Autoreactivity and Broad Neutralization of Antibodies Against HIV-1 Are Governed by Distinct Mutations: Implications for Vaccine Design Strategies

2022 ◽  
Author(s):  
Xiaojun Li ◽  
Dongmei Liao ◽  
Zhengyang Li ◽  
Jixi Li ◽  
Marilyn Diaz ◽  
...  
Keyword(s):  
Vaccine Design ◽  
Design Strategies ◽  
Hiv 1

Broadly Neutralizing Antibodies (BNAbs): templates for HIV-1 vaccine design

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Lixin Yan ◽  
◽  
Lihong Liu ◽  
Yilin Wang ◽  
Xi Huang ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Vaccine Design ◽  
Broadly Neutralizing Antibodies ◽  
Hiv 1

HIV-1 Superinfection and its Implications for Vaccine Design

2010 ◽  
Vol 8 (8) ◽  
pp. 596-601 ◽  
Author(s):  
Bhavna H. Chohan ◽  
Anne Piantadosi ◽  
Julie Overbaugh
Keyword(s):  
Vaccine Design ◽  
Hiv 1

scholarly journals 2G12-Expressing B Cell Lines May Aid in HIV Carbohydrate Vaccine Design Strategies

2012 ◽  
Vol 87 (4) ◽  
pp. 2234-2241 ◽  
Author(s):  
K. J. Doores ◽  
M. Huber ◽  
K. M. Le ◽  
S.-K. Wang ◽  
C. Doyle-Cooper ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lines ◽  
Vaccine Design ◽  
Design Strategies

scholarly journals The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies

2020 ◽  
pp. 107051
Author(s):  
Soheila Molaei ◽  
Masoomeh Dadkhah ◽  
Vahid Asghariazar ◽  
Chiman Karami ◽  
Elham Safarzadeh
Keyword(s):  
Immune Response ◽  
Immune Evasion ◽  
Vaccine Design ◽  
Design Strategies

scholarly journals Broadly neutralizing antibodies and vaccine design against HIV-1 infection

2019 ◽  
Vol 14 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Qian Wang ◽  
Linqi Zhang
Keyword(s):  
Neutralizing Antibodies ◽  
Vaccine Development ◽  
Vaccine Design ◽  
Therapeutic Interventions ◽  
Type I ◽  
Broadly Neutralizing Antibodies ◽  
Dynamic Studies ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Remarkable Progress

AbstractRemarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I (HIV-1) through antiretroviral therapy. However, vaccine development has remained challenging. Recent discoveries in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody response. Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein (Env) during infection. Our review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development.

Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties

2017 ◽  
Vol 139 ◽  
pp. 865-883 ◽  
Author(s):  
Murugaiah A.M. Subbaiah ◽  
Nicholas A. Meanwell ◽  
John F. Kadow
Keyword(s):  
Protease Inhibitors ◽  
Design Strategies ◽  
Pharmaceutical Properties ◽  
Hiv 1

scholarly journals Single-Molecule FRET Reveals an Additional Conformational State of HIV-1 Envelope Glycoprotein Critical for Vaccine Design

2018 ◽  
Vol 114 (3) ◽  
pp. 27a
Author(s):  
Maolin Lu ◽  
Xiaochu Ma ◽  
Castillo-Menendez Luis R. ◽  
Utz Ermel ◽  
Terry Daniel S. ◽  
...  
Keyword(s):  
Single Molecule ◽  
Envelope Glycoprotein ◽  
Vaccine Design ◽  
Conformational State ◽  
Single Molecule Fret ◽  
Hiv 1

scholarly journals Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

2018 ◽  
Vol 24 (6) ◽  
pp. 857-867 ◽  
Author(s):  
Kai Xu ◽  
Priyamvada Acharya ◽  
Rui Kong ◽  
Cheng Cheng ◽  
Gwo-Yu Chuang ◽  
...  
Keyword(s):  
Vaccine Design ◽  
Fusion Peptide ◽  
Hiv 1

scholarly journals PI-6 Construction and analysis of V3 glycopeptide antigens for HIV-1 vaccine design

2019 ◽  
Vol 81 ◽  
pp. 78
Author(s):  
Roushu Zhang ◽  
Hui Cai ◽  
Jared Orwenyo ◽  
John Giddens ◽  
Qiang Yang ◽  
...  
Keyword(s):  
Vaccine Design ◽  
Hiv 1
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