Second Primary Cancers After Gastric Cancer, and Gastric Cancer as Second Primary Cancer

257 Background: Breast cancer survivors have slightly increased risk of second primary cancers. Importance of screening for second cancers has been raised due to increased survival in those populations. Not only having genetic risk such as BRCA mutation, but also treatment-related risk presents. The most common second primary cancer is breast cancer. Colon cancer, uterine cancer, and ovarian cancer showed increased cumulative incidence. In this study, we assessed development second primary cancers in breast cancer survivors. Methods: Medical record of breast cancer patients was reviewed retrospectively in three tertiary medical institutions. Available data of ICD-9 record after breast cancer diagnosis was evaluated. Diagnosis of second primary breast cancer was excluded in evaluation. Results: Since Jan 1989 to Jan 2014, available medical records were reviewed in breast cancer patients(N = 5880) in three institutions(one urban and the other two rural institutions). Cumulative incidence of overall second primary cancers was 4.57%. Among 269 second primary cancers, thyroid cancer(44.2%) was most common second primary cancer, followed by gastric cancer(10.0%). Gastric cancers were more common in rural institution than urban area(14.2 % vs 5.5%), while incidence of thyroid cancer is elevated in urban institution(57.8% vs 31.9%). Among 9 patients who has been diagnosed endometrial cancer, 7 patients had history of selective estrogen receptor modulator(tamoxifen or toremifen) treatment. Development of lung cancer was not related to breast cancer radiation treatment(4 of 15 patients). Leukemia after breast cancer treatment was diagnosed in 5 patients (8.5% of second primary cancers), three of them were adult T cell leukemia and two of them were acute myeloid leukemia. Conclusions: Incidence of cancer in general population was reflected to development of second primary cancer in breast cancer survivors. Endocrine treatment was related increased incidence of endometrial cancer, respectively. Application of personalized cancer screening plan would be important in this patient group.

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Second primary cancers and recurrence in patients after resection of colorectal cancer: An integrated analysis of trials by Japan Clinical Oncology Group: JCOG1702A

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyaa184 ◽

2020 ◽

Author(s):

Kiyo Tanaka ◽

Gakuto Ogawa ◽

Junki Mizusawa ◽

Tomohiro Kadota ◽

Kenichi Nakamura ◽

...

Keyword(s):

Colorectal Cancer ◽

General Population ◽

Cumulative Incidence ◽

National Database ◽

Integrated Analysis ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer ◽

Surveillance Strategy ◽

Second Primary Cancers

Abstract Background Improvements in early detection and treatment have resulted in an increasing number of long-term survivors of colorectal cancer (CRC). For the survivors, second primary cancer and recurrence are important issues; however, evidence for an appropriate surveillance strategy remains limited. This study aimed to investigate the frequency and timing of second primary cancer in patients after surgery for exploring an appropriate surveillance strategy by using an integrated analysis of three large-scale randomized controlled trials in Japan. Methods The eligibility criteria of three trials included histologically confirmed CRC and having received surgery. The timing, site and frequency of second primary cancers and recurrence were investigated. Risk factors associated with second primary cancers were also examined. The standardized incidence ratio (SIR) of second primary cancers compared with the national database of the Japan Cancer Registry was estimated. Results A total of 2824 patients were included in this study. The cumulative incidence of second primary cancer increased over time. The SIR of any second primary cancer was 1.07 (95% CI: 0.94–1.21). The SIR for second primary cancers of colon was 1.09 (95% CI: 0.79–1.47). The cumulative incidence of recurrence almost reached plateau at 3 years. Conclusions A common surveillance strategy for the general population can be applied even for curatively resected CRC patients, as the risk of second primary cancers was almost the same as that of the general population.

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Second primary cancers and recurrence in patients after resection of colorectal cancer: An integrated analysis of trials by Japan Clinical Oncology Group: JCOG0205, JCOG0212, JCOG0404 (JCOG1702A).

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.4_suppl.561 ◽

2018 ◽

Vol 36 (4_suppl) ◽

pp. 561-561

Author(s):

Kiyo Tanaka ◽

Gakuto Ogawa ◽

Junki Mizusawa ◽

Junko Eba ◽

Hiroshi Katayama ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Cumulative Incidence ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer ◽

Surveillance Strategy ◽

Second Primary Cancers ◽

Over Time

561 Background: Improvements in early detection and treatment have resulted in an increasing number of long-term survivors of colorectal cancer (CRC). For the survivors, Second primary cancers and recurrence are important issues, but the evidence for appropriate surveillance strategy is limited. The aim of this study was to investigate the frequency and the timing of second primary cancers and recurrence in patients (pts) after surgery using 3 randomized trials (J0205, J0212 and J0404) conducted by Colorectal Cancer Study Group of JCOG. Methods: Eligibility criteria included histologically proven CRC and having received surgery. The timing, site and frequency of second primary cancer and recurrence were investigated. Risk factors associated with the events were explored. Standardized incidence ratio (SIR) about second primary cancer compared with national database of Japan Cancer Registry was estimated. Results: A total of 2,824 pts with a median follow-up time of 6 years were included. Median age was 62 years old (23-75), male/female was 58%/42%, and stage 0/I/II/III/IV was 0.2%/8.7%/25.4%/64.8%/0.9%. Pts with 5-FU based adjuvant chemotherapy were 63%. Cumulative incidence of second primary cancer increased constantly over time (Table). Among 240 pts, the most common site was lung (37), stomach (35) and colon (32). In multivariable analysis, age (over 64 years old) and sex (male) were risk factors (age HR: 1.60 (95% CI: 1.24-2.07), sex HR: 1.36 (95% CI: 1.04-1.78)). The SIR of any second primary cancers was 1.07 (95% CI: 0.94-1.21). The SIR for second primary cancers of colon was 1.09 (95% CI: 0.79-1.47). On the other hand, cumulative incidence of recurrence almost reached at 3 years. Conclusions: Common surveillance strategy can be applied even for curatively resected CRC pts after 3 years from surgery, because the risk of second primary cancer was almost same as general population over time. The necessity of intensive follow-up to detect recurrence decreases after 3 years. [Table: see text]

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Occurrence of second primary cancer after curative resection of cholangiocarcinoma: a report of 5 cases

International Surgery Journal ◽

10.18203/2349-2902.isj20171157 ◽

2017 ◽

Vol 4 (4) ◽

pp. 1455

Author(s):

Hao Long ◽

Menghao Wang ◽

Jianping Gong ◽

Lan Hu

Keyword(s):

Curative Resection ◽

Early Stage ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer ◽

Second Primary Cancers ◽

History Of ◽

Well Differentiated ◽

Operative Excision ◽

History Of Cancer

The second primary cancer, a new cancer subsequent to the initial cancer, usually occurs in a person who has a history of cancer or the patient treated with curative resection. Although the pathogenesis of second primary cancer is unclear, it is always found that occurrence of second primary cancer is related to the age and family history. In our 5 cases’ reports, second primary cancer occurs after curative resection of cholangiocarcinoma. And most of the second primary cancers belong to well differentiated adenocarcinomas which grow slowly and never metastasize distally in early stage. Therefore, operative excision is the most effective treatment. At the same time, conventional examination after operation could improve early diagnosis and timely surgical treatment.

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Features of Second Primary Cancer in Patients with Gastric Cancer

Oncology ◽

10.1159/000072335 ◽

2003 ◽

Vol 65 (2) ◽

pp. 113-117 ◽

Cited By ~ 54

Author(s):

Yoichi Ikeda ◽

Motonori Saku ◽

Hirofumi Kawanaka ◽

Michiyasu Nonaka ◽

Kohji Yoshida

Keyword(s):

Gastric Cancer ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer

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Mo1140 Characteristics of Second Primary Cancer in Patients With Early Gastric Cancer After Endoscopic Resection

Gastroenterology ◽

10.1016/s0016-5085(13)62174-5 ◽

2013 ◽

Vol 144 (5) ◽

pp. S-590

Author(s):

Jung-Wook Kim ◽

Jae-Young Jang ◽

Hoehoon Chung ◽

Chang Kyun Lee

Keyword(s):

Gastric Cancer ◽

Early Gastric Cancer ◽

Endoscopic Resection ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer

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Effective follow-up for recurrence or a second primary cancer in patients with early gastric cancer

British Journal of Surgery ◽

10.1002/bjs.4758 ◽

2005 ◽

Vol 92 (2) ◽

pp. 235-239 ◽

Cited By ~ 54

Author(s):

Y. Ikeda ◽

M. Saku ◽

F. Kishihara ◽

Y. Maehara

Keyword(s):

Gastric Cancer ◽

Early Gastric Cancer ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer

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Surgical Outcome of Synchronous Second Primary Cancer in Patients with Gastric Cancer

Yonsei Medical Journal ◽

10.3349/ymj.2007.48.6.981 ◽

2007 ◽

Vol 48 (6) ◽

pp. 981 ◽

Cited By ~ 20

Author(s):

Tae Kyung Ha ◽

Ji Yeong An ◽

Ho Geun Youn ◽

Jae Hyung Noh ◽

Tae Sung Sohn ◽

...

Keyword(s):

Gastric Cancer ◽

Surgical Outcome ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer

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Second Primary Cancers in Thyroid Cancer Patients: A Multinational Record Linkage Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2005-2009 ◽

2006 ◽

Vol 91 (5) ◽

pp. 1819-1825 ◽

Cited By ~ 110

Author(s):

Thekkepat C. Sandeep ◽

Mark W. J. Strachan ◽

Rebecca M. Reynolds ◽

David H. Brewster ◽

Ghislaine Scélo ◽

...

Keyword(s):

Thyroid Cancer ◽

Record Linkage ◽

Cancer Registries ◽

Linkage Study ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer ◽

Second Primary Cancers ◽

Increased Risk ◽

Shared Risk

Context: Increasing incidence and improved prognosis of thyroid cancer have led to concern about the development of second primary cancers, especially after radioiodine treatment. Thyroid cancer can also arise as a second primary neoplasm after other cancers. Objective: The objective of the study was to assess the risk of second primary cancer after thyroid cancer and vice versa. Design: This was a multinational record linkage study. Setting: The study was conducted at 13 population-based cancer registries in Europe, Canada, Australia, and Singapore. Patients or Other Participants: A cohort of 39,002 people (356,035 person-yr of follow-up) with primary thyroid cancer were followed up for SPN for up to 25 yr, and 1,990 cases of thyroid cancer were diagnosed after another primary cancer. Main Outcome Measures: To assess any possible excess of second primary neoplasms after thyroid cancer, the observed numbers of neoplasms were compared with expected numbers derived from age-, sex-, and calendar period-specific cancer incidence rates from each of the cancer registries, yielding standardized incidence ratios (SIRs). The SIR of second primary thyroid cancer after various types of cancer was also calculated. Results: During the observation period, there were 2821 second primary cancers (all sites combined) after initial diagnosis of thyroid cancer, SIR of 1.31 (95% confidence interval 1.26–1.36) with significantly elevated risks for many specific cancers. Significantly elevated risks of second primary thyroid cancer were also seen after many types of cancer. Conclusion: Pooled data from 13 cancer registries show a 30% increased risk of second primary cancer after thyroid cancer and increased risks of thyroid cancer after various primary cancers. Although bias (detection, surveillance, misclassification) and chance may contribute to some of these observations, it seems likely that shared risk factors and treatment effects are implicated in many. When following up patients who have been treated for primary thyroid cancer, clinicians should maintain a high index of suspicion for second primary cancers.

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