Dyslipidemia Associates with Respiratory Resistance Assessed by Forced Oscillation Technique in Asthmatic Children

Abstract Purpose: This study evaluated the correlation between dyslipidemia and pulmonary function parameters assessed by spirometry and force oscillation technique in asthmatic children.Methods: Asthmatic children (aged 5–18 years old) were measured for fasting serum lipid profiles, including low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) and C-reactive protein (CRP). Pulmonary function tests were assessed by spirometry and forced oscillation technique (FOT). Results: One hundred forty-one asthmatic children were enrolled with the mean (sd) age of 11.82 (3.38) years. Eighty-eight children (62.4%) were males, 64 children (45.4%) had dyslipidemia, and 20 (14.2 %) children were obese. Of 64 children with dyslipidemia, high LDL-C was the most common dyslipidemia (65.6%), followed by TC (57.8%), non-HDL-C (53.1%), TG (35.9%), and low HDL-C (15.6%). There were no significant differences in spirometry parameters and FOT parameters between asthmatic children who had dyslipidemia and normal lipid levels. Asthmatic children who had high LDL-C had significantly higher expiratory phase respiratory resistance at 5 Hz (R5), whole breath R20 and expiratory phase R20 evaluated by FOT than those with normal LDL-C (p < 0.05). There were no significant differences in weight, height, obesity status, and CRP level between children with high and normal LDL-C. Conclusion: The prevalence of dyslipidemia in children with asthma is high. LDL-C is associated with more elevated respiratory resistance assessed by FOT in asthmatic children. Intervention lowering LDL-C may have a benefit on lung function in asthmatic children.

Download Full-text

TG/HDL-C Ratio Independent of Obesity Associates With Airflow Obstruction in Asthmatic Children

10.21203/rs.3.rs-308371/v1 ◽

2021 ◽

Author(s):

Pakvirin Nanakorn Chanachon ◽

Wanlapa Jotikasthira ◽

Potjanee Kiewngam ◽

Adithep Sawatchai ◽

Watcharoot Kanchongkittiphon ◽

...

Keyword(s):

Pulmonary Function ◽

Low Density Lipoprotein ◽

Airflow Obstruction ◽

Density Lipoprotein ◽

Significant Negative Correlation ◽

Lipoprotein Cholesterol ◽

Clinical Trial Registration ◽

Asthmatic Children ◽

Children With Asthma ◽

C 50

Abstract There is conflicting evidence on the association between dyslipidemia and asthma. This study was to evaluate the correlation between dyslipidemia and pulmonary function parameters in asthmatic children.Asthmatic children (aged 5–18 years old) were measured for fasting serum lipid profiles, including low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) and C-Reactive protein (CRP). A pulmonary function test was assessed by spirometry.One hundred-fifty asthmatic children were enrolled with the mean (sd) age 11.82 (3.38) years. Ninety-four children (62.7%) were males, and 70 children (46.7%) had dyslipidemia. Of 70 children with dyslipidemia, 15 children (21.4%) were obese. LDL-C was the most common dyslipidemia (62.85%), followed by TC (55.71%), non-HDL-C (50%), TG (34.28%), and HDL-C (17.14%). The significant correlations between % FEV1/FVC ratio and the level of serum HDL-C and TC and TG/HDL-C ratio were observed (r=0.215, r=0.831 and r=0.17, p<0.03). There was a significant negative correlation between the level of CRP and HDL-C, and % FEV1/FVC ratio and TG/HDL-C (r =-0.236, p=0.004 and r=-0.170, p=0.038). Children with airflow obstruction (% FEV1/FVC ratio<90) had significantly higher TG, TG/HDL-C ratio, LDL-C/HDL-C ratio but lower HDL-C. After adjusting with other blood lipids, body weight, BMI z-score, and obesity status, multiple logistic regression model demonstrated that only TG/HDL-C ratio was associated with % FEV1/FVC ratio<90, OR 2.78; 95% CI 1.5-5.15, p =0.001.Conclusion: The prevalence of dyslipidemia in children with asthma is high. TG/HDL-C ratio is associated with airflow obstruction in asthmatic children.Clinical Trial Registration: TCTR20200305005 date of registration 2020-03-04 retrospectively registered

Download Full-text

Assessing regional lung mechanics by combining electrical impedance tomography and forced oscillation technique

Biomedical Engineering / Biomedizinische Technik ◽

10.1515/bmt-2016-0196 ◽

2018 ◽

Vol 63 (6) ◽

pp. 673-681 ◽

Cited By ~ 3

Author(s):

Chuong Ngo ◽

Sarah Spagnesi ◽

Carlos Munoz ◽

Sylvia Lehmann ◽

Thomas Vollmer ◽

...

Keyword(s):

Pulmonary Function ◽

Electrical Impedance Tomography ◽

High Frequency ◽

Electrical Impedance ◽

Forced Oscillation ◽

Pulmonary Function Tests ◽

Lung Mechanics ◽

Forced Oscillation Technique ◽

Impedance Tomography ◽

Regional Lung

Abstract There is a lack of noninvasive pulmonary function tests which can assess regional information of the lungs. Electrical impedance tomography (EIT) is a radiation-free, non-invasive real-time imaging that provides regional information of ventilation volume regarding the measurement of electrical impedance distribution. Forced oscillation technique (FOT) is a pulmonary function test which is based on the measurement of respiratory mechanical impedance over a frequency range. In this article, we introduce a new measurement approach by combining FOT and EIT, named the oscillatory electrical impedance tomography (oEIT). Our oEIT measurement system consists of a valve-based FOT device, an EIT device, pressure and flow sensors, and a computer fusing the data streams. Measurements were performed on five healthy volunteers at the frequencies 3, 4, 5, 6, 7, 8, 10, 15, and 20 Hz. The measurements suggest that the combination of FOT and EIT is a promising approach. High frequency responses are visible in the derivative of the global impedance index $\Delta {Z_{{\text{eit}}}}(t,{f_{{\text{os}}}}).$ The oEIT signals consist of three main components: forced oscillation, spontaneous breathing, and heart activity. The amplitude of the oscillation component decreases with increasing frequency. The band-pass filtered oEIT signal might be a new tool in regional lung function diagnostics, since local responses to high frequency perturbation could be distinguished between different lung regions.

Download Full-text

A modified forced oscillation technique for measurements of respiratory resistance

Journal of Applied Physiology ◽

10.1152/jappl.1977.42.4.650 ◽

1977 ◽

Vol 42 (4) ◽

pp. 650-655 ◽

Cited By ~ 23

Author(s):

H. Aronsson ◽

L. Solymar ◽

J. Dempsey ◽

J. Bjure ◽

T. Olsson ◽

...

Keyword(s):

Forced Oscillation ◽

Signal To Noise Ratio ◽

Optimization Technique ◽

Forced Oscillation Technique ◽

Respiratory Resistance ◽

Asthmatic Children ◽

The Difference ◽

Resistance Value ◽

Automated Determination

We present a modification of forced oscillation technique for automated determination of total respiratory resistance during inspiration. The modifications consist of a computerized signal averaging and an optimization technique in the assessment of the resistance value. Thereby a favorable signal-to-noise ratio is obtained, allowing very low superimposed pressure oscillations. The method is validated by comparison with a conventional esophageal balloon method, by estimating added mechanical resistances in healthy subjects and by measuring the effect of bronchodilation in asthmatic children. The coefficient of variation as obtained from day-to-day measurements was about 7%. Mechanical resistances, estimated as the difference in total resistance with and without external resistance, were within 7% of their values determined for the resistances alone. A significant decrease in resistance was obtained in each of the asthmatic children following bronchodilation.

Download Full-text