A Study on Estimation of plasma Fibrinogen and plasma fibrin degradation product FDP in women with preeclamptic pregnanc

Abstract Objective: This study aimed to assess the role of coagulation-related indicators such as plasma ﬁbrinogen (FIB), D-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) and their association with disease activity.Methods: Data from 105 RA patients and 102 age- and gender- matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide the RA patients into inactive group (DAS28-CRP ≤ 2.7) and active group (DAS28-CRP > 2.7). The association between plasma FIB, D-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Receiver operating characteristic (ROC) curve was applied to determine the area under curve (AUC) value. The prognostic value of plasma FIB, D-dimer, and FDP in the RA disease activity was tested by logistical regression analysis.Results: RA patients showed higher FAR levels of plasma FIB, D-dimer, and FDP than the controls (P < 0.01). Plasma FIB, D-dimer, and FDP were also increased in active group of RA patients than those in inactive group (P < 0.001). Spearman analysis showed that plasma FIB, D-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. ROC curve analyses revealed that the AUC of D-dimer was higher than ESR and RF, and that of FDP was higher than RF in RA patients. In addition, the optimal cut-oﬀ value of plasma FIB, D-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 μg/L, and 1.45 mg/L, respectively. Logistical regression analyses showed that D-dimer (odds ratio = 2.862, 95% conﬁdence interval: 1.851-4.426, P < 0.001) was a predictor for RA disease activity.Conclusions: FIB, D-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. D-dimer may act as a novel inﬂammatory parameter for predicting disease activity in RA patients.

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Plasma Fibrinogen and Fibrin Degradation Product (FDP) in Preeclamptic and Normal Pregnant Women in the Third Trimester of Pregnancy

International Journal of Contemporary Surgery ◽

10.5958/2321-1024.2016.00038.6 ◽

2016 ◽

Vol 4 (1) ◽

pp. 178

Author(s):

Alla Satyanarayana Reddy

Keyword(s):

Pregnant Women ◽

Degradation Product ◽

Plasma Fibrinogen ◽

Third Trimester ◽

Fibrin Degradation Product ◽

The Third

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Evaluation of platelet number and function and fibrinogen level in patients bitten by snakes of the Bothrops genus

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86821995000100004 ◽

1995 ◽

Vol 28 (1) ◽

pp. 19-24 ◽

Cited By ~ 2

Author(s):

Fábio Cardoso Luan ◽

Izolete Aparecida Thomazini ◽

Iracema Carvalho ◽

Delane Mercedes Gonçalves Carreira ◽

Valter José Cassinelli ◽

...

Keyword(s):

Platelet Function ◽

Degradation Product ◽

Statistical Difference ◽

Fibrinogen Level ◽

Plasma Fibrinogen ◽

Fibrin Degradation Product ◽

Platelet Number ◽

And Function

Platelet function and plasma fibrinogen levels were evaluated in 14 patients, 10 males and 4females, aged 13-59years bitten by Bothrops genus snakes. There was a statistical difference (p < 0.05) among plasma fibrinogen levels evaluated 24 and 48 hours after envenomation. There was a tendency towards normalization after 48 hours of treatment. The low platelet number was clear in 24-48 hour evaluations with a tendency towards normalization after 48 hours of treatment (p<0.05). Fibrinogen levels and fibrin degradation product (FDP) levels appeared to be altered in 83.33% of patients evaluated. The authors suggest that platelet hypoaggregation is related to decreased fibrinogen and increased FDP levels.</

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Plasma Fibrinogen Performs Better Than Plasma d-Dimer and Fibrin Degradation Product in the Diagnosis of Periprosthetic Joint Infection and Determination of Reimplantation Timing

The Journal of Arthroplasty ◽

10.1016/j.arth.2020.03.055 ◽

2020 ◽

Vol 35 (8) ◽

pp. 2230-2236 ◽

Cited By ~ 3

Author(s):

Hao Wu ◽

Zhichao Meng ◽

Liping Pan ◽

Heng Liu ◽

Xin Yang ◽

...

Keyword(s):

Periprosthetic Joint Infection ◽

Degradation Product ◽

Joint Infection ◽

Plasma Fibrinogen ◽

Fibrin Degradation Product ◽

D Dimer ◽

Better Than

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Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis

Scientific Reports ◽

10.1038/s41598-021-96349-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Li Xue ◽

Li Tao ◽

Xueyi Li ◽

Yan Wang ◽

Biao Wang ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Regression Analysis ◽

Disease Activity ◽

Roc Curve ◽

Degradation Product ◽

Plasma Fibrinogen ◽

Fibrin Degradation Product ◽

Activity Data ◽

Logistical Regression ◽

Logistical Regression Analysis

AbstractThis study aimed to assess the association of coagulation-related indicators such as plasma fibrinogen (FIB), d-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) with the disease activity. Data from 105 RA patients and 102 age- and gender-matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide RA patients into low activity group (DAS28-CRP ≤ 2.7) and active group (DAS28-CRP > 2.7). Receiver operating characteristic (ROC) curve was applied to determine area under the curve (AUC). The association between plasma FIB, d-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Logistical regression analysis was used to identify the independent variables associated with RA disease activity. RA patients showed higher levels of plasma FIB, d-dimer, and FDP than the controls (P < 0.01). Plasma FIB, d-dimer, and FDP were also increased in active groups of RA patients than those in inactive groups (P < 0.001). ROC curve analyses revealed that the AUC of d-dimer was higher than erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF), and that of FDP was higher than RF in RA patients. In addition, the optimal cut-off value of plasma FIB, d-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 μg/L, and 1.45 mg/L, respectively. Spearman analysis showed that plasma FIB, d-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. Logistical regression analysis showed that d-dimer (odds ratio 2.862, 95% confidence interval 1.851–5.426, P < 0.001) was an independent variable associated with RA disease activity. FIB, d-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. d-dimer may act as a novel inflammatory indice for indicating disease activity in RA patients.

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Purification and characterization of fibrinolytic protease from Bacillus amyloliquefaciens MCC2606 and analysis of fibrin degradation product by MS/MS

Preparative Biochemistry & Biotechnology ◽

10.1080/10826068.2017.1421964 ◽

2018 ◽

Vol 48 (2) ◽

pp. 172-180 ◽

Cited By ~ 6

Author(s):

Yogesh Devaraj ◽

Savita Kumari Rajender ◽

Prakash Motiram Halami

Keyword(s):

Degradation Product ◽

Bacillus Amyloliquefaciens ◽

Purification And Characterization ◽

Fibrin Degradation Product

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Plasma Fibrin Degradation Product and D-Dimer Are of Limited Value for Diagnosing Periprosthetic Joint Infection

The Journal of Arthroplasty ◽

10.1016/j.arth.2019.05.009 ◽

2019 ◽

Vol 34 (10) ◽

pp. 2454-2460 ◽

Cited By ~ 26

Author(s):

Hong Xu ◽

Jinwei Xie ◽

Qiang Huang ◽

Yiting Lei ◽

Shaoyun Zhang ◽

...

Keyword(s):

Periprosthetic Joint Infection ◽

Degradation Product ◽

Joint Infection ◽

Fibrin Degradation Product ◽

D Dimer

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Fibrin fragment D-dimer and fibrinogen B beta peptides in plasma as markers of clot lysis during thrombolytic therapy in acute myocardial infarction

Blood ◽

10.1182/blood.v76.7.1341.1341 ◽

1990 ◽

Vol 76 (7) ◽

pp. 1341-1348 ◽

Cited By ~ 29

Author(s):

CM Lawler ◽

EG Bovill ◽

DC Stump ◽

DJ Collen ◽

KG Mann ◽

...

Keyword(s):

Myocardial Infarction ◽

Degradation Product ◽

Degradation Products ◽

Tissue Type ◽

Clot Lysis ◽

Fibrin Degradation Product ◽

Fibrin Degradation Products ◽

Group 2 ◽

D Dimer ◽

Group 1

Abstract The validity of markers in plasma of in vitro thrombolysis was investigated in 12 patients with extensive fibrinogen breakdown (greater than 80%, group 1) and in 12 patients with minimal breakdown (less than 20%, group 2). The patients were treated with 100 mg of recombinant tissue-type plasminogen activator (rt-PA) in the “Thrombolysis in Myocardial Infarction II” (TIMI II) trial. Cross- linked fibrin degradation product levels were measured with two variant enzyme-linked immunosorbent assays (ELISAs), both using a fibrin fragment D-dimer specific capture antibody. In one instance, a tag antibody was used that cross-reacts with fibrinogen (pan-specific tag ELISA); in the other, the tag antibody was specific for fibrin fragment D (fibrin-specific tag ELISA). Apparent concentrations of cross-linked fibrin degradation products at baseline were within normal limits with both assays in most patients. At 8 hours after rt-PA infusion, the measured cross-linked fibrin degradation products were increased about twofold to fourfold in group 2 with both assays. However, in group 1, levels were significantly higher with the pan-specific tag ELISA (5.8 +/- 4.2 micrograms/mL) compared with the fibrin-specific tag ELISA (1.5 +/- 1.3 micrograms/mL). This observation was most likely a result of detection of fibrinogen degradation products in the pan-specific ELISA. Apparent levels of fibrinopeptide B beta 1–42, a marker of fragment X formation, increased during thrombolysis from 4.2 +/- 2.8 pmol/mL to 2,000 +/- 230 pmol/mL in group 1 and from 4.1 +/- 2.1 pmol/mL to 300 +/- 43 pmol/mL in group 2, and were correlated significantly with the extent of fibrinogen breakdown (r = -0.8). Fibrinopeptide beta 15–42 levels increased from 4.3 +/- 3 pmol/mL to 70 +/- 19 pmol/mL in group 1, but did not increase in group 2. The apparent increase in group 1 could be explained by cross-reactivity of fibrinopeptide B beta 1–42 in the fibrinopeptide beta 15–42 assay. We conclude that cross-linked fibrin degradation product levels as measured with a pan-specific tag ELISA and fibrinopeptide beta 15–42 levels as measured with certain monoclonal antibody-based ELISA are influenced by the extent of fibrinogen degradation. Fibrinopeptide B beta 1–42 is a marker specific for fibrinogen breakdown. Cross-linked fibrin degradation product levels, measured with a fibrin-specific tag ELISA, appear to be markers specific for thrombolysis. Consequently, assays similar to the fibrin- specific tag ELISA may provide more accurate information when correlated with clinical endpoints.

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