Sleep restriction increases white blood cells, mainly neutrophil count, in young healthy men: A pilot study

I would like to thank Drs Carraccio, Blotny, and Fisher1 for their recent study on cerebrospinal fluid (CSF) analysis. However, the presented data do not define the CSF absolute neutrophil count (ANC), upper limit of ANC, and standard deviation of ANC for their patients. I would like to review this potentially valuable information. The authors referred to the study by Rodewald et al2 who found nucleated and segmented leukocyte counts to be important CSF indicators.

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Supplementation with a Fish Oil-Enriched, High-Protein Medical Food Leads to Rapid Incorporation of EPA into White Blood Cells and Modulates Immune Responses within One Week in Healthy Men and Women

Journal of Nutrition ◽

10.3945/jn.110.132985 ◽

2011 ◽

Vol 141 (5) ◽

pp. 964-970 ◽

Cited By ~ 51

Author(s):

Joyce Faber ◽

Marloes Berkhout ◽

Arjan P. Vos ◽

John W. C. Sijben ◽

Philip C. Calder ◽

...

Keyword(s):

Immune Responses ◽

Fish Oil ◽

Blood Cells ◽

White Blood Cells ◽

High Protein ◽

Medical Food ◽

Men And Women ◽

Healthy Men ◽

Rapid Incorporation

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Effects of diet supplementation with different level of Celmanax® in rainbow trout (Oncorhyncus mykiss)

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.20339 ◽

2019 ◽

Vol 70 (1) ◽

pp. 1347

Author(s):

A. KHODADADI ◽

A. HAGHIGHI ◽

H. MALEKINEJADH ◽

A. TUKMECHI ◽

M. AFSHARNASAB

Keyword(s):

Rainbow Trout ◽

Neutrophil Count ◽

Blood Cells ◽

Biochemical Parameters ◽

White Blood Cells ◽

Haemoglobin Concentration ◽

Serum Biochemical Parameters ◽

Control Groups ◽

Serum Biochemical ◽

And Control

The aim of this study was to evaluate the effect of a prebiotic (Celmanax®) containing yeast cell wall with mannan oligosaccharides on the haematological and serum biochemical parameters in rainbow trout. Three levels of prebiotic (0, 0.1, 0.5 and 1 %) were mixed into pellets. Fish (19.08±1.45 g) were fed a supplemented commercial diet for 60 days. Blood samples were colected from the onset and on days 30 and 60 of the trial to measure the haematological and serum biochemical parameters in rainbow trout. The results showed significant differences in haemoglobin, mean corpuscular volume,mean corpuscular haemoglobin concentration, white blood cells and neutrophil count between control and all test groups (p<0.05). The highest and the lowest white blood cells and neutrophil count (on day 60) were observed in the 0.1 %, prebiotic-received and control groups, respectively. Also, the result showed significant differences in Alkaline phosphatase enzymes, serum glutamic oxaloacetic transaminase, Serum glutamic-pyruvic transaminase, between the test and control groups(p<0.05) while non-significant elevation of blood urea nitrogen, creatinine and total protein levels was found in the Celmanax®-received groups (p>0.05). These results suggest that the Celmanax® supplementation enhances white blood cells and neutrophil count, and changes some biochemical parameters in rainbow trout.

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Typical signature of DNA damage in white blood cells: a pilot study on etheno adducts in Danish mother-newborn child pairs

Carcinogenesis ◽

10.1093/carcin/bgn264 ◽

2008 ◽

Vol 30 (2) ◽

pp. 282-285 ◽

Cited By ~ 16

Author(s):

K. Arab ◽

M. Pedersen ◽

J. Nair ◽

M. Meerang ◽

L. E. Knudsen ◽

...

Keyword(s):

Dna Damage ◽

Pilot Study ◽

Blood Cells ◽

White Blood Cells ◽

Newborn Child

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Ultrastructural changes in murine lymphoma cells exposed to ultraviolet-A radiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010008482x ◽

1991 ◽

Vol 49 ◽

pp. 104-105

Author(s):

Delma P. Thomas ◽

Dianne E. Godar

Keyword(s):

Medical Devices ◽

Blood Cells ◽

White Blood Cells ◽

Consumer Products ◽

Ultrastructural Changes ◽

Ultraviolet A ◽

Uv Spectrum ◽

Lymphoma Cells ◽

Murine Lymphoma ◽

Transmission Electron

Ultraviolet radiation (UVR) from all three waveband regions of the UV spectrum, UVA (320-400 nm), UVB (290-320 nm), and UVC (200-290 nm), can be emitted by some medical devices and consumer products. Sunlamps can expose the blood to a considerable amount of UVR, particularly UVA and/or UVB. The percent transmission of each waveband through the epidermis to the dermis, which contains blood, increases in the order of increasing wavelength: UVC (10%) < UVB (20%) < UVA (30%). To investigate the effects of UVR on white blood cells, we chose transmission electron microscopy to examine the ultrastructure changes in L5178Y-R murine lymphoma cells.

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The Effect of Red Blood Cells on the ADP-induced Aggregation of Human Platelets in Flow Through Tubes

Thrombosis and Haemostasis ◽

10.1055/s-0038-1645696 ◽

1990 ◽

Vol 63 (01) ◽

pp. 112-121 ◽

Cited By ~ 18

Author(s):

David N Bell ◽

Samira Spain ◽

Harry L Goldsmith

Keyword(s):

Platelet Aggregation ◽

Shear Rate ◽

Red Blood Cells ◽

Blood Cells ◽

Platelet Rich Plasma ◽

Mean Transit Time ◽

White Blood Cells ◽

Aggregate Size ◽

Human Platelets ◽

Induced Aggregation

SummaryThe effect of red blood cells, rbc, and shear rate on the ADPinduced aggregation of platelets in whole blood, WB, flowing through polyethylene tubing was studied using a previously described technique (1). Effluent WB was collected into 0.5% glutaraldehyde and the red blood cells removed by centrifugation through Percoll. At 23°C the rate of single platelet aggregtion was upt to 9× greater in WB than previously found in platelet-rich plasma (2) at mean tube shear rates Ḡ = 41.9,335, and 1,920 s−1, and at both 0.2 and 1.0 µM ADP. At 0.2 pM ADP, the rate of aggregation was greatest at Ḡ = 41.9 s−1 over the first 1.7 s mean transit time through the flow tube, t, but decreased steadily with time. At Ḡ ≥335 s−1 the rate of aggregation increased between t = 1.7 and 8.6 s; however, aggregate size decreased with increasing shear rate. At 1.0 µM ADP, the initial rate of single platelet aggregation was still highest at Ḡ = 41.9 s1 where large aggregates up to several millimeters in diameter containing rbc formed by t = 43 s. At this ADP concentration, aggregate size was still limited at Ḡ ≥335 s−1 but the rate of single platelet aggregation was markedly greater than at 0.2 pM ADP. By t = 43 s, no single platelets remained and rbc were not incorporated into aggregates. Although aggregate size increased slowly, large aggregates eventually formed. White blood cells were not significantly incorporated into aggregates at any shear rate or ADP concentration. Since the present technique did not induce platelet thromboxane A2 formation or cause cell lysis, these experiments provide evidence for a purely mechanical effect of rbc in augmenting platelet aggregation in WB.

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White blood cells levels and PCOS: direct and indirect relationship with insulin resistance, but not with hyperandogenemia

Endocrine Abstracts ◽

10.1530/endoabs.32.p579 ◽

2013 ◽

Author(s):

Olga Papalou ◽

Sarantis Livadas ◽

Athanasios Karachalios ◽

Nektarios Benetatos ◽

George Boutzios ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Cells ◽

White Blood Cells ◽

Indirect Relationship

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Endogenous Heparinoids Detected by anti-Xa Activity are Present in Blood during Acute Variceal Bleeding in Cirrhosis. A Prospective Study

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.232.cht1 ◽

2014 ◽

Vol 23 (2) ◽

pp. 187-194 ◽

Cited By ~ 4

Author(s):

Christos Triantos ◽

Emmanuel Louvros ◽

Maria Kalafateli ◽

Anne Riddell ◽

Ulrich Thalheimer ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Variceal Bleeding ◽

Blood Cells ◽

Venous Pressure ◽

White Blood Cells ◽

International Normalized Ratio ◽

Ulcer Bleeding ◽

Factor X ◽

Packed Red Blood Cells ◽

Bacterial Peritonitis

Background & Aims: Endogenous heparinoids have been detected by thromboelastography and quantified by clotting based anti-Xa activity assays in patients with cirrhosis, but their presence in variceal bleeding has not been established yet.Methods: Clotting based anti-Xa activity was measured in A) 30 cirrhotics with variceal bleeding, B) 15 noncirrhotics with peptic ulcer bleeding, C) 10 cirrhotics without infection or bleeding, and D) 10 cirrhotics with hepatocellular carcinoma (HCC).Results: Anti-Xa activity was not detected in ulcer bleeders or in cirrhotics without infection or bleedingbut was present in seven (23%) variceal bleeders (median levels: 0.03 u/mL (0.01-0.07)) and was quantifiable for 3 days in six of seven patients. Four of seven variceal bleeders with anti-Xa activity present had HCC (p=0.023). Age, creatinine, platelet count and total infections the second day from admission were significantly correlated with the presence of measureable anti-Xa levels (p=0.014, 0.032, 0.004 and 0.019, respectively). In the HCC group, anti-Xa activity was present in three patients (30%) [median levels: 0.05 u/mL (0.01-0.06)].Conclusions: In this study, variceal bleeders and 30% of the patients with HCC had endogenous heparinoids that were detected by a clotting based anti-Xa activity assay, whereas there was no anti Xa activity present in patients with cirrhosis without infection, or bleeding or HCC, nor in those with ulcer bleeding. Thus, the anti-Xa activity is likely to be a response to bacterial infection and/or presence of HCC in cirrhosis.List of abbreviations: AFP, alpha-fetoprotein; aPTT, activated partial thromboplastin time; CP, Child-Pugh; FXa, activated factor X; GAGS, glycosaminoglycans; Hb, hemoglobin; HCC, hepatocellular carcinoma; HVPG, hepatic venous pressure gradient; INR, International normalized ratio; LMWHs, low molecular weight heparins; MELD, Model for End-stage Liver Disease; PPP, platelet-poor plasma; PRBC, packed red blood cells; PT, prothrombin time; SBP, sponataneous bacterial peritonitis; TEG, thromboelastography; WBC, white blood cells.

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