scholarly journals Calcium-Enriched Nanofibrillated Cellulose/Poloxamer in-situ Forming Hydrogel Scaffolds as a Controlled Delivery System of Raloxifene HCl for Bone Engineering

2021 ◽  
Vol Volume 16 ◽  
pp. 6807-6824
Author(s):  
Rabab Kamel ◽  
Nahla A El-Wakil ◽  
Nermeen A Elkasabgy
Keyword(s):  
Delivery System ◽  
Nanofibrillated Cellulose ◽  
Controlled Delivery ◽  
Bone Engineering ◽  
Hydrogel Scaffolds ◽  
In Situ Forming ◽  
Raloxifene Hcl

Long lasting in-situ forming implant loaded with raloxifene HCl: An injectable delivery system for treatment of bone injuries

2019 ◽  
Vol 571 ◽  
pp. 118703 ◽  
Author(s):  
Nermeen A. Elkasabgy ◽  
Fatma S. Abdel-Salam ◽  
Azza A. Mahmoud ◽  
Emad B. Basalious ◽  
Mohammed S. Amer ◽  
...  
Keyword(s):  
Delivery System ◽  
In Situ Forming ◽  
Raloxifene Hcl

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming

scholarly journals Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Elham Khodaverdi ◽  
Fatemeh Kheirandish ◽  
Farnaz Sadat Mirzazadeh Tekie ◽  
Bibi Zahra Khashyarmanesh ◽  
Farzin Hadizadeh ◽  
...  
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Phase Transition Temperature ◽  
Delivery System ◽  
In Vitro Release ◽  
In Situ Forming ◽  
Release Study ◽  
Vitro Release

In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration.

scholarly journals In situ forming microporous gelatin methacryloyl hydrogel scaffolds from thermostable microgels for tissue engineering

2020 ◽  
Vol 5 (3) ◽  
Author(s):  
Nicole Zoratto ◽  
Donatella Di Lisa ◽  
Joseph Rutte ◽  
Md Nurus Sakib ◽  
Angelo Roncalli Alves e Silva ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hydrogel Scaffolds ◽  
In Situ Forming

Benzoyl Peroxide In Situ Forming Antimicrobial Gel for Periodontitis Treatment

2013 ◽  
Vol 545 ◽  
pp. 63-68 ◽  
Author(s):  
Jongjan Mahadlek ◽  
Juree Charoenteeraboon ◽  
Thawatchai Phaechamud
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Activity ◽  
Drug Release ◽  
Delivery System ◽  
Periodontal Pocket ◽  
Peppermint Oil ◽  
In Situ Gel ◽  
In Situ Forming ◽  
In Situ Forming Gel

Periodontitis is an inflammatory disease of the supporting structures of the tooth caused by bacterial infection which can result in tooth loss. The local intra-pocket drug delivery system was interesting and highly effective for periodontitis treatment. In situ forming gel system is the polymeric solution which could transform into gel for localizing and sustaining the drug release at desired site. This system has been recommended as one of suitable delivery system for this purpose. Benzoyl peroxide (BPO) in situ forming gels were developed using Eudragit RS as polymer dispersed in N-methyl-pyrrolidone (NMP). Peppermint oil and polyethylene glycol 1500 were also incorporated as the excipients. The prepared systems were evaluated for rheology, syringeability (using texture analyzers), in situ gel formation (after injection into PBS pH 6.8), antimicrobial activity (against Streptococcus mutans with agar diffusion) and drug release (with dialysis method in PBS pH 6.8 at 50 rpm, 37 °C). The viscosity and syringeability of the prepared systems was increased as the amount of BPO, peppermint oil or PEG 1500 was increased. All prepared gels showed the Newtonian flow which the viscosity was decreased as the temperature was increased. All prepared gels comprising peppermint oil and PEG 1500 could form in situ gel in used medium which the pH was close to the environment pH of periodontal pocket. The inhibition zone against Streptococcus mutans of the prepared system was significantly decreased when the peppermint oil and PEG 1500 was incorporated owing to the higher viscous environment and thereafter retardation of drug diffusion was evident. This effect could prolong the drug release. From drug release test, all prepared gels could sustain the BPO release for at least 96 hrs. Release kinetic obtained from curve fitting with various release equations using least square fit technique indicated that the release patterns were as Higuchi’s model therefore the release of BPO was performed with diffusion control. This developed BPO in situ forming gel presented its ability as the controlled drug delivery system for localized antimicrobial activity at periodontal pocket.

scholarly journals In Situ Forming Injectable Thermoresponsive Hydrogels for Controlled Delivery of Biomacromolecules

ACS Omega ◽  
2020 ◽  
Vol 5 (28) ◽  
pp. 17531-17542
Author(s):  
Kingshuk Dutta ◽  
Ritam Das ◽  
Jing Ling ◽  
Rafael Mayoral Monibas ◽  
Ester Carballo-Jane ◽  
...  
Keyword(s):  
Controlled Delivery ◽  
In Situ Forming ◽  
Thermoresponsive Hydrogels
Sign in / Sign up

Export Citation Format

Share Document