scholarly journals Brucellosis Spinal Epidural Abscess: A Case Series of Fourteen Patients

2020 ◽  
Author(s):  
WeiLiang Su ◽  
GuoHua Dai ◽  
Zhu Guo ◽  
Chang Liu ◽  
Shuai Yang ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Blood Culture ◽  
Clinical Features ◽  
Epidural Abscess ◽  
Spinal Pain ◽  
Latex Agglutination ◽  
Agglutination Test ◽  
Latex Agglutination Test ◽  
Spinal Epidural Abscess ◽  
Spinal Epidural

Abstract Objective: In the present study, we aimed to describe the clinical features, diagnosis, treatment and prognosis of Brucellosis spinal epidural abscess (BSEA). Methods: The complete clinical data of 14 BSEA patients who were treated in our hospital system from January 2014 to February 2019 were retrospectively analyzed. Moreover, the clinical features, diagnosis, treatment and prognosis of 60 BSEA cases collected from the English literature from 1994 to 2019 were also investigated. Results: 3 cases were positive for blood culture, 6 cases were positive for Brucella latex agglutination test, and 9 cases were positive for tissue culture. All 14 cases showed focal spinal pain, 11 cases showed neurological deficits, and 7 cases showed fever. Of the 14 cases, 12 involved the lumbosacral spine and 2 involved the cervical spine. 13 cases were cured, 1 case left limb numbness, and the follow-up time was 12-20 months. Conclusion: The classic diagnosis of triad (focal spinal pain, neurological deficit and fever) is less specific for the diagnosis of BSEA. MRI examination can find epidural abscess, brucella latex agglutination test, blood culture, tissue culture and biopsy can be used for etiological diagnosis. Brucellosis is an uncommon cause of epidural abscess. For BSEA, early detection, early diagnosis, and early treatment should be performed, and the most suitable treatment method should be selected through comprehensive evaluation.

Adult spinal epidural abscess: clinical features and prognostic factors

2002 ◽  
Vol 104 (4) ◽  
pp. 306-310 ◽  
Author(s):  
Cheng-Hsien Lu ◽  
Wen-Neng Chang ◽  
Chen-Chung Lui ◽  
Ping-Yu Lee ◽  
Hsueh-Wen Chang
Keyword(s):  
Prognostic Factors ◽  
Clinical Features ◽  
Epidural Abscess ◽  
Spinal Epidural Abscess ◽  
Spinal Epidural

scholarly journals Use of Protein-Specific Monoclonal Antibody-Based Latex Agglutination for Rapid Diagnosis of Burkholderia pseudomallei Infection in Patients with Community-Acquired Septicemia

2007 ◽  
Vol 14 (6) ◽  
pp. 811-812 ◽  
Author(s):  
Pattama Ekpo ◽  
Utane Rungpanich ◽  
Supinya Pongsunk ◽  
Pimjai Naigowit ◽  
Vimon Petkanchanapong
Keyword(s):  
Monoclonal Antibody ◽  
Blood Culture ◽  
Burkholderia Pseudomallei ◽  
Latex Agglutination ◽  
Rapid Diagnosis ◽  
Agglutination Test ◽  
Latex Agglutination Test ◽  
Specific Monoclonal Antibody ◽  
Predictive Values ◽  
Sensitivity Specificity

ABSTRACT A latex agglutination test employing monoclonal antibody specific to a 30-kDa protein of Burkholderia pseudomallei was used to detect the organisms in blood culture specimens from 1,139 patients with community-acquired septicemia. The sensitivity, specificity, and positive and negative predictive values of the test were 96.75%, 99.61%, 96.75%, and 99.61%, respectively.

Comparison of operative and nonoperative management of spinal epidural abscess: a retrospective review of clinical and laboratory predictors of neurological outcome

2013 ◽  
Vol 19 (1) ◽  
pp. 119-127 ◽  
Author(s):  
David E. Connor ◽  
Prashant Chittiboina ◽  
Gloria Caldito ◽  
Anil Nanda
Keyword(s):  
Blood Culture ◽  
Peripheral Blood ◽  
Epidural Abscess ◽  
Nonoperative Management ◽  
Spinal Epidural Abscess ◽  
Patient Age ◽  
Focal Neurological Deficit ◽  
Radiology Reports ◽  
Patient Âgé ◽  
Spinal Epidural

Object Spinal epidural abscess (SEA), once considered a rare occurrence, has showed a rapid increase in incidence over the past 20–30 years. Recent reports have advocated for conservative, nonoperative management of this devastating disorder with appropriate risk stratification. Crucial to a successful management strategy are decisive diagnosis, prompt intervention, and consistent follow-up care. The authors present a review of their institutional experience with operative and nonoperative management of SEA to assess morbidity and mortality and the accuracy of microbiological diagnosis. Methods A retrospective analysis of patient charts, microbiology reports, operative records, and radiology reports was performed on all cases involving patients admitted with the diagnosis of SEA between July 1998 and May 2009. Results Seventy-seven cases were reviewed (median patient age 51.4 years, range 17–78 years). Axial pain was the most common presenting symptom (67.5% of cases). Presenting signs included focal weakness (55.8%), radiculopathy (28.6%), and myelopathy (5.2%). Abscesses were localized to the lumbar, thoracic, and cervical spine, respectively, in 39 (50.6%), 20 (26.0%), and 18 (23.4%) of the patients. Peripheral blood cultures were negative in 32 (45.1%) of 71 patients. Surgical site or interventional biopsy cultures were diagnostic in 52 cases (78.8%), with concordant blood culture results in 36 (60.0%). Methicillin-resistant Staphylococcus aureus (MRSA) was the most frequent isolate in 24 cases (31.2%). The mean time from admission to surgery was 5.5 days (range 0–42 days; within 72 hours in 66.7% of cases). Outcome data were available in 72 cases. At discharge, patient condition had improved or resolved in 57 cases (79.2%), improved minimally in 6 (8.3%), and showed no improvement or worsening in 9 (12.5%). Patient age and premorbid weakness were the only factors found to be significantly associated with outcome (p = 0.04 and 0.012, respectively). Conclusions These results strongly support immediate surgical decompression combined with appropriately tailored antibiotic therapy for the treatment of symptomatic SEA presenting with focal neurological deficit. The nonsuperiority discovered in other patient subsets may be due to allocation biases between surgically treated and nonsurgically treated cohorts. The present data demonstrate the accuracy of peripheral blood culture for the prediction of causative organisms and confirm patient age as a predictor of outcomes.

Spinal Epidural Abscess

2017 ◽  
Author(s):  
Minal A. Shah ◽  
Rabih O. Darouiche
Keyword(s):  
Infectious Disease ◽  
Emergency Medicine ◽  
Early Intervention ◽  
Clinical Features ◽  
Multidisciplinary Team ◽  
Epidural Abscess ◽  
Spinal Epidural Abscess ◽  
Optimal Management ◽  
Infectious Disease Specialists ◽  
Spinal Epidural

Spinal epidural abscess is a rare and debilitating illness that requires prompt recognition to prevent unfavorable outcomes. Despite increased awareness of the disease and improved imaging methods, spinal epidural abscess sometimes remains a diagnostic and therapeutic challenge; as a result, morbidity and mortality can be high. Optimal management of spinal epidural abscess requires early intervention and coordination with a multidisciplinary team, including emergency medicine physicians, infectious disease specialists, radiologists, neurosurgeons, orthopedists, internists, and hospitalists. This chapter reviews the epidemiology, microbiology, pathogenesis, clinical features, diagnosis, treatment, and outcome of spinal epidural abscess.

Spinal epidural abscess in a juvenile dog

2005 ◽  
Vol 18 (03) ◽  
pp. 186-188 ◽  
Author(s):  
W. B. Thomas ◽  
C. W. Schmiedt
Keyword(s):  
Epidural Space ◽  
Rectal Temperature ◽  
Epidural Abscess ◽  
Spinal Pain ◽  
Neurological Deficits ◽  
Spinal Epidural Abscess ◽  
Intact Female ◽  
Haemolytic Streptococcus ◽  
Spinal Epidural

SummaryA six-month-old, intact female, Miniature Pinscher was admitted with signs of progressive neurological deficits in the hind legs, an elevated rectal temperature, and spinal pain of 48 hours duration. A myelogram was performed which demonstrated a dorsal, left sided compressive lesion extending from T11-T13. A leftsided hemilaminectomy was performed from T11-T13. A friable, poorly organized, pale tan and red mass was identified within the epidural space. Cytopathological and histopathological analyses of the mass demonstrated marked, subacute, suppurative cellulitis. A culture of the purulent material revealed beta haemolytic Streptococcus sp.

Detection of rotavirus in sewage and drinking water by Latex agglutination test

2019 ◽  
Vol 9 (2) ◽  
pp. p8694
Author(s):  
Muhammad Shoaib ◽  
Kokab Furqan ◽  
Sajjad ur Rahman ◽  
Ahsan Naveed ◽  
Amjad Islam Aqib ◽  
...  
Keyword(s):  
Drinking Water ◽  
Latex Agglutination ◽  
Agglutination Test ◽  
Latex Agglutination Test

Aggregatibacter aphrophilus spinal epidural abscess

2020 ◽  
Vol 13 (7) ◽  
pp. e235320
Author(s):  
Antoine Altdorfer ◽  
Pierre Gavage ◽  
Filip Moerman
Keyword(s):  
Risk Factors ◽  
Lower Limb ◽  
Rare Case ◽  
Epidural Abscess ◽  
Spinal Epidural Abscess ◽  
Surgical Drainage ◽  
Eikenella Corrodens ◽  
Aggregatibacter Aphrophilus ◽  
Progressive Neurological Deficit ◽  
Spinal Epidural

A 76-year-old woman with a rare case of spinal epidural abscess (SEA) that had no risk factors for such type of infection, presented symptoms of back pain, progressive neurological deficit of the lower limb and loss of sphincter control. A gadolinium-enhanced MRI confirmed the diagnosis of an SEA. The patient underwent laminectomy with surgical drainage, where cultures showed the presence of Aggregatibacter aphrophilus, a bacterium of the HACEK group (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species), rarely involved in SEA. Following surgery, the patient was treated with intravenous ceftriaxone for 6 weeks, and this gave excellent results.

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