Prognosis and risk factors of cardiac valve calcification in Chinese end-stage renal disease patients

Abstract Background Cardiac valve calcification (CVC) was an important risk factor for cardiovascular complication. But the prevalence, clinical features and risk factors for CVC in ESRD patients were not fully clear at present. In this study, we explored the possible risk factors and clinical characteristics of CVC happened in Chinese ESRD patients. Methods We conducted a retrospective case-control study on 433 cases of ESRD patients who received maintenance dialysis (MHD) for at least 3 months in the First Affiliated Hospital of Chongqing Medical University from October 2014 to December 2015. 93 patients were confirmed to happen cardiac valve calcification (CVC) by echocardiography, and 200 patients without CVC in the same period as control, matched with age and gender. The demographic data, clinical characteristics, and laboratory parameters of the two groups were analyzed. Results Of 433 cases of ESRD patients, the average annual incidence of CVC was 30.3%. The most common calcification was in aortic valve, followed by mitral valve. Dialysis age (P = 0.006, OR = 2.25), serum calcium (P = 0.046, OR = 2.04), diabetes (P = 0.037, OR = 1.81), and pulse pressure ( P < 0.001, OR = 3.22) were the risk factors of CVC, but serum albumin ( P = 0.047, OR = 0.54) was a protective factor for CVC. The ESRD patients with CVC were also more likely to suffer from arrhythmia, heart failure and coronary heart disease (CHD), and the all-cause mortality also increased significantly. Conclusions High prevalence of CVC happened in Chinese ESRD patients, which was a risk signal for severe atherosclerosis, more morbidity and mortality of cardiovascular events in ESRD patients. Dialysis age, serum calcium, diabetes, and pulse pressure were the independent risk factors of CVC in ESRD patients, while serum albumin was a protective factor.

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Risk Factors Associated with Left-Sided Cardiac Valve Calcification: A Case Control Study

Cardiology ◽

10.1159/000443203 ◽

2016 ◽

Vol 134 (1) ◽

pp. 26-33 ◽

Cited By ~ 2

Author(s):

Minyong Jiang ◽

Lan Wang ◽

Qinkao Xuan ◽

Yongfeng Shao ◽

Xiangqing Kong ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Valve Replacement ◽

Protective Factor ◽

Cardiac Valve ◽

Valve Calcification ◽

Factors Associated ◽

Cardiac Valve Calcification ◽

Glutamyl Transferase ◽

Valve Lesion

Objectives: To identify risk factors associated with cardiac valve calcification that is easily detectable through routine blood tests in patients who received valve replacement therapy. Methods: Four hundred patients with valvular heart disease who underwent valve replacement surgery between December 2009 and January 2013 were enrolled in this study. Of these, 77 had valve calcification; the other 323 did not. Multivariate logistic regression analysis was used to assess for risk factors associated with valve calcification. Results: In our study population, rheumatic valve lesions were the most common reason for valve replacement. Degenerative nonstenotic valve lesion was a protective factor and degenerative stenotic valve lesion was a strong risk factor for valve calcification. Serum levels of gamma-glutamyl transferase (GGT) of between 30 and 46 IU/l and >90 IU/l and total bilirubin (TBIL) of between 15 and 20 μmol/l were positively correlated with valve calcification. Meanwhile, serum calcium (Ca2+) levels of between 2.3 and 2.4 mmol/l were negatively correlated with rheumatic valve calcification. Conclusions: Degenerative stenotic lesion is a risk factor and degenerative nonstenotic lesion a protective factor for cardiac valve calcification. Serum GGT and TBIL levels are positively correlated and serum Ca2+ levels negatively correlated with rheumatic cardiac valve calcification.

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Intelligent diagnosis of cardiac valve calcification in ESRD patients with peritoneal dialysis based on improved Takagi-Sugeno-Kang fuzzy system

International Journal of Bio-Inspired Computation ◽

10.1504/ijbic.2019.10021693 ◽

2019 ◽

Vol 13 (4) ◽

pp. 277

Author(s):

Raymond F. Muzic <suffix>Jr.</suffix> ◽

Liang Wang ◽

Yizhang Jiang ◽

Yue Zhang ◽

Jia Hua ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Fuzzy System ◽

Cardiac Valve ◽

Valve Calcification ◽

Intelligent Diagnosis ◽

Cardiac Valve Calcification ◽

Takagi Sugeno ◽

Esrd Patients

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Intelligent diagnosis of cardiac valve calcification in ESRD patients with peritoneal dialysis based on improved Takagi-Sugeno-Kang fuzzy system

International Journal of Bio-Inspired Computation ◽

10.1504/ijbic.2019.100147 ◽

2019 ◽

Vol 13 (4) ◽

pp. 277

Author(s):

Jing Xue ◽

Yizhang Jiang ◽

Yue Zhang ◽

Jia Hua ◽

Weiwei Li ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Fuzzy System ◽

Cardiac Valve ◽

Valve Calcification ◽

Intelligent Diagnosis ◽

Cardiac Valve Calcification ◽

Takagi Sugeno ◽

Esrd Patients

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P1391PROGRESSION OF CALCIFICATION AND ITS RISK FACTORS IN CHINESE DIALYSIS PATIENTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p1391 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Zhihong Liu

Keyword(s):

Risk Factors ◽

Computed Tomography ◽

Vascular Calcification ◽

Multivariate Logistic Regression Analysis ◽

Cardiac Valve ◽

Dialysis Patients ◽

Valve Calcification ◽

Predictive Values ◽

Cardiac Valve Calcification

Abstract Background and Aims The China Dialysis Calcification Study (CDCS) aims to investigate prevalence and progression of vascular calcification (VC) as well as predictive values of VC in Chinese dialysis patients. This abstract reports VC progression and its risk factors during 4-year follow-up. Method The CDCS is a nationwide, multicenter observational study. 1497 dialysis patients from 24 centers in China were enrolled from 2014-2015 and continuously followed up for 4 years. Coronary artery calcification (CAC), abdominal aortic calcification (AAC) and cardiac valve calcification (CVC) were assessed at baseline and 4-year follow-up. CAC was assessed by Agatston score measured by electron beam computed tomography or multi-detector computed tomography. AAC was assessed by Kauppila score measured by plain lateral lumbar radiograph. CVC was measured by echocardiography. Progression was defined by comparing VC images at baseline with those at 4-year. When CAC/AAC scores at 4-year were greater than baseline, CAC/AAC were considered progressed; when there were more cardiac valves involved at 4-year than baseline, CVC was considered progressed. Logistic progression model was used to investigate the risk factors for calcification progression. Results 711 patients completed 4-year follow-up and 680 of them had calcification tests. Patients had the same type assessments (CAC, AAC or CVC) at both baseline and 4-year were included in analysis. At the 4-year follow-up, 89.4% (608/680) patients had at least one site vascular calcification (CAC, AAC or CVC), CAC affected the highest proportion of patients. Prevalence of CAC, AAC and CVC were 81.0% (517/638), 79.3% (310/391) and 45.6% (308/675), respectively. Progression of CAC was observed in 93.9% (368/392) patients with presence of baseline CAC, and 51.3% (123/240) patients without baseline CAC. CAC progression at 4-year follow-up was stratified by baseline CAC score (Figure1). Progression of AAC was observed in 96.5% (165/171) patients with presence of baseline AAC, and 63.8% (139/218) patients without baseline AAC. AAC progression at 4-year follow-up was stratified by baseline AAC score (Figure2). Progression of CVC from single to double cardiac valve calcification was observed in 33.3% (40/120) patients, and cardiac valve calcification occurred in 33.4% (162/485) patients without baseline CVC after 4-year follow-up. Multivariate logistic regression analysis results are showed in Figure3. Variables significantly increased the risk of calcification progression were baseline calcification score, abdominal obesity, hypertension, and calcium, phosphorous, iPTH during 4-year follow-up. Conclusion In the 4 years follow-up, progression of calcification is common among dialysis patient, and is associated with higher baseline severity, medical history and disease management.

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Cardiac valve calcification in predialysis chronic kidney disease patients: Prevalence and risk factors

Timocki medicinski glasnik ◽

10.5937/tmg1401005t ◽

2014 ◽

Vol 39 (1) ◽

pp. 5-13

Author(s):

Biserka Tirmenstajn-Jankovic ◽

Dusan Bastac ◽

Sanja Milosevic ◽

Svetlana Zikic ◽

Milenko Zivanovic

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Cardiac Valve ◽

Valve Calcification ◽

Cardiac Valve Calcification

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Risk Factors for New-Onset Cardiac Valve Calcification in Patients on Maintenance Peritoneal Dialysis

Cardiorenal Medicine ◽

10.1159/000443620 ◽

2016 ◽

Vol 6 (2) ◽

pp. 150-158 ◽

Cited By ~ 3

Author(s):

Yunhuan Tian ◽

Sheng Feng ◽

Zhoubing Zhan ◽

Ying Lu ◽

Yancai Wang ◽

...

Keyword(s):

Risk Factors ◽

Peritoneal Dialysis ◽

Antihypertensive Drugs ◽

Mineral Metabolism ◽

Multivariate Logistic Regression Analysis ◽

Cardiac Valve ◽

Valve Calcification ◽

Dialysis Duration ◽

Cardiac Valve Calcification ◽

New Onset

Objective: Patients with end-stage renal disease are susceptible to cardiac valve calcification (CVC) due to mineral metabolism disorders and other factors. The purpose of this study was to investigate the risk factors for new-onset CVC in patients on maintenance peritoneal dialysis (PD). Methods: This study included patients who underwent PD catheter insertion from January 2006 to June 2013 in our Peritoneal Dialysis Center. Clinical data were collected on CVC status during echocardiography evaluations (twice) at an interval of >6 months. The data collected included intact parathyroid hormone, C-reactive protein (CRP), serum phosphorus (P), serum calcium (Ca), albumin (Alb), prealbumin and the use of five types of antihypertensive drugs, statins, active vitamin D3 and Ca tablets. Results: In total, 194 patients - 105 (54.1%) men, average age 60.5 ± 13.0 years - were included. CVC was present in 50 (25.8%) patients during PD catheter placement. After an average PD duration of 20.9 ± 10.4 months, CVC was detected in 97 patients (50.0%). New-onset CVC was found in 62 patients (32.0%). Multivariate logistic regression analysis revealed that only serum P levels (p = 0.01, OR = 2.569), Alb levels (p = 0.04, OR = 0.935), dialysis duration (p = 0.03, OR = 1.039) and CRP levels (p = 0.02, OR = 1.031) were associated with CVC. Conclusion: Serum P, Alb and CRP levels as well as dialysis duration are independent risk factors for CVC.

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