scholarly journals Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort

2021 ◽  
Author(s):  
Sirena Soriano ◽  
Kristen Curry ◽  
Saeed Sadrameli ◽  
Qi Wang ◽  
Michael Nute ◽  
...  
Keyword(s):  
Head Injury ◽  
Gut Microbiome ◽  
Bacterial Species ◽  
Division I ◽  
Blood Levels ◽  
Football Players ◽  
Athletic Activity ◽  
Biomarker Analysis ◽  
Collegiate Football

Abstract Concussions, both single and repetitive, during contact sports cause brain and body alterations in athletes. The role of the brain-gut connection and changes in the microbiota have not been well established after a head injury or concussion-related health consequences. We recruited 33 Division I Collegiate football players and collected blood, stool, and saliva samples throughout the athletic season. Analysis of the gut microbiome reveals a decrease in abundance for two bacterial species, Eubacterium rectale and Anaerostipes hadrus, after a diagnosed concussion. No significant differences were found regarding the salivary microbiome. Serum biomarker analysis shows an increase in GFAP blood levels in athletes during athletic activity. Additionally, S100β and SAA blood levels were positively correlated with the abundance of Eubacterium rectale species among athletes exposed to subconcussive impacts. These novel findings provide evidence that detecting changes in the gut microbiome may pave the way for improved concussion diagnosis following head injury.

scholarly journals Alterations to the gut microbiome after sport-related concussion and subconcussive impacts in a collegiate football players cohort.

2021 ◽  
Author(s):  
Sirena Soriano ◽  
Kristen Curry ◽  
Saeed Sadrameli ◽  
Qi Wang ◽  
Michael Nute ◽  
...  
Keyword(s):  
Head Injury ◽  
Gut Microbiome ◽  
Bacterial Species ◽  
Division I ◽  
Blood Levels ◽  
Football Players ◽  
Biomarker Analysis ◽  
Subconcussive Impacts ◽  
Collegiate Football

Concussions, both single and repetitive, during contact sports cause brain and body alterations in athletes. The role of the brain-gut connection and changes in the microbiota have not been well established after a head injury or concussion-related health consequences. We recruited 33 Division I Collegiate football players and collected blood, stool, and saliva samples throughout the athletic season. Analysis of the gut microbiome reveals a decrease in abundance for two bacterial species, Eubacterium rectale and Anaerostipes hadrus, after a diagnosed concussion. No significant differences were found regarding the salivary microbiome. Serum biomarker analysis shows an increase in GFAP blood levels in athletes during athletic activity. Additionally, S100β and SAA blood levels were positively correlated with the abundance of Eubacterium rectale species among athletes exposed to subconcussive impacts. These novel findings provide evidence that detecting changes in the gut microbiome may pave the way for improved concussion diagnosis following head injury.

scholarly journals Protective Football Headgear and Peripheral Visuomotor Ability in NCAA Football Athletes: The Role of Facemasks and Visors

2021 ◽  
Vol 6 (2) ◽  
pp. 34
Author(s):  
Christopher G. Ballmann ◽  
Anna C. Covington ◽  
Rachel A. Miller ◽  
Rebecca R. Rogers
Keyword(s):  
Reaction Time ◽  
Division I ◽  
Football Players ◽  
Visual Areas ◽  
Peripheral Areas ◽  
Player Performance ◽  
Collegiate Football ◽  
Visuomotor Performance

The purpose of this investigation was to determine the effects of varying facemask reinforcement and visor tint on peripheral visuomotor abilities in collegiate football players. Division I NCAA football players (n = 14) completed two peripheral visuomotor experiments: (1) Varying facemask reinforcement, (2) Varying visor tinting. In experiment 1, participants were tested under the following conditions: baseline (no helmet; BL), helmet + light (HL), helmet + medium (HM), helmet + heavy (HH), and helmet + extra heavy (HXH) reinforced facemasks. In experiment 2, participants were tested under the following conditions: baseline (no helmet; BL), helmet only (HO), helmet + clear (HCV), helmet + smoke-tinted (HSV), and helmet + mirror-tinted (HMV) visors. For each condition, a 60 s peripheral visuomotor test was completed on a Dynavision D2 visuomotor board. For experiment 1, the BL peripheral reaction time (PRT) was faster than all facemask conditions (p < 0.05). Furthermore, PRT was impaired with the HXH compared to HL (p < 0.001), HM (p < 0.001), and HH (p = 0.001). Both HH and HXH resulted in the potentiation of PRT impairments in the outermost and inferior peripheral visual areas (p < 0.05). In experiment 2, BL PRT was faster than all helmeted conditions (p < 0.05). Additionally, PRT was slower in HSV (p = 0.013) and HMV (p < 0.001) conditions compared to HO. HMV resulted in slower PRT in all peripheral areas (p < 0.05) while PRT was impaired only in outer areas for HSV (p < 0.05). Wearing protective football headgear impairs peripheral visuomotor ability. Lighter reinforced facemasks and clear visors do not appear to exacerbate impairment. However, heavier reinforced facemasks and tinted visors further decrease visuomotor performance in outer and inferior visual areas, indicating a potential need for considerations of on-field player performance and safety.

scholarly journals Association of Flavonifractor plautii, a Flavonoid-Degrading Bacterium, with the Gut Microbiome of Colorectal Cancer Patients in India

mSystems ◽  
2019 ◽  
Vol 4 (6) ◽  
Author(s):  
Ankit Gupta ◽  
Darshan B. Dhakan ◽  
Abhijit Maji ◽  
Rituja Saxena ◽  
Vishnu Prasoodanan P.K. ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Gut Microbiome ◽  
Association Studies ◽  
Bacterial Species ◽  
Developed Countries ◽  
Learning Approaches ◽  
Gene Markers ◽  
Degrading Bacterium

ABSTRACT Recently, dysbiosis in the human gut microbiome and shifts in the relative abundances of several bacterial species have been recognized as important factors in colorectal cancer (CRC). However, these studies have been carried out mainly in developed countries where CRC has a high incidence, and it is unclear whether the host-microbiome relationships deduced from these studies can be generalized to the global population. To test if the documented associations between the microbiome and CRC are conserved in a distinct context, we performed metagenomic and metabolomic association studies on fecal samples from 30 CRC patients and 30 healthy controls from two different locations in India, followed by a comparison of CRC data available from other populations. We confirmed the association of Bacteroides and other bacterial taxa with CRC that have been previously reported in other studies. However, the association of CRC with Flavonifractor plautii in Indian patients emerged as a novel finding. The plausible role of F. plautii appears to be linked with the degradation of beneficial anticarcinogenic flavonoids, which was also found to be significantly correlated with the enzymes and modules involved in flavonoid degradation within Indian CRC samples. Thus, we hypothesize that the degradation of beneficial flavonoids might be playing a role in cancer progression within this Indian cohort. We also identified 20 potential microbial taxonomic markers and 33 potential microbial gene markers that discriminate the Indian CRC from healthy microbiomes with high accuracy based on machine learning approaches. IMPORTANCE This study provides novel insights on the CRC-associated microbiome of a unique cohort in India, reveals the potential role of a new bacterium in CRC, and identifies cohort-specific biomarkers, which can potentially be used in noninvasive diagnosis of CRC. The study gains additional significance, as India is among the countries with a very low incidence of CRC, and the diet and lifestyle in India have been associated with a distinct gut microbiome in healthy Indians compared to other global populations. Thus, in this study, we hypothesize a unique relationship between CRC and the gut microbiome in an Indian population.

scholarly journals Frequency of Head-Impact–Related Outcomes by Position in NCAA Division I Collegiate Football Players

2015 ◽  
Vol 32 (5) ◽  
pp. 314-326 ◽  
Author(s):  
Christine M. Baugh ◽  
Patrick T. Kiernan ◽  
Emily Kroshus ◽  
Daniel H. Daneshvar ◽  
Philip H. Montenigro ◽  
...  
Keyword(s):  
Ncaa Division I ◽  
Head Impact ◽  
Division I ◽  
Football Players ◽  
Collegiate Football

Lifetime prevalence of injuries in incoming division I collegiate football players

2017 ◽  
Vol 45 (4) ◽  
pp. 458-462 ◽  
Author(s):  
Nikolas Sarac ◽  
William Haynes ◽  
Angela Pedroza ◽  
Christopher Kaeding ◽  
James Borchers
Keyword(s):  
Division I ◽  
Lifetime Prevalence ◽  
Football Players ◽  
Collegiate Football

scholarly journals Metagenome-wide association study of gut microbiome features for myositis

2021 ◽  
Author(s):  
Yimin Li ◽  
Jun Xu ◽  
Zijun Li ◽  
Yixue Guo ◽  
Xiaoyan Xing ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Gut Microbiome ◽  
Association Studies ◽  
Bacterial Species ◽  
Biological Pathways ◽  
Healthy Controls ◽  
E Coli

Objective: The clinical relevance and pathogenic role of gut microbiome in both myositis and its associated interstitial lung disease (ILD) are still unclear. The purpose of this study was to investigate the role of gut microbiome in myositis through comprehensive metagenomic-wide association studies (MWAS). Methods We conducted MWAS of the myositis gut microbiome in a Chinese cohort by using whole-genome shotgun sequencing of high depth, including 30 myositis patients and 31 healthy controls (HC). Among the myositis patients, 11 developed rapidly progressive interstitial lung disease (RP-ILD) and 10 had chronic ILD (C-ILD). Our MWAS consisted of both overall distribution level of the bacteria analysis and pathway analysis. Receiver operating characteristic curve (ROC) analysis was performed to identify novel gut bacterial species associated with myositis or myositis-associated RP-ILD, and to evaluate their diagnostic values. Results Apparent discrepancy in β diversities of metagenome was found in the comparison of myositis and HC, RP-ILD and C-ILD in myositis. Analysis for overall distribution level of the bacteria showed Alistipes onderdonkii, Parabacteroides distasonis and Escherichia coli were upregulated, Lachnospiraceae bacterium GAM79, Roseburia intestinalis, and Akkermansia muciniphila were downregulated in patients with myositis compared to HC. Bacteroides thetaiotaomicron, Parabacteroides distasonis and Escherichia coli were upregulated, Bacteroides A1C1 and Bacteroides xylanisolvens were downregulated in RP-ILD cases compared with C-ILD cases. A variety of biological pathways related to metabolism were enriched in the myositis and HC, RP-ILD and C-ILD comparison. And in the analyses for microbial contribution in metagenomic biological pathways, we have found that E. coli played an important role in the pathway expression in both myositis group and myositis-associated RP-ILD group. Anti-PL-12 antibody, anti-Ro-52 antibody, and anti-EJ antibody were found to have positive correlation with bacterial diversity (Shannon-wiener diversity index and Chao1, richness estimator) between myositis group and control groups. The combination of E. coli and R. intestinalis could distinguish myositis group from Healthy controls effectively. R. intestinalis can also be applied in the distinguishment of RP-ILD group vs. C-ILD group in myositis paitents. Conclusion Our MWAS study first revealed the link between gut microbiome and pathgenesis of myositis, which may help us understand the role of gut microbiome in the etiology of myositis and myositis-associated RP-ILD.

Characteristics of the Electrocardiogram of Incoming Division I Freshmen or Transfer Collegiate Football Players

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S29
Author(s):  
Stephen F. Crouse ◽  
Brent E. Hansen ◽  
Thomas H. Meade ◽  
Greg S. Miller ◽  
Grady Kaiser ◽  
...  
Keyword(s):  
Division I ◽  
Football Players ◽  
Collegiate Football

Examination of Body Mass Changes Among Division I Collegiate Football Players With Sickle Cell Trait

2021 ◽  
pp. 1-6
Author(s):  
Rebecca M. Hirschhorn ◽  
Jessica L. Phillips Gilbert ◽  
Danielle A. Cadet ◽  
Tenley E. Murphy ◽  
Clinton Haggard ◽  
...  
Keyword(s):  
Body Mass ◽  
Sickle Cell ◽  
Student Athletes ◽  
Sickle Cell Trait ◽  
American Football ◽  
Division I ◽  
Football Players ◽  
Significant Difference ◽  
Body Mass Changes ◽  
Collegiate Football

American football athletes are frequently hypohydrated before and during activity. Hypohydration increases the risk of exertional sickling in student-athletes with sickle cell trait (SCT). The authors examined weight charts from the 2010/2011 to 2018/2019 seasons at one Division I institution to determine if differences in percentage body mass losses (%BML) exist between those with and without SCT. Seventeen student-athletes with SCT and 17 matched-controls were included. A Bonferroni correction was applied to account for multiple comparisons (0.05/8), resulting in p < .006 considered significant. There was a significant difference for %BML between groups (SCT: 0.84 ± 0.65% vs. control: 1.21 ± 0.71%; p = .002) but not for the number of days %BML exceeded 2% (SCT: 0 ± 1 vs. control: 1 ± 1; p = .016). Implementation of proper hydration strategies minimized %BML in athletes with SCT, decreasing the risk of hypohydration and exertional sickling. The same strategies ensured all players remained below threshold to optimize performance and reduce heat illness risk.

Sweat and Sodium Losses in NCAA Football Players: A Precursor to Heat Cramps?

2005 ◽  
Vol 15 (6) ◽  
pp. 641-652 ◽  
Author(s):  
John R. Stofan ◽  
Jeffrey J. Zachwieja ◽  
Craig A. Horswill ◽  
Robert Murray ◽  
Scott A. Anderson ◽  
...  
Keyword(s):  
Fluid Intake ◽  
Division I ◽  
Football Players ◽  
Sweat Loss ◽  
Fluid Deficit ◽  
Wide Variability ◽  
History Of ◽  
Collegiate Football ◽  
Fluid Losses ◽  
Sweat Sodium

This observational study was designed to determine whether football players with a history of heat cramps have elevated fluid and sodium losses during training. During a “two-a-day” training camp, five Division I collegiate football players (20.2 ± 1.6 y, 113 ± 20 kg) with history of heat cramps (C) were matched (weight, age, race and position) with a cohort of teammates (19.6 ± 0.6 y, 110 ± 20 kg) who had never cramped (NC). Change in body weight (adjusted by fluid intake) determined gross sweat loss. Sweat samples (forearm patch) were analyzed for sodium and potassium concentrations. Adlibitum fluid intake was measured by recording pre- and post-practice bottle weights. Average sweat sodium loss for a 2.5-h practice was projected at 5.1 ± 2.3 g (C) vs. 2.2 ± 1.7 g (NC). When averaged across two practices within the day, fluid intake was similar between groups (C: 2.6 ± 0.8 L vs. NC: 2.8 ± 0.7 L), as was gross sweat loss (C: 4.0 ± 1.1 L vs. NC: 3.5 ± 1.6 L). There was wide variability in the fluid deficit incurred for both C and NC (1.3 ± 0.9 vs. 0.7 ± 1.2%) due to fluid intake. Sweat potassium was similar between groups, but sweat sodium was two times higher in C versus NC (54.6 ± 16.2 vs. 25.3 ± 10.0 mmol/L). These data indicate that sweat sodium losses were comparatively larger in cramp-prone football players than in NC. Although both groups consumed sodium-containing fluids (on-field) and food (off-field), both appeared to experience an acute sodium deficit at the end of practices based on sweat sodium losses. Large acute sodium and fluid losses (in sweat) may be characteristic of football players with a history of heat cramping.

Sign in / Sign up

Export Citation Format

Share Document