Effect of Thyroid Stimulating Hormone and Thyroid Hormone on Progesterone Synthesis in Cultured Granulosa Cells of Japanese Quail.

AbstractThyroid hormone reference intervals are crucial for diagnosing and monitoring thyroid dysfunction during early pregnancy, and the dynamic change trend of thyroid hormones during pregnancy can assist clinicians to assess the thyroid function of pregnant women. This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Reference individuals in database* were used to establish gestational age-specific reference intervals for thyroid hormones and early pregnancy related thyroid hormones models for pregnant women. Individuals in database# were apparently healthy non-pregnant women. The thyroid hormones levels of individuals in database# were compared with that of individuals in database* using nonparametric methods and the comparative confidence interval method. The differences in thyroid stimulating hormone and free thyroxine between early pregnant and non-pregnant women were statistically significant (p<0.0001). The reference intervals of thyroid stimulating hormone, free thyroxine and free triiodothyronine for early pregnant women were 0.052–3.393 μIU/ml, 1.01–1.54 ng/dl, and 2.51–3.66 pg/ml, respectively. Results concerning thyroid stimulating hormone and free thyroxine reference intervals of early pregnancy are comparable with those from other studies using the same detection platform. Early pregnancy related thyroid hormones models showed various change patterns with gestational age for thyroid hormones. Early pregnancy related thyroid hormones models and reference intervals for pregnant women were established, so as to provide accurate and reliable reference basis for the diagnosing and monitoring of maternal thyroid disfunction in early pregnancy.

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Economic Evaluation of Recombinant Human Thyroid Stimulating Hormone Stimulation vs. Thyroid Hormone Withdrawal Prior to Radioiodine Ablation for Thyroid Cancer: The Korean Perspective

Endocrinology and Metabolism ◽

10.3803/enm.2015.30.4.531 ◽

2015 ◽

Vol 30 (4) ◽

pp. 531 ◽

Cited By ~ 6

Author(s):

Seo Young Sohn ◽

Hye Won Jang ◽

Yoon Young Cho ◽

Sun Wook Kim ◽

Jae Hoon Chung

Keyword(s):

Thyroid Cancer ◽

Economic Evaluation ◽

Thyroid Hormone ◽

Thyroid Stimulating Hormone ◽

Human Thyroid ◽

Thyroid Hormone Withdrawal ◽

Hormone Stimulation ◽

Radioiodine Ablation ◽

Stimulating Hormone

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Misleading results from immunoassays of serum free thyroxine in the presence of rheumatoid factor

Clinical Chemistry ◽

10.1093/clinchem/43.6.957 ◽

1997 ◽

Vol 43 (6) ◽

pp. 957-962 ◽

Cited By ~ 50

Author(s):

Anthony G W Norden ◽

Rodwin A Jackson ◽

Lorraine E Norden ◽

A Jane Griffin ◽

Margaret A Barnes ◽

...

Keyword(s):

Thyroid Hormone ◽

Rheumatoid Factor ◽

Equilibrium Dialysis ◽

Thyroid Stimulating Hormone ◽

Normal Serum ◽

Free Thyroxine ◽

Free Triiodothyronine ◽

Serum Free ◽

Serum Free Thyroxine ◽

Stimulating Hormone

Abstract A novel interference with measurements of serum free thyroxine (FT4) caused by rheumatoid factor (RhF) is described. We found misleading, sometimes gross, increases of FT4 results in 5 clinically euthyroid elderly female patients with high RhF concentrations. All 5 patients had high FT4 on Abbott AxSYM® or IMx® analyzers. “NETRIA” immunoassays gave misleading results in 4 of the 5 patients; Amerlex-MAB® in 2 of 4 patients; AutoDELFIA®in 2 of the 5; and Corning ACS-180® and Bayer Diagnostics Immuno 1® in 1 of the 5. BM-ES700® system results for FT4 in these women remained within the reference range. Results for serum T4, thyroid-stimulating hormone, free triiodothyronine, thyroid-hormone-binding globulin, and FT4 measured by equilibrium dialysis were normal in all 5 patients. Drugs, albumin-binding variants, and anti-thyroid-hormone antibodies were excluded as interferences. Addition to normal serum of the RhF isolated from each of the 5 patients increased the apparent FT4 (Abbott AxSYM). Screening of 83 unselected patients demonstrated a highly significant positive correlation between FT4 (Abbott AxSYM) and RhF concentrations. Discrepant, apparently increased FT4 with a normal result for thyroid-stimulating hormone should lead to measurement of the patient’s RhF concentration.

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