scholarly journals Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD [Corrigendum]

2018 ◽  
Vol Volume 13 ◽  
pp. 603-604
Author(s):  
Ran Ma ◽  
Xuefang Gong ◽  
Hua Jiang ◽  
Chunyi Lin ◽  
Yuqin Chen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Cigarette Smoke ◽  
Muscle Atrophy ◽  
Serum Response Factor ◽  
Nuclear Translocation ◽  
Skeletal Muscle Atrophy ◽  
Response Factor ◽  
Serum Response

scholarly journals New Role for Serum Response Factor in Postnatal Skeletal Muscle Growth and Regeneration via the Interleukin 4 and Insulin-Like Growth Factor 1 Pathways

2006 ◽  
Vol 26 (17) ◽  
pp. 6664-6674 ◽  
Author(s):  
Claude Charvet ◽  
Christophe Houbron ◽  
Ara Parlakian ◽  
Julien Giordani ◽  
Charlotte Lahoute ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Growth Factor ◽  
Serum Response Factor ◽  
Muscle Growth ◽  
Interleukin 4 ◽  
Specific Gene ◽  
Response Factor ◽  
Insulin Like Growth Factor ◽  
Serum Response

ABSTRACT Serum response factor (SRF) is a crucial transcriptional factor for muscle-specific gene expression. We investigated SRF function in adult skeletal muscles, using mice with a postmitotic myofiber-targeted disruption of the SRF gene. Mutant mice displayed severe skeletal muscle mass reductions due to a postnatal muscle growth defect resulting in highly hypotrophic adult myofibers. SRF-depleted myofibers also failed to regenerate following injury. Muscles lacking SRF had very low levels of muscle creatine kinase and skeletal alpha-actin (SKA) transcripts and displayed other alterations to the gene expression program, indicating an overall immaturity of mutant muscles. This loss of SKA expression, together with a decrease in beta-tropomyosin expression, contributed to myofiber growth defects, as suggested by the extensive sarcomere disorganization found in mutant muscles. However, we observed a downregulation of interleukin 4 (IL-4) and insulin-like growth factor 1 (IGF-1) expression in mutant myofibers which could also account for their defective growth and regeneration. Indeed, our demonstration of SRF binding to interleukin 4 and IGF-1 promoters in vivo suggests a new crucial role for SRF in pathways involved in muscle growth and regeneration.

scholarly journals Effects of Nandrolone in the Counteraction of Skeletal Muscle Atrophy in a Mouse Model of Muscle Disuse: Molecular Biology and Functional Evaluation

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129686 ◽  
Author(s):  
Giulia Maria Camerino ◽  
Jean-François Desaphy ◽  
Michela De Bellis ◽  
Roberta Francesca Capogrosso ◽  
Anna Cozzoli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Molecular Biology ◽  
Mouse Model ◽  
Muscle Atrophy ◽  
Skeletal Muscle Atrophy ◽  
Functional Evaluation ◽  
Muscle Disuse

scholarly journals Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle.

1993 ◽  
Vol 13 (2) ◽  
pp. 1264-1272 ◽  
Author(s):  
C K Vincent ◽  
A Gualberto ◽  
C V Patel ◽  
K Walsh
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Cardiac Muscle ◽  
Serum Response Factor ◽  
Sequence Motif ◽  
Regulatory Sequences ◽  
Response Factor ◽  
Specific Expression ◽  
Serum Response

Regulatory sequences of the M isozyme of the creatine kinase (MCK) gene have been extensively mapped in skeletal muscle, but little is known about the sequences that control cardiac-specific expression. The promoter and enhancer sequences required for MCK gene expression were assayed by the direct injection of plasmid DNA constructs into adult rat cardiac and skeletal muscle. A 700-nucleotide fragment containing the enhancer and promoter of the rabbit MCK gene activated the expression of a downstream reporter gene in both muscle tissues. Deletion of the enhancer significantly decreased expression in skeletal muscle but had no detectable effect on expression in cardiac muscle. Further deletions revealed a CArG sequence motif at position -179 within the promoter that was essential for cardiac-specific expression. The CArG element of the MCK promoter bound to the recombinant serum response factor and YY1, transcription factors which control expression from structurally similar elements in the skeletal actin and c-fos promoters. MCK-CArG-binding activities that were similar or identical to serum response factor and YY1 were also detected in extracts from adult cardiac muscle. These data suggest that the MCK gene is controlled by different regulatory programs in adult cardiac and skeletal muscle.

Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice

Life Sciences ◽  
2019 ◽  
Vol 235 ◽  
pp. 116800 ◽  
Author(s):  
Jingjing Ding ◽  
Fang Li ◽  
Yanfei Cong ◽  
Jianing Miao ◽  
Di Wu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cigarette Smoke ◽  
Muscle Atrophy ◽  
Trichostatin A ◽  
Smoke Exposure ◽  
Skeletal Muscle Atrophy ◽  
Cigarette Smoke Exposure

scholarly journals Physiological Control of Smooth Muscle-specific Gene Expression through Regulated Nuclear Translocation of Serum Response Factor

2000 ◽  
Vol 275 (39) ◽  
pp. 30387-30393 ◽  
Author(s):  
Blanca Camoretti-Mercado ◽  
Hong-W. Liu ◽  
Andrew J. Halayko ◽  
Sean M. Forsythe ◽  
John W. Kyle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Serum Response Factor ◽  
Nuclear Translocation ◽  
Specific Gene ◽  
Response Factor ◽  
Physiological Control ◽  
Specific Gene Expression ◽  
Serum Response
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