scholarly journals Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of chronic obstructive pulmonary disease

2017 ◽  
Vol Volume 12 ◽  
pp. 581-587 ◽  
Author(s):  
Ran Ma ◽  
Xuefang Gong ◽  
Hua Jiang ◽  
Chunyi Lin ◽  
Yuqin Chen ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Skeletal Muscle ◽  
Mouse Model ◽  
Serum Response Factor ◽  
Nuclear Translocation ◽  
Skeletal Muscle Atrophy ◽  
Chronic Obstructive ◽  
Response Factor ◽  
Obstructive Pulmonary Disease ◽  
Serum Response

scholarly journals Presence or Absence of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease is Associated With Distinct Phenotypes

2021 ◽  
Vol 57 (4) ◽  
pp. 264-272
Author(s):  
Clayton L. Cruthirds ◽  
Barbara S. van der Meij ◽  
Agata Wierzchowska-McNew ◽  
Nicolaas E.P. Deutz ◽  
Mariëlle P.K.J. Engelen
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Skeletal Muscle ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Muscle Dysfunction ◽  
Obstructive Pulmonary Disease ◽  
Skeletal Muscle Dysfunction

scholarly journals Skeletal muscle is associated with exercise tolerance evaluated by cardiopulmonary exercise testing in Japanese patients with chronic obstructive pulmonary disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroki Tashiro ◽  
Koichiro Takahashi ◽  
Masahide Tanaka ◽  
Hironori Sadamatsu ◽  
Yuki Kurihara ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Skeletal Muscle ◽  
Exercise Tolerance ◽  
Cardiopulmonary Exercise Testing ◽  
Peak Exercise ◽  
Chronic Obstructive ◽  
Clinical Parameters ◽  
Obstructive Pulmonary Disease ◽  
Cardiopulmonary Exercise ◽  
Copd Assessment Test

AbstractDecreasing exercise tolerance is one of the key features related to a poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Cardiopulmonary exercise testing (CPET) is useful for evaluating exercise tolerance. The present study was performed to clarify the correlation between exercise tolerance and clinical parameters, focusing especially on the cross-sectional area (CSA) of skeletal muscle. The present study investigated 69 patients with COPD who underwent CPET. The correlations between oxygen uptake ($${{\dot{\text{V}} \text{O}}}_{2}$$ V ˙ O 2 ) at peak exercise and clinical parameters of COPD, including skeletal muscle area measured using single-section axial computed tomography (CT), were evaluated. The COPD assessment test score (ρ = − 0.35, p = 0.02) was weakly correlated with $${{\dot{\text{V}} \text{O}}}_{2}$$ V ˙ O 2 at peak exercise. In addition, forced expiratory volume in one second (FEV1) (ρ = 0.39, p = 0.0009), FEV1/forced vital capacity (ρ = 0.33, p = 0.006), and the CSA of the pectoralis muscles (PMs) (ρ = 0.36, p = 0.007) and erector spinae muscles (ECMs) (ρ = 0.39, p = 0.003) were correlated with $${{\dot{\text{V}} \text{O}}}_{2}$$ V ˙ O 2 at peak exercise. Multivariate analysis adjusted by age and FEV1 indicated that PMCSA was weakly correlated after adjustment (β value [95% confidence interval] 0.175 [0.03–0.319], p = 0.02). In addition, ECMCSA tended to be correlated, but not significantly after adjustment (0.192 [− 0.001–0.385] p = 0.052). The COPD assessment test, FEV1, FEV1/FVC, PMCSA, and ECMCSA were significantly correlated with $${{\dot{\text{V}} \text{O}}}_{2}$$ V ˙ O 2 at peak exercise.

scholarly journals A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

2013 ◽  
Vol 131 (3) ◽  
pp. 752-762.e7 ◽  
Author(s):  
Emma L. Beckett ◽  
Richard L. Stevens ◽  
Andrew G. Jarnicki ◽  
Richard Y. Kim ◽  
Irwan Hanish ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Mast Cell ◽  
Mouse Model ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Mast Cell Tryptase ◽  
Short Term ◽  
Obstructive Pulmonary Disease
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