EFFECT OF ETRETINATE (AROMATIC RETINOID) TREATMENT DURING GESTATION AND LACTATION PERIODS ON VIABILITY AND SOMATIC GROWTH IN F1 RATS

The role of the circadian clock in the reproductive development of Syrian hamsters (Mesocricetus auratus was examined in wild type and circadian tau mutant hamsters reared from birth to 26 weeks of age under constant dim red light. Testis diameter and body weights were determined at weekly intervals in male hamsters from 4 weeks of age. In both genotypes, testicular development, subsequent regression and recrudescence exhibited a similar time course. The age at which animals displayed reproductive photosensitivity, as exhibited by testicular regression, was unrelated to circadian genotype (mean +/- SEM: 54 +/- 3 days for wild type and 59 +/- 5 days for tau mutants). In contrast, our studies revealed a significant impact of the mutation on somatic growth, such that tau mutants weighed 18% less than wild types at the end of the experiment. Our study reveals that the juvenile onset of reproductive photoperiodism in Syrian hamsters is not timed by the circadian system.

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Faculty Opinions recommendation of Gene-environment interactions: the potential role of contaminants in somatic growth and the development of the reproductive system of the American alligator.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.721858855.793547080 ◽

2018 ◽

Author(s):

John Wise

Keyword(s):

Reproductive System ◽

Potential Role ◽

Somatic Growth ◽

American Alligator ◽

Gene Environment

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Congenital Lymphatic Malformation and Aortic Aneurysm in a Patient with TSC2 Mutation

Neuropediatrics ◽

10.1055/s-0039-1694985 ◽

2019 ◽

Vol 51 (01) ◽

pp. 057-061 ◽

Cited By ~ 2

Author(s):

Adelheid Wiemer-Kruel ◽

Hans Mayer ◽

Peter Ewert ◽

Stefan Martinoff ◽

Hans-Henning Eckstein ◽

...

Keyword(s):

Adverse Effect ◽

Side Effects ◽

Aortic Aneurysm ◽

Tuberous Sclerosis ◽

Somatic Growth ◽

Lymphatic Malformation ◽

Aortic Aneurysms ◽

Operative Intervention

AbstractWe present a 7-year-old boy with tuberous sclerosis and congenital segmental lymphedema (CSL) of the left leg, as well as two aortic aneurysms. He was treated with everolimus (EVE) since the age of 14 months. His CSL regressed under treatment with EVE. His first aneurysms required operative intervention at age of 17 months. Four months afterward a new aortic aneurysm had been detected above the Dracon graft, but this one remained stable since that time. The patient didn't experience severe side effects. EVE has been well tolerated without disturbance of somatic growth or serious adverse effect.

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Ultrasound Evaluation of the Effectiveness of the Use of Acitretin in the Treatment of Nail Psoriasis

Journal of Clinical Medicine ◽

10.3390/jcm10102122 ◽

2021 ◽

Vol 10 (10) ◽

pp. 2122

Author(s):

Magdalena Krajewska-Włodarczyk ◽

Zbigniew Żuber ◽

Agnieszka Owczarczyk-Saczonek

Keyword(s):

Morphological Changes ◽

Nail Plate ◽

Clinical Signs ◽

Extensor Tendon ◽

Control Group ◽

Nail Bed ◽

Nail Psoriasis ◽

Ultrasound Evaluation ◽

Tendon Thickness ◽

Retinoid Treatment

The study aimed to evaluate the effect of retinoid treatment on the morphological changes in the nail apparatus in patients with nail psoriasis. Material and methods: 41 patients aged 32 to 64 with nail psoriasis, without clinical signs of psoriatic arthritis, started on acitretin 0.6 to 0.8 mg kg b.w./d, for six months and 28 people in the control group were included in the study. Both groups had ultrasound examination of fingernails and digital extensor tendon in the distal interphalangeal joints. In psoriatic patients, US examination was conducted before starting the treatment and after six months. A total of 685 nails were examined. Results: After six months of treatment, there was a reduction in the thickness of the nail bed and nail matrix (p = 0.046 and p = 0.031, respectively). The thickness of the nail plates decreased, although it was statistically insignificant (p = 0.059) and it was higher than in the control group (p = 0.034). The reduced severity of clinical nail changes after six months of retinoid treatment did not correlate with the reduction in extensor tendon thickness in any group of patients. Conclusions: In patients with nail psoriasis, acitretin treatment resulted in a rapid decrease in the thickness of the nail bed and matrix, but it did not affect the thickness of the nail plate after six months. There was no effect of acitretin on the digital extensor tendon thickness or the increased blood supply to the tendon area. The results of the study may indicate the usefulness of ultrasound nail examinations in patients with nail psoriasis not only to assess the advancement of morphological changes and response to treatment, but also to choose the potential treatment.

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Relationships among somatic growth, climate, and fisheries production in an overexploited marine fish from the Gulf of California, Mexico

Fisheries Oceanography ◽

10.1111/fog.12537 ◽

2021 ◽

Author(s):

Brad E. Erisman ◽

Erin M. Reed ◽

Martha J. Román ◽

Ismael Mascareñas‐Osorio ◽

Peter Sleen ◽

...

Keyword(s):

Marine Fish ◽

Gulf Of California ◽

Somatic Growth

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Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders

Scientific Reports ◽

10.1038/s41598-020-80734-y ◽

2021 ◽

Vol 11 (1) ◽

Cited By ~ 1

Author(s):

Amanda H. Mahnke ◽

Georgios D. Sideridis ◽

Nihal A. Salem ◽

Alexander M. Tseng ◽

R. Colin Carter ◽

...

Keyword(s):

Fetal Alcohol Spectrum Disorders ◽

Cardiac Development ◽

Prenatal Alcohol Exposure ◽

Skeletal Development ◽

Somatic Growth ◽

Alcohol Exposure ◽

Cardiovascular Development ◽

Relevant Effect ◽

Cell Cycle Inhibition ◽

Neurobehavioral Deficits

AbstractPrenatal alcohol exposure (PAE) can result in cognitive and behavioral disabilities and growth deficits. Because alcohol-related neurobehavioral deficits may occur in the absence of overt dysmorphic features or growth deficits, there is a need to identify biomarkers of PAE that can predict neurobehavioral impairment. In this study, we assessed infant plasma extracellular, circulating miRNAs (exmiRNAs) obtained from a heavily exposed Cape Town cohort to determine whether these can be used to predict PAE-related growth restriction and cognitive impairment. PAE, controlling for smoking as a covariate, altered 27% of expressed exmiRNAs with clinically-relevant effect sizes (Cohen’s d ≥ 0.4). Moreover, at 2 weeks, PAE increased correlated expression of exmiRNAs across chromosomes, suggesting potential co-regulation. In confirmatory factor analysis, the variance in expression for PAE-altered exmiRNAs at 2 weeks and 6.5 months was best described by three-factor models. Pathway analysis found that factors at 2 weeks were associated with (F1) cell maturation, cell cycle inhibition, and somatic growth, (F2) cell survival, apoptosis, cardiac development, and metabolism, and (F3) cell proliferation, skeletal development, hematopoiesis, and inflammation, and at 6.5 months with (F1) neurodevelopment, neural crest/mesoderm-derivative development and growth, (F2) immune system and inflammation, and (F3) somatic growth and cardiovascular development. Factors F3 at 2 weeks and F2 at 6.5 months partially mediated PAE-induced growth deficits, and factor F3 at 2 weeks partially mediated effects of PAE on infant recognition memory at 6.5 months. These findings indicate that infant exmiRNAs can help identify infants who will exhibit PAE-related deficits in growth and cognition.

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