scholarly journals Characterizing Gas Exchange Physiology in Healthy Young Electronic-Cigarette Users with Hyperpolarized 129Xe MRI: A Pilot Study

2021 ◽  
Vol Volume 16 ◽  
pp. 3183-3187
Author(s):  
Mu He ◽  
Kun Qing ◽  
Nicholas J Tustison ◽  
Zach Beaulac ◽  
Tabitha W King ◽  
...  
Keyword(s):  
Pilot Study ◽  
Gas Exchange ◽  
Electronic Cigarette ◽  
Hyperpolarized 129Xe

scholarly journals Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI

2020 ◽  
Vol 27 (8) ◽  
pp. e193-e203 ◽  
Author(s):  
Mu He ◽  
Ziyi Wang ◽  
Leith Rankine ◽  
Sheng Luo ◽  
John Nouls ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Gradient Echo ◽  
Hyperpolarized 129Xe

scholarly journals Magnetic resonance imaging of the time course of hyperpolarized 129Xe gas exchange in the human lungs and heart

2018 ◽  
Vol 29 (5) ◽  
pp. 2283-2292 ◽  
Author(s):  
Ozkan Doganay ◽  
Mitchell Chen ◽  
Tahreema Matin ◽  
Marzia Rigolli ◽  
Julie-Ann Phillips ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Gas Exchange ◽  
Time Course ◽  
Resonance Imaging ◽  
Human Lungs ◽  
Hyperpolarized 129Xe

1-Octadecene as a Solvent for Ferrofluids for Intraocular use

1997 ◽  
Vol 7 (3) ◽  
pp. 288-293
Author(s):  
P. Tejada ◽  
M.J. Méndez ◽  
S. Madero ◽  
C. Cava ◽  
A. Barcelo ◽  
...  
Keyword(s):  
Double Bond ◽  
Pilot Study ◽  
Gas Exchange ◽  
Inflammatory Response ◽  
Light Microscopy ◽  
Salt Solution ◽  
Cytotoxic Effect ◽  
Gas Injection ◽  
Preliminary Information ◽  
Hematoxylin And Eosin

Purpose. 1-Octadecene is a hydrocarbon with one double bond in its structure that could serve as a solvent for ferrofluids. The aim of this pilot study was to obtain preliminary information on intraocular tolerance to 1-octadecene. Methods. Vitreous compression with perfluoropropane gas was achieved in 20 eyes of albino rabbits. Four days after gas injection a fluid-gas exchange was undertaken. Sixteen eyes received 1-octadecene. Four eyes received balanced salt solution. Eyes were obtained at 3, 7, 14 and 30 days. The samples were fixed in 10% buffered formalin, processed in paraffin and sections were stained with hematoxylin and eosin. Results. Emulsification of the oil bubble was observed in 31.25% of the cases by the fifth day; light microscopy showed normal retinal architecture in all the eyes and epiretinal and vitreous macrophages in 50% of the eyes. Conclusions. 1-Octadecene does not appear to have any retinal cytotoxic effect but elicits an inflammatory response in the vitreous activity.

scholarly journals Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129Xe MRI

2020 ◽  
Vol 7 (1) ◽  
pp. eabc8180
Author(s):  
Haidong Li ◽  
Xiuchao Zhao ◽  
Yujin Wang ◽  
Xin Lou ◽  
Shizhen Chen ◽  
...  
Keyword(s):  
Lung Function ◽  
Gas Exchange ◽  
Recovery Process ◽  
Blood Exchange ◽  
Structural Abnormalities ◽  
Hyperpolarized 129Xe ◽  
Magnetic Resonance Imaging Mri ◽  
And Function ◽  
Exchange Function ◽  
The Impact

The recovery process of COVID-19 patients is unclear. Some recovered patients complain of continued shortness of breath. Vasculopathy has been reported in COVID-19, stressing the importance of probing pulmonary microstructure and function at the alveolar-capillary interface. While computed tomography (CT) detects structural abnormalities, little is known about the impact of disease on lung function. 129Xe magnetic resonance imaging (MRI) is a technique uniquely capable of assessing ventilation, microstructure, and gas exchange. Using 129Xe MRI, we found that COVID-19 patients show a higher rate of ventilation defects (5.9% versus 3.7%), unchanged microstructure, and longer gas-blood exchange time (43.5 ms versus 32.5 ms) compared with healthy individuals. These findings suggest that regional ventilation and alveolar airspace dimensions are relatively normal around the time of discharge, while gas-blood exchange function is diminished. This study establishes the feasibility of localized lung function measurements in COVID-19 patients and their potential usefulness as a supplement to structural imaging.

scholarly journals Correlation of lung comet score with decreased gas exchange in patients with acute pulmonary edema: a pilot study

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 1) ◽  
pp. P267
Author(s):  
G Guiotto ◽  
F Dello Vicario ◽  
R Marino ◽  
F Paladino ◽  
S Scott ◽  
...  
Keyword(s):  
Pilot Study ◽  
Gas Exchange ◽  
Pulmonary Edema ◽  
Acute Pulmonary Edema

scholarly journals Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized 129Xe MRI in Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Atsuomi Kimura ◽  
Seiya Utsumi ◽  
Akihiro Shimokawa ◽  
Renya Nishimori ◽  
Neil J. Stewart ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gas Exchange ◽  
Cancer Progression ◽  
Ethyl Pyruvate ◽  
Late Phase ◽  
Precancerous Lesion ◽  
Lung Ventilation ◽  
Negative Control ◽  
Functional Changes ◽  
Hyperpolarized 129Xe

This study aimed to assess the suitability of hyperpolarized 129Xe (HPXe) MRI for noninvasive longitudinal evaluation of pulmonary function in preclinical lung cancer models. A mouse model of lung cancer (LC) was induced in 5 mice by intraperitoneal injection of urethane, while a negative-control (NC) mice (N = 5) was prepared by injection of saline solution. Longitudinal HPXe MRI was performed over a 5-month period to monitor lung ventilation and gas exchange. The treatment efficacy of ethyl pyruvate (EP), an anti-inflammatory drug, to the mouse LC model was monitored using HPXe MRI by commencing administration of EP pre (early-phase) and 1-month post (late-phase) injection of urethane (N = 5 mice for each group). Gas-exchange function in LC mice was significantly reduced at 1-month after urethane injection compared with NC mice administered with saline ( P < 0.01 ). Thereafter, it remained consistently lower than that of the NC group for the full 5-month measurement period. In contrast, the ventilation function of the LC model mice was not significantly different to that of the NC mice. Histological analysis revealed alveolar epithelial hyperplasia in LC mice alveoli at 1 month after urethane injection, and adenoma was confirmed 3 months after the injection. The early- and late-phase EP interventions were found to improve HPXe MRI metrics (reduced at 1 month postinjection of urethane) and significantly inhibit tumor growth. These results suggest that HPXe MRI gas-exchange metrics can be used to quantitatively assess changes in the precancerous lesion microenvironment and to evaluate therapeutic efficacy in cancer. Thus, HPXe MRI can be utilized to noninvasively monitor pulmonary pathology during LC progression and can visualize functional changes during therapy.

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