scholarly journals Clinical course and management of 73 hospitalized moderate patients with COVID-19 outside Wuhan

2020 ◽  
Author(s):  
Xiaojuan Peng ◽  
Qi Qi Liu ◽  
Zhaolin Chen ◽  
Guiyan Wen ◽  
Qing Li ◽  
...  
Keyword(s):  
Median Duration ◽  
Active Treatment ◽  
Medical Records ◽  
Clinical Course ◽  
Good Prognosis ◽  
Chest Tightness ◽  
Medical Observation ◽  
Sources Of Infection ◽  
Acid Test

Abstract Background: Moderate cases account for the majority in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and can also progress to severe/critical condition. Here, we investigated the clinical course and management of hospitalized moderate SARS-CoV-2 patients.Methods: The medical records and follow-up data were analyzed from the SARS-CoV-2 patients outside Wuhan.Results: A total of 73 moderate patients (38 men, 35 women) were included, with median age of 47.0 (38.5-57.5) years. Among them, only one patient (1.4%) died using active treatment to improve symptoms. The median duration of the four main symptoms cough, fever, chest tightness, and fatigue were about 1-2 weeks; the median duration of the positive nucleic acid test (NAT) results for SARS-CoV-2 was slightly more than 2 weeks; the median hospitalization time was almost four weeks in 72 moderate survivors. The duration of cough and fever was positively correlated with the duration of the positive NAT results. On admission, 50% had lymphopenia; less than 30% had abnormal blood biochemistry findings involving hyperglycemia, liver function and myocardial enzymes. At discharge, the laboratory indexes were substantially improved. Two weeks after discharge, 5.6% survivors experienced a recurrence of the positive NAT results. Conclusions: Moderate SARS-CoV-2 patients have a good prognosis by the active treatment. After discharge, it is necessary that moderate survivors undergo at least a 2-week collective medical observation in quarantine places, which can identify and treat a proportion of patients with re-positive NAT results and to prevent the spread of the potential sources of infection.

scholarly journals Clinical Course and Management of 73 Hospitalized Moderate Patients with COVID-19 Outside Wuhan

2020 ◽  
Author(s):  
Xiaojuan Peng ◽  
Qi Liu ◽  
Zhaolin Chen ◽  
Guiyan Wen ◽  
Qing Li ◽  
...  
Keyword(s):  
Median Duration ◽  
Active Treatment ◽  
Medical Records ◽  
Clinical Course ◽  
Good Prognosis ◽  
Chest Tightness ◽  
Medical Observation ◽  
Sources Of Infection ◽  
Acid Test

Abstract Background: Moderate cases account for the majority in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and can also progress to severe/critical condition. Here, we investigated the clinical course and management of hospitalized moderate SARS-CoV-2 patients.Methods: The medical records and follow-up data were analyzed from the SARS-CoV-2 patients outside Wuhan.Results: A total of 73 moderate patients (38 men, 35 women) were included, with median age of 47.0 (38.5-57.5) years. Among them, only one patient (1.4%) died using active treatment to improve symptoms. The median duration of the four main symptoms cough, fever, chest tightness, and fatigue were about 1-2 weeks; the median duration of the positive nucleic acid test (NAT) results for SARS-CoV-2 was slightly more than 2 weeks; the median hospitalization time was almost four weeks in 72 moderate survivors. The duration of cough and fever was positively correlated with the duration of the positive NAT results. On admission, 50% had lymphopenia; less than 30% had abnormal blood biochemistry findings involving hyperglycemia, liver function and myocardial enzymes. At discharge, the laboratory indexes were substantially improved. Two weeks after discharge, 5.6% survivors experienced a recurrence of the positive NAT results. Conclusions: Moderate SARS-CoV-2 patients have a good prognosis by the active treatment. After discharge, it is necessary that moderate survivors undergo at least a 2-week collective medical observation in quarantine places, which can identify and treat a proportion of patients with re-positive NAT results and to prevent the spread of the potential sources of infection.

scholarly journals Clinical course and management of 73 hospitalized moderate patients with COVID-19 outside Wuhan

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0249655
Author(s):  
Xiaojuan Peng ◽  
Qi Liu ◽  
Zhaolin Chen ◽  
Guiyan Wen ◽  
Qing Li ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Liver Function ◽  
Median Duration ◽  
Active Treatment ◽  
Medical Records ◽  
Clinical Course ◽  
Good Prognosis ◽  
Chest Tightness ◽  
Acid Test

Moderate cases account for the majority in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and can also progress to severe/critical condition. Here, we investigated the clinical course and management of hospitalized moderate SARS-CoV-2 patients. The medical records and follow-up data were analyzed from the SARS-CoV-2 patients outside Wuhan. A total of 73 moderate patients (38 men, 35 women) were included, with median age of 47.0 (38.5–57.5) years. Among them, only one patient (1.4%) died using active treatment to improve symptoms. The median duration of the four main symptoms cough, fever, chest tightness, and fatigue were 11.0, 8.0, 11.0, and 7.0 days, respectively; the median duration of the positive nucleic acid test (NAT) results for SARS-CoV-2 was 16.5 days; the median hospitalization time was 25.0 days in 72 moderate survivors. The duration of cough and fever was positively correlated with the duration of the positive NAT results. On admission, 50% had lymphopenia; less than 30% had abnormal blood biochemistry findings involving hyperglycemia, liver function and myocardial enzymes. At discharge, the laboratory indexes were substantially improved. Two weeks after discharge, 5.6% survivors experienced a recurrence of the positive NAT results. Moderate SARS-CoV-2 patients have a good prognosis by the active treatment. A small proportion of the recovered moderate patients still may be virus carriers and require an additional round of viral detection.

Fibromuscular Dysplasia of the Internal Carotid Artery

Neurosurgery ◽  
1982 ◽  
Vol 10 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Ralph P. Wells ◽  
Robert R. Smith
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Medical Records ◽  
Fibromuscular Dysplasia ◽  
Internal Carotid ◽  
Clinical Course ◽  
Oral Anticoagulants ◽  
Specific Therapy ◽  
The Mean

Abstract The natural course of fibromuscular dysplasia (FMD) of the internal carotid artery (ICA). a stenosing angiopathy associated with cerebrovascular insufficiency, has not been described. A search of medical records located 16 female patients with angiographically demonstrated FMD of the ICA. The identical twin of 1 patient was included in the registry on the basis of noninvasive studies consistent with FMD of the ICA. The mean age at diagnosis was 58 years. Follow-up examinations were performed an average of 3.8 years after diagnosis (range, 1 to 9 years); the evaluation included clinical, angiographic, and Doppler studies. Fifteen patients showed no evidence of progression of FMD, whereas 2 patients with coincident atherosclerotic disease had suffered strokes. One patient had undergone surgical dilatation of the ICA. 3 had received oral anticoagulants, and 13 had received either aspirin or no specific therapy. In light of the apparently benign clinical course of uncomplicated FMD of the ICA, it is concluded that dilatation is rarely warranted.

Synchronous Pancreatic and Pulmonary Metastases from Solitary Fibrous Tumor of the Pleura: Report of a Case

2017 ◽  
Vol 103 (1_suppl) ◽  
pp. S9-S11 ◽  
Author(s):  
Nicola Tamburini ◽  
Nicolò Fabbri ◽  
Gabriele Anania ◽  
Pio Maniscalco ◽  
Francesco Quarantotto ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Pulmonary Metastases ◽  
Clinical Course ◽  
Good Prognosis ◽  
Pancreatic Metastasis ◽  
Case Presentation ◽  
First Case ◽  
Fibrous Tumor ◽  
Uncommon Tumor

Introduction Solitary fibrous tumor of the pleura is an uncommon tumor with an indolent course and a good prognosis after surgical resection. However, the tumor occasionally follows an unpredictable clinical course and malignant transformation has been reported to increase the rate of local recurrence. Solitary extrathoracic metastasis from solitary fibrous tumor of the pleura is an uncommon finding. Case Presentation In this case report we present the first case of a synchronous single pulmonary and pancreatic metastasis treated with minimally invasive surgery. Conclusions Pancreatic recurrence should be considered in the postoperative follow-up in patients with solitary fibrous tumor of the pleura.

scholarly journals Urine nucleic acid test positive in an asymptomatic patient with novel coronavirus 2019 infection: a case report

2020 ◽  
Author(s):  
Yaoyong Wang ◽  
Xinjian Chang ◽  
Jianguo Ren ◽  
Dongyan Li ◽  
Changfei Wang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Throat Swab ◽  
Asymptomatic Patient ◽  
Clinical Manifestations ◽  
Nucleic Acid Test ◽  
Asymptomatic Patients ◽  
Sources Of Infection ◽  
Novel Coronavirus ◽  
Acid Test

Abstract Background: With the emergence of coronavirus disease 2019 in many places around the world, the main medical resources currently focus on the treatment of confirmed patients and the screening of suspected cases. Asymptomatic patients are difficult to detect, but they may be contagious, which makes epidemic control more difficult. We found a case of asymptomatic patient with positive urine coronavirus nucleic acid test, and we hope to attract attention of all circles.Case presentation: An asymptomatic patient with novel coronavirus infection was found in an epidemiological investigation of patients with confirmed coronavirus disease 2019. The patient was admitted to the hospital on February 24, 2020. She had no clinical manifestations such as fever, dry cough, and fatigue, and no abnormal signs. The examination showed that her throat swab was negative for nucleic acid but the urine was positive for nucleic acid. She was given antiviral and symptomatic supportive treatment. On February 26, her throat swab was checked for nucleic acid positive. On March 3 and 5, her throat swab and urine nucleic acid were negative. On March 9 and 12, her throat swab nucleic acid were negative. The patient was discharged from the hospital on March 13 and continued to be isolated and observed outside the hospital. Follow-up was conducted on March 26, the patient did not have any discomfort, the throat swab nucleic acid test was negative, and the isolation was lifted.Conclusion: There are asymptomatic patients with coronavirus disease 2019, and their urine may be one of the sources of infection.

Epithelioid hemangioendothelioma of the lung: CT findings and clinical course of 35 cases

2020 ◽  
Vol 50 (10) ◽  
pp. 1195-1200
Author(s):  
Yasuyuki Onishi ◽  
Masahiko Kusumoto ◽  
Yasushi Goto ◽  
Sawako Kaku ◽  
Noriko Motoi
Keyword(s):  
Computed Tomography ◽  
Clinical Course ◽  
Clinical Information ◽  
Good Prognosis ◽  
Epithelioid Hemangioendothelioma ◽  
Lesion Pattern ◽  
Pulmonary Epithelioid Hemangioendothelioma ◽  
Single Lesion ◽  
Multiple Nodules

Abstract Objectives To evaluate computed tomography findings and assess the clinical course of patients with pulmonary epithelioid hemangioendothelioma. Methods Patients diagnosed with pulmonary epithelioid hemangioendothelioma at our institution between 2000 and 2019 were retrospectively analyzed. Patients with pleural involvement were excluded. Computed tomography findings of the lung at diagnosis were classified into three patterns: multiple small nodules pattern (˂15 mm), multiple nodules with large lesions pattern (≥15 mm) and single lesion pattern. Additionally, the clinical course of patients was evaluated. Results Thirty-five patients (15 men and 20 women; median age, 44 years) with pulmonary epithelioid hemangioendothelioma were identified. The multiple small nodules pattern, multiple nodules with large lesions pattern and single lesion pattern were observed in 25 (71.4%), 8 (22.9%) and 2 (5.7%) patients, respectively. In 22 (62.9%) patients, extra-pulmonary epithelioid hemangioendothelioma lesions were found. Most patients were followed without initial treatment, while two patients with single lesion pattern underwent surgical resection. The median follow-up period was 63 months. Five-year overall survival rate of all patients was 96.3%. Latest clinical information revealed that 20 (20/25, 80%) patients with multiple small nodules pattern were alive without symptoms. In patients with multiple nodules with large lesion pattern, four (4/8, 50%) patients were alive without symptoms, three (3/8, 37.5%) patients were alive with symptoms and one (1/8, 12.5%) died. No recurrence was observed in patients with single lesion pattern. Conclusions Multiple small nodules pattern was the most common findings of pulmonary epithelioid hemangioendothelioma. Patients with pulmonary epithelioid hemangioendothelioma have good prognosis.

SÍNDROME DE BART NA INFÂNCIA

2018 ◽  
Vol 5 (2) ◽  
pp. 50-54
Author(s):  
ANDRESSA OLIVEIRA MATOS ◽  
HELY ANDRADE ALVES CORRÊA ◽  
RAISSA CARVALHO MARINHO ◽  
JÉSSICA SANTOS ANDRADE ◽  
ISABELLA PEREIRA MOURA ◽  
...  
Keyword(s):  
Epidermolysis Bullosa ◽  
Medical Records ◽  
Autosomal Dominant ◽  
Clinical Course ◽  
Dominant Inheritance ◽  
Transmission Of Knowledge ◽  
Type Vii Collagen ◽  
Therapeutic Choice ◽  
Diagnostic Hypothesis

RESUMO Introdução: A Síndrome de Bart é uma herança autossômica dominante, que ocorre devido à mutação no gene do colágeno tipo VII no cromossomo, sendo caracterizada por ausência localizada de pele (presente ao nascimento), epidermólise bolhosa (EB) e alterações ungueais. Objetivo: Relatar um caso clínico de paciente de 5 anos assistida na Policlínica, Gurupi-TO, com diagnostico tardio de epidermolise bolhosa. Método: Estudo descritivo, sobre o curso clínico da síndrome cuja ocorrência vem desde o nascimento, abordando sobre o diagnóstico, a escolha terapêutica e os principais diagnósticos diferenciais. As informações foram obtidas na Policlínica, por meio de revisão de prontuário, obtenção de registro fotográfico e análise de exames. Resultados: O diagnóstico da Síndrome de Bart é clínico e foi realizado pelas alterações características, porém houve biópsia para confirmação de EB após 5 anos do nascimento. O tratamento foi feito com curativos, pomadas e cremes nos locais afetados, evitando-se traumas nas regiões. Houve o aconselhamento da mãe e da enfermeira acerca dos cuidados com a pele. Conciderações finais: A transmissão de conhecimento sobre as patologias menos frequentes se mostra essencial para o levantamento da hipótese diagnóstica correta e o tratamento precoce. Desse modo, quando um médico deparar-se com um recém-nascido apresentando a tríade (aplasia cutânea, epidermólise bolhosa e alterações ungueais), deverá iniciar as medidas gerais bem como acompanhamento multidisciplinar, sendo essencial o diagnóstico precoce a fim de garantir um melhor prognóstico ao paciente.   Palavras-chave: Epidermólise bolhosa, Aplasia Cutânea, Mutação. ABSTRACT Introduction: Bart's syndrome is an autosomal dominant inheritance, due to the mutation in the type VII collagen gene in the chromosome. It is characterized by localized absence of skin (present at birth), epidermolysis bullosa (EB) and nail abnormalities. Objective: To report a clinical case of a 5-year-old patient assisted in the Policlínica, Gurupi-TO, with late diagnosis of epidermolysis bullosa. Method: A descriptive study about the clinical course of the syndrome whose occurrence comes from birth, addressing the diagnosis, the therapeutic choice and the main differential diagnoses. The information was obtained at the Policlínica, through a review of medical records, obtaining a photographic record and exam analysis. Results: The diagnosis of Bart syndrome was clinical and was performed by the characteristic alterations, but there was a biopsy to confirm EB after 5 years of birth. The treatment was done with dressings, ointments and creams in the affected places, avoiding traumas in the regions. The mother and the nurse were advised of skin care. Final concluding remarks: The transmission of knowledge about the less frequent pathologies is essential for the collection of the correct diagnostic hypothesis and the early treatment. Thus, when a physician encounters a newborn presenting the triad (cutaneous aplasia, epidermolysis bullosa and nail abnormalities), he should initiate general measures as well as multidisciplinary follow-up, with an early diagnosis essential in order to guarantee a better prognosis to the patient. Keywords: Epidermolysis bullosa, Cutaneous Aplasia, Mutation.

scholarly journals Characteristics of pulmonary cryptococcosis in patients with rheumatoid arthritis

2021 ◽  
Vol 8 (1) ◽  
pp. e000805
Author(s):  
Chiaki Hosoda ◽  
Takashi Ishiguro ◽  
Ryuji Uozumi ◽  
Miyuki Ueda ◽  
Naomi Takata ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Medical Records ◽  
High Frequency ◽  
Clinical Course ◽  
Antifungal Treatment ◽  
Pulmonary Cryptococcosis ◽  
Radiological Findings ◽  
Antirheumatic Therapy ◽  
Negative Effect

Background and objectiveA high frequency of infections complicating rheumatoid arthritis (RA) has been reported due to the immunomodulatory effect of RA or to agents with immunosuppressive effects used in its treatment. We aimed to assess clinical and radiological characteristics of pulmonary cryptococcosis in patients with and without RA.MethodsWe retrospectively reviewed the medical records of 52 patients with pulmonary cryptococcosis and divided them into two groups, those with RA and without RA, and compared clinical characteristics and radiological findings between them.ResultsEleven (21.2%) of the 52 patients had RA. Median follow-up periods were 51.2 (range: 1.1–258.7) months for patients with RA and 19.1 (range: 0.63–246.9) months for patients without RA. Among the patients with RA, 81.8% were women, with a mean age of 68.1 years. Female sex and respiratory comorbidities were significantly more frequent in patients with RA than in patients without RA. Frequencies of concomitant cryptococcal meningitis and respiratory failure were not different between the groups. There were no significant differences in frequency of any radiological findings, locations and number between the two groups. Among patients with RA, all but one responded well to antifungal treatment. During the antifungal treatment course, one (9.1%) patient with RA died of cryptococcosis. Despite continuing antirheumatic drugs, no patients had recurrence of pulmonary cryptococcosis during follow-up.ConclusionOther than some differences in background, there were no clinical, radiological or prognostic differences between the patients with and without RA with pulmonary cryptococcosis. The administration of antirheumatic therapy had no negative effect on the clinical course of antifungal treatment.

J 5 — A Data Processing System for Medical Information

1967 ◽  
Vol 06 (01) ◽  
pp. 1-6
Author(s):  
P. Hall ◽  
Ch. Mellner ◽  
T. Danielsson
Keyword(s):  
Medical Records ◽  
Medical Information ◽  
Health Care Systems ◽  
Processing System ◽  
Linear Pattern ◽  
Flexible Form ◽  
Care Systems ◽  
Pattern Recognition Analysis ◽  
Numeric Information

A system for medical information has been developed. The system is a general and flexible one which without reprogramming or new programs can accept any alphabetic and/or numeric information. Coded concepts and natural language can be read, stored, decoded and written out. Medical records or parts of records (diagnosis, operations, therapy, laboratory tests, symptoms etc.) can be retrieved and selected. The system can process simple statistics but even make linear pattern recognition analysis.The system described has been used for in-patients, outpatients and individuals in health examinations.The use of computers in hospitals, health examinations or health care systems is a problem of storing information in a general and flexible form. This problem has been solved, and now it is possible to add new routines like booking and follow-up-systems.

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