Factors associated with high brachial–ankle pulse wave velocity in non-hypertensive and appropriately treated hypertensive patients with atherosclerotic risk factors

Although the associations between arterial calcification or advanced atherosclerosis and osteopenia have been well documented, it is not clear whether the one is the result of the other or they coprogress from the early stages through common mechanisms. Thus, we measured pulse wave velocity (PWV), which reflects earlier phase atherosclerosis, and osteo-sono assessment index (OSI), which correlates with bone mineral density, in 7865 Japanese subjects (4183 males and 3682 females, aged 50 ± 12 yr) and analyzed their association. PWV was determined by the volume rendering method; OSI was measured by the calcaneal quantitative ultrasound method. We evaluated the influence of age, gender, menopausal state, and established atherosclerotic risk factors on this association. In a linear regression analysis, OSI negatively correlated with PWV in both genders, and this association was more prominent in females (r = −0.38, P < 0.01) than in males (r = −0.17, P < 0.01). In females, this relationship was stronger after the menopause. In a multivariate analysis, PWV was significantly associated with OSI independent of age and conventional atherosclerotic risk factors. In females, this association was independent from menopause. These results suggest that common or related mechanisms, which may be accelerated after menopause, control both atherosclerosis and osteoporosis from the early stages.

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Relationships between brachial-ankle pulse wave velocity and conventional atherosclerotic risk factors in community-dwelling people

Preventive Medicine ◽

10.1016/j.ypmed.2004.04.026 ◽

2004 ◽

Vol 39 (6) ◽

pp. 1135-1142 ◽

Cited By ~ 18

Author(s):

Yoshinori Fujiwara ◽

Paulo Chaves ◽

Ryutaro Takahashi ◽

Hidenori Amano ◽

Shu Kumagai ◽

...

Keyword(s):

Risk Factors ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Community Dwelling ◽

Atherosclerotic Risk Factors

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Risk factors associated with brachial–ankle pulse wave velocity among peritoneal dialysis patients in Macao

BMC Nephrology ◽

10.1186/1471-2369-13-143 ◽

2012 ◽

Vol 13 (1) ◽

Cited By ~ 9

Author(s):

Ding-Wei Kuang ◽

Chiu-Leong Li ◽

Un-I Kuok ◽

Kin Cheung ◽

Weng-In Lio ◽

...

Keyword(s):

Risk Factors ◽

Peritoneal Dialysis ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Dialysis Patients ◽

Factors Associated

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Risk Factors Associated With Diabetic Foot Ulcers and Its Relationship With ABI and Brachial-Ankle Pulse Wave Velocity

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734620982233 ◽

2021 ◽

pp. 153473462098223

Author(s):

Jialu Wu ◽

Min Liu ◽

Hui Huang

Keyword(s):

Risk Factors ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Diabetic Foot ◽

Pulse Wave ◽

Ankle Brachial Index ◽

Foot Ulcers ◽

Binary Logistic Regression Analysis ◽

Diabetic Foot Ulcers ◽

Factors Associated

To evaluate the risk factors associated with diabetic foot ulcers (DFUs) and to analyze the relationship of DFUs and the value of Ankle-Brachial Index (ABI) and brachial-ankle pulse wave velocity (baPWV). In this retrospective study, the risk factors associated with DFUs were analyzed, and the value of ABI and baPWV were measured to find its relationship with DFUs. Binary logistic regression analysis indicated that neuropathy and ABI were independent risk factors for DFUs. The patients were divided into 2 groups according to the value of ABI. For patients with DFUs, the value of baPWV decreased with the decrease of ABI. In normal or high ABI group, about a quarter of patients who suffered from DFUs had a higher value of baPWV than the others without DFUs. The pathogenesis of DFUs was multifactorial. Regarding the occurrence and development of foot ulcers, the action of vascular occlusion was more important than vascular sclerosis. ABI measurements should be taken more seriously in patients with DFUs. baPWV should be taken with care in the follow-up of the patients without DFUs. However, in patients with a normal value of ABI, the degree of vascular sclerosis of patients with DFUs may be greater than those without ulceration.

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Pulse-Wave Velocity in Hypertensive Patients Depending on the Category of Cardiovascular Risk

HYPERTENSION ◽

10.22141/2224-1485.3.47.2016.76373 ◽

2016 ◽

Vol 0 (3.47) ◽

pp. 90

Author(s):

E.P. Kolesnik ◽

H.V. Dziak

Keyword(s):

Cardiovascular Risk ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Hypertensive Patients

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Elevated levels of urine isocitrate, hydroxymethylglutarate, and formiminoglutamate are associated with arterial stiffness in Korean adults

Scientific Reports ◽

10.1038/s41598-021-89639-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Ji-Hee Haam ◽

Young-Sang Kim ◽

Doo-Yeoun Cho ◽

Hyejin Chun ◽

Sang-Woon Choi ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Cardiovascular Risk Factors ◽

Wave Velocity ◽

Pulse Wave ◽

Urinary Metabolites ◽

Metabolic Disturbances ◽

Liquid Chromatograph

AbstractRecent evidence suggests that cellular perturbations play an important role in the pathogenesis of cardiovascular diseases. Therefore, we analyzed the association between the levels of urinary metabolites and arterial stiffness. Our cross-sectional study included 330 Korean men and women. The brachial-ankle pulse wave velocity was measured as a marker of arterial stiffness. Urinary metabolites were evaluated using a high-performance liquid chromatograph-mass spectrometer. The brachial-ankle pulse wave velocity was found to be positively correlated with l-lactate, citrate, isocitrate, succinate, malate, hydroxymethylglutarate, α-ketoisovalerate, α-keto-β-methylvalerate, methylmalonate, and formiminoglutamate among men. Whereas, among women, the brachial-ankle pulse wave velocity was positively correlated with cis-aconitate, isocitrate, hydroxymethylglutarate, and formiminoglutamate. In the multivariable regression models adjusted for conventional cardiovascular risk factors, three metabolite concentrations (urine isocitrate, hydroxymethylglutarate, and formiminoglutamate) were independently and positively associated with brachial-ankle pulse wave velocity. Increased urine isocitrate, hydroxymethylglutarate, and formiminoglutamate concentrations were associated with brachial-ankle pulse wave velocity and independent of conventional cardiovascular risk factors. Our findings suggest that metabolic disturbances in cells may be related to arterial stiffness.

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