scholarly journals Trends in Hepatocellular Carcinoma Incidences in Japan Between 1996 and 2019

2021 ◽  
Author(s):  
Masahito Nakano ◽  
Hiroshi Yatsuhashi ◽  
Shigemune Bekki ◽  
Yuko Takami ◽  
Yasuhito Tanaka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Age Distribution ◽  
The Elderly ◽  
Hcv Infection ◽  
Newly Diagnosed ◽  
Disease Etiology ◽  
Cancer Study Group ◽  
B Virus ◽  
Liver Cancer Study Group ◽  
Epidemiological Trends

Abstract Background: While the proportion of hepatocellular carcinoma (HCC) cases with non-viral etiology continues to increase in Japan, the epidemiological trends in the sex and age distribution of new HCC cases remain unclear. This study examines the epidemiological trends, including the distribution of sex, age, and disease etiology, in HCC incidence over 24 years.Methods: Data of 20,547 newly diagnosed HCC patients in 1996–2019 at 19 institutions participating in the Liver Cancer Study Group of Kyushu were analyzed in this prospective study. We divided the study period into four 6-year quarters. HCC etiology was categorized as hepatitis B virus (HBV) infection, HBV+hepatitis C virus (HCV) infection, HCV infection, and both negative (non-BC). Results: The incidences of HCC per quarter of the study period were 4,311 (21.0%), 5,505 (26.8%), 5,776 (28.1%), and 4,955 (24.1%) cases, sequentially. Overall, 14,020 (68.2%) patients were male. The number of HCC cases in patients ≤50 years, 60–69 years, 70–79 years, and ≥80 years were 3,711 (18.1%), 6,652 (32.4%), 7,448 (36.2%), and 2,736 (13.3%), respectively. The average age of newly diagnosed patients increased in each quarter. HCC was associated with HBV, HBV+HCV, and HCV infections and non-BC in 2,997 (14.6%), 187 (0.9%), and 12,019 (58.5%), and 5,344 (26.0%) cases, respectively. The number of HCV-associated cases decreased in each quarter, while that of non-BC-associated cases increased.Conclusions: HCC incidence tends to increase in the elderly and in non-BC patients; in contrast, HCC incidence due to HCV tends to decrease. In countries where HCV infection is likely the predominant cause of HCC, similar trends in HCC incidence are anticipated in the future.

scholarly journals Association of Hepatocellular Carcinoma (HCC) With Hepatitis B Virus (HBV) Versus Hepatitis C Virus (HCV) Infection Among Different Asian Subgroups

2011 ◽  
Vol 140 (5) ◽  
pp. S-924-S-925 ◽  
Author(s):  
Hillary Lin ◽  
Nghiem B. Ha ◽  
Deawodi Ladzekpo ◽  
Aijaz Ahmed ◽  
Walid Ayoub ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hcv Infection ◽  
B Virus

Prevalence of Hepatitis B Surface Antigen and HCV Antibodies in Hepatocellular Carcinoma Cases in Karachi, Pakistan

1997 ◽  
Vol 27 (1) ◽  
pp. 45-46 ◽  
Author(s):  
Syed Abdul Mujeeb ◽  
Qamar Jamal ◽  
Rafique Khanani ◽  
Nayyer Iqbal ◽  
Shahnaz Kaher
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Intervention Strategy ◽  
Hcv Infection ◽  
Serological Study ◽  
Invasive Procedures ◽  
Hbv Vaccination ◽  
Common Cancer ◽  
B Virus

Hepatocellular carcinoma (HCC) is a common cancer the world over. In Pakistan it has an incidence of 8/100 000 per annum. To assess the prevalence of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections in biopsy proven cases of HCC a serological study was conducted at Screening Laboratory of Blood Transfusion Services, Jinnah Postgraduate Medical Centre. Of 54 sera of HCC tested for HBV and HCV infections, 67% showed HBV infection, and 33% HCV infection. Among them 24% were positive for both HBV and HCV infections. No HBV and HCV infection was found in 24% cases of HCC. Our findings suggest viral association for most of the HCC cases reported in the country. We suggest an immediate intervention strategy to prevent the spread of HBV and HCV infections by mandatory screening of blood for HBV and HCV infections, and the use of disposable/sterilized needles, instruments for all invasive procedures. For the prevention of vertical transmission of HBV infections all pregnant women should be screened and vaccinated and HBV vaccination should also be included in EPI (expanded programme for immunization).

scholarly journals A hepatocellularis carcinoma előfordulása és kezelésének tanulságai az északkelet-magyarországi régióban

2016 ◽  
Vol 157 (45) ◽  
pp. 1793-1801
Author(s):  
Renáta Papp ◽  
Mária Papp ◽  
István Tornai ◽  
Zsuzsanna Vitális
Keyword(s):  
Hepatocellular Carcinoma ◽  
Metabolic Syndrome ◽  
Survival Data ◽  
Delayed Diagnosis ◽  
Tumor Stage ◽  
Tumor Treatment ◽  
Management Options ◽  
Disease Etiology ◽  
Results Of Treatment ◽  
Epidemiological Trends

Introduction: The increasing incidence and poor prognosis of hepatocellular carcinoma places huge burden on healthcare. Aim: After reviewing literature on epidemiological trends, risk factors, diagnosis and management options for hepatocellular carcinoma, the authors investigated results of treatment and survival data of patients in Northeastern Hungary. Method: In a retrospective study, the authors analyzed medical records of 187 patients with hepatocellular carcinoma (etiology, presence of cirrhosis, stage of the tumor, treatment and disease outcome). Results: Seventy-one patients (38%) had known cirrhosis at the diagnosis of hepatocellular carcinoma, while in 52 patients (28%) the presence of cirrhosis was established at the time of the diagnosis of hepatocellular carcinoma. Fifteen patients (8%) had no cirrhosis and in 49 patients (26%) no data were available regarding cirrhosis. Etiological factors were alcohol consumption (52%), viral hepatitis (41%) and metabolic syndrome (44%). In cases of metabolic syndrome, hepatocellular carcinoma frequently occurred without cirrhosis. In 83% of the cases, the tumor was discovered in an advanced stage. Median survival time was significantly associated with tumor stage (Barcelona A stage vs. B/C vs. D: 829 vs. 387 vs. 137 days, respectively p<0.001) but not with disease etiology (virus 282 days, metabolic syndrome 335 days and alcohol 423 days, p = 0.65). Conclusions: High mortality of hepatocellular carcinoma was mainly attributed to the delayed diagnosis of the disease. Screening of patients with cirrhosis could only result in a partial improvement since in a great proportion cirrhosis was diagnosed simultaneously with the tumor. Screening of diabetic and obese patients by ultrasonography should be considered. Management of baseline liver disease is of importance in the care of hepatocellular carcinoma. Orv. Hetil., 2016, 157(45), 1793–1801.

Surveillance and Diagnostic Algorithm for Hepatocellular Carcinoma Proposed by the Liver Cancer Study Group of Japan: 2014 Update

Oncology ◽  
2014 ◽  
Vol 87 (s1) ◽  
pp. 7-21 ◽  
Author(s):  
Masatoshi Kudo ◽  
Osamu Matsui ◽  
Namiki Izumi ◽  
Hiroko Iijima ◽  
Masumi Kadoya ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Diagnostic Algorithm ◽  
Study Group ◽  
Cancer Study ◽  
Cancer Study Group ◽  
Liver Cancer Study Group

Non-Invasive Diagnostic Criteria for Hepatocellular Carcinoma in Hepatitis B Virus-Endemic Areas: Is Cirrhosis Indispensable?

2018 ◽  
Vol 36 (3) ◽  
pp. 228-235 ◽  
Author(s):  
Xiao-wen Huang ◽  
Bing Liao ◽  
Yang Huang ◽  
Jin-yu Liang ◽  
Quan-yuan Shan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Diagnostic Criteria ◽  
Hcv Infection ◽  
Vascular Pattern ◽  
Non Invasive ◽  
B Virus ◽  
Endemic Areas

Aim: To confirm whether cirrhosis is indispensable for the non-invasive diagnostic criteria for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-endemic areas. Methods: Between January 2014 and December 2014, a total of 409 patients with pathologically proven focal liver lesions who underwent contrast-enhanced ultrasound (CEUS) were recruited from our institution. Clinical liver cirrhosis, HBV/HCV infection and HCC-typical vascular pattern of the targeted lesion on CEUS were evaluated. The following 3 criteria were applied to these patients to diagnose HCC: criterion 1, clinical liver cirrhosis and HCC-typical vascular pattern; criterion 2, HBV/HCV infection and HCC-typical vascular pattern; criterion 3, HBV/HCV infection or clinical liver cirrhosis and HCC-typical vascular pattern. Pathological reports were considered the gold standard. Results: A total of 311 patients had confirmed HCC by pathology. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value and area under the ROC curve for criterion 1 were 29.6, 90.8, 44.3, 91.1, 28.9, and 0.60% respectively. For criterion 2, they were 83.3, 74.5, 81.2, 91.2, 58.4, and 0.79%, respectively, and for criterion 3, they were 86.2, 72.5, 82.9, 90.9, 62.3, and 0.79% respectively. Conclusions: In HBV-endemic areas, when using the HBV/HCV infection instead of cirrhosis as the precondition of the non-invasive diagnostic criteria for HCC, we should be aware of the potential false positive. Cirrhosis still plays an important role in the non-invasive diagnostic criteria for HCC because of the high specificity.

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