Salivary Melatonin in Oral Squamous Cell Carcinoma Patients: A Cross-sectional Study

2020 ◽  
Author(s):  
Ivan Salaric ◽  
Ivana Karmelic ◽  
Jasna Lovric ◽  
Ksenija Bazdaric ◽  
Marko Rozman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Sleep Quality ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Concentration Limit ◽  
Poor Sleep ◽  
Cross Sectional ◽  
Detailed Medical History ◽  
Salivary Melatonin

Abstract BACKGROUND: Around 55% of oral squamous cell carcinoma (OSCC) patients are diagnosed in the advanced stage. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. Melatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and anti-inflammatory properties. The purpose of this study is to determine salivary melatonin (MLT) levels in OSCC patients, compare the salivary MLT levels with those in healthy individuals and compare the salivary and serum levels in OSCC patients. Furthermore, the aim is to evaluate sleep quality and to investigate the potential relationship between sleep quality and salivary MLT levels in OSCC patients. METHODS: Unstimulated and stimulated saliva were sampled from patients with T1N0M0 and T2N0M0 OSCC (N=34) and 33 sex and age matched healthy subjects. Serum samples were taken from 11 OSCC patients. Detailed medical history was taken before sampling and sleep quality measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire. RESULTS: Melatonin levels in UWS and SWS were significantly higher in the OSCC group. Sleep quality was significantly lower in patients with OSCC (U=249.50; P = 0.0001). ROC analysis was found to be significant (P <0.001) in evaluating the MLT concentration limit in diagnosing OSCC. CONCLUSIONS: The expected relationship between sleep quality and salivary MLT levels in OSCC patients was not observed. Salivary melatonin could present a potential OSCC biomarker. However, larger prospective studies should validate the clinical utility of MLT as an OSCC biomarker.

scholarly journals Salivary melatonin in oral squamous cell carcinoma patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ivan Salarić ◽  
Ivana Karmelić ◽  
Jasna Lovrić ◽  
Ksenija Baždarić ◽  
Marko Rožman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Sleep Quality ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Concentration Limit ◽  
Poor Sleep ◽  
Potential Biomarker ◽  
Whole Saliva ◽  
Salivary Melatonin

AbstractMelatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and anti-inflammatory properties. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. The purpose of this study is to determine salivary melatonin (MLT) levels in oral squamous cell carcinoma (OSCC) patients, compare the salivary MLT levels with those in healthy individuals and compare the salivary and serum levels in OSCC patients. Furthermore, the aim is to investigate the potential relationship between sleep quality and salivary MLT levels in OSCC patients. Unstimulated (UWS) and stimulated (SWS) whole saliva was sampled from patients with T1N0M0 and T2N0M0 OSCC (N = 34) and 33 sex and age matched healthy subjects. Serum samples were taken from 11 OSCC patients. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire. Melatonin levels in UWS and SWS were significantly higher in the OSCC group. Sleep quality was significantly lower in patients with OSCC (P = 0.0001). ROC analysis was found to be significant (P < 0.001) in evaluating MLT concentration limit in diagnosing OSCC. The expected relationship between sleep quality and salivary MLT levels in OSCC patients was not observed. Our results suggest salivary MLT as a potential biomarker that might facilitate non-invasive detection of early stage OSCC.

scholarly journals Oral squamous cell carcinoma: a clinicopathological study on 194 cases in northeastern Brazil. A cross-sectional retrospective study

2018 ◽  
Vol 136 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Amanda Almeida Leite ◽  
Augusto César Leal da Silva Leonel ◽  
Jurema Freire Lisboa de Castro ◽  
Elaine Judite de Amorim Carvalho ◽  
Pablo Agustin Vargas ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Northeastern Brazil ◽  
Cross Sectional ◽  
Clinicopathological Study

scholarly journals ORAL SQUAMOUS CELL CARCINOMA

2015 ◽  
Vol 22 (01) ◽  
pp. 018-026
Author(s):  
Sofia Ali Syed ◽  
Mulazim Hussain Bukhari ◽  
Riaz Ahmed Warraich ◽  
Fauzia Quadir ◽  
Asifa Iqbal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Maxillofacial Surgery ◽  
Nucleolar Organizer Regions ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Poorly Differentiated ◽  
Well Differentiated

Background: The aim of this study was to evaluate clinico-pathologicalparameters and the status of argyrophilic nucleolar organizer regions stain in various histologicalgrades of oral squamous cell carcinoma. Materials and Methods: A cross sectional studywas conducted on fifty cases of oral squamous cell carcinoma. The specimen were collectedfrom the department of Oral & Maxillofacial Surgery and processed for hematoxylin and eosinstain and AgNOR stain Pathology Laboratory, King Edward Medical University Lahore. Results:Bidi smoking is associated with oral squamous cell carcinoma. The AgNOR (mAgNOR andpAgNOR) status was significantly low in well differentiated and moderately differentiatedcompared to poorly differentiated oral squamous cell carcinoma (p =0.001). AgNOR size inpoorly differentiated was significantly higher than the AgNOR size in well differentiated oralsquamous cell carcinoma. Similarly the distribution of AgNOR in moderately and poorlydifferentiated oral squamous cell carcinoma was significantly high. The AgNORs index wassignificantly high in poorly differentiated squamous cell carcinoma as compared to welldifferentiated and moderately differentiated squamous cell carcinoma. Conclusions: The useof AgNORs stain is easy, valid and reliable method to assess the histological grading of oralsquamous cell carcinoma and should be used to predict the prognosis of patients.

Prognostic potential of CK-19 managing disseminated oral squamous cell carcinomas in Pakistan: A descriptive cross-sectional study

2020 ◽  
pp. 1-13
Author(s):  
Waqas Iqbal ◽  
Uzma Tariq ◽  
Arhama Surwaich ◽  
Surwaich Ali channa ◽  
Abdul Majid ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cross Sectional Study ◽  
Squamous Cell Carcinomas ◽  
Sectional Study ◽  
College Hospital ◽  
Cross Sectional ◽  
Oral Squamous Cell Carcinomas

Abstract A cross-sectional study was conducted to assess the adoptability of CK-19 as a routine diagnostic assay and potential prognostic marker following disseminated oral squamous cell carcinoma in Pakistani population. The current descriptive study was conducted at Isra Dental College Hospital, Isra University, Hyderabad, Pakistan. Suspected patients of oral squamous cell carcinomas (OSCC), who visited the Isra Dental College Hospital’s outpatient department from January 2014 up to January 2015 with four year follow up (from January 2015 up to December 2019), were included after ethical approval of the Institutional board. SPSS version 21.0 was used for data analysis. Sixty cases of oral squamous cell carcinoma (OSCC) were selected for CK-19 quantification by using PCR before and after incisional biopsy.    

scholarly journals Frequency and Determinants of Tongue Lesions among Patients Reported in a Teaching Institute: A Cross-Sectional Study

2021 ◽  
pp. 59-68
Author(s):  
Mehwish Feroz Ali ◽  
Gulrukh Askary ◽  
Shahrukh Saran ◽  
Adnan Zaidi ◽  
Farwa Sajjad ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Study Design ◽  
Squamous Cell ◽  
Oral Submucous Fibrosis ◽  
Cross Sectional Study ◽  
Oral Lesions ◽  
Sectional Study ◽  
Cross Sectional

Aims: The purpose of the study is to evaluate the frequency, distribution and determinants of tongue lesions in our teaching institute. Also to find an association of common tongue lesions with various study variables. Study Design: Cross-sectional study design. Place and Duration of Study: The study was conducted at Fatima Jinnah Dental College & Hospital, Karachi, Pakistan. All the lesions presented on the tongue were included reported from January 2017 to December 2020. Methodology: There were 670 oral lesions documented in the Department of Oral Pathology and Oral Medicine out of which 93 (13.8%) represented tongue lesions. We included 93 patients with tongue lesions (45 men, 48 women; age range 18-80 years). These lesions include the atrophic tongue, geographic tongue, candidiasis, keratotic lesion, ulceration, oral pigmentation, fibroma, black hairy tongue, traumatic neuroma, herpes infection, oral submucous fibrosis, and oral squamous cell carcinoma. Results: In the study, common clinical presentations on the tongue were ulceration (29%), erythematous/depapillated tongue (22.6%), white keratotic and plaque-like lesions (21.6%), and black discoloration (8.6%). The clinical presentation was statistically associated with gender (p=0.03), age (p=0.04) and site of lesion (p<.001). Atrophic glossitis (19.4%), traumatic ulcer (12.9%), pseudomembranous candidiasis (12.9%), oral pigmentation (8.6%), oral squamous cell carcinoma (7.5%), geographic tongue (6.5%), recurrent aphthous stomatitis (6.5%), and frictional keratosis (6.5%) were most commonly reported tongue lesions. There was a relationship of tongue lesions with causes and site of the lesion (P<0.001). Conclusion: Initial tongue lesions may reflect underlying massive abnormal changes and this could be an early diagnostic parameter.  Through vigilant screening of the oral mucosa, we may be able to detect such mucosal alterations and search out the possible cause in order to provide effective treatment to the patient. In this way, we may also prevent the malignant transformation of any susceptible oral lesions.

scholarly journals Epidemiological study of oral squamous cell carcinoma: A hospital based study in Dhaka city

2018 ◽  
Vol 28 (2) ◽  
pp. 22-25
Author(s):  
Md Abul Hossain ◽  
Md Mahiuddin Ahmed ◽  
AFM Shahidur Rahman ◽  
Md Nasim Haider ◽  
AKM Serajul Alam
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Dhaka City ◽  
Cross Sectional ◽  
Total Prevalence ◽  
Level Hospital

Objective: To find out the prevalence of oral squamous cell carcinoma among the tertiary and specialized level hospital in Dhaka cityMaterials and methods: A cross sectional study was carried out in the department of Oral and Maxillofacial surgery of DDCH, NICRH, BSMMU and ShSMCH from january2009 to july 2010 .A total of 324 patient of histopatholgically proven cases of oscc were selected as a sample size. Both primary and secondary data were collected for the study. The prevalence OSCC were calculated by dividing the OSCC patient by total number of patient multiplying 100.Results: The total prevalence of OSCC 3.55% among the 4 tertiary and specialized level hospital in Dhaka city.Conclusion: The prevalence of OSCC among tertiary and specialized level hospital of Dhaka city was 3.55%.The rate is quite high. The prevalence of risk factor includes betel quit, smokeless tobacco, smoking and poor oral hygiene mas also high. The majority of the patient were present in advance stage of the diseases.TAJ 2015; 28(2): 22-25

scholarly journals Oral Submucous Fibrosis with and without Associated Oral Squamous Cell Carcinoma

2021 ◽  
pp. 351-355
Author(s):  
Ahmad Masoud ◽  
Muzzamil Shafique ◽  
Faiza Arif
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Statistical Significance ◽  
Oral Submucous Fibrosis ◽  
Age Distribution ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Submucous Fibrosis

Introduction: Oral submucous fibrosis (OSF) is a potentially malignant disorder of the oral cavity. Aims and Objectives: The core objective of the study is to analyze the oral submucous fibrosis with and without associated oral squamous cell carcinoma (OSCC). Materials and Methods: This cross sectional study was conducted in Baqai Dental College Karachi during October 2020 to June 2021. The data was collected from 100 patients of both genders who were confirmed with OSF on the basis of history and clinical examinations were included in the study. Demographic and clinical information were recorded. Results: The data were collected from 100 patients of both females and males. The age distribution of the sample was analyzed. The patients were mostly above 50 years of age in both categories. However, the number of patients who were with OSCC at an age below 50 was greater in the OSF-positive group (23.8% vs. 21.9%). Similarly, the mean age of OSF + OSCC patients was 57.5 years while this value was 59.5 years for those without. Conclusion: It is concluded that tumors show well-differentiated histology and less lymph node involvement. However, a statistical significance was not observed among these variables, when comparing the OSCC patients with OSF to those who are without.

scholarly journals Different tumour grading in smokeless tobacco (Naswar) user and non-user in squamous cell carcinoma.

2020 ◽  
Vol 27 (05) ◽  
pp. 1054-1058
Author(s):  
Amna Sarfaraz ◽  
Sahd Rashid ◽  
Muhammad Irshad ◽  
Maria Tasneem Khattak ◽  
Hina Shabir
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histological Grade ◽  
Oral Pathology ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Tumour Grading ◽  
History Of

Objectives: To determine the relationship of Naswar with different tumour grading in squamous cell carcinoma. Study Design: Comparative cross-sectional study using non-probability, consecutive sampling. Setting: Department of Oral Pathology, Rehman College of Dentistry, Peshawar, Khyber Pakhtunkhwa, Pakistan. Period: January 2017 till June 2017. Material & Methods: 60 cases of oral squamous cell carcinoma were included. Half the cases (30) had a history of Naswar use while the other half (30) had no history of Naswar use. Data was analysed using SPSS v 22. Results: This study included 60% male and 40% female cases, ranging from 40 years to 80 years (mean = 57.6 + 11 years). Majority of patients 80% had well differentiated squamous cell carcinoma, while the rest (20%) had poorly differentiated. Distribution of male and female across both groups was equal (p 0.598). Both the groups were comparable in terms of grade of tumour (p 0.519). Conclusion: Naswar use was not associated with any particular histological grade of oral squamous cell carcinoma in our study. However, further research is needed to explore this association.

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