Modified Frailty Index Independently Predicts Postoperative Pulmonary Infection in Elderly Patients Undergoing Radical Gastrectomy for Gastric Cancer

Background: Ageing is a global fact affecting both developed and developing countries.It brings out various catabolic changes in body resulting in frailty(i.e. the person is not able to with stand minor stresses of the environment, due to reduced reserves in psychologicalreserve of several organ system).Thus causing a great burden of disease, dependence & health care cost. Sarcopenia is the leading component for frailty in the elderly population, but very few studies have been done in India for correlating frailty with sarcopenia. Aim: To compare sarcopenia with modified frailty index (MFI) as a predictor of adverse outcomes in critically ill elderly patients. Methodology: Cross-sectional study will be performed on all the critically ill geriatric subjects/patients coming to all the ICU's of AVBRH, Sawangi (M), Wardha who will satisfy various inclusion and exclusion criteria for selection and all standard parametric & non-parametric data will be assessed by using standard descriptive & inferential statistics. Expected Results: In our study, we are anticipating that the Modified frailty index to be a better predictor of adverse outcomes in terms of mortality as compared to sarcopenia in the critically ill elderly patients. Also, we are anticipating that sarcopenia to be the most important contributor of frailty in critically ill elderly patients and the prevalence of frailty will be high in critically ill elderly patients. Limitation: Due to limited time frame & resources we will not be able to follow up the patients.

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The Utility of the Modified Frailty Index in Outcome Prediction for Elderly Patients with Acute Traumatic Subdural Hematoma

Journal of Neurotrauma ◽

10.1089/neu.2019.6943 ◽

2020 ◽

Vol 37 (23) ◽

pp. 2499-2506

Author(s):

Hui Lee ◽

Caleb Tan ◽

Vanessa Tran ◽

Joseph Mathew ◽

Mark Fitzgerald ◽

...

Keyword(s):

Elderly Patients ◽

Subdural Hematoma ◽

Outcome Prediction ◽

Frailty Index ◽

Modified Frailty Index

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Feasibility of radical gastrectomy for elderly patients with gastric cancer

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2015.11.013 ◽

2016 ◽

Vol 42 (2) ◽

pp. 303-311 ◽

Cited By ~ 17

Author(s):

C.-J. Zhou ◽

F.-F. Chen ◽

C.-L. Zhuang ◽

W.-Y. Pang ◽

F.-Y. Zhang ◽

...

Keyword(s):

Gastric Cancer ◽

Elderly Patients ◽

Radical Gastrectomy

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The 5-Factor Modified Frailty Index Predicts Complications and Worsening After Meningioma Surgery in Non-elderly Rather Than Elderly Patients: A Nationwide Registry Study

10.21203/rs.3.rs-411629/v1 ◽

2021 ◽

Author(s):

Fusao Ikawa ◽

Nobuaki Michihata ◽

Soichi Oya ◽

Toshikazu Hidaka ◽

Shingo Matsuda ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Elderly Patients ◽

Frailty Index ◽

Age Groups ◽

Significant Risk ◽

Significant Risk Factor ◽

Nationwide Registry ◽

Modified Frailty Index ◽

Meningioma Surgery

Abstract The simplified 5-factor modified frailty index (mFI-5) is a useful indicator of outcome for patients undergoing surgeries and considered as an important risk factor in elderly patients. However, its usefulness has not been validated based on age groups. We aimed to investigate the risk factors including the mFI-5 across age groups for complications and worse outcomes in meningioma surgery using data obtained from the nationwide database in Japan. We extracted data from the nationwide registry database in Japan between 2010 and 2015. Age (< 65, 65–74, and ≥ 75 years), sex, Barthel Index (BI), mFI-5 scores, and complications were evaluated. Multivariate logistic regression analyses identified risk factors across all age groups for worsening BI scores and complications after surgery. In 8,138 included cases, an mFI-5 score ≥ 2 items was a significant risk factor for worsening BI scores in patients aged < 65 years (odds ratio: 2.00; 95% confidence interval: 1.31-3.06), but not in patients aged 65-74 years and those aged ≥ 75 years. Similar results were noted for complications in patients aged < 65 years (2.40; 1.67–3.44), but not in patients aged 65-74 years and those aged ≥ 75 years. In conclusion, the mFI-5 scores can predict the risk of worsening outcome and complications in non-elderly patients aged < 65 years rather than in elderly patients aged ≥ 65 years. In meningioma surgeries, care must be taken when making decisions using the mFI-5 scores based on the patients’ age.Trial RegistrationName: Study on treatment method, age group, complications, and outcome of meningiomas and hemangioblastomas using DPC, URL: http://www.umin.ac.jp/ctr/index-j.htmID: UMIN000038486, No.: R000043856

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Fast-track surgery protocol in elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer: a randomized controlled trial

OncoTargets and Therapy ◽

10.2147/ott.s107443 ◽

2016 ◽

pp. 3345 ◽

Cited By ~ 5

Author(s):

Linpayi Chen ◽

Guozheng Liu ◽

Fengguo Jian ◽

Xiuqin Wang

Keyword(s):

Gastric Cancer ◽

Randomized Controlled Trial ◽

Elderly Patients ◽

Fast Track ◽

Controlled Trial ◽

Radical Gastrectomy ◽

Fast Track Surgery ◽

Randomized Controlled

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Laparoscopic radical gastrectomy versus traditional open surgery in elderly patients with gastric cancer: Benefits and complications

Molecular and Clinical Oncology ◽

10.3892/mco.2014.283 ◽

2014 ◽

Vol 2 (4) ◽

pp. 530-534 ◽

Cited By ~ 15

Author(s):

HONGTAO LI ◽

XIAOPENG HAN ◽

LIN SU ◽

WANKUN ZHU ◽

WEI XU ◽

...

Keyword(s):

Gastric Cancer ◽

Elderly Patients ◽

Open Surgery ◽

Radical Gastrectomy ◽

Surgery In Elderly

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Risk Stratification of Elderly Patients Undergoing Spinal Surgery Using the Modified Frailty Index

Global Spine Journal ◽

10.1177/2192568221999650 ◽

2021 ◽

pp. 219256822199965

Author(s):

Barry Ting Sheen Kweh ◽

Hui Qing Lee ◽

Terence Tan ◽

Kim Siong Tew ◽

Ronald Leong ◽

...

Keyword(s):

Risk Stratification ◽

Elderly Patients ◽

Surgical Site Infection ◽

Spine Surgery ◽

Complication Rate ◽

Frailty Index ◽

Major Complication ◽

Site Infection ◽

Modified Frailty Index ◽

Major Complication Rate

Study Design: Retrospective cohort. Objectives: To validate the 11-item modified Frailty Index (mFI) as a perioperative risk stratification tool in elderly patients undergoing spine surgery. Methods: All consecutive cases of spine surgery in patients aged 65 years or older between July 2016 and June 2018 at a state-wide trauma center were retrospectively reviewed. The primary outcome was post-operative major complication rate (Clavien-Dindo Classification ≥ III). Secondary outcome measures included the rate of all complications, 6-month mortality and surgical site infection. Results: A total of 348 cases were identified. The major complication rate was significantly lower in patients with an mFI of 0 compared to ≥ 0.45 (18.3% versus 42.5%, P = .049). As the mFI increased from 0 to ≥ 0.45 there was a stepwise increase in risk of major complications ( P < .001). Additionally, 6-month mortality rate was considerably lower when the mFI was 0 rather than ≥ 0.27 (4.2% versus 20.4%, P = .007). Multivariate analysis demonstrated an mFI ≥ 0.27 was significantly associated with an increased incidence of major complication (OR 2.80, 95% CI 1.46-5.35, P = .002), all complication (OR 2.93, 95% CI 1.70-15.11, P < .001), 6-month mortality (OR 7.39, 95% CI 2.55-21.43, P < .001) and surgical site infection (OR 4.43, 95% CI 1.71-11.51, P = .002). The American Society of Anesthesiologists’ (ASA) index did not share a stepwise relationship with any outcome. Conclusion: The mFI is significantly associated in a gradated fashion with increased morbidity and mortality. Patients with an mFI ≥ 0.27 are at greater risk of major complications, all-complications, 6-monthy mortality, and surgical site infection.

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