Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study

Migraine is a primary headache disorder marked by recurrent unilateral headache episodes. Calcitonin gene related peptide (CGRP) plays major role in migraine pathophysiology. CGRP is multifunctional, and its vasodilating activity within the central and peripheral blood vessels is one in all its primary functions. The intention is to prove serum calcitonin gene related peptide (CGRP) as an early diagnostic tool for migraine and the novelty is to correlate it with characteristics of migraine so that it helps in early initiation of treatment. Methods. 100 subjects including 90 patients with migraine and 10 with non-headache (NH) age-matched controls were prospectively recruited in our current study. The subjects were aged from 15- 50 years. The clinical assessment was made every month for the three months after the start of therapy. The subjects were compared based on the serum CGRP values. Serum CGRP concentrations were measured by using CGRP ELISA kit. Results. Out of total subjects selected, the maximum (23.3%) subjects were between age 26 and 30 years and least effected age group was 46-50 years (4.44%). Females’ predominance with 82% than males with 18%.Stress was major trigger occurring in 57% of cases. Throbbing pain with elevated CGRP levels 130.44±114.22 and p value (p = 0.01). The average CGRP levels was higher in test group 149.00±93.86 compared to control 61.30±24.37 with p value (p = 0.02). Conclusions. The serum CGRP levels were statistically more in migraine patients correlated with characteristics like throbbing type of pain, stress and inadequate sleep. Hence, the serum CGRP levels estimation can be considered as a diagnostic tool for migraine when the clinical character’s over lap or early in the course of migraine when all criteria for diagnosis are not yet fulfilled.

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Comparative evaluation of serum calcitonin gene related peptide level in patients with migraine headache with and without aura

10.21203/rs.3.rs-201874/v1 ◽

2021 ◽

Author(s):

Mostafa Rezaee ◽

Nahid Ashja zadeh ◽

Sadegh Izedi ◽

Farinaz Fakhri

Keyword(s):

Correlation Coefficient ◽

Rank Correlation ◽

Calcitonin Gene Related Peptide ◽

Clinical Findings ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Serum Calcitonin ◽

Related Peptide ◽

Spearman’S Rank Correlation ◽

Calcitonin Gene

Abstract Background During a migraine attack, trigeminal activation results in the release of calcitonin gene-related peptide (CGRP), which stimulates the release of inflammatory cytokines playing an important role in migraine. We analyze the serum level of CGRP between two groups of migrainous patients (with aura and without aura) Materials and Methods Thirty six migraine patients (included 18 patients with aura and 18 without aura) additionally 18 healthy volunteers consisted control group were selected from the clinic of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran, between March 2020 and November 2020. The CGRP level were determined from the sera of patients with migraine and control subjects by enzyme-linked immunosorbent assay kits. Spearman's rank correlation coefficient was also determined to calculate the correlation between CGRP and clinical findings. Results The level of CGRP in groups were significantly different between groups (P = 0.00). Also, the level of CGRP in aura group were significantly higher than non-aura group (P = 0.045). The Spearman’s correlation coefficient revealed a positive and significant correlation between the CGRP concentration and age (p = 0.042, r = 0.172), BMI (p = 0.013, r = 0.08), VAS (P = 0.006 ,r = 0.09), frequency of attacks (p = 0.005, r = 0.9), duration of each attack (p = 0.016, r = 0.23), Migraine Disability Assessment Scale.(p = 0.00, r = 0.785), average of number of Medication (p = 0.00, r = 0.694). However, no significant correlation was observed with gender. (P > 0.05 ) Conclusions In our study, we found migraine patients had a higher CGRP level than healthy controls and the level of CGRP was related significantly with the duration, BMI, frequency of headache, age, number of headaches per day. In conclusion, our results confirmed that CGRP may be involved in the pathogenesis of migraine attacks and related with the multiple clinical characteristics.

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Serum calcitonin gene-related peptide facilitates adipose tissue lipolysis during exercise via PIPLC/IP3 pathways

Endocrine ◽

10.1007/s12020-018-1640-2 ◽

2018 ◽

Vol 61 (3) ◽

pp. 462-472 ◽

Cited By ~ 4

Author(s):

Malihe Aveseh ◽

Maryam Koushkie-Jahromi ◽

Javad Nemati ◽

Saeed Esmaeili-Mahani

Keyword(s):

Adipose Tissue ◽

Calcitonin Gene Related Peptide ◽

Serum Calcitonin ◽

Related Peptide ◽

Calcitonin Gene ◽

Adipose Tissue Lipolysis

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Periodontal inflammation is related to increased serum calcitonin gene‐related peptide levels in patients with chronic migraine

Journal of Periodontology ◽

10.1002/jper.19-0051 ◽

2019 ◽

Vol 90 (10) ◽

pp. 1088-1095 ◽

Cited By ~ 2

Author(s):

Yago Leira ◽

Pablo Ameijeira ◽

Clara Domínguez ◽

Esteban López‐Arias ◽

Paulo Ávila‐Gómez ◽

...

Keyword(s):

Chronic Migraine ◽

Calcitonin Gene Related Peptide ◽

Serum Calcitonin ◽

Related Peptide ◽

Periodontal Inflammation ◽

Calcitonin Gene

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Serum calcitonin gene-related peptide levels in women with polycystic ovary syndrome

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-012-2689-4 ◽

2012 ◽

Vol 287 (6) ◽

pp. 1235-1239

Author(s):

Semin Melahat Fenkci ◽

Veysel Fenkci ◽

Ozer Oztekin ◽

Simin Rota

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Calcitonin Gene Related Peptide ◽

Ovary Syndrome ◽

Serum Calcitonin ◽

Related Peptide ◽

Calcitonin Gene

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Low Serum Calcitonin Gene-Related Peptide Level is Associated with Severity of Coronary Stenosis

Clinical & Investigative Medicine ◽

10.25011/cim.v44i4.37593 ◽

2021 ◽

Vol 44 (4) ◽

pp. E23-30

Author(s):

Xian-Feng Dong ◽

Jia-Xin Zhong ◽

Yuan-Ming Yan ◽

Ming-Fang Ye ◽

Qiong Jiang ◽

...

Keyword(s):

Coronary Stenosis ◽

Cardiovascular Events ◽

Calcitonin Gene Related Peptide ◽

Major Adverse Cardiovascular Events ◽

Control Group ◽

Syntax Score ◽

Serum Calcitonin ◽

Negatively Associated ◽

Related Peptide ◽

Calcitonin Gene

Purpose: To evaluate the relationship between the serum calcitonin gene-related peptide (CGRP) level and severity of coronary stenosis. Methods: A total of 233 eligible patients who underwent coronary angiography were divided into two groups: a control and a coronary heart disease (CHD) group. The angiographic severity of coronary stenosis was evaluated by SYNTAX and Gensini scores. The incidence of major adverse cardiovascular events within two years was collected. Results: A negative correlation between serum CGRP levels and Gensini scores was observed in all patients (r=-0.352, p<0.001), the control group (r=-0.422, p<0.001) and the CHD group (r=-0.393, p<0.001). Serum CGRP levels were negatively associated with SYNTAX scores in the CHD group (r=-0.522, p<0.001). The area under the curve of CGRP for identifying high SYNTAX scores (>22) was 0.772 [95% confidence interval (CI): 0.673-0.870, p<0.001], and for identifying high Gensini scores was 0.744 (95% CI: 0.646-0.842, p<0.001). A CGRP concentration of 25.05 pg/ml was selected as the cutoff point. A low CGRP level (<25.05 pg/ml) was an independent predictor of severe coronary stenosis, a SYNTAX score >22 [odds ratio (OR) =5.819, 95% CI: 2.240-15.116; p<0.001] and a high Gensini score (>64) (OR=4.943, 95% CI: 2.020-12.095; p<0.001). The low CGRP group had a higher incidence of major adverse cardiovascular events within two years (11.1 vs. 3.1%, p=0.031). Conclusion: In coronary atherosclerosis patients without acute myocardial injury, serum CGRP levels were negatively associated with the severity of coronary stenosis.

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