scholarly journals Cohort Profile: The China Metal-Exposed Workers Cohort Study (Jinchang Cohort)

2021 ◽  
Author(s):  
Yana Bai ◽  
Jingli Yang ◽  
Zhiyuan Cheng ◽  
Desheng Zhang ◽  
Ruonan Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Intervention Measures ◽  
Icp Ms ◽  
Specimen Bank ◽  
Plasma Mass Spectrometry ◽  
Urine And Serum ◽  
Three Phases

Abstract The Jinchang Cohort was an ongoing 20-year ambispective cohort with unique metal exposures of an occupational population. Until now, the Jinchang Cohort has completed three phases of follow-up from January 2014 to December 2019. The baseline cohort was completed from June 2011 to December 2013, and a total of 48 001 people were included. Three phases of follow-ups included 46 713, 41 888 and 40 530 participants, respectively. The death data was collected from 2001 to 2020. The epidemiological, physical examination, physiological and biochemical data of the cohort were collected by using the methods of cross-section and prospective cohort study. Biological specimens were collected on baseline to establish a biological specimen bank. The concentrations of metals in urine and serum were detected by inductively coupled plasma mass spectrometry (ICP-MS). The new areas of research aim to study the all-cases mortality, the burden of diseases, heavy metals and diseases, and course of the chain from disease to high-risk outcomes using a combination of macro and micro means, which provided scientific basic to explore pathogenesis of multi-etiology and multi-disease, and to evaluate the effects of the intervention measures in the population.

scholarly journals Minimizing interferences in the quantitative multielement analysis of trace elements in biological fluids by inductively coupled plasma mass spectrometry

1997 ◽  
Vol 43 (12) ◽  
pp. 2303-2311 ◽  
Author(s):  
Chiung-Sheng Hsiung ◽  
Joseph D Andrade ◽  
Robert Costa ◽  
K Owen Ash
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Matrix Effects ◽  
Biological Fluids ◽  
External Calibration ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Target Values ◽  
Plasma Mass Spectrometry ◽  
Urine And Serum

Abstract The determination of trace and ultratrace elements in biological fluids, including urine and serum, by inductively coupled plasma mass spectrometry (ICP-MS) is discussed. Nonspectral interferences and their corrections by external calibration and calibrator addition are discussed in detail. External calibration with internal calibration and dilution is mostly sufficient to correct for encountered biological matrix effects. For some elements, such as Cs and Zn, the use of calibrator addition provides more accurate results. The importance of spectral interferences and their elimination by isotope selection was also studied. Two examples, Cu and Zn, demonstrate the prime importance of selecting an isotope with minimal polyatomic interferences for analysis. By using 65Cu and 68Zn, accurate results for urine and serum can be obtained without excessive pretreatment of samples. Two reference materials, Bio-Rad Lyphochek urine and Kaulson Contox sera, were analyzed. Accuracy was evaluated by comparison with target values, and precision was estimated by the CV within 95% confidence.

Recent applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for biological sample analysis: a follow-up review

2017 ◽  
Vol 32 (5) ◽  
pp. 890-919 ◽  
Author(s):  
D. Pozebon ◽  
G. L. Scheffler ◽  
V. L. Dressler
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Biological Sample ◽  
Biological Tissues ◽  
Sample Analysis ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Information provided by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in the analysis of biological tissues is expanding.

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

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