scholarly journals Preoperative Low 25-hydroxyvitamin D Level Is Associated With Poor Prognosis of Papillary Thyroid Cancer

2021 ◽  
Author(s):  
Munire Abuduwaili ◽  
Zhichao Xing ◽  
Yuan Fei ◽  
Baoying Xia ◽  
Jingqiang Zhu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Poor Prognosis ◽  
Central Area ◽  
Papillary Thyroid ◽  
Prognosis Factors ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
D 20

Abstract Purpose: To evaluate the relationship between preoperative 25-hydroxyvitamin D (25[OH]D) level and poor prognosis factors of papillary thyroid cancer.Methods: A total of 1198 patients diagnosed of papillary thyroid cancer were analyzed retrospectively. Patients were categorized into vitamin D deficiency (VDD) group and normal group according to preoperative 25(OH)D＜20 ng/mL and 25(OH)D≥20 ng/mL. Differences of demographic date and clinicopathological characteristics were analyzed between two groups. Liner and logistic regression analysis to determine the effect of 25(OH)D on the established poor prognosis factors of papillary thyroid cancer were also applied.Results: We observed a negative liner correlation between 25(OH)D levels and tumor size and an independent relationship between VDD and lymph node metastasis in central area. Additionally, there was a significant correlation between preoperative 25(OH)D and thyroid-stimulating hormone (TSH) levels.Conclusions: 25(OH)D level significantly associated with certain poor prognosis factors of papillary thyroid cancer. Assessing and supplementing vitamin D may be an important addition to preoperative management of patients with papillary thyroid cancer.

Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer

Thyroid ◽  
2016 ◽  
Vol 26 (3) ◽  
pp. 429-433 ◽  
Author(s):  
Hwa Young Ahn ◽  
Yun Jae Chung ◽  
Kwang-Yeol Park ◽  
Bo Youn Cho
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals MKL1 overexpression predicts poor prognosis in patients with papillary thyroid cancer and promotes nodal metastasis

2019 ◽  
Vol 132 (16) ◽  
pp. jcs231399 ◽  
Author(s):  
Xian Cheng ◽  
Shichen Xu ◽  
Jie Pan ◽  
Jiangxia Zheng ◽  
Xiaowen Wang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Poor Prognosis ◽  
Nodal Metastasis ◽  
Papillary Thyroid

scholarly journals Blood prognostic predictors of treatment response for patients with papillary thyroid cancer

2020 ◽  
Vol 40 (10) ◽  
Author(s):  
Xiangxiang Liu ◽  
Zhongke Huang ◽  
Xianghui He ◽  
Xiangqian Zheng ◽  
Qiang Jia ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Poor Prognosis ◽  
Response To Therapy ◽  
Prognostic Indicators ◽  
High Morbidity ◽  
American Thyroid Association ◽  
Papillary Thyroid ◽  
Distribution Width ◽  
Prognosis Group

Abstract Background: Papillary thyroid cancer (PTC) is a very common malignant disease with high morbidity. We needed some pretreatment indicators to help us predict prognosis and guide treatment. We conducted a study about some pretreatment prognostic indicators. Methods: This clinical study recruited 705 postoperative PTC patients (211 males, 494 females). Clinical data before radioactive iodine (RAI) treatment were collected. Patients’ response to therapy were classified into two categories: ‘Good Prognosis Group’ (GPG) and ‘Poor Prognosis Group’ (PPG), according to ‘2015 American Thyroid Association Guidelines’. Differences of indicators between different prognosis groups were compared. Odds ratios (ORs) were calculated by univariate/multiple binary logistic regression models. Difference of body mass index (BMI) changes before and after RAI treatment between different prognosis groups was also compared. Results: A total of 546 (77.45%) belonged to GPG, and 159 (22.55%) belonged to PPG. Platelet (PLT), neutrophil (NEUT), PLT subgroups, and combination of red blood cell distribution width (RDW) and BMI (COR-BMI) were different between two prognosis groups. The significance of the difference between the two groups of BMI disappeared after the Bonferroni correction. PLT and PLT subgroups had detrimental effects on the risk of PPG; T stage had a positive effect on the risk of PPG. PLT subgroup showed a detrimental effect on the risk of PPG when we included additional covariates. Conclusions: We found that lower pretreatment PLT levels may indicate a poor prognosis for PTC. The relationship between platelet-derived growth factor (PDGF) and radiation sensitivity may be the key to this association.

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