Microbiome Profile in Adult Balanoposthitis Patients: Relationship with Redundant Prepuce, Skin Physical Barrier Status and Inflammation

Abstract Background: Balanoposthitis is a common inflammatory condition of male genitalia, the microbiota spectrum have not been determined thus far. To profile the microbiome in patients with balanoposthitis (BP), and healthy controls (HC), and investigate its correlation with redundant prepuce, severity of inflammation, and disrupted skin barrier function, including skin pH, Transepidermal Water Loss (TEWL), and skin hydration.Results: In general, the microbiota between BP and HC were similar. The microbiota composition was different between BP and HC with redundant prepuce. Staphylococcus warneri and Prevotella bivia are two most abundant BP-associated Species, and positively correlated with disease severity. The physio-barrier function is markedly impaired in BP, shown by decreased skin hydration, while increased TEWL and pH.Conclusions: Staphylococcus warneri and Prevotella bivia showed a strong correlation with balanoposthitis and may be pathogenic for the condition.

Download Full-text

Effect of Topically Applied Wikstroemia dolichantha Diels on the Development of Atopic Dermatitis-Like Skin Symptoms in Mice

Nutrients ◽

10.3390/nu11040914 ◽

2019 ◽

Vol 11 (4) ◽

pp. 914 ◽

Cited By ~ 1

Author(s):

Jonghwan Jegal ◽

No-June Park ◽

Tae-Young Kim ◽

Sangho Choi ◽

Sang Woo Lee ◽

...

Keyword(s):

Atopic Dermatitis ◽

Barrier Function ◽

Immunoglobulin E ◽

Skin Barrier ◽

Skin Lesions ◽

Transepidermal Water Loss ◽

Skin Hydration ◽

Interleukin 4 ◽

Skin Barrier Function ◽

Skin Symptoms

Plants of the genus Wikstroemia are traditionally used to treat inflammatory diseases like bronchitis and rheumatoid arthritis. In the present study, the anti-atopic effects of an EtOH extract of Wikstroemia dolichantha (WDE) on oxazolone- and DNCB (2,4-dinitrochlorobenzene)-induced dermatitis in mice were investigated. Both ears of BALB/c mice were exposed to oxazolone, and dorsal skins of SKH-1 hairless mice were sensitized with DNCB to induce acute eczematous atopic skin lesions. 1% WDE was applied daily to oxazolone- and DNCB-induced AD mice for two or three weeks, respectively. Total IL-4 and IgE concentrations in serum, transepidermal water loss (TEWL) and skin hydration were assessed. High-performance liquid chromatography/mass spectrometry (HPLC/MS) was used to determine the composition of WDE. Dermal application of 1% WDE grossly and histopathologically improved oxazolone- and DNCB-induced AD skin symptoms. Epidermal thickness and mast cell infiltration were significantly lower in animals treated with WDE than in vehicle controls. Furthermore, in addition to reducing DNCB-induced increases in serum IL-4 (interleukin 4) and IgE (immunoglobulin E) levels, WDE also decreased TEWL and increased skin hydration (indicative of improved skin barrier function). The four flavonoids taxifolin, aromadendrin, padmatin and chamaejasmine were tentatively identified in WDE by HPLC-DAD/QTOF-MS. The above results show WDE protected against oxazolone- and DNCB-induced AD in mice by down-regulating the TH2-associated cytokine IL-4 and improving skin barrier function and suggest WDE might be useful for the management of atopic dermatitis.

Download Full-text

Two New Dexpanthenol-Containing Wash Gels: Skin Hydration, Barrier Function and Cosmetic Performance upon Single and Repeated Usage in Subjects with Dry Skin

Cosmetics ◽

10.3390/cosmetics8020044 ◽

2021 ◽

Vol 8 (2) ◽

pp. 44

Author(s):

Ana Barrionuevo-Gonzalez ◽

Sonja Trapp ◽

Raffaella de Salvo ◽

Rozalia Olsavszky ◽

Elena Alina Nanu ◽

...

Keyword(s):

Barrier Function ◽

Skin Barrier ◽

Transepidermal Water Loss ◽

The Body ◽

Skin Hydration ◽

Skin Barrier Function ◽

Lauryl Sulfate ◽

Dry Skin ◽

Study Results ◽

Forearm Skin

Two novel body/face wash gels enriched with emollient ingredients (including dexpanthenol) were developed for the daily care of dry skin. Two similarly designed 2-week studies (N = 42 each) were conducted to assess the biophysical and cosmetic performance of each of the new wash gels in healthy adults with dry skin. Instrumental measurements quantified the effects of the wash gels on stratum corneum (SC) hydration and transepidermal water loss (TEWL) (with and without a previous sodium lauryl sulfate (SLS) challenge) after single and repeated usage. Following single and repeated applications of the face wash gel to facial skin, as well as to dry SLS-undamaged and SLS-damaged skin of the forearm, skin hydration significantly increased. Similarly, after single and repeated usage of the body wash gel to dry SLS-undamaged and SLS-damaged skin of the forearm, skin moisturization increased significantly from baseline; comparisons with control areas provided inconsistent results for SLS-undamaged skin. No effects on TEWL were observed for either product. Both wash gels were well tolerated and the cosmetic performances were appreciated by the subjects. The study results suggest that daily use of the new wash gels was associated with significant skin-moisturizing effects without adversely affecting skin barrier function and repair.

Download Full-text

Effect of Ectoin Dermatitis Cream 7% on Skin Hydration and Skin Barrier Function

Case Medical Research ◽

10.31525/ct1-nct04097327 ◽

2019 ◽

Author(s):

Keyword(s):

Barrier Function ◽

Skin Barrier ◽

Skin Hydration ◽

Skin Barrier Function

Download Full-text

Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity

Journal of Clinical Medicine ◽

10.3390/jcm10020359 ◽

2021 ◽

Vol 10 (2) ◽

pp. 359 ◽

Cited By ~ 1

Author(s):

Trinidad Montero-Vilchez ◽

María-Victoria Segura-Fernández-Nogueras ◽

Isabel Pérez-Rodríguez ◽

Miguel Soler-Gongora ◽

Antonio Martinez-Lopez ◽

...

Keyword(s):

Atopic Dermatitis ◽

Disease Severity ◽

Water Loss ◽

Barrier Function ◽

Skin Barrier ◽

Transepidermal Water Loss ◽

Diagnostic Tools ◽

Psoriatic Skin ◽

Skin Barrier Function ◽

Healthy Controls

Multiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objectively measured and could help clinicians to evaluate disease severity accurately. Thus, the aims of this study are: (1) to compare skin barrier function between healthy skin, psoriatic skin and AD skin; and (2) to assess if skin barrier function parameters could predict disease severity. A cross-sectional study was designed, and epidermal barrier function parameters were measured. The study included 314 participants: 157 healthy individuals, 92 psoriatic patients, and 65 atopic dermatitis patients. TEWL was significantly higher, while stratum corneum hydration (SCH) (8.71 vs. 38.43 vs. 44.39 Arbitrary Units (AU)) was lower at psoriatic plaques than at uninvolved psoriatic skin and healthy controls. Patients with both TEWL > 13.85 g·m−2h−1 and temperature > 30.85 °C presented a moderate/severe psoriasis (psoriasis area severity index (PASI) ≥ 7), with a specificity of 76.3%. TEWL (28.68 vs. 13.15 vs. 11.60 g·m−2 h−1) and temperature were significantly higher, while SCH (25.20 vs. 40.95 vs. 50.73 AU) was lower at AD eczematous lesions than uninvolved AD skin and healthy controls. Patients with a temperature > 31.75 °C presented a moderate/severe AD (SCORing Atopic Dermatitis (SCORAD) ≥ 37) with a sensitivity of 81.8%. In conclusion, temperature and TEWL values may help clinicians to determine disease severity and select patients who need intensive treatment.

Download Full-text

Light TCA peels for skin rejuvenation: Effects on skin hydration, skin barrier function and skin elasticity

Journal of the European Academy of Dermatology and Venereology ◽

10.1016/s0926-9959(98)95062-0 ◽

1998 ◽

Vol 11 ◽

pp. S139

Author(s):

P TEOFOLI

Keyword(s):

Barrier Function ◽

Skin Barrier ◽

Skin Hydration ◽

Skin Barrier Function ◽

Skin Elasticity ◽

Skin Rejuvenation

Download Full-text

Immediate and long-term effects of polysaccharides-based formulations on human skin

Brazilian Journal of Pharmaceutical Sciences ◽

10.1590/s1984-82502012000300022 ◽

2012 ◽

Vol 48 (3) ◽

pp. 547-555 ◽

Cited By ~ 7

Author(s):

Flavio Bueno de Camargo Junior ◽

Lorena Rigo Gaspar ◽

Patrícia Maria Berardo Gonçalves Maia Campos

Keyword(s):

Barrier Function ◽

Skin Barrier ◽

Skin Hydration ◽

Skin Barrier Function ◽

Cell Renewal ◽

Myrtus Communis ◽

Long Term Effects ◽

Subjective Analysis ◽

Cosmetic Formulations

A new trend in cosmetic formulations is the use of biotechnological raw materials as the polysaccharides from Klebsiella pneumoniae, which are supposed to enhance cell renewal, improve skin hydration and micro-relief. Botanical extracts of Myrtus communis leaves contain different sugars, which may provide the same benefits. Thus, the objective of this study was to evaluate through objective and subjective analysis the immediate and long-term effects of cosmetic formulations containing polysaccharides biotechnologically-originated and / or the ones contained in Myrtus communis extracts. Three polysaccharide-based and placebo formulations were applied on the forearm skin of 40 volunteers. Skin hydration, transepidermal water loss (TEWL), viscoelasticity and skin micro-relief measurements were made before and 2 hours after a single application and after 15 and 30 day-periods of daily applications. Answers to a questionnaire about perceptions of formulation cosmetic features constituted the subjective analysis. All polysaccharide-based formulations enhanced skin hydration. Formulations with isolated or combined active substances improved skin barrier function as compared to placebo, in the short and long term studies. Formulations containing Myrtus communis extracts had the highest acceptance. Results suggest that daily use of formulations containing these substances is important for protection of the skin barrier function.

Download Full-text

Effects of Cast Immobilisation on Skin Barrier Function

Annals of the Academy of Medicine, Singapore ◽

10.47102/annals-acadmedsg.2019170 ◽

2020 ◽

Vol 49 (6) ◽

pp. 354-359

Author(s):

Chin Yee Woo ◽

Mark JA Koh ◽

Winnie KY Fung ◽

Cheri SH Chan ◽

Chong Bing Chua ◽

...

Keyword(s):

Stratum Corneum ◽

Water Loss ◽

Barrier Function ◽

Skin Irritation ◽

Skin Barrier ◽

Transepidermal Water Loss ◽

Skin Barrier Function ◽

Hair Density ◽

Cast Immobilisation ◽

Volar Surface

Introduction: Cast immobilisation remains the mainstay of treatment for various fractures in paediatric patients, yet patients commonly complain of skin irritation and discomfort. This study aimed to perform a qualitative and quantitative evaluation of the effects of cast immobilisation on the skin of children and adolescents. Materials and Methods: Patients aged 6–17 years of age with a fracture treated in a fiberglass short-arm or short-leg cast were recruited. Transepidermal water loss (TEWL), stratum corneum (SC) hydration, hair density and presence of any skin signs were assessed before and after cast. Patients were required to complete a weekly questionnaire to rate itch, malodour, warmth, and dampness of the skin under the cast. Results: A total of 60 subjects completed the study. Thirty-six patients received a short-arm cast; 24 received a short-leg cast. Upon cast removal, TEWL was significantly increased on the volar surface of the arms and legs (P <0.05), and the dorsal surface of the arm (P <0.05). Likewise, SC hydration was significantly increased at most sites (P <0.05), except the volar surface of the leg (P = 0.513). There was no change in hair density. Throughout the duration of casting, there was an increase in itch and malodour scores. Conclusions: Moderate but significant changes in TEWL, SC hydration and subjective symptoms were observed during the duration of cast immobilisation, demonstrating that cast immobilisation for up to 4 weeks exerts moderate adverse impact on patients’ skin. Further studies to explore the use of better materials for cast immobilisation to improve skin barrier function and overall patient satisfaction are warranted. Ann Acad Med Singapore 2020;49:285–93 Ann Acad Med Singapore 2020;49:354–59 Key words: Cast immobilisation, Transepidermal water loss, Stratum corneum hydration

Download Full-text