scholarly journals Lipid Emulsion And Isoflurane: The Quality Assessment of Anesthesia Parameters In Pigeons

2021 ◽  
Author(s):  
Alireza Ghazanfariasl ◽  
Ebrahim Shahroozian ◽  
Keyvan Keramati ◽  
Hamidreza Moslemi
Keyword(s):  
Lipid Emulsion ◽  
Columba Livia ◽  
Depth Of Anesthesia ◽  
Fat Emulsion ◽  
Hemoglobin Oxygen Saturation ◽  
Rapid Induction ◽  
Hemodynamic Variables ◽  
Delayed Recovery ◽  
Isoflurane Treatment ◽  
Anesthesia Depth

Abstract An objective was to evaluate the efficacy of intravenous (IV) emulsified isoflurane formulation for maintenance of general anesthesia and to compare with IV lipid emulsion infusion with inhalation isoflurane in pigeons. The animals was total of 21 healthy, mature pigeons (Columba livia domestica), weighing 318 ± 13 g. Pigeons were anesthetized by emulsified isoflurane (treatment IΙΙ), inhalation isoflurane with IV lipid emulsion (treatment ΙΙ ), and inhalation isoflurane (treatment Ι) alone. Over 50 minutes, wing tone, toe pinch (pedal), and feather pluck reflex were tested every 10 minutes. Data was recorded at 10, 20 and 30 minutes for temperature (T), peripheral hemoglobin oxygen saturation (SpO2) heart rate (HR), and respiratory rate (fR). A scoring system was used to assess parameters related to anesthesia duration and depth. There were no significant differences in hemodynamic variables between the treatment Ι and treatments ΙΙ and IΙΙ, in treatments associated with fat emulsion have shown faster induction, longer anesthesia, more immobilization, and longer recovery time. Furthermore, in anesthesia depth percentages evaluation it was observed that emulsified isoflurane entered the anesthesia deep stage earlier and was removed immediately after discontinuation of administration.Administration of 8% v/v emulsified isoflurane IV was effective in anesthesia rapid induction, stability in depth of anesthesia, rapid withdrawal from anesthesia depth by discontinuation of the infusion, delayed recovery, cardiorespiratory and (T) stability.

Pulmonary Vascular Lipid Deposition After Administration of Intravenous Fat to Infants

PEDIATRICS ◽  
1987 ◽  
Vol 79 (1) ◽  
pp. 99-102
Author(s):  
Robert J. Shulman ◽  
Claire Langston ◽  
Richard J. Schanler
Keyword(s):  
Risk Factor ◽  
Lipid Emulsion ◽  
Clinical Course ◽  
Serum Triglyceride ◽  
Peak Serum ◽  
Lipid Deposition ◽  
Fat Emulsion ◽  
Intravenous Fat Emulsion ◽  
Intravenous Lipid Emulsion ◽  
The Relationship

The incidence of pulmonary vascular lipid deposits in infants who did or did not receive intravenous lipid emulsion was determined through a review of the pulmonary histopathology and clinical course of 39 neonates who died during a two-year period. The relationship between pulmonary vascular lipid deposits and the duration and amount of administered intravenous fat emulsion was assessed. In addition, the effect of monitored serum triglyceride levels on the development of pulmonary vascular lipid deposits was evaluated. The incidence of pulmonary vascular lipid deposits was greater in the group that received intravenous fat emulsion (P < .02). Both the amount (grams per kilogram per day) and duration (days) of intravenous fat emulsion infusion were correlated positively with severity (P < .05) in infants who had pulmonary vascular lipid deposits. No relationship was seen between peak serum triglyceride levels, the frequency of elevated triglycerides, and pulmonary vascular lipid deposits. Although administered fat emulsion was a risk factor for the development of pulmonary vascular deposits, two of 13 infants who had not received intravenous fat emulsion had such deposits.

Relationships between a proprietary index, bispectral index, and hemodynamic variables as a means for evaluating depth of anesthesia in dogs anesthetized with sevoflurane

2004 ◽  
Vol 65 (8) ◽  
pp. 1128-1135 ◽  
Author(s):  
Maria S. Carrasco-Jimenez ◽  
Maria F. Martin Cancho ◽  
Juan R. Lima ◽  
Veronica Crisostomo ◽  
Jesus Uson-Gargallo ◽  
...  
Keyword(s):  
Bispectral Index ◽  
Depth Of Anesthesia ◽  
Hemodynamic Variables

Application of Back Propagation Neural Network and Information Entropy in Deep Detection of Anesthesia

2020 ◽  
Vol 10 (8) ◽  
pp. 1875-1879
Author(s):  
Yujuan Zhou ◽  
Lei Wang ◽  
Jintai Jia ◽  
Gema Monasterio
Keyword(s):  
Neural Network ◽  
General Anesthesia ◽  
Back Propagation ◽  
Back Propagation Neural Network ◽  
Sample Entropy ◽  
Depth Of Anesthesia ◽  
Eeg Signals ◽  
Entropy Index ◽  
Wavelet Entropy ◽  
Anesthesia Depth

In order to study the monitoring of anesthesia depth during general anesthesia, the EEG (electroencephalogram) signals of 30 patients with laparoscopic general anesthesia were taken as the research objects. The approximate entropy, sample entropy, ranking entropy, and wavelet entropy of EEG signals under different anesthesia conditions were compared by BP (Back Propagation) neural network. The results showed that with the deepening of anesthesia, the four kinds of information entropies of EEG signal showed a downward trend. Among them, the sample entropy algorithm, ranking entropy algorithm, and wavelet entropy algorithm had a higher accuracy in the classification of anesthesia depth. Whereas, the network model established by combining sample entropy index and wavelet entropy index had the highest accuracy in judging anesthesia depth, which was 99.98%. To sum up, the method presented to monitor the depth of anesthesia by combining the characteristics of various EEG signals provides a new reference for the monitoring of the depth of anesthesia.

scholarly journals Hemodynamic changes in lipid emulsion therapy (SMOFlipid) for bupivacaine toxicity in swines

2012 ◽  
Vol 27 (4) ◽  
pp. 318-324 ◽  
Author(s):  
Marcos De Simone Melo ◽  
Matheus Rodrigues Bonfim ◽  
Elisabeth Dreyer ◽  
Betina Silvia Beozzo Bassanezi ◽  
Artur Udelsmann
Keyword(s):  
Blood Pressure ◽  
Cardiac Index ◽  
Lipid Emulsion ◽  
Control Group ◽  
Hemodynamic Changes ◽  
Large White ◽  
Hemodynamic Variables ◽  
Arterial Blood ◽  
Bupivacaine Toxicity ◽  
Invasive Pressure Monitoring

PURPOSE: To evaluate the hemodynamic changes following SMOFlipid emulsion therapy with after bupivacaine intoxication in swines. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, 5 mg.kg-1 of bupivacaine by intravenous injection was administered and new hemodynamic measures were performed 1 minute later; the animals were than randomly divided into two groups and received 4 ml.kg-1 of saline solution or 4 ml.kg-1 of SMOFlipid emulsion 20%. Hemodynamic changes were then re-evaluated at 5, 10, 15, 20 and 30 minutes. RESULTS: Bupivacaine intoxication caused fall in arterial blood pressure, cardiac index, ventricular systolic work index mainly and no important changes in vascular resistances. SMOFlipid emulsion therapy was able to improve blood pressure mainly by increasing vascular resistance since the cardiac index had no significant improvement in our study. Hemodynamic results of the use of lipid emulsion in bupivacaine intoxication were better than the control group. CONCLUSION: The SMOFlipid emulsion is a option for reversing hypotension in cases of intoxication by bupivacaine.

Administration of Lipid-Emulsion Versus Conventional Amphotericin B in Patients with Neutropenia

1995 ◽  
Vol 29 (12) ◽  
pp. 1197-1201 ◽  
Author(s):  
Begoña Pascual ◽  
Ana Ayestaran ◽  
José B Montoro ◽  
Juan Oliveras ◽  
Antero Estibalez ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Lipid Emulsion ◽  
Fungal Infections ◽  
Hematologic Malignancies ◽  
Fat Emulsion ◽  
Sodium Potassium ◽  
Significant Difference ◽  
Emulsion Group ◽  
Group 2 ◽  
Group 1

Objective: To evaluate the usefulness of a 20% lipid emulsion as a delivery system for amphotericin B (1 mg/mL) administered over 1 hour to patients with neutropenia with hematologic malignancies compared with amphotericin B (0.1 mg/mL) administered in dextrose 5% solution over the same time. Design: A prospective, comparative, randomized, labeled study. Setting: Hematology unit, pharmacy service, university general hospital. Participants: Twenty patients with neutropenia with hematologic malignancies and proven or suspected fungal infections, 10 in the fat emulsion group (group 1) and 10 in the dextrose 5% group (group 2). Main Outcome Measures: Clinical tolerance (i.e., fever, shaking chills, nausea, blood pressure, pulse rate) and biologic tolerance (i.e., urea, creatinine, sodium, potassium). Results: Clinical tolerance was comparable in both groups although amphotericin B in fat emulsion was better tolerated. Medication for symptoms related to the administration of amphotericin B was given in 6 cases in group 1 and in 8 cases in group 2. There was a statistically significant difference in the urea concentrations between the 2 groups (p = 0.023); there was an observed increase between the initial and the final serum urea (56.8 mg/d in group 1, 79.8 mg/dL in group 2). Statistically significant differences in creatinine serum concentrations (84.9 μmol/L in group 1, 123.8 μmol/L in group 2) (p = 0.047) were found. No differences were found in the antifungal efficacy of the treatment. However, as amphotericin B was started in the majority of cases (75%) as empiric treatment for fever unresponsive to antibiotic therapy, it is difficult to compare the efficacy of both preparations. Conclusions: The clinical tolerance of lipid-emulsion infusions is similar to that of conventionally administered amphotericin B therapy. Renal toxicity appears to be decreased when the drug is administered in a fat emulsion. This type of preparation permits the reduction of the volume and the time of administration for amphotericin B therapy.

scholarly journals Monitoring depth of anesthesia using combination of EEG measure and hemodynamic variables

2014 ◽  
Vol 9 (1) ◽  
pp. 41-51 ◽  
Author(s):  
R. Shalbaf ◽  
H. Behnam ◽  
H. Jelveh Moghadam
Keyword(s):  
Depth Of Anesthesia ◽  
Hemodynamic Variables

scholarly journals ESTIMATION OF THE DEPTH OF ANESTHESIA BY ELECTROENCEPHALOGRAM USING NEURAL NETWORKS

2019 ◽  
Vol 22 (3) ◽  
pp. 106-112
Author(s):  
Mokhammed A. Al-Ghaili ◽  
Alexander N. Kalinichenko
Keyword(s):  
Neural Networks ◽  
The State ◽  
Depth Of Anesthesia ◽  
Eeg Signals ◽  
Spectral Edge Frequency ◽  
Complex Processes ◽  
Spectral Components ◽  
Waking State ◽  
The Brain ◽  
Anesthesia Depth

Introduction. Monitoring of the depth of anesthesia during surgery is a complex task. Since electroencephalogram (EEG) signals contain valuable information about processes in the brain, EEG analysis is considered to be one of the most useful methods for study and assessment of the depth of anesthesia in clinical applications. Anesthetics affect the frequency composition of the EEG. EEG of awake persons, as a rule, contains mixed alpha and beta rhythms. Changes in the EEG, caused by the transition from the waking state to the state of deep anesthesia, manifest as a shift of the spectral components of the signal to the lower part of the frequency range. Anesthetics cause a whole range of neurophysiological changes, which cannot be correctly assessed with just one indicator. Objective. In order to describe complex processes during the transition from the waking state to the state of deep anesthesia adequately, it is required to propose a method for assessing the depth of anesthesia, using a comprehensive set of parameters reflecting changes in the EEG signal. The article presents the results of study the possibility of building a regression model based on artificial neural networks (ANN) to determine levels of anesthesia using a set of parameters calculated by EEG. Materials and methods. The authors of the article propose the method for assessing the level of anesthesia, based on the use of neural networks, which input parameters are time and frequency EEG parameters, namely: spectral entropy (SE); burst-suppression ratio (BSR); spectral edge frequency (SEF95) and log power ratio of the spectrum (RBR) for three pairs of frequency ranges. Results. The optimal parameters of ANN were determined, at which the highest level of regression is achieved between the calculated and the verified values of the anesthesia depth indices. Conclusion. In order to create a practical version of the algorithm, it is necessary to investigate further the noise stability of the proposed method and develop a set of algorithmic solutions, which ensure a reliable operation of the algorithm in the presence of noise.

Simultaneous application of intravenous fat emulsion and charcoal hemoperfusion in quetiapine overdose case

Open Medicine ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. 505-507 ◽  
Author(s):  
Shasine Veli ◽  
Vasil Atanasov ◽  
Jordan Angelov ◽  
Kamen Kanev
Keyword(s):  
Blood Pressure ◽  
Blood Concentration ◽  
Lipid Emulsion ◽  
Fast Recovery ◽  
Fat Emulsion ◽  
Simultaneous Application ◽  
Intravenous Fat Emulsion ◽  
Patient Status ◽  
Charcoal Hemoperfusion ◽  
Initial Blood

AbstractThe simultaneous application of intravenous fat emulsion and charcoal hemoperfusion in the case of severe quetiapine poisoning is described. The initial blood concentration of quetiapine was 5.9 µg/mL and rapid deterioration in the patient status was observed. When a lipid emulsion was infused a fast blood pressure recovery occurred which allows to perform extracorporeal clearance using charcoal hemoperfusion. At the end of the procedure the quetiapine concentration was decreased down to 1.5 µg//mL and fast recovery of the patient was observed.

scholarly journals Effect of BIS monitoring on sevoflurane consumption in patients undergoing breast cancer surgeries under general anesthesia—a prospective observational study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Archana Nair ◽  
Sudha Padmam ◽  
Subha Ravindran ◽  
Rachel Cherian Koshy ◽  
K. M. Jagathnath Krishna
Keyword(s):  
Breast Cancer ◽  
Control Group ◽  
Depth Of Anesthesia ◽  
Hemodynamic Variables ◽  
Institutional Review ◽  
Physical Status Classification ◽  
Recovery Profile ◽  
Eye Opening ◽  
American Society ◽  
American Society Of Anesthesiologists

Abstract Background The bispectoral index (BIS), a parameter derived from electroencephalogram, has been used to assess the depth of anesthesia. The objectives of this study were to evaluate the effect of BIS monitoring on sevoflurane consumption and recovery profile at the end of anesthesia. After obtaining Institutional Review Board approval and written informed consent, 25 American Society of Anesthesiologists (ASA) physical status classification 1 and 2 patients undergoing breast cancer surgeries who had BIS monitoring in addition to standard ASA monitoring (BIS GROUP) were compared against 25 controls (control group). In the control group, adequate depth of anesthesia was maintained using routine clinical parameters like heart rate (HR), mean arterial pressure (MAP), and minimum alveolar concentration (MAC) of sevoflurane, while in the BIS group, it was maintained by keeping the BIS score between 40 and 60 (mean 50). Data including demographics, sevoflurane consumption, hemodynamic variables, and recovery profile at the end of anesthesia was assessed in terms of time for eye opening (TEO), time for motor response (TMR), time for extubation (TE), and modified Aldrete scoring (MAS). Results The mean sevoflurane consumption was lower (P = 0.019) in the BIS group. TEO (P = 0.001), TMR (P = 0.0001), and TE (0.003) were shorter in the BIS group. Difference in MAS between the 2 groups was not statistically significant (P = 0.085). Conclusions BIS monitoring during anesthesia resulted in significant reduction in the sevoflurane consumption. Patients who had BIS monitoring awoke earlier and had better recovery profile at the end of anesthesia.

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