Serum Calcitonin Gene-Related Peptide and Receptor Protein Levels in Patients With Fibromyalgia Syndrome: A Cross-Sectional Study

Background: Higher vitamin E intake has been widely related to lower risks of cognitive decline and dementia. Animal models suggest that this relationship might be (partially) explained by the protection of vitamin E against presynaptic protein oxidation. Objective: In this cross-sectional study, we aimed to examine the associations between brain tocopherols and presynaptic protein levels in elderly humans. Methods: We examined associations of α- and γ-tocopherol brain levels with presynaptic protein levels in 113 deceased participants (age 88.5±6.0 years, 45 (40%) female) from the prospective Memory and Aging project. Three distinct presynaptic proteins, a SNARE protein composite, a synaptotagmin synaptophysin composite and the protein-protein interaction between synaptosomal-associated protein 25 (SNAP-25), and syntaxin were measured in two cortical brain regions. Linear regression models assessed associations of brain tocopherols with presynaptic protein levels. Results: Higher brain γ-tocopherol levels were associated with higher levels of the SNARE protein composite, complexin-I, complexin-II, the synaptotagmin synaptophysin composite, and septin-5 in the midfrontal cortex (B(SE) = 0.272 to 0.412 (0.084 to 0.091), p < 0.001 to 0.003). When additionally adjusted for global Alzheimer’s disease pathology, cerebral infarcts, and Lewy body disease pathology, these associations remained largely similar. No associations were found between α-tocopherol and presynaptic protein levels. Conclusion: In this cross-sectional study, we found higher brain γ-tocopherol levels were associated with presynaptic protein levels in the midfrontal cortex. These results are consistent with a proposed role of vitamin E to maintain presynaptic protein levels.

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Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population: A cross-sectional study

Clinica Chimica Acta ◽

10.1016/j.cca.2013.03.012 ◽

2013 ◽

Vol 421 ◽

pp. 147-151 ◽

Cited By ~ 4

Author(s):

Kenichiro Enooku ◽

Reiko Kato ◽

Hitoshi Ikeda ◽

Makoto Kurano ◽

Yukio Kume ◽

...

Keyword(s):

Blood Pressure ◽

Pulse Pressure ◽

Pressure Pulse ◽

Cross Sectional Study ◽

Health Examination ◽

Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Protein Levels ◽

Reactive Protein

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Prevalence and overlap of somatic symptom disorder, bodily distress syndrome and fibromyalgia syndrome in the German general population: A cross sectional study

Journal of Psychosomatic Research ◽

10.1016/j.jpsychores.2020.110111 ◽

2020 ◽

Vol 133 ◽

pp. 110111 ◽

Cited By ~ 3

Author(s):

Winfried Häuser ◽

Constanze Hausteiner-Wiehle ◽

Peter Henningsen ◽

Elmar Brähler ◽

Bjarne Schmalbach ◽

...

Keyword(s):

General Population ◽

Fibromyalgia Syndrome ◽

Somatic Symptom ◽

Distress Syndrome ◽

Cross Sectional Study ◽

Somatic Symptom Disorder ◽

Sectional Study ◽

Cross Sectional ◽

Bodily Distress Syndrome

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Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy

Romanian Journal of Neurology ◽

10.37897/rjn.2021.3.13 ◽

2021 ◽

Vol 20 (3) ◽

pp. 342-348

Author(s):

Sofia Khatoon ◽

◽

Noorunissa Begum ◽

Hafeeza Sultana ◽

Maryam Rashed ◽

...

Keyword(s):

Diagnostic Tool ◽

Test Group ◽

Primary Headache ◽

Headache Disorder ◽

Calcitonin Gene Related Peptide ◽

P Value ◽

Diagnostic Efficacy ◽

Serum Calcitonin ◽

Related Peptide ◽

Calcitonin Gene

Migraine is a primary headache disorder marked by recurrent unilateral headache episodes. Calcitonin gene related peptide (CGRP) plays major role in migraine pathophysiology. CGRP is multifunctional, and its vasodilating activity within the central and peripheral blood vessels is one in all its primary functions. The intention is to prove serum calcitonin gene related peptide (CGRP) as an early diagnostic tool for migraine and the novelty is to correlate it with characteristics of migraine so that it helps in early initiation of treatment. Methods. 100 subjects including 90 patients with migraine and 10 with non-headache (NH) age-matched controls were prospectively recruited in our current study. The subjects were aged from 15- 50 years. The clinical assessment was made every month for the three months after the start of therapy. The subjects were compared based on the serum CGRP values. Serum CGRP concentrations were measured by using CGRP ELISA kit. Results. Out of total subjects selected, the maximum (23.3%) subjects were between age 26 and 30 years and least effected age group was 46-50 years (4.44%). Females’ predominance with 82% than males with 18%.Stress was major trigger occurring in 57% of cases. Throbbing pain with elevated CGRP levels 130.44±114.22 and p value (p = 0.01). The average CGRP levels was higher in test group 149.00±93.86 compared to control 61.30±24.37 with p value (p = 0.02). Conclusions. The serum CGRP levels were statistically more in migraine patients correlated with characteristics like throbbing type of pain, stress and inadequate sleep. Hence, the serum CGRP levels estimation can be considered as a diagnostic tool for migraine when the clinical character’s over lap or early in the course of migraine when all criteria for diagnosis are not yet fulfilled.

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Comparative evaluation of serum calcitonin gene related peptide level in patients with migraine headache with and without aura

10.21203/rs.3.rs-201874/v1 ◽

2021 ◽

Author(s):

Mostafa Rezaee ◽

Nahid Ashja zadeh ◽

Sadegh Izedi ◽

Farinaz Fakhri

Keyword(s):

Correlation Coefficient ◽

Rank Correlation ◽

Calcitonin Gene Related Peptide ◽

Clinical Findings ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Serum Calcitonin ◽

Related Peptide ◽

Spearman’S Rank Correlation ◽

Calcitonin Gene

Abstract Background During a migraine attack, trigeminal activation results in the release of calcitonin gene-related peptide (CGRP), which stimulates the release of inflammatory cytokines playing an important role in migraine. We analyze the serum level of CGRP between two groups of migrainous patients (with aura and without aura) Materials and Methods Thirty six migraine patients (included 18 patients with aura and 18 without aura) additionally 18 healthy volunteers consisted control group were selected from the clinic of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran, between March 2020 and November 2020. The CGRP level were determined from the sera of patients with migraine and control subjects by enzyme-linked immunosorbent assay kits. Spearman's rank correlation coefficient was also determined to calculate the correlation between CGRP and clinical findings. Results The level of CGRP in groups were significantly different between groups (P = 0.00). Also, the level of CGRP in aura group were significantly higher than non-aura group (P = 0.045). The Spearman’s correlation coefficient revealed a positive and significant correlation between the CGRP concentration and age (p = 0.042, r = 0.172), BMI (p = 0.013, r = 0.08), VAS (P = 0.006 ,r = 0.09), frequency of attacks (p = 0.005, r = 0.9), duration of each attack (p = 0.016, r = 0.23), Migraine Disability Assessment Scale.(p = 0.00, r = 0.785), average of number of Medication (p = 0.00, r = 0.694). However, no significant correlation was observed with gender. (P > 0.05 ) Conclusions In our study, we found migraine patients had a higher CGRP level than healthy controls and the level of CGRP was related significantly with the duration, BMI, frequency of headache, age, number of headaches per day. In conclusion, our results confirmed that CGRP may be involved in the pathogenesis of migraine attacks and related with the multiple clinical characteristics.

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