New ultrasound marker to assess the cervix when predicting preterm birth in the first trimester of pregnancy

Mapping Intimacies ◽

10.21516/2413-1458-2019-18-1-48-53 ◽

2019 ◽

Author(s):

V.G. Volkov, O.V. Chursina

Keyword(s):

Preterm Birth ◽

Preterm Labor ◽

First Trimester ◽

Routine Practice ◽

Cervical Canal ◽

Average Correlation ◽

First Trimester Of Pregnancy ◽

Direct Average ◽

Correlation Strength ◽

Low Sensitivity

The marker for preterm labor in routine practice at this time is only the measurement of the length of the cervix. However, the low sensitivity of this test (approximately 38 % in the first trimester of pregnancy) initiates a search for new markers of the threat of preterm labor. The indicators of the glandular zone of the cervical canal (GI, CGA, EGE), studied using statistical methods in the first trimester of pregnancy, showed the presence of a direct average correlation strength of this indicators and the term of labor, the sensitivity of 57 % with a specificity of 98,9 %. Thus, performing cervicometry during pregnancy, especially in early periods, it is necessary to evaluate not only the length, but also the structure of the cervix. The echo negative zone of the cervical canal is presented to the authors of this article as a kind of "ultrasonic marker for fibronectin" and undoubtedly requires further study.

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Evidence for HPV DNA in the placenta of women who resorted to elective abortion

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-03937-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Maria Teresa Bruno ◽

Salvatore Caruso ◽

Francesca Bica ◽

Giulia Arcidiacono ◽

Sara Boemi

Keyword(s):

Preterm Birth ◽

First Trimester ◽

Hpv Infection ◽

Cervical Canal ◽

Chorionic Villi ◽

Hpv Dna ◽

Elective Abortion ◽

Placental Villi ◽

First Trimester Of Pregnancy ◽

Papillomavirus Dna

Abstract Background It is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth. In clinical cases of placental villi positive for HPV DNA reported by other authors, contamination is suspected in the act of crossing the cervical canal. We analyzed placental samples of women who resorted to elective abortion obtained by hysterosuction of ovular material, bypassing any contact with the cervical canal and vagina. Methods We studied the chorionic villi of the placenta of 64 women who resorted to voluntary termination of pregnancy, in the first trimester. To avoid contamination of the villi by the cervical canal, we analyzed placental samples obtained by hysterosuction of ovular material, bypassing any contact with the cervical canal and vagina. All samples of chorionic villi were manually selected from the aborted material and subjected to research for HPV DNA. Results HPV DNA was detected in 10 out of 60 women (16.6%). The HPV DNA identified in the placenta belonged to genotypes 6, 16, 35, 53, and 90. Conclusion The study shows that papillomavirus DNA can infect the placenta and that placenta HPV infection can occur as early as the first trimester of pregnancy.

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Faculty Opinions recommendation of Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1162475.623996 ◽

2009 ◽

Author(s):

Steven Witkin

Keyword(s):

Preterm Birth ◽

Bacterial Vaginosis ◽

Predictive Value ◽

First Trimester ◽

Vaginal Flora ◽

Aerobic Vaginitis ◽

First Trimester Of Pregnancy ◽

Abnormal Vaginal Flora

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Investigation of Metronidazole Use during Pregnancy and Adverse Birth Outcomes

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.06477-11 ◽

2012 ◽

Vol 56 (9) ◽

pp. 4800-4805 ◽

Cited By ~ 46

Author(s):

Catherine A. Koss ◽

Dana C. Baras ◽

Sandra D. Lane ◽

Richard Aubry ◽

Michele Marcus ◽

...

Keyword(s):

New York ◽

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Congenital Anomalies ◽

New York State ◽

Multivariable Analysis ◽

Preterm Births ◽

First Trimester ◽

First Trimester Of Pregnancy

ABSTRACTTo assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital. Of 2,829 singleton/mother pairs, 922 (32.6%) mothers were treated with metronidazole for clinical indications, 348 (12.3%) during the first trimester of pregnancy and 553 (19.5%) in the second or third trimester. There were 333 (11.8%) preterm births, 262 (9.3%) infants of low birth weight, and 52 infants (1.8%) with congenital anomalies. In multivariable analysis, no association was found between metronidazole treatment and preterm birth (odds ratio [OR], 1.02 [95% confidence interval [CI], 0.80 to 1.32]), low birth weight (OR, 1.05 [95% CI, 0.77 to 1.43]), or treatment in the first trimester and congenital anomalies (OR, 0.86 [0.30 to 2.45]). We found no association between metronidazole treatment during the first or later trimesters of pregnancy and preterm birth, low birth weight, or congenital anomalies.

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The effect of a major earthquake experienced during the first trimester of pregnancy on the risk of preterm birth

Australian and New Zealand Journal of Obstetrics and Gynaecology ◽

10.1111/ajo.12797 ◽

2018 ◽

Vol 59 (1) ◽

pp. 82-88 ◽

Cited By ~ 1

Author(s):

Georgina Hawkins ◽

Joanna Gullam ◽

Laura Belluscio

Keyword(s):

Preterm Birth ◽

First Trimester ◽

Major Earthquake ◽

First Trimester Of Pregnancy

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First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

Nutrients ◽

10.3390/nu11123042 ◽

2019 ◽

Vol 11 (12) ◽

pp. 3042 ◽

Cited By ~ 2

Author(s):

Isabelle Monier ◽

Amandine Baptiste ◽

Vassilis Tsatsaris ◽

Marie-Victoire Senat ◽

Jacques Jani ◽

...

Keyword(s):

Preterm Birth ◽

Gestational Age ◽

Small For Gestational Age ◽

Skin Color ◽

First Trimester ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

First Trimester Of Pregnancy ◽

Maternal Vitamin D Status ◽

Multicenter Prospective Cohort

Maternal 25-hydroxyvitamin D (25-OHD) deficiency during pregnancy may increase the risk of preterm and small-for-gestational age (SGA) birth, but studies report conflicting results. We used a multicenter prospective cohort of 2813 pregnant women assessed for 25-OHD levels in the first trimester of pregnancy to investigate the association between maternal 25-OHD concentrations and risks of preterm birth (<37 weeks) and SGA (birthweight <10th percentile). Odds ratios were adjusted (aOR) for potential cofounders overall and among women with light and dark skin separately, based on the Fitzpatrick scale. 25-OHD concentrations were <20 ng/mL for 45.1% of the cohort. A total of 6.7% of women had a preterm birth. The aOR for preterm birth associated with the 1st quartile of 25-OHD concentrations compared to the 4th quartile was 1.53 (95% confidence interval (CI): 0.97–2.43). In stratified analyses, an association was observed for women with darker skin (aOR = 2.89 (95% CI: 1.02–8.18)), and no association with lighter skin. A total of 11.9% of births were SGA and there was no association overall or by skin color. Our results do not provide support for an association between maternal first trimester 25-OHD deficiency and risk of preterm or SGA birth overall; the association with preterm birth risk among women with darker skin requires further investigation.

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Echogenic intracardiac focus – existence in the first trimester and the role of microRNAs

Folia Medica ◽

10.3897/folmed.63.e54171 ◽

2021 ◽

Vol 63 (1) ◽

pp. 142-147

Author(s):

Antonios Koutras ◽

Zacharias Fasoulakis ◽

Arzou Halil ◽

Emmanuel N. Kontomanolis

Keyword(s):

Trisomy 21 ◽

Fetal Heart ◽

First Trimester ◽

Papillary Muscles ◽

Ultrasound Scan ◽

Second Trimester ◽

Ultrasound Study ◽

First Trimester Of Pregnancy ◽

Low Sensitivity

Echogenic intracardiac focus (EIF) constitutes a finding in the ultrasound study that indicates an area which is echogenically bright in the fetal heart and is as bright as the bone that moves synchronically to the atrioventricular valves. Microcalcifications of the papillary muscles or chordae tendinae are being represented by this echogenicity and are mostly present in the left ventricle (90% of cases). EIF appears usually at the ultrasound that is realized in the mid-trimester in a percentage that reaches 3.5% in euploid fetuses and 15% to 30% in fetuses with trisomy 21. In the current paper, the rare and curious case of a 21-year-old primigravida woman is described, who presented for ultrasound scan at the 12th week of gestation. The scan revealed the presence of EIF, which is very rare, as it is well-known that it usually appears in the second trimester of pregnancy. Counseling and debriefing for dismissing parents’ anxiety is necessary as well as further examinations, because EIF has low sensitivity. This specific case report could constitute a beginning in the research of whether investigating EIF in the first trimester of pregnancy is possible and which are the benefits of its detection for the mother, the fetus and the whole family, in clinical practice.

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PERINATAL PECULIARITIES IN WOMEN WITH BENIGN OVARIAN TUMORS

World Science ◽

10.31435/rsglobal_ws/30082021/7658 ◽

2021 ◽

Author(s):

Hulii D. Ya. ◽

Boichuk O. H.

Keyword(s):

Retrospective Analysis ◽

Preterm Labor ◽

Ovarian Neoplasms ◽

First Trimester ◽

Ovarian Tumors ◽

First Trimester Of Pregnancy ◽

Benign Ovarian Tumors ◽

Adnexal Tumors ◽

Mechanical Influence

Ovarian tumors may be found in women of any age and the period of pregnancy is no exception. Besides, this period is related to some specific adnexal tumors. A systematic use of ultrasonography in the first trimester of pregnancy has led to a wider detection of symptomless adnexal tumors. The majority of adnexal tumors diagnosed during pregnancy are accidental findings of routine examinations of pregnancy. According to various estimations, the incidence of adnexal neoplasms during pregnancy makes up from 0.19 to 8.8 %. Most of cases are diagnosed in the first trimester and their incidence gradually decreases as the period of pregnancy grows: Trimester 1 – from 21.4 to 75.7 %; Trimester 2 – from 10.9 to 44.4 %; Trimester 3 – from 4 to 22.2 %; after labor – from 0 to 7.1 %. Most of adnexal tumors during pregnancy are benign and physiological and often regress spontaneously. Depending on their size and location, ovarian tumors may be related to an adverse obstetrical result caused by mechanical influence. They increase the risk of abortion (from 0 to 6 %), preterm labor (from 5.8 to 10.4 %) and mechanical impediment to labor. In view of the above mentioned considerations, one of the objectives of our research is to make a retrospective analysis of perinatal peculiarities in women with benign ovarian neoplasms.

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LABOR COURSE AND CONDITION OF NEWBORNS IN WOMEN WITH PLACENTAL DYSFUNCTION DUE TO GESTATIONAL ENDOTHELIOPATHY

World Science ◽

10.31435/rsglobal_ws/30092019/6704 ◽

2019 ◽

Vol 2 (9(49)) ◽

pp. 4-8

Author(s):

V. V. Lazurenko ◽

I. B. Borzenko ◽

D. Yu. Tertyshnik

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Caesarean Section ◽

Fetal Growth ◽

Fetal Distress ◽

First Trimester ◽

Control Group ◽

Perinatal Complications ◽

Placental Dysfunction ◽

First Trimester Of Pregnancy

The purpose of the study is to evaluate the effect of placental dysfunction caused by gestational endotheliopathy on the course of labor and the condition of the newborn. The first group consisted of 70 patients with placental dysfunction with gestational endotheliopathy confirmed by laboratory-instrumental findings in the first trimester of pregnancy. The control group included 30 pregnant women with physiological gestational course. PD secondary to GE leads to preterm birth, fetal distress, increases the percentage of caesarean section, contributes to the delay of fetal growth and birth weight, poor infant status and perinatal complications.

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