Association of VDR gene TaqI polymorphism with the susceptibility to prostate cancer in Asian population evaluated by an updated systematic meta-analysis

Abstract Background: Tuberculosis is one of the top ten causes of deaths worldwide. The deficiency of vitamin D was reported to be associated with the increased susceptibility of tuberculosis. Various previous reports were published to check the association of FokI polymorphism of the vitamin D receptor gene with tuberculosis risk. But their results were inconsistent so, we performed a meta-analysis to know the exact relation of the two.Methods: Different databases were screened up to November, 2020 with the keywords “Vitamin D receptor”, “VDR”, and “FokI”, along with “Tuberculosis” and “TB” to find the suitable articles. All the statistical analyses were performed by the Open Meta-Analyst program and all p-values were two-tailed with a significance level of 0.05.Results: No statistically significant association was observed in the allele contrast model (ORfvs.F= 1.11, 95%CI= 0.99-1.24, p= 0.05, I2= 73.46%), in the dominant model (ORff+Ffvs.FF= 1.11, 95%CI= 0.96-1.28, p= 0.14, I2= 71.39%), and in the co-dominant model (ORFfvs.FF= 1.05, 95%CI= 0.92-1.21, p= 0.41, I2= 65.97%). However, a significant association was found in the homozygote model (ORffvs.FF= 1.32, 95%CI= 1.03-1.69, p= 0.02, I2= 67.02%) and in the recessive model (ORFF+Ff vs.ff= 1.26, 95%CI= 1.03-1.54, p= 0.02, I2= 58.01%). Further analysis was performed on the bases of the ethnicity. In Asian population a significant association was found in the homozygote model (ORffvs.FF= 1.57, 95%CI= 1.12-2.21, p= 0.008, I2= 70.37%) and in the recessive model (ORFF+Ff vs.ff= 1.43, 95%CI= 1.08-1.89, p= 0.01, I2= 63.13%).Conclusion: In conclusion, a significant association of FokI with tuberculosis susceptibility was found in the overall analysis and in the Asian population.

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Meta-analysis of the Relation Between the VDR Gene TaqIpolymorphism and Genetic Susceptibility to Prostate Cancer in Asian Populations

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2012.13.9.4441 ◽

2012 ◽

Vol 13 (9) ◽

pp. 4441-4444 ◽

Cited By ~ 5

Author(s):

Ya-Jie Guo ◽

Ze-Ming Shi ◽

Jun-Da Liu ◽

Ning Lei ◽

Qiu-Hong Chen ◽

...

Keyword(s):

Prostate Cancer ◽

Genetic Susceptibility ◽

Meta Analysis ◽

Vdr Gene ◽

Asian Populations

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HOGG1 C1245G Gene Polymorphism Associated with Prostate Cancer: A Meta-Analysis

The International Journal of Biological Markers ◽

10.5301/jbm.5000144 ◽

2015 ◽

Vol 30 (2) ◽

pp. 161-168 ◽

Cited By ~ 3

Author(s):

Yang Chen ◽

Jie Li ◽

Tianyu Li ◽

Zengnan Mo

Keyword(s):

Prostate Cancer ◽

Meta Analysis ◽

Asian Population ◽

Pooled Analysis ◽

Positive Relation ◽

Knowledge Infrastructure ◽

Hardy Weinberg Equilibrium ◽

Mixed Populations ◽

Oxoguanine Glycosylase 1 ◽

Chinese National Knowledge Infrastructure

Background Prostate cancer (Pca) is one of the most frequently encountered multifactorial malignant diseases worldwide. The human oxoguanine glycosylase 1 ( hOGG1) C1245G polymorphism (rs1052133) has been found to be associated with Pca. However, the conclusions have been controversial. Methods Based on the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases, this meta-analysis was conducted with 4 models. Eleven qualified studies were included. Results Although no positive relation was discovered in the pooled analysis, significant associations between rs1052133 and Pca were found in the Asian population (recessive: odds ratio [OR] = 1.580, 95% confidence interval [95% CI], 1.189-2.098; GG vs. GC: OR = 1.504, 95% CI, 1.114-2.030; GG vs. CC: OR = 1.677, 95% CI, 1.201-2.342; allele analysis: OR = 1.249, 95% CI, 1.077-1.449), whites (dominant: OR = 2.138, 95% CI, 1.483-3.083; recessive: OR = 3.143, 95% CI, 1.171-8.437; GG vs. CC: OR = 3.992, 95% CI, 1.891-8.431; allele analysis: OR = 1.947, 95% CI, 1.467-2.586) and mixed populations (recessive: OR = 0.636, 95% CI, 0.484-0.834; GG vs. GC: OR = 0.654, 95% CI, 0.492-0.871; GG vs. CC: OR = 0.624, 95% CI, 0.473-0.823; allele analysis: OR = 0.857, 95% CI, 0.771-0.954). After excluding studies deviating from the Hardy-Weinberg equilibrium, a significant association was also found in the same ethnic groups. In addition, a new positive relation was identified in the “other country” subgroup (with China, South Korea and Australia included) (dominant: OR = 1.622, 95% CI, 1.163-2.261; recessive: OR = 1.773, 95% CI, 1.308-2.404; GG vs. GC: OR = 1.614, 95% CI, 1.169-2.230; GG vs. CC: OR = 2.108, 95% CI, 1.456-3.051; allele analysis: OR = 1.494, 95% CI, 1.235-1.808) and among the Chinese-Korean population. Conclusions In conclusion, we suggest that the hOGG1 C1245G polymorphism might be potentially associated with Pca risk in different ethnicities and countries, especially among Asians. Further studies are needed to confirm these relations.

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Association of select vitamin D receptor gene polymorphisms with the risk of tobacco-related cancers – a meta-analysis

Scientific Reports ◽

10.1038/s41598-019-52519-5 ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Lukasz Laczmanski ◽

Izabela Laczmanska ◽

Felicja Lwow

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Receptor Gene ◽

P Value ◽

Vdr Gene ◽

Taqi Polymorphism ◽

Vdr Gene Polymorphisms

Abstract The observed increase in morbidity and mortality due to tobacco-related cancers, especially those in the respiratory system and esophagus, is becoming a public health challenge. Smoking cigarettes is one of the main risk factors predisposing individuals to many types of cancers. The aim of this study was to determine the role of select vitamin D receptor (VDR) gene polymorphisms as risk factors in tobacco-related cancers. The MEDLINE and ResearchGate databases were used to search for articles up to June 2017, and 12 articles including 26 studies concerning FokI, ApaI, TaqI and BsmI polymorphisms and lung, neck, head, esophageal and oral cancers were chosen. In total, 5 113 cases and 5 657 controls were included in the pooled analysis. We found a significant relationship between tobacco-related cancers and the occurrence of the “t” allele in the TaqI polymorphism of VDR. The occurrence of the “t” allele reduced the risk of tobacco-related cancers by 17% (OR = 0.83, 0.72–0.96 95% CI, p-value = 0.0114). Our analysis revealed that there is a correlation between the TaqI polymorphism of VDR and the risk of tobacco-related cancers.

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Interleukin- 10 (IL-10) gene polymorphisms and prostate cancer susceptibility: evidence from a meta-analysis

10.1101/2020.11.09.20228825 ◽

2020 ◽

Author(s):

Upendra Yadav ◽

Pradeep Kumar ◽

Vandana Rai

Keyword(s):

Prostate Cancer ◽

Gene Polymorphisms ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Asian Population ◽

Interleukin 10 ◽

Caucasian Population ◽

Contrast Model ◽

Prostate Cancer Susceptibility ◽

Different Populations

AbstractProstate cancer is the second most frequent cancer in men. The frequency of the prostate cancer is greatly varies in different populations of the world. Three common polymorphisms in promoter region of interleukin-10 (IL-10) gene viz. -1082 A>G, -819 C>T and -592 C>A are extensively studied in prostate cancer with inconclusive results. So, a meta-analysis was performed to assess the association between these three IL-10 gene polymorphisms and risk of prostate cancer susceptibility. Suitable studies were retrieved by electronic databases search and odds ratios (ORs) with 95% confidence intervals (CIs) were used as association measure. All the statistical analyses were conducted in the Open Meta-Analyst program.In our meta-analysis we included 17 studies (10,718 samples), 11 studies (8,391 samples) and 13 studies (7,801 samples) for -1082 A>G, -819 C>T and -592 C>A polymorphisms respectively. The result of the -592 C>A polymorphism revealed low heterogeneity with no association in the overall analysis (ORAvs.C= 1.05, 95% CI= 0.99-1.12, p= 0.09, I2= 35.89%). In ethnicity based stratified analyses, significant association was found in Caucasian population with prostate cancer using allele contrast model (ORAvs.C= 1.08, 95% CI= 1.01-1.16, p= 0.02, I2= 19.37%), homozygote model (ORAAvs.CC= 1.24, 95% CI= 1.00-1.52, p= 0.04, I2= 0%), and dominant model (ORAA+CAvs.CC= 1.10, 95% CI= 1.00-1.22, p= 0.05, I2= 32.57%). No such results were found in the Asian population. In the other two polymorphisms i.e. -1082 A>G and -819 C>T, no significant association with prostate cancer was observed.In conclusion, results of present meta-analysis suggested that IL-10 -592 C>A polymorphism plays a role in the progression of the prostate cancer in the Caucasian population.

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Associations of CYP1 polymorphisms with risk of prostate cancer: an updated meta-analysis

Bioscience Reports ◽

10.1042/bsr20181876 ◽

2019 ◽

Vol 39 (3) ◽

Cited By ~ 3

Author(s):

Wei Zhu ◽

Hailang Liu ◽

Xinguang Wang ◽

Jinjin Lu ◽

Huiping Zhang ◽

...

Keyword(s):

Prostate Cancer ◽

Meta Analysis ◽

Random Effect ◽

Asian Population ◽

Caucasian Population ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Cyp1a1 Gene ◽

Major Allele

Abstract Background. The results of previous studies on the association between polymorphisms of CYP1A1 and CYP1B1 and prostate cancer (PCa) susceptibility are inconsistent. The aim of the present study was to conduct a meta-analysis in order to better estimate this association. Methods. A systematic search was carried out on PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases for relevant articles published up to 15 August 2018. Pooled odds ratios (ORs) and 95% confidence intervals were obtained using fixed-effect or random-effect models. Results. A significant association was found between the CYP1A1 rs1048943 polymorphism and PCa in the overall population (B [the minor allele] vs. A [the major allele]: OR = 1.20, 95% confidence interval (CI) = 1.04–1.39, P=0.014; AB vs. AA: OR = 1.24, 95% CI = 1.02–1.51, P=0.029; BB + AB vs. AA: OR = 1.25, 95% CI = 1.04–1.50, P=0.018) and Asian population (B vs. A: OR = 1.32, 95% CI = 1.11–1.56, P=0.001; BB vs. AA: OR = 1.81, 95% CI = 1.20–2.72, P=0.005; AB vs. AA: OR = 1.30, 95% CI = 1.03–1.64, P=0.029; BB + AB vs. AA: OR = 1.38, 95% CI = 1.11–1.73, P=0.004; BB vs. AA + AB: OR = 1.58, 95% CI = 1.08–2.01, P=0.019), but not in the Caucasian population. Moreover, we found that the rs4646903 polymorphism was associated with a significant increase in the risk of PCa in the Asian population (AB vs. AA: OR = 1.43, 95% CI = 1.13–1.80, P=0.003) and Caucasian population (BB vs. AA: OR = 2.12, 95% CI = 1.29–3.49, P=0.003). Conclusion. This meta-analysis revealed a clear association between rs1048943 and rs4646903 polymorphisms of the CYP1A1 gene but not between CYP1B1 rs10012, rs162549, rs1800440, and rs2551188 polymorphisms and the risk of PCa.

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The Association Between Three Genetic Variants in MicroRNAs (Rs11614913, Rs2910164, Rs3746444) and Prostate Cancer Risk

Cellular Physiology and Biochemistry ◽

10.1159/000491671 ◽

2018 ◽

Vol 48 (1) ◽

pp. 149-157 ◽

Cited By ~ 12

Author(s):

Yuanyuan Mi ◽

Kewei Ren ◽

Jiangang Zou ◽

Yu Bai ◽

Lifeng Zhang ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Genetic Variants ◽

Genetic Model ◽

Meta Analysis ◽

Prostate Cancer Risk ◽

Asian Population ◽

Published Data ◽

Common Genetic Variants ◽

The Impact

Background/Aims: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules which play a significant role in transcriptional and translational regulation. Published data on the association between the miRNA SNPs and prostate cancer (PCa) risk are somewhat inconclusive. Methods: We performed a meta-analysis of all available studies including 2,227 patients and 2,331 control subjects to evaluate the impact of three common genetic variants of microRNAs in prostate cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to investigate the strength of the association. Results: For miR-499 polymorphism, a significant association was observed between the rs3746444 A>G polymorphism and PCa risk in heterozygote comparison and dominant genetic model, in particular in Asian population subgroup. For miR-146a polymorphism, the rs2910164 CC genotype was associated with decreased PCa risk in Asian population in homozygote comparison. In addition, rs2910164 CC genotype had a weekly higher percentage value in subgroup of Gleason score < 7. Similar results were also indicated in localized prostate cancer in subgroup analysis by tumor stage. For miR-196a2 polymorphism, no association was observed between this variant and PCa risk in the overall group. However, in stratified analysis by ethnicity, we found that rs11614913 T allele was a risk factor for Asian PCa patients. Conclusions: Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants. Moreover, miR-146a rs2910164 polymorphism was related to PCa prognosis.

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Association between Vitamin D receptor (VDR) polymorphisms and the risk of Multiple sclerosis (MS): An updated meta-analysis

10.21203/rs.2.17139/v2 ◽

2019 ◽

Author(s):

Danyal Imani ◽

Bahman Razi ◽

Morteza Motallebnezhad ◽

Ramazan rezaei

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Gene Polymorphism ◽

Vitamin D Receptor ◽

Subgroup Analysis ◽

Large Scale ◽

Meta Analysis ◽

Asian Population ◽

Vdr Gene ◽

Increased Risk

Abstract Background The association between the vitamin D receptor ( VDR ) gene polymorphism and the risk of Multiple sclerosis (MS) has been evaluated in several studiese. However, the findings were inconsistent and inconclusive.Methods All relevant studies reporting the association between the FokI (rs2228570) or/and TaqI (rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232) polymorphisms of the VDR and susceptibility to multiple sclerosis published up to September 2019 were identified by comprehensive systematic database search in web of science, Scopus, and PubMed.Results A total of 30 case–control studies were included in this meta-analysis. The overall results suggested a significant association between TaqI gene polymorphism and MS risk under heterozygote contrast (OR = 1.27, 95%CI = 1.01–1.59, REM). Moreover, the pooled results of subgroup analysis decline presence of significant association under all defined genotype model. In subgroup analysis, BsmI gene polymorphism was associated with increased risk of MS under the recessive model in Asian population. In other hand, ApaI gene polymorphism was associated with decreased risk of MS under recessive and homozygote contrast (aa vs AA) models in Asian population.Conclusions This meta-analysis suggested a significant association between TaqI gene polymorphism and MS susceptibility. Furthermore, BsmI gene polymorphism was associated with an increased risk of MS in Asian population. In contrast, ApaI gene polymorphism was associated with a decreased risk of MS in Asian population. Future large scale studies on gene–environment and gene– gene interactions are required to estimate related risk factors and assist early diagnosis of patients at high risk for MS.

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