Population-based estimation of renal function in healthy young Indian adults based on body mass index and sex correlating renal volume, serum creatinine, and cystatin C

Background: Cystatin C (Cys-C) is a sensitive biomarker of renal function and an independent predictor of all-cause mortality (ACM) in patients with chronic kidney and cardiovascular disease (CVD). Although higher levels of Cys-C are associated with increased body mass index (BMI), the interplay between serum Cys-C, BMI and ACM in adults with normal renal function is unknown. Methods: Utilizing data from the National Health and Nutrition Examination Survey (1999-2002), analysis was conducted on participants (≥18 years) with normal renal function [glomerular filtration rate (GFR) ≥90 ml/min)]. BMI (kg/m2) was categorized as Normal (BMI:18.5-24.9); Overweight (BMI:25-29.9); Obese (BMI >30), while Cys-C (mg/L) was categorized into weight based quartiles [Q1:<0.72(ref); Q2: ≥0.72-0.80; Q3: ≥0.80-0.89; Q4: ≥0.89]. Mortality information was obtained from the National Death Index using probabilistic matching. Cox proportional hazards models (and associated 95% CI’s) estimated the likelihood of ACM by Cys-C quartiles in each BMI category. Results: The mean(±) age and GFR of 2649 participants (51% females) was 50±20 years and 123±28 mL/min, while the median (IQR) of CRP and Cys-C was 0.19(0.07-0.44) mg/dL and 0.80(0.72-0.89) mg/L, respectively. Approximately, 33% of the cohort was normal, 34% overweight, and 33% were obese. After a mean(SD) follow up of 5.9(1.3) years, 213 deaths (all-cause) were observed. Cys-C levels increased with increasing BMI (p trend <0.05), however, significant difference was only seen in obese when compared with normal weight adults (p<0.05). Within each BMI category, increasing Cys-C was associated with increased risk of ACM (p trend <0.05), however, the hazard ratio were statistically significant only at elevated Cys-C levels (Q4 vs.Q1) in normal and overweight adults (both p values <0.05). Conclusions: Independent of traditional CVD risk factors, elevated Cys-C levels predicts risk of ACM in normal and overweight but not in obese adults who have normal renal function based on GFR.

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1480: The Association of Body Mass Index and Serum Prostate Specific Antigen Levels in a Population-Based Study

The Journal of Urology ◽

10.1016/s0022-5347(18)35614-3 ◽

2005 ◽

Vol 173 (4S) ◽

pp. 401-401

Author(s):

Javier Hernandez ◽

Jacques Baillargeon ◽

Brad Pollock ◽

Alan R. Kristal ◽

Patrick Bradshaw ◽

...

Keyword(s):

Body Mass Index ◽

Prostate Specific Antigen ◽

Body Mass ◽

Specific Antigen ◽

Population Based ◽

Population Based Study ◽

Serum Prostate Specific Antigen

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Faculty Opinions recommendation of Diabetes and body mass index in relation to risk of active tuberculosis: a prospective population-based cohort.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737293826.793570593 ◽

2020 ◽

Author(s):

Anthony Harries ◽

Kudakwashe C Takarinda

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Population Based ◽

Active Tuberculosis

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Impact of age, body mass index, and renal function for severe hypotension caused by oral 5-aminolevulinic acid administration in patients undergoing transurethral resection of bladder tumor

Photodiagnosis and Photodynamic Therapy ◽

10.1016/j.pdpdt.2021.102179 ◽

2021 ◽

Vol 33 ◽

pp. 102179 ◽

Cited By ~ 1

Author(s):

Jimpei Miyakawa ◽

Taketo Kawai ◽

Katsuhiro Makino ◽

Yoshiyuki Akiyama ◽

Yuta Yamada ◽

...

Keyword(s):

Body Mass Index ◽

Renal Function ◽

Body Mass ◽

Transurethral Resection ◽

Bladder Tumor ◽

Aminolevulinic Acid ◽

Severe Hypotension ◽

Acid Administration

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Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study

BMJ ◽

10.1136/bmj.n365 ◽

2021 ◽

pp. n365

Author(s):

Buyun Liu ◽

Yang Du ◽

Yuxiao Wu ◽

Linda G Snetselaar ◽

Robert B Wallace ◽

...

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Ethnic Groups ◽

Body Mass ◽

Body Fat ◽

Lean Mass ◽

The United States ◽

Population Based ◽

Body Fat Percentage ◽

Fat Percentage

AbstractObjectiveTo examine the trends in obesity and adiposity measures, including body mass index, waist circumference, body fat percentage, and lean mass, by race or ethnicity among adults in the United States from 2011 to 2018.DesignPopulation based study.SettingNational Health and Nutrition Examination Survey (NHANES), 2011-18.ParticipantsA nationally representative sample of US adults aged 20 years or older.Main outcome measuresWeight, height, and waist circumference among adults aged 20 years or older were measured by trained technicians using standardized protocols. Obesity was defined as body mass index of 30 or higher for non-Asians and 27.5 or higher for Asians. Abdominal obesity was defined as a waist circumference of 102 cm or larger for men and 88 cm or larger for women. Body fat percentage and lean mass were measured among adults aged 20-59 years by using dual energy x ray absorptiometry.ResultsThis study included 21 399 adults from NHANES 2011-18. Body mass index was measured for 21 093 adults, waist circumference for 20 080 adults, and body fat percentage for 10 864 adults. For the overall population, age adjusted prevalence of general obesity increased from 35.4% (95% confidence interval 32.5% to 38.3%) in 2011-12 to 43.4% (39.8% to 47.0%) in 2017-18 (P for trend<0.001), and age adjusted prevalence of abdominal obesity increased from 54.5% (51.2% to 57.8%) in 2011-12 to 59.1% (55.6% to 62.7%) in 2017-18 (P for trend=0.02). Age adjusted mean body mass index increased from 28.7 (28.2 to 29.1) in 2011-12 to 29.8 (29.2 to 30.4) in 2017-18 (P for trend=0.001), and age adjusted mean waist circumference increased from 98.4 cm (97.4 to 99.5 cm) in 2011-12 to 100.5 cm (98.9 to 102.1 cm) in 2017-18 (P for trend=0.01). Significant increases were observed in body mass index and waist circumference among the Hispanic, non-Hispanic white, and non-Hispanic Asian groups (all P for trend<0.05), but not for the non-Hispanic black group. For body fat percentage, a significant increase was observed among non-Hispanic Asians (30.6%, 29.8% to 31.4% in 2011-12; 32.7%, 32.0% to 33.4% in 2017-18; P for trend=0.001), but not among other racial or ethnic groups. The age adjusted mean lean mass decreased in the non-Hispanic black group and increased in the non-Hispanic Asian group, but no statistically significant changes were found in other racial or ethnic groups.ConclusionsAmong US adults, an increasing trend was found in obesity and adiposity measures from 2011 to 2018, although disparities exist among racial or ethnic groups.

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