The Effects of The Royal Jelly On Dry Mouth Sensation With Normal Saliva Function: A Double-Blind, Placebo-Controlled, Cross-Over Trial Clinical Study

Abstract Background: Because there are no standardized treatment methods for dry mouth sensation with normal salivary function, cases of dry mouth sensation continually suffer. The aim of this clinical study was to evaluate the effects of a royal jelly tablets on dry mouth sensation, in patients with normal salivary function. Methods: This double-blind randomized clinical trial was carried out in the Department of Oral and Maxillofacial Surgery, Tokyo Medical and Dental University Hospital between November, 2019 and April, 2020. This clinical trial was randomized, double-blind, and of a crossover design, with a four-week washout period. Each participant received either 800 mg of royal jelly tablets or placebo, daily for 12 weeks. Results: Differences in VAS scores between royal jelly tablets and placebo were evaluated at 4 and 12 weeks, and were significant. Differences in HADS and GHQ12 scores between those exposed to royal jelly tablets and placebo, at the evaluation period of 12 weeks, were statistically significant. A statistically significant decrease in HADS scores in the royal jelly tablet group, was observed over time. Conclusions: These findings show that daily consumption of royal jelly (800 mg) for 12 weeks was effective in alleviating dry mouth sensation with normal saliva function.Clinical trial registration numbers and the full date of first registration: ClinicalTrials.gov (jRCTs031190067); 02/08/2019

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Value of Whole-Body Washing With Chlorhexidine for the Eradication of Methicillin-ResistantStaphylococcus aureus:A Randomized, Placebo-Controlled, Double-Blind Clinical Trial

Infection Control and Hospital Epidemiology ◽

10.1086/519929 ◽

2007 ◽

Vol 28 (9) ◽

pp. 1036-1043 ◽

Cited By ~ 88

Author(s):

C. Wendt ◽

S. Schinke ◽

M. Württemberger ◽

K. Oberdorfer ◽

O. Bock-Hensley ◽

...

Keyword(s):

Clinical Trial ◽

Placebo Group ◽

Treatment Group ◽

Solution Treatment ◽

University Hospital ◽

Whole Body ◽

Double Blind ◽

Antiseptic Solution ◽

Double Blind Clinical Trial ◽

Double Blinded

Background.Whole-body washing with antiseptic solution has been widely used as part of eradication treatment for colonization with methicillin-resistantStaphylococcus aureus(MRSA), but evidence for the effectiveness of this measure is limited.Objective.To study the efficacy of whole-body washing with chlorhexidine for the control of MRSA.Design.Randomized, placebo-controlled, double-blinded clinical trial.Setting.University Hospital of Heidelberg and surrounding nursing homes.Patients.MRSA carriers who were not treated concurrently with antibiotics effective against MRSA were eligible for the study.Intervention.Five days of whole-body washing with either 4% chlorhexidine solution (treatment group) or with a placebo solution. All patients received mupirocin nasal ointment and chlorhexidine mouth rinse. The outcome was evaluated 3, 4, 5, 9, and 30 days after treatment with swab samples taken from several body sites.Results.Of 114 patients enrolled in the study (56 in the treatment group and 58 in the placebo group), 11 did not finish treatment (8 from the treatment group and 3 from the placebo group [P= .02]). At baseline, the groups did not differ with regard to age, sex, underlying condition, site of MRSA colonization, or history of MRSA eradication treatment. Eleven patients were MRSA-free 30 days after treatment (4 from the treatment group and 7 from the placebo group [P= .47]). Only groin-area colonization was significantly better eradicated by the use of chlorhexidine. The best predictor for total eradication was a low number of body sites positive for MRSA. Adverse effects were significantly more frequent in the treatment group than in the placebo group (any symptom, 71% vs 33%) but were reversible in most cases.Conclusion.Whole-body washing can reduce skin colonization, but it appears necessary to extend eradication measures to the gastrointestinal tract, wounds, and/or other colonized body sites if complete eradication is the goal.Trial Registration.ClinicalTrials.gov identifier: NCT00266448.

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Clinical study of Besvion in oral and maxillofacial surgery.

Japanese Journal of Oral & Maxillofacial Surgery ◽

10.5794/jjoms.36.1397 ◽

1990 ◽

Vol 36 (5) ◽

pp. 1397-1403

Author(s):

Katsuhiro MINAMI ◽

Motohiro TSUJINO ◽

Yoshihide MORI ◽

Kinya HIGUCHI ◽

Hiroyuki HAMAGUCHI ◽

...

Keyword(s):

Clinical Study ◽

Maxillofacial Surgery ◽

Oral And Maxillofacial Surgery

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The provision of surgical tracheostomies by maxillofacial surgeons in the UK: time for a dedicated tracheostomy team?

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2017.0173 ◽

2018 ◽

Vol 100 (2) ◽

pp. 116-119

Author(s):

P Chohan ◽

R Elledge ◽

MK Virdi ◽

GM Walton

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Telephone Survey ◽

Percutaneous Dilatational Tracheostomy ◽

Maxillofacial Surgery ◽

University Hospital ◽

Oral And Maxillofacial Surgery ◽

Surgical Tracheostomy ◽

Surgical Teams ◽

The Uk

Surgical tracheostomy is a commonly provided service by surgical teams for patients in intensive care where percutaneous dilatational tracheostomy is contraindicated. A number of factors may interfere with its provision on shared emergency operating lists, potentially prolonging the stay in intensive care. We undertook a two-part project to examine the factors that might delay provision of surgical tracheostomy in the intensive care unit. The first part was a prospective audit of practice within the University Hospital Coventry. This was followed by a telephone survey of oral and maxillofacial surgery units throughout the UK. In the intensive care unit at University Hospital Coventry, of 39 referrals, 21 (53.8%) were delayed beyond 24 hours. There was a mean (standard deviation) time to delay of 2.2 days (0.9 days) and the most common cause of delay was surgeon decision, accounting for 13 (61.9%) delays. From a telephone survey of 140 units nationwide, 40 (28.4%) were regularly involved in the provision of surgical tracheostomies for intensive care and 17 (42.5%) experienced delays beyond 24 hours, owing to a combination of theatre availability (76.5%) and surgeon availability (47.1%). There is case for having a dedicated tracheostomy team and provisional theatre slot to optimise patient outcomes and reduce delays. We aim to implement such a move within our unit and audit the outcomes prospectively following this change.

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Effects of individually chosen homoeopathic medicines on recurrent URTI in children

British Homeopathic Journal ◽

10.1016/s0007-0785(96)80018-4 ◽

1996 ◽

Vol 85 (01) ◽

pp. 4-14

Author(s):

J. Blommers ◽

D.J. Kuik ◽

L. Feenstra ◽

P.D. Bezemer ◽

E.S.M. De Lange-De Klerk

Keyword(s):

Clinical Trial ◽

University Hospital ◽

Controlled Clinical Trial ◽

Upper Respiratory Tract ◽

Eligibility Criteria ◽

Double Blind ◽

Upper Respiratory ◽

The University ◽

Current Standards

AbstractThe effects of homoeopathic medicines on children suffering from recurrent upper respiratory tract infection (URTI) were studied in a randomized double-blind placebo-controlled clinical trial conducted at the paediatric outpatients department of the university hospital of the Vrije Universiteit in Amsterdam from 1987 to 1992.The study was designed to meet both the requirements of proper homoeopathic practice and the current standards of a clinical trial. The purpose of a randomized placebo-controlled double-blind trial is to identify the effects of the agents under investigation by equalizing the effects of other factors that may influence outcome.The object of the trial, eligibility criteria, follow-up period, treatments and concurrent interventions, data collection and effect measures are discussed in the light of homoeopathic thinking.

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The Effect of Korean Red Ginseng on Sexual Function in Premenopausal Women: Placebo-Controlled, Double-Blind, Crossover Clinical Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/913158 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Ho Seok Chung ◽

Insang Hwang ◽

Kyung Jin Oh ◽

Mi Na Lee ◽

Kwangsung Park

Keyword(s):

Clinical Trial ◽

Clinical Study ◽

Sexual Dysfunction ◽

Sexual Function ◽

Premenopausal Women ◽

Placebo Treatment ◽

Female Sexual Function ◽

Red Ginseng ◽

Korean Red Ginseng ◽

Double Blind

This study investigated whether Korean red ginseng (KRG) extracts could improve sexual function in premenopausal women. Forty-one premenopausal women participated in this placebo-controlled, double-blind, and crossover clinical study with administration of either three ginseng capsules (1 g per capsule) or placebo daily. After 8 weeks of medication of KRG or placebo, medication was changed for the subjects to placebo or KRG after 2 weeks of washout period. The efficacy of KRG extracts was measured by using Female Sexual Function Index (FSFI).Results. Twenty-three women completed the study. Total FSFI scores increased after KRG treatment (from20.13±2.87to23.98±4.10,p=0.015) and placebo treatment (from20.06±2.64to23.78±3.28,p=0.003). However, this change was not significantly different between the two groups (p=0.702). KRG treatment significantly improved sexual desire, arousal, orgasm, and satisfaction domains; however, there was no treatment effect compared with placebo. There was a case of gastric discomfort after taking KRG extracts. Oral administration of KRG extracts improved sexual function in premenopausal women; however, there were no statistical significant changes compared to placebo. It implies that KRG extracts have a substantial placebo effect in premenopausal women with sexual dysfunction.

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