scholarly journals RGD Peptide and PAD4 Inhibitor-Loaded Gold Nanorods for Chemo-Photothermal Combined Therapy to Inhibit Tumor Growth, Prevent Lung Metastasis and Improve Biosafety

2021 ◽  
Vol Volume 16 ◽  
pp. 5565-5580
Author(s):  
Yu Lu ◽  
Zidong Peng ◽  
Di Zhu ◽  
Yijiang Jia ◽  
Ayijiang Taledaohan ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Metastasis ◽  
Gold Nanorods ◽  
Combined Therapy ◽  
Rgd Peptide ◽  
Inhibit Tumor Growth

scholarly journals Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells

2013 ◽  
Vol 2 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Hideki Kitajima ◽  
Yuji Komizu ◽  
Hideaki Ichihara ◽  
Koichi Goto ◽  
Ryuichi Ueoka
Keyword(s):  
Tumor Growth ◽  
Lung Metastasis ◽  
Osteosarcoma Cells ◽  
Inhibit Tumor Growth ◽  
Murine Osteosarcoma

scholarly journals A Dual-Targeting Ruthenium Nanodrug that Inhibits Primary Tumor Growth and Lung Metastasis by the PARP/ATM Pathway

2020 ◽  
Author(s):  
Yu Lu ◽  
Di Zhu ◽  
Lin Gui ◽  
Yuanming Li ◽  
Wenjing Wang ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Metastasis ◽  
Dna Cleavage ◽  
Tumor Tissue ◽  
Chloride Ions ◽  
Inhibit Tumor Growth ◽  
Dual Targeting ◽  
Cd31 Expression

Abstract Many studies have found that ruthenium complexes have unique biochemical characteristics and thus inhibit tumor growth or metastasis. Our aim was to report a novel dual-targeting ruthenium candidate 2b with both antitumor and antimetastatic functions that could target tumor sites using both EPR effects and TF/TFR. It was composed of ruthenium-complexed carboline acid and four chloride ions. In vitro, 2b could trigger DNA cleavage and thus block the cell cycle and cause apoptosis by the PARP/ATM pathway. In vivo, 2b could inhibit not only LLC tumor growth but also lung metastasis. We found apoptosis and decrease in CD31 expression in tumor tissue. In addition, we also found that 2b could collect in tumor tissue. Thus, we concluded that 2b could target tumors, inhibit tumor growth and prevent lung metastasis.

Nerve Growth Factor overexpression in Clara cells suppresses metastasis and tumor growth in a mouse model of experimental lung metastasis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
K Seidler ◽  
A Sydykov ◽  
S Müller-Brüsselbach ◽  
R Müller ◽  
N Weißmann ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mouse Model ◽  
Tumor Growth ◽  
Lung Metastasis ◽  
Clara Cells ◽  
Nerve Growth

Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth

Science ◽  
2006 ◽  
Vol 313 (5789) ◽  
pp. 971-975 ◽  
Author(s):  
J. M. Pinkston
Keyword(s):  
Tumor Growth ◽  
Life Span ◽  
Inhibit Tumor Growth ◽  
C Elegans

scholarly journals A new antisarcoma strategy: multisubtype heat shock protein/peptide immunotherapy combined with PD-L1 immunological checkpoint inhibitors

2021 ◽  
Author(s):  
H. Li ◽  
X. Sui ◽  
Z. Wang ◽  
H. Fu ◽  
Z. Wang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Lung Metastasis ◽  
Checkpoint Inhibitors ◽  
Combined Therapy ◽  
Peptide Vaccine ◽  
Tumor Environment ◽  
Immune Check Point Inhibitor ◽  
Shock Proteins ◽  
Sarcoma Treatment

AbstractOsteosarcoma, a common malignant tumor in orthopedics, often has a very poor prognosis after lung metastasis. Immunotherapy has not achieved much progress in the treatment because of the characteristics of solid tumors and immune environment of osteosarcoma. The tumor environment is rather essential for sarcoma treatment. Our previous study demonstrated that heat shock proteins could be used as antitumor vaccines by carrying tumor antigen peptides, and we hypothesize that an anti-osteosarcoma effect may be increased with an immune check point inhibitor (PD-L1 inhibitor) as a combination treatment strategy. The present study prepared a multisubtype mixed heat shock protein osteosarcoma vaccine (mHSP/peptide vaccine) and concluded that the mHSP/peptide vaccine was more effective than a single subtype heat shock protein, like Grp94. Therefore, we used the mHSP/peptide vaccine in combination with a PD-L1 inhibitor to treat osteosarcoma, and the deterioration of osteosarcoma was effectively hampered. The mechanism of combined therapy was investigated, and AKT expression participates with sarcoma lung metastasis. This study proposed an antisarcoma strategy via stimulation of the immune system as a further alternative approach for sarcoma treatment and elucidated the mechanism of combined therapy.

scholarly journals G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer

2020 ◽  
Vol 180 (3) ◽  
pp. 635-646 ◽  
Author(s):  
Kaitlyn J. Andreano ◽  
Suzanne E. Wardell ◽  
Jennifer G. Baker ◽  
Taylor K. Desautels ◽  
Robert Baldi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Animal Models ◽  
Tumor Growth ◽  
Inhibit Tumor Growth

scholarly journals 499 MicroRNA-203 inhibits SLUG and suppresses melanoma cell motility, tumor growth and lung-metastasis

2016 ◽  
Vol 136 (9) ◽  
pp. S245
Author(s):  
W. Lohcharoenkal ◽  
K. Das Mahapatra ◽  
L. Zhang ◽  
N. Landén ◽  
L. Girnita ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cell Motility ◽  
Lung Metastasis ◽  
Melanoma Cell

scholarly journals Polysaccharides to Inhibit Tumor Growth

1989 ◽  
Vol 7 (12) ◽  
pp. 1222-1222
Author(s):  
Bernard Dixon
Keyword(s):  
Tumor Growth ◽  
Inhibit Tumor Growth
Sign in / Sign up

Export Citation Format

Share Document