Effects of Hamo NK hard capsule on experimental atherosclerosis model

This study evaluated the effects of Hamo NK hard capsule on athresclerosis using experimental atherosclerosis model. NewZealand White rabbits were fed a high-fat diet (HFD) containing cholesterol and peanut oil. The animals received oral administration of HFD and Hamo NK hard capsule at two doses of 0.126 and 0.378 g/kg bw/day for 8 consecutive weeks. Blood samples were collected for analyis of biochemical parameters at before treatment, week 4 and week 8. Histopathology assessments of the aortic artery and liver were carried out at the end of the experiment. Hamo NK was effective in reducing serum triglyceride level after 8 weeks of the experiment. In addition, Hamo NK at two doses of 0.126 g/kg b.w and 0.378 g/kg b.w for 8 consecutive weeks did not affect the cholesterol, LDL-C and HDL-C concentrations induced by a HFD. Hamo NK at the dose of 0.126 g/kg bw/day was not only able to decrease significant aortic surface lesions but also capable of managing atherosclerosis plaques formation in aorta; whereas theses activities were not notiaceable at the dose of 0.378 g/kg b.w.

“Wilkie’s Syndrome: Case Report”

Superior Mesenteric Artery or Wilkie Syndrome is a rare cause of duodenal obstruction and results from compression of the third portion of the duodenum by the superior mesenteric artery and the aortic artery.

880. Artificial Neural Networks to Predict Surgical Site Infection in Aorta Artery Aneurysm Correction

Background A survey was conducted in three hospitals, between July 2016 and June 2018, about surgical site infection (SSI) in patients undergoing surgeries to correct aortic artery aneurysms in the city of Belo Horizonte, with more than 3,000,000 of inhabitants. The general objective is to statistically evaluate such incidences and enable an analysis of the predictive power of SSI, through MLP (Multilayer Perceptron) pattern recognition algorithms. Methods Through the Hospital Infection Control Committees (CCIH) of the hospitals involved in the research, data collection on SSI was carried out. Such data is used in the analysis during your routine SSI surveillance procedures. Thus, three procedures were performed: a treatment of the database collected for use of intact samples; a statistical analysis on the profile of the collected hospitals and; an assessment of the predictive power of five types of MLPs (Backpropagation Standard, Momentum, Resilient Propagation, Weight Decay and Quick Propagation) for SSI prediction. The MLPs were tested with 3, 5, 7 and 10 neurons in the hidden layer and with a division of the database for the resampling process (65% or 75% for testing, 35% or 25% for validation). They were compared by measuring the AUC (Area Under the Curve - ranging from 0 to 1) for each of the configurations. Results From 600 records, 575 were complete for analysis. It was found that: the average age is 68 years (from 24 to 98 years); the average hospital stay is 9 days (with a maximum of 127 days), the death rate reached 6.43% and the SSI rate 2.78%. A maximum prediction power of 0.75 was found. Conclusion There was a loss of 4% of the database samples due to the presence of noise. It was possible to evaluate the profile of the three hospitals. The predictive process presented configurations with results that reached 0.75, which promises the use of the structure for the monitoring of automated SSI for patients undergoing surgery to correct aortic artery aneurysms. To optimize data collection, enable other hospitals to use the prediction tool and minimize noise from the database, two mobile application were developed: one for monitoring the patient in the hospital and another for monitoring after hospital discharge. The SSI prediction analysis tool is available at www.nois.org.br. Disclosures All Authors: No reported disclosures

Acute thermal stress promotes morphological and molecular changes in the heart of broiler chickens

This study aimed to understand the possible effects of acute thermal stress (32ºC, 12 hours) on body temperature using two measurement methods (via probe and rectal), on the morphometric aspects of the heart and aortic artery, on gene expression (superoxide dismutase, glutathione peroxidase-3, nitric oxide synthase, angiotensin-converting enzyme and esterified cholesterol transfer protein), inflammatory parameters (myeloperoxidase and N-acetylglycosaminidase), oxidative stress parameters and nitrite levels in broilers (Cobb 500) at 42 days of age. 36 broilers with 42 days of age were used, distributed in a 2x2 factorial scheme: two thermal environments (comfort at 18ºC and stress at 32ºC) and two methods of measuring body temperature (via probe and rectal). Thermal stress triggered an increase in body temperature regardless of the measurement method. There was a significant effect on the thickness of the aortic artery wall and on the lateral lateral and posterior antero diameters (P <0.05). Likewise, there was a difference in the dosages of lipid hydroperoxides, in the quantification of reactive oxygen species and in the dosage of nitrite (P <0.05). The quantification of the mRNA of the induced nitric oxide synthase, angiotensin-converting enzyme and esterified cholesterol transfer protein genes were significantly higher in animals subjected to heat stress. Thus, it can be concluded that acute thermal stress was able to promote several morphological and molecular changes in the heart and aorta artery of broilers.