The Clinical and Pathological Characteristics of Mammary Neoplasms with Malignant Mesenchymal Components in Female Dogs

Abstract Mammary neoplasms with malignant mesenchymal components are not common in female dogs, and they are poorly understood. As such, this study aimed to describe the clinical presentation, histological findings, and the COX-2 immunohistochemical expression of mammary neoplasms in female dogs with malignant mesenchymal components, as well as verify the relationships between the different neoplasm types and these aspects. We selected 41 female mammary neoplasms (23 carcinosarcomas, 16 sarcomas, and 2 sarcomas in mixed tumors). Medical records were reviewed to obtain clinical data. Subsequently, histological slides were analysed to establish histological parameters, and immunohistochemistry was used to assess the expression of COX-2 receptors. Carcinosarcomas and sarcomas developed as large tumours, mainly in the abdominal and inguinal mammary glands, with frequent intratumoral necrosis and a low frequency of nodal metastasis. Fifty-eight percent of the cases of malignant mesenchymal proliferation were identified as osteosarcomatous, and 24.5% chondrosarcomatous and fibrosarcomastous each. The osteosarcomatous pattern was the most predominant type in sarcomas and carcinosarcomas, and was the only one that resulted in vascular invasion, regional lymph node metastases, and higher histologic grades. High COX-2 expression was detected in 10% of the carcinosarcomas and 25% of the sarcomas. In conclusion, sarcomas and carcinosarcomas showed similar results regarding the clinical and pathological aspects. Discovering carcinosarcomas and sarcomas with high COX-2 expression suggests that, in some cases, these neoplasms may respond to therapy with COX-2 inhibitors.

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Prognostic delineation of papillary cholangiocarcinoma based on the invasive proportion.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.4119 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 4119-4119

Author(s):

Shunsuke Onoe ◽

Yoshie Shimoyama ◽

Tomoki Ebata ◽

Yukihiro Yokoyama ◽

Tsuyoshi Igami ◽

...

Keyword(s):

Regional Lymph Node ◽

Surgical Margin ◽

Nodal Metastasis ◽

University Hospital ◽

Positive Surgical Margin ◽

Non Invasive ◽

Intraductal Papillary Neoplasm ◽

Invasive Component ◽

Papillary Lesions ◽

Node Metastases

4119 Background: Intraductal papillary neoplasm of the bile duct (IPNB) is a presumed precursor lesion in biliary carcinogenesis, clinicopathologically overlapping with papillary cholangiocarcinoma (PCC); however, as IPNB has no standardized definition, this relationship remains equivocal. Here, we aimed to develop a new PCC prognostic model, focusing on the invasive proportion. Methods: Among 605 patients with surgically resected cholangiocarcinoma in Nagoya University Hospital between 2000 and 2011, 173 (29%) had intraductal exophytic papillary lesions. These were divided into four subsets based on the invasive component: non-invasive (PCC-1, n = 13), ≤10% (PCC-2, n = 30), 11-50% (PCC-3, n = 55), and >50% (PCC-4, n = 75). Results: Invasion beyond the ductal wall was observed in 83% of PCCs and 99% of non-papillary cholangiocarcinomas (NPCC, n = 432; P < 0.001). Regional lymph node metastases were more frequent in NPCC (48%) than PCC (32%; P < 0.001). Five-year survival was better for PCC (52%) than NPCC (37%; P < 0.001), indicating the papillary component to be a significant independent prognosticator. PCC-4 and NPCC had similar clinicopathological features and overlapping survival curves: 32% and 37% at 5 years (P = 0.877), both lower than those of PCC-1, PCC-2, and PCC-3 (respectively, 91%, 71%, and 60% at 5 years; P < 0.01 in all combinations). Multivariate analysis in PCC showed >50% invasive component, nodal metastasis, and positive surgical margin as independent predictors. Conclusions: The presence of an intraductal papillary component was an important determinant of better survival in cholangiocarcinoma. PCC exhibited a more aggressive histologic character and worse survival with progression of the invasive component. PCC with >50% invasive component was morphologically and prognostically similar to NPCC. Therefore, we propose that IPNB should be nosologically applied only for PCC cases with ≤50% invasive component.

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