 0.90–1.63; I vs D: OR =1.15, 95% CI = 0.95–1.39). In the subgroup analysis by ethnicity, no significant association between this polymorphism and lung cancer risks was also found among Asia and Caucasian populations for the comparison of II vs ID + DD, II + ID vs DD and I vs D genetic models.Conclusion: Our study indicated that the ACE I/ D polymorphism was not associated with the risk of lung cancer.

scholarly journals Associations between I/D polymorphism in the ACE gene and lung cancer: an updated systematic review and a meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Junjian Chen ◽  
Mao Sun ◽  
Min Zhou ◽  
Renfu Lu
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Rank Test ◽  
Case Control Studies ◽  
Funnel Plot ◽  
Random Ratio ◽  
Q Statistic

Abstract Background We evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by performing a meta-analysis. Methods The heterogeneity in the study was tested using the Cochran χ2-based Q statistic test and I2 test, and then the random ratio or fixed effect was utilized to merge the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. Sensitivity analysis was also performed. Using funnel plot and Begg’s rank test, we investigated the publication bias. All statistical analyses were performed using Stata 12.0 and RevMan 5.3. Results A total of 4307 participants (2181 patients; 2126 controls) were included in the 12 case–control studies. No significant association was found between the ACE I/D polymorphism and lung cancer risk (II vs. ID + DD: OR = 1.22, 95% CI = 0.89–1.68; II + ID vs. DD: OR = 1.21, 95% CI = 0.90–1.63; I vs. D: OR = 1.15, 95% CI = 0.95–1.39). In the subgroup analysis by ethnicity, no significant association between the ACE I/D polymorphism and lung cancer risk was found among Asian and Caucasian populations for the comparisons of II vs. ID + DD, II + ID vs. DD, and I vs. D genetic models. Conclusion The ACE I/D polymorphism is not associated with the risk of lung cancer.

scholarly journals The MPO−463G>A Polymorphism and Lung Cancer Risk: A Meta-Analysis Based on 22 Case–Control Studies

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65778 ◽  
Author(s):  
Jun-Ping Yang ◽  
Wen-Bo Wang ◽  
Xiao-Xi Yang ◽  
Lei Yang ◽  
Li Ren ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals ERCC2/XPD Lys751Gln and Asp312Asn Gene Polymorphism and Lung Cancer Risk: A Meta-Analysis Involving 22 Case–Control Studies

2010 ◽  
Vol 5 (9) ◽  
pp. 1337-1345 ◽  
Author(s):  
Ping Zhan ◽  
Qin Wang ◽  
Shu-Zhen Wei ◽  
Jing Wang ◽  
Qian Qian ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Gene Polymorphism ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Association Between the LIG1 Polymorphisms and Lung Cancer Risk: A Meta-analysis of Case–Control Studies

2015 ◽  
Vol 73 (2) ◽  
pp. 381-387 ◽  
Author(s):  
Dan Li ◽  
Ruoran Li ◽  
Jinghao Zhang ◽  
Ke Li ◽  
Yanmin Wu
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Cannabis Smoking And Risk Of Lung Cancer - A Systematic Review And Meta-Analysis

2014 ◽  
Vol 1 (2) ◽  
pp. 31-37 ◽  
Author(s):  
Khalid Bouti ◽  
Rajae Borki ◽  
Hicham Fenane ◽  
Laila Harrak
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Case Control ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Open Access Journals ◽  
Increased Risk ◽  
Cannabis Smoking

Background: Cannabis is the illicit psychoactive substance the most consumed in the world. Little is known about the association between the use of cannabis and the risk of lung cancer. Objective:The objective of this meta-analysis is to determine whether use of cannabis is a risk factor for lung cancer. Methods: We conducted a systematic review and meta-analyses of all languages articles using relevant computerised databases. MEDLINE (online PubMed), Web of knowledge, Embase, EBSCO CINAHL, ScienceDirect, Scopus, Cochrane Library, and Directory of Open Access Journals were searched to September 2014 for cohorts and case-control studies that assessed the risk of lung cancer associated with cannabis smoking. The literature search was performed with a combination of medical subject headings terms, "cannabis" and "lung neoplasms". Data extraction: Two investigators independently analysed and extracted results from eligible studies. Our study's registration number on PROSPERO is CRD42014008872. Results: The search strategy identified 2476 citations. 13 studies were eligible for inclusion: 2 pooled analysis of 9 case-control studies, one case-control study and 3 cohorts. The cumulative analysis for all the studies under a fixed-effects model showed that cannabis smoking determined an increased risk of developing lung cancer in the future (relative risk 1.22, 95% confidence interval 0.999–1.5; p=0.051), with no evidence of heterogeneity across the studies (I2: 34%; p¼0.01). Conclusions: The use of cannabis with or without tobacco smoking is associated with an increased risk for lung cancer

scholarly journals Incidence of lung cancer and mortality among civil construction industry workers: A protocol for a systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250377
Author(s):  
Rita Stella Maria Cahuana Pinto ◽  
Alana Castro Panzenhagen ◽  
Luis Felipe Silva Oliveira ◽  
José Claudio Fonseca Moreira ◽  
Carlos Eduardo Schnorr
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Occupational Exposure ◽  
Cancer Risk ◽  
Construction Industry ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Construction Workers ◽  
Case Control Studies ◽  
Chemical Agents

Background The construction sector is one of the most stable growth industries in the world. However, many studies have suggested an association between occupational exposure in civil construction and lung cancer risk. Thus, this study aims to assess lung cancer risk in civil construction workers occupationally exposed to physical and chemical agents through a systematic review and meta-analysis. Methods/design Studies will be identified by searching PUBMED, Embase, SCOPUS, WEB OF SCIENCE and the reference list of included articles. Eligible study designs will be cohort, cross-sectional, and case-control studies that report occupational exposure to physical or chemical agents and lung cancer risk through mortality or incidence outcomes. A meta-analysis will be used to combine odds ratios (ORs) from case-control studies and relative risks (RR) from cohort studies. Two reviewers will independently screen articles, extract data, and assess scientific quality using standardized forms and ROBINS-E tool if available. Otherwise, the New-Castle Ottawa rating scale will be used. Any of those will also be used in combination with the GRADE approach for quality of evidence. Overall risk estimates and their corresponding 95% confidence intervals (CIs) will be obtained using the random-effects model meta-analysis. This systematic review and meta-analysis will be conducted following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. Results will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Discussion This review will identify and synthesize studies investigating the association between occupational exposure in the construction industry and lung cancer. The findings will help governmental entities and researchers with evidence-based decision-making because they will integrate and validate the evidence on construction workers’ health effects due to occupational exposure. Systematic review registration PROSPERO CRD42020164209

Indoor radon exposure and lung cancer risk: a meta-analysis of case-control studies

2017 ◽  
Vol 6 (S5) ◽  
pp. S934-S943 ◽  
Author(s):  
Carmine Garzillo ◽  
Mariagabriella Pugliese ◽  
Filomena Loffredo ◽  
Maria Quarto
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Indoor Radon ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Radon Exposure
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