<p>Predictive value of high sensitivity C-reactive protein on progression to heart failure occurring after the first myocardial infarction</p>

Background The role of chronic inflammation in the pathogenesis of atherosclerosis has been unequivocally proven. However, the prognostic impact of C-reactive protein, a marker of inflammatory response in patients with acute myocardial infarction has not been fully clarified. Furthermore, there is no direct comparison of the diagnostic accuracy of C-reactive protein and high sensitivity C-reactive protein in the acute myocardial infarction population. Methods In this prospective observational cohort study, 344 patients with acute myocardial infarction were enrolled. All-cause mortality was a primary endpoint. Patients were followed prospectively for a median of six years. Results The correlation between high sensitivity C-reactive protein and C-reactive protein ( r = 0.99; P < 0.001) and the diagnostic accuracy (98.6%) was high. The ROC analysis revealed that C-reactive protein and high sensitivity C-reactive protein had a low AUC for prediction of mortality (C-reactive protein: 0.565, 95% CI [0.462–0.669], vs. high sensitivity C-reactive protein: 0.572, 95% CI [0.470–0.675]) or major adverse cardiac events (C-reactive protein: AUC 0.607, 95% CI [0.405–0.660], vs. high sensitivity C-reactive protein: AUC 0.526, 95% CI [0.398–0.653]) when assessed at time point of acute myocardial infarction. In contrast, longitudinal inflammatory risk assessment with serial C-reactive protein measurements in the stable phase of the disease revealed a 100% specificity, 100% negative predictive value, 32% sensitivity and 12% positive predictive value of C-reactive protein to predict long-term mortality. The Kaplan Meier analysis showed a significant survival benefit for patients at low residual inflammatory risk ( P = 0.014). Conclusion C-reactive protein and high sensitivity C-reactive protein provide a similar diagnostic accuracy, highlighting that C-reactive protein might replace high sensitivity C-reactive protein in routine assessments. Furthermore, low inflammatory status during the stable phase after acute myocardial infarction predicts favourable six-year survival.

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IMPACT OF HIGH-SENSITIVITY C-REACTIVE PROTEIN ON LIPOPROTEIN(A)-ASSOCIATED CARDIOVASCULAR RISK IN CHINESE PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERWENT PERCUTANEOUS CORONARY INTERVENTION

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(21)02915-6 ◽

2021 ◽

Vol 77 (18) ◽

pp. 1558

Author(s):

Ying Wang ◽

Xiaoxiao Zhao ◽

Peng Zhou ◽

Chen Liu ◽

Zhaoxue Sheng ◽

...

Keyword(s):

Myocardial Infarction ◽

High Sensitivity ◽

Coronary Intervention ◽

Chinese Patients ◽

C Reactive Protein ◽

St Segment Elevation ◽

Reactive Protein ◽

Segment Elevation Myocardial Infarction ◽

St Segment ◽

Percutaneous Coronary

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High-sensitivity c-reactive protein (hs-CRP) value with 90 days mortality in patients with heart failure

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/125/1/012124 ◽

2018 ◽

Vol 125 ◽

pp. 012124 ◽

Cited By ~ 1

Author(s):

Nursyamsiah ◽

R Hasan

Keyword(s):

Heart Failure ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Patients With Heart Failure ◽

Hs Crp

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High Sensitivity C-Reactive Protein Predicts Nonresponders and Cardiac Deaths in Severe Heart Failure Patients After CRT Implantation

International Heart Journal ◽

10.1536/ihj.53.306 ◽

2012 ◽

Vol 53 (5) ◽

pp. 306-312 ◽

Cited By ~ 20

Author(s):

Masashi Kamioka ◽

Hitoshi Suzuki ◽

Shinya Yamada ◽

Yoshiyuki Kamiyama ◽

Shu-ichi Saitoh ◽

...

Keyword(s):

Heart Failure ◽

Severe Heart Failure ◽

High Sensitivity ◽

C Reactive Protein ◽

Heart Failure Patients ◽

Reactive Protein

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Acute-Phase Plasma PCSK9 Levels and Recurrent Cardiovascular Events in a Chinese Acute Myocardial Infarction Cohort

Cardiology ◽

10.1159/000493785 ◽

2018 ◽

Vol 141 (2) ◽

pp. 88-97 ◽

Cited By ~ 1

Author(s):

Yan Gao ◽

Yan Qiu ◽

Jihua Wu ◽

Wei Diao ◽

Haibo Zhang ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Acute Phase ◽

Recurrent Events ◽

Density Lipoprotein ◽

High Sensitivity ◽

Female Gender ◽

C Reactive Protein ◽

Reactive Protein ◽

Increased Risk

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising target for lowering plasma low-density lipoprotein cholesterol and preventing cardiovascular (CV) disease. Whether plasma PCSK9 measured during the acute phase predicts recurrent CV events in patients with acute myocardial infarction (AMI) remains unresolved. Methods and Results: Plasma PCSK9 levels were measured in 1,646 patients with AMI from the China PEACE-Prospective AMI Study at the acute phase. Additionally, 248 patients were resampled and measured at 1 month post-AMI. Associations of acute-phase PCSK9 tertiles with clinical characteristics and recurrent CV events within 1 year were assessed. Female gender (OR 1.94, 95% CI 1.24–3.03), premature coronary heart disease (CHD; OR 2.12, 95% CI 1.37–3.26), higher high-sensitivity C-reactive protein (OR 1.67, 95% CI 1.44–1.95), and higher triglycerides (OR 1.46, 95% CI 1.03–2.09) were associated with higher baseline PCSK9. Plasma PCSK9 levels in the highest tertile (versus lowest) did not have an increased risk of 1-year recurrent CV events in the AMI cohort (HR 0.78, 95% CI 0.52–1.16) or any subgroup. There was also no association between percentage changes in PCSK9 over the first month and 1-year recurrent events, although there was a trend of differences between patients in the upper versus lower tertiles. Conclusion: Plasma PCSK9 levels measured during the acute phase were associated with high-sensitivity C-reactive protein, triglycerides, premature CHD, and gender in patients with AMI but did not predict recurrent CV events within 1 year. Dynamic changes in PCSK9 suggested a trend yet no significance value in predicting recurrent CV events.

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Anticipation of High-Sensitivity C-Reactive Protein Effect on Post Myocardial Infarction Depression Disorder

Galen Medical Journal ◽

10.31661/gmj.v10i0.1512 ◽

2021 ◽

Vol 10 ◽

pp. e1512

Author(s):

Parichehr Alizadeh ◽

Ehsan Bahramali ◽

Arvin Hedayati ◽

Azizallah Dehghan

Keyword(s):

Myocardial Infarction ◽

High Sensitivity ◽

Intima Media Thickness ◽

Public Health Issue ◽

C Reactive Protein ◽

Mild Depression ◽

Reactive Protein ◽

Depressed Patients ◽

Inflammatory State ◽

Hs Crp

Background: The natural history of acute myocardial infarction (AMI) as the most prevalent public health issue in Iran has changed with the introduction of novel therapeutic strategies that have reduced its mortality significantly. Major depressive disorder (MDD) is a prevalent and disabling psychiatric disorder and frequently co-exist with AMI. There are proposed pathophysiological links between the two diseases among which inflammation is the most important. With more patients surviving a myocardial infarction (MI) event, post-MI depression has become an important determinant of disability and mortality. Materials and Methods: In this study we defined a 1-month post-MI depressive scale of 200 patients using Beck’s inventory questionnaire II and measured serum high Sensitivity C-Reactive Protein (hs-CRP) and carotid intima-media thickness (CIMT) to look for the association between inflammatory state and atherosclerosis in different depression score categories. Results: Minimum and maximum Beck scores were 1 and 43, respectively with a mean of 13±8. The mean CIMT was 0.77±0.26 mm. Serum hs-CRP level was measured with a mean of 1.51±1.6 mg/L. According to BDI-II scores, 44.2% of patients 1-month post-MI suffered from more than mild depression. Being affected was not correlated with either the level of hs-CRP or CIMT. Nearly 44 percent of patients suffered more than mild depression. There was a negative association between serum hs-CRP level and CIMT as a measure of atherosclerosis in groups of depressed versus non-depressed patients. This may indicate that the extent of atherosclerosis is not correlated with the inflammatory state after MI in depressed versus non-depressed patients. Conclusions: The results of this study indicate that the extent of atherosclerosis is not correlated with the inflammatory state after MI in depressed versus non-depressed patients. Nonetheless, the prognostic indications of increased hs-CRP and depression after AMI remains to be investigated further. [GMJ.2021;10:e1512]

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VALIDITY OF C- REACTIVE PROTEIN IN DIAGNOSIS OF NEONATAL SEPSIS.

10.36106/ijsr/1506241 ◽

2020 ◽

pp. 1-4

Author(s):

Ghongade P. G. ◽

Khaire P. B.

Keyword(s):

Birth Weight ◽

Neonatal Sepsis ◽

Predictive Value ◽

Screening Test ◽

Treatment Strategies ◽

High Sensitivity ◽

C Reactive Protein ◽

Suspected Sepsis ◽

Adequate Treatment ◽

Reactive Protein

Background: Neonatal sepsis with its high incidence &grave prognosis, in spite of adequate treatment with modern antibiotics, has been a challenge for all times. Optimal diagnosis and treatment strategies are difficult to define. It is essential to diagnose early with laboratory investigation like serial CRP; so that a feasible, rapid and a relatively economic method to diagnose neonatal sepsis at earliest can be instituted even at basic health care level. hence a study was planned to find out the role of CRP against blood culture in early detection of neonatal sepsis. Aim & Objective: To evaluate Validity of C-Reactive Protein as a screening test in neonatal sepsis. Material and Method: This prospective study was carried out inpaediatric dept of medical college. 100 neonates (≤ 28 days) with suspected neonatal sepsis having a birth weight of ≥ 1000 grams admitted during a period from January 2020 to March 2020 were screened primarily with C-Reactive Protein. Serial level of CRPon the day of admission,2nd ,4th ,6th ,8th& 10th day was compared with the serial blood cultureon the day of admission,8th,15th& 21st day to establish the validity of CRP as a screening test.Data analysis carried out by Percentages, Chi Square test, Sensitivity, Specificity, Positive predictive value, Negative predictive value. Results: Amongst 100neonate 76% were early neonates,65% were low birth weight,CRP was having high sensitivity & specificity(78.57%,76.74% respectively). ROC analysis showed AUC 0.8 with p<0.001.Conclusion: CRP is a good screening test & establishes its validity in diagnosing suspected sepsis.

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