Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study

Aims: This study was aimed at comparing the incidence of arterial hypertension and blood pressure (BP) variance in hospital and out-of-hospital hemodialysis (HD) patients during HD sessions. Methods: A cross-sectional study was conducted for 1 week at all the HD centers in Dalmatia, Croatia. The pre-, intra-, and post-dialysis BP values were collected for 3 consecutive HD sessions per patient. Results: Of the 399 subjects, 73.9% were hypertensives, who showed higher interdialytic weight gain compared to the normotensives (2.58 vs. 2.40). Hospital and out-of-hospital HD patients received identical antihypertensive therapies, except that beta blockers were more frequently administered to out-of-hospital HD patients. Higher pre-, intra-, and post-dialysis BP values were recorded in patients at out-of-hospital HD centers. Conclusion: The differences in BP variability and antihypertensive therapies administered to hospital HD patients as compared to out-of-hospital HD patients may reflect differing approaches by the nephrologists at these centers.

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A Prospective Cohort Study Showing No Association Between Serum Sclerostin Level and Mortality in Maintenance Hemodialysis Patients

Kidney & Blood Pressure Research ◽

10.1159/000490824 ◽

2018 ◽

Vol 43 (3) ◽

pp. 1023-1033 ◽

Cited By ~ 7

Author(s):

Madoka Sato ◽

Norio Hanafusa ◽

Hiroshi Kawaguchi ◽

Ken Tsuchiya ◽

Kosaku Nitta

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Hemodialysis Patients ◽

Maintenance Hemodialysis ◽

Sclerostin Level ◽

Maintenance Hemodialysis Patients

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Cross-sectional small intestinal surveillance of maintenance hemodialysis patients using video capsule endoscopy: SCHEMA study

Endoscopy International Open ◽

10.1055/s-0042-105203 ◽

2016 ◽

Vol 04 (05) ◽

pp. E589-E596 ◽

Cited By ~ 4

Author(s):

Naoki Hosoe ◽

Shigeaki Matsukawa ◽

Yoshihiko Kanno ◽

Makoto Naganuma ◽

Hiroyuki Imaeda ◽

...

Keyword(s):

Capsule Endoscopy ◽

Hemodialysis Patients ◽

Video Capsule Endoscopy ◽

Maintenance Hemodialysis ◽

Cross Sectional ◽

Small Intestinal ◽

Maintenance Hemodialysis Patients

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Appraising Stroke Risk in Maintenance Hemodialysis Patients: A Large Single-Center Cohort Study

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2011.07.016 ◽

2012 ◽

Vol 59 (2) ◽

pp. 249-257 ◽

Cited By ~ 58

Author(s):

Albert Power ◽

Kakit Chan ◽

Seema K. Singh ◽

David Taube ◽

Neill Duncan

Keyword(s):

Cohort Study ◽

Stroke Risk ◽

Hemodialysis Patients ◽

Maintenance Hemodialysis ◽

Single Center ◽

Maintenance Hemodialysis Patients

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Lower serum sodium level predicts higher risk of infection-related hospitalization in maintenance hemodialysis patients: an observational cohort study

BMC Nephrology ◽

10.1186/1471-2369-14-276 ◽

2013 ◽

Vol 14 (1) ◽

Cited By ~ 20

Author(s):

Shintaro Mandai ◽

Michio Kuwahara ◽

Yuri Kasagi ◽

Keita Kusaka ◽

Tomomi Tanaka ◽

...

Keyword(s):

Cohort Study ◽

Sodium Level ◽

Serum Sodium Level ◽

Hemodialysis Patients ◽

Observational Cohort Study ◽

Maintenance Hemodialysis ◽

Risk Of Infection ◽

Lower Serum ◽

Observational Cohort ◽

Maintenance Hemodialysis Patients

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Association of Anabolic Effect of Calcitriol with Osteoclast-Derived Wnt 10b Secretion

Nutrients ◽

10.3390/nu10091164 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1164 ◽

Cited By ~ 5

Author(s):

Chien-Lin Lu ◽

Jia-Fwu Shyu ◽

Chia-Chao Wu ◽

Chi-Feng Hung ◽

Min-Tser Liao ◽

...

Keyword(s):

Bone Development ◽

Cross Sectional Study ◽

Hemodialysis Patients ◽

Maintenance Hemodialysis ◽

Tartrate Resistant Acid Phosphatase ◽

Dependent Manner ◽

Mesenchymal Progenitor Cells ◽

Micro Computed Tomography ◽

Cross Sectional ◽

Maintenance Hemodialysis Patients

Canonical Wnt (Wingless/Integrated) signaling is crucial in bone development and the Wnt ligand can promote osteoblast differentiation from mesenchymal progenitor cells. Calcitriol, an active vitamin D3, is used clinically for treatment of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients. The bone effects of calcitriol in SHPT remains uncertain. We hypothesized that calcitriol improves bone mass by suppressing osteoclast activity, and simultaneously promoting Wnt ligand secretion. We designed a cross-sectional study in maintenance hemodialysis patients to explore the effects of calcitriol on different bone turnover markers and specifically emphasized the Wnt 10b levels. Then, we explored the source of Wnt 10b secretion by using osteoclasts and osteoblasts treated with calcitriol in cell culture studies. Finally, we explored the effects of calcitriol on bone microarchitectures in CKD mice, using the 5/6 nephrectomy CKD animal model with analysis using micro-computed tomography. Calcitriol promoted the growth of both trabecular and cortical bones in the CKD mice. Wnt 10b and Procollagen 1 N-terminal Propeptide (P1NP) significantly increased, but Tartrate-resistant acid phosphatase 5b (Trap 5b) significantly decreased in the calcitriol-treated maintenance hemodialysis patients. Calcitriol enhanced Wnt 10b secretion from osteoclasts in a dose-dependent manner. Treatment of SHPT with calcitriol improved the bone anabolism by inhibiting osteoclasts and promoting osteoblasts that might be achieved by increasing the Wnt 10b level.

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