Short-term effects of a hypocaloric diet and a physical activity programme on weight loss and exercise capacity in obese subjects with chronic ischaemic heart disease: a study in everyday practice

2008 ◽  
Vol 63 (2) ◽  
pp. 153-159 ◽  
Author(s):  
L.A. Gondoni ◽  
A.M. Titon ◽  
F. Nibbio ◽  
G. Caetani ◽  
G. Augello ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Exercise Capacity ◽  
Hypocaloric Diet ◽  
Everyday Practice ◽  
Short Term ◽  
Physical Activity Programme ◽  
Obese Subjects

scholarly journals Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1–4, and IGFBPs-1–3 protease activity in obese subjects

2006 ◽  
Vol 155 (4) ◽  
pp. 575-581 ◽  
Author(s):  
Michael Højby Rasmussen ◽  
Anders Juul ◽  
Lise Lund Kjems ◽  
Jannik Hilsted
Keyword(s):  
Weight Loss ◽  
Protease Activity ◽  
Biologically Active ◽  
Hypocaloric Diet ◽  
Short Term ◽  
Igf I ◽  
Igf Binding ◽  
Acid Labile Subunit ◽  
Obese Subjects ◽  
Acid Labile

Objective: Decreased levels of GH and total IGF-I have been reported in obesity. It has been hypothesized that increased free (biologically active) IGF-I levels generated from IGF-binding protein (IGFBP) protease activity could be the mechanism for the low GH release in dieting obese subjects. However, no published data exist on free IGF-I levels, acid labile subunit (ALS), or IGFBP protease activity in relation to GH release during a hypocaloric diet. The main purpose of this study was to determine free IGF-I, ALS, IGFBPs-1–4, and IGFBPs-1–3 protease activity in relation to 24-h GH release before and after a short-term very low-calorie diet (VLCD). Design: Six obese subjects before weight loss, five after an average weight loss of 36.1 kg, and five age-and sex-matched lean controls underwent a 4-day VLCD. All subjects were studied on two occasions, once during normal basic diet and again during the last day of the VLCD (1.6 MJ). Methods: Free IGF-I was determined by a non-competitive immunoradiometric assay. Results: Free IGF-I levels decreased in concert with increased ALS and unchanged blunted GH release after a VLCD in the obese subjects. IGFBPs-1–3 proteolytic activity was found to be unchanged by hypocaloric diet in all groups. Conclusions: We conclude that free IGF-I decreases after a short-term hypocaloric diet in obese subjects with no concomitant change in 24-h GH release. Circulating free IGF-I per se cannot be the main mechanism of the attenuated GH release in dieting obese subjects.

scholarly journals Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet

2011 ◽  
Vol 165 (2) ◽  
pp. 249-254 ◽  
Author(s):  
Greeshma K Shetty ◽  
Giuseppe Matarese ◽  
Faidon Magkos ◽  
Hyun-Seuk Moon ◽  
Xiaowen Liu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Hypocaloric Diet ◽  
Short Term ◽  
Obese Adults ◽  
Neuroendocrine Function ◽  
Term Energy ◽  
Obese Subjects ◽  
Energy Deprivation ◽  
To Receive

ObjectiveShort-term energy deprivation reduces leptin concentrations and alters the levels of circulating hormones of the hypothalamic–pituitary–peripheral axis in lean subjects. Whether the reduction in leptin concentration during long-term weight loss in obese individuals is linked to the same neuroendocrine changes seen in lean, leptin-sensitive subjects remains to be fully clarified.MethodsIn this study, 24 overweight and obese adults (16 women and eight men; body mass index (BMI): 27.5–38.0 kg/m2) were prescribed a hypocaloric diet (−500 kcal/day) and were randomized to receive recombinant methionyl leptin (n=18, metreleptin, 10 mg/day self-injected s.c.) or placebo (n=6, same volume and time as metreleptin) for 6 months.ResultsMetreleptin administration did not affect weight loss beyond that induced by hypocaloric diet alone (P for interaction=0.341) but increased the serum concentrations of total leptin by six- to eight-fold (P<0.001) and led to the generation of anti-leptin antibodies. Despite free leptin concentration (P for interaction=0.041) increasing from 9±1 ng/ml at baseline to 43±15 and 36±12 ng/ml at 3 and 6 months, respectively, changes in circulating hormones of the thyroid and IGF axes at 3 and 6 months were not significantly different in the placebo- and metreleptin-treated groups.ConclusionsLeptin does not likely mediate changes in neuroendocrine function in response to weight loss induced by a mild hypocaloric diet in overweight and obese subjects.

Effects of a Low Carbohydrate Weight Loss Diet on Exercise Capacity and Tolerance in Obese Subjects

Obesity ◽  
2009 ◽  
Author(s):  
Grant D. Brinkworth ◽  
Manny Noakes ◽  
Peter M. Clifton ◽  
Jonathan D. Buckley
Keyword(s):  
Weight Loss ◽  
Exercise Capacity ◽  
Weight Loss Diet ◽  
Low Carbohydrate ◽  
Obese Subjects

scholarly journals P47 The impact of comorbid ischaemic heart disease on exercise capacity in COPD patients

Thorax ◽  
2011 ◽  
Vol 66 (Suppl 4) ◽  
pp. A87-A87
Author(s):  
A. R. C. Patel ◽  
A. D. Alahmari ◽  
G. C. Donaldson ◽  
B. Kowlessar ◽  
A. J. Mackay ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Exercise Capacity ◽  
Copd Patients ◽  
The Impact

Ischaemic heart disease, skeletal muscle fibres and exercise capacity

1992 ◽  
Vol 13 (6) ◽  
pp. 758-762 ◽  
Author(s):  
J. KARLSSON ◽  
B. DIAMANT ◽  
K. FOLKERS ◽  
H. ÅSTRÖM ◽  
S. GUNNES ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Exercise Capacity ◽  
Muscle Fibres ◽  
Skeletal Muscle Fibres

Comparison of the effect of 12- and 24-session cardiac rehabilitation on physical, psychosocial and biomedical factors in ischemic heart disease patients

2020 ◽  
Vol 41 (1) ◽  
Author(s):  
Masoumeh Sadeghi ◽  
Abdullah Izadi ◽  
Mohammad Mahdi Hadavi ◽  
Mohammad Rafati Fard ◽  
Hamidreza Roohafza
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cardiac Rehabilitation ◽  
Ischemic Heart ◽  
Life Questionnaire ◽  
Short Term ◽  
Significant Difference

AbstractBackgroundCardiac rehabilitation (CR) is a key component of effective care for patients with a wide spectrum of cardiac problems. It seems that the short-term provision of these services can facilitate their use and meeting of related needs for patients participating in the CR programs.Materials and methodsIn this interventional study on patients with ischemic heart disease (IHD) referred to the Cardiac Rehabilitation Center of Chamran Hospital, Isfahan, Iran. One-hundred and twelve patients were randomly divided into two groups of 12 and 24 sessions of CR [mean age: 59.2 ± (9.02) and 60.7 ± (9.3) years, respectively] and underwent a CR program. All information was collected in two stages, before the beginning of the program and after completion of 12- and 24-session rehabilitation programs. The data collection tools were demographics questionnaire, the International Physical Activity Questionnaires (IPAQ), McNew Quality of Life Questionnaire, Beck Depression Inventory (BDI), and Zung Self-Rating Anxiety Scale (SAS).ResultsThe results of this study showed that in both groups, total physical activity (PA) and functional capacity increased, and the quality of life (QOL) was statistically improved. Comparison of changes in mean differences at the end of the rehabilitation periods between the two groups, showed that only the weight, body mass index (BMI), waist circumference (WC) and high-density lipoprotein (HDL) in the 24-session group significantly decreased compared to the 12-session group and, but no significant difference in other variables was observed.ConclusionOverall, the findings of this study support the overall benefits of the CR program in both the short and the long term. Therefore it can be suggested that a short-term program can still be a valuable option for reducing the risk in cardiac patients and meeting their service needs.

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