The micronized progesterone in complex therapy of pregnant women with missed abortion in the anamnesis

The study presents data of different authors, as well as its own data on the frequency of multiple trisomies among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of chromosomal abnormalities (CA) in I and II trimesters of gestation. The objective: determining the frequency of occurrence of double (DT) and multiple trisomies (MT) among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of occurrence of HA in I and II trimesters of gestation; establishment of the most common combinations of diesel fuel and the timing of their deaths compared with single regular trisomy; comparative assessment materinskogo age with single, double and multiple trisomies. Patients and methods. During the period from 1997 to 2016, the first (primary) group of products in 1808 the concept of missed abortion (ST) of I trimester was formed from women who live in Dnepropetrovsk, Zaporozhye, Kirovograd, Cherkasy, Kherson, Mykolaiv regions. The average term of the ST was 8±3 weeks. The average age of women was 29±2 years. The second group (control) consisted of 1572 sample product concepts received during medical abortion in women (mostly residents of Krivoy Rog) in the period of 5-11 weeks of pregnancy, the average age was 32 years. The third group was made prenatally karyotyped fruits (n = 9689) pregnant women with high risk of HA of the above regions of Ukraine, directed the Centre to invasive prenatal diagnosis for individual indications: maternal age, changes in the fetus by ultrasound (characteristic malformations and echo markers HA) and high risk of HA on the results of the combined prenatal screening I and II trimesters. From 11 th to 14 th week of pregnancy, chorionic villus sampling was performed (n=1329), with the 16th week – platsentotsentez (n=2240), 18 th and 24 th week – amniocentesis (n=6120). Results. A comparative evaluation of maternal age and the prevalence anembriony among multiple trisomies. Analyzed 13,069 karyotyped embryonic and fetal I-II trimester of which have found 40 cases of multiple trisomies – 31 cases in the group in 1808 missed abortion (2.84% of total HA), 3 cases including 1 572 induced medabortov and 7 cases during 9689 prenatal research (0.51% of HA). Determined to share the double trisomies preembrionalny, fetal, early, middle and late periods of fetal development. Conclusion. There were no significant differences either in terms of destruction of single and multiple trisomies or in maternal age or in fractions anembrionalnyh pregnancies in these groups. Key words: multiple trisomies, double trisomy, missed abortion, prenatal diagnosis.

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Clinical and microbiological aspects of vaginal microbiota at pregnant with threat of late miscarriages during treatment with vaginal gestagens forms

HEALTH OF WOMAN ◽

10.15574/hw.2017.117.68 ◽

2017 ◽

pp. 68-73

Author(s):

I.P. Polishchuk ◽

Keyword(s):

Pregnant Women ◽

Therapeutic Effect ◽

Local Treatment ◽

Vaginal Microbiota ◽

Control Group ◽

Before And After ◽

Low Efficiency ◽

Late Miscarriage ◽

Microbiological Aspects ◽

Micronized Progesterone

The objective: was to examine the effectiveness of treatment of late miscarriage threat by micronized form of progesterone for 100 mg – 3 times a day in the form of gelatin pills and vaginal tablets with lactose. Patients and methods. Under our supervision there were 70 pregnant women with normocenosis of vagina (NCV) without extragenital pathology, which were not performed systemic or local treatment with antibacterial drugs in the last 4 weeks. Among them 25 pregnant women with TLSM treated by gelatin tablets of micronized progesterone (GTP) (group 1); 25 pregnant women with TLSM, treated by vaginal micronized progesterone tablets (VPT) (2nd group) and 20 healthy women with physiological pregnancy – PV (control group). The distribution of women in the group adhered to the principles of randomization. The age of examined women ranged from 19 to 32 years, most pregnant women were aged under 30 years (89.02%). General clinical examination was carried out according to the standard scheme according to the Order MH of Ukraine № 620. Results. During the research we have determined the colpocytologcal dynamics and state of vaginal microbiota in pregnant women with threatened late miscarriage with initial vaginal normocenosis before and after treatment whit vaginal forms of progesterone. Conclusion. The received results showed low efficiency of micronized progesterone gelatin dragee at threat of the late miscarriage that at small therapeutic effect has led to the development of vaginal dysbiosis in all surveyed. In contrast, the use of micronized progesterone vaginal tablets – the maximally rapid therapeutic effect without disturbance of vaginal normocenosis. Key words: the threat of a late miscarriage, vaginal micronized forms of progesterone.

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Phthalate levels in urine of pregnant women and their associated missed abortion risk

Reproductive Biology ◽

10.1016/j.repbio.2020.100476 ◽

2021 ◽

Vol 21 (1) ◽

pp. 100476

Author(s):

Juanjuan He ◽

Kewei Chang ◽

Sha Liu ◽

Jingru Ji ◽

Liangpo Liu ◽

...

Keyword(s):

Pregnant Women ◽

Missed Abortion

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Modern view on the problem of optimization of therapy in pregnant women with functional cervical insufficiency

Reports of Vinnytsia National Medical University ◽

10.31393/reports-vnmedical-2018-22(1)-33 ◽

2018 ◽

Vol 22 (1) ◽

pp. 173-177

Author(s):

V. F. Oleshko

Keyword(s):

Blood Serum ◽

Pregnant Women ◽

Main Group ◽

Control Group ◽

Cervical Insufficiency ◽

Progesterone Concentration ◽

Therapeutic Dosage ◽

Hormonal Balance ◽

Magnesium Orotate ◽

Micronized Progesterone

A functional cervical insufficiency plays an important role in the etiology of miscarriage and premature birth. The aim of research was to estimate the hormonal balance indexes during the course of pregnancy in pregnant women with functional cervical insufficiency and to correct the revealed violations in order to prevent obstetric complications. 101 pregnant women with confirmed diagnosis of a functional cervical insufficiency in term of gestation 22–32 weeks of pregnancy (the main group) and 34 pregnant women and women in labor with physiological condition of the cervix (the control group) were examined. The content of estradiol, progesterone, cortisol and prolactin was examined in the blood serum. On the second stage of examination 63 pregnant women obtained general basic therapy (I main group) and 38 pregnant women (II main group) received a developed treatment complex which included progesterone support by the micronized progesterone 200–400 mg twice a day up to 34–35 weeks of pregnancy, magnesium support by the magnesium orotate dehydrate in the therapeutic dosage and arginine glutamate in the therapeutic dosage. The correction of cervical insufficiency was performed with the help of a cervical pessary (according to indications). The examination of hormonal balance revealed an accurate decease of progesterone concentration on the background of high concentration of estradiol and increased levels of stress-associated hormones. Propitious influence of the developed therapy is proved by increase of progesterone concentration in the blood serum, normalization in stress-associated hormones balance according to gestational age. All this provideded the decrease of specific weight of threatened preterm labors, placental dysfunction, vaginitis, bacterial vaginosis and delay the labors up to 38–39 weeks of gestation in 97,4% of pregnant women (82,5% in the I main group). Prescription of micronized progesterone, magnesium orotate dehydrate, arginine glutamate to pregnant women with a cervical insufficiency is reasonable and effective one comparing with general and traditional therapy.

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Retrochorial hematoma: principles of complex therapy

Journal of obstetrics and women s diseases ◽

10.17816/jowd614104-108 ◽

2012 ◽

Vol 61 (4) ◽

pp. 104-108 ◽

Cited By ~ 1

Author(s):

Lilia Dmitriyevna Solovova ◽

Olga Igorevna Lineva ◽

Yulia Anatolyevna Artych ◽

Anna Vladimirovna Kazakova ◽

Inna Alekseyevna Berdnikova

Keyword(s):

Pregnant Women ◽

Standard Method ◽

Complex Therapy ◽

Abortion Clinic

In the article there are the hormonal and immunological aspects of pathogenesis retroсhorial hematomas in women with treatened abortion, clinic and diagnosis of this complication. Analysis of efficiency complex therapy with using of Dydrogesterone and Wobenzym were carried out among 80 pregnant women in comparison with standard method of therapy.

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The effectiveness of different forms of micronized progesterone in the treatment of abortion

HEALTH OF WOMAN ◽

10.15574/hw.2017.121.74 ◽

2017 ◽

pp. 74-77

Author(s):

V. Pyrohova ◽

◽

I. Kozlovskyy ◽

N. Veresnyuk ◽

M. Malachynska ◽

...

Keyword(s):

Pregnant Women ◽

Key Words ◽

Route Of Administration ◽

Dynamic Changes ◽

Laboratory Course ◽

Routes Of Administration ◽

Threatened Miscarriage ◽

Progesterone Treatment ◽

Large Hematoma ◽

Micronized Progesterone

The research for the purpose of efficiency compared application of vaginal and sublingual form of micronized progesterone in the treatment of a threatened miscarriage of І and II trimesters of pregnancy. Under the supervision were 58 pregnant women who were found during the test retrohorial hematoma. Depending on the route of administration of micronized progesterone patients were divided into 2 groups. The first group included 28 women who were prescribed according to the instructions vaginal tablets Luteina. The second group consisted of 30 patients who used sublingually Luteina. Monitoring the effectiveness of treatment carried out by clinical and laboratory course of the disease based on the dynamic changes of patients complaints, evaluations of ultrasound data in dynamics. The results showed that the effectiveness of treatment when using sublingual or vaginal routes of administration Luteina did not differ significantly, the use of micronized progesterone possible to maintain pregnancy in 79.3% of patients with retrohorial hematomas. Unfavorable factors for the development of pregnancy is central and retrohorial large hematoma. Key words: threatened miscarriage, retrohorial hematomas, micronized progesterone, treatment.

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Великі акушерські синдроми – сучасні можливості профілактики

HEALTH OF WOMAN ◽

10.15574/hw.2018.132.67 ◽

2018 ◽

pp. 67-72

Author(s):

T.G. Romanenko ◽

◽

O.M. Sulimenko ◽

Keyword(s):

Statistical Analysis ◽

High Risk ◽

Pregnant Women ◽

Fetal Distress ◽

Placental Insufficiency ◽

Control Group ◽

Fetal Growth Retardation ◽

Prophylactic Measures ◽

Pathological Pregnancy ◽

Micronized Progesterone

The objective: was to reduce the incidence and severity of the development of «Great Obstetrical Syndromes»: miscarriage of pregnancy, placental insufficiency, fetal growth retardation and / or fetal distress, preeclampsia, premature detachment of a normally located placenta, premature delivery, by developing an algorithm for prophylaxis during pregnancy in women at high risk for their development. Materials and methods. Clinical and statistical analysis of pregnancy in 88 pregnant women with high risk of decompensation of placental insufficiency was conducted. Depending on the method of preventing complications, 2 groups were formed. The I group included 58 pregnant women who were offered the following algorithm: micronized progesterone 200 mg PV from 6 to 20 weeks of gestation; from 21 to 26 weeks of gestation and from 31 to 36 weeks; phleboprotector with ultra-micronized fractions of bioflavonoids (Flego) 15 ml per os; with subsequent appointment from 21 to 26 weeks of gestation; and from 31 to 36 weeks. Group II included 30 pregnant women who had abandoned any proposed prophylactic measures. The control group consisted of 30 healthy pregnant women. Clinical and statistical analysis of pregnancy in the study groups was conducted. During statistical processing, personal computer and software Microsoft Excel XP and Statistica 6.0 Windows, methods of descriptive statistics, correlation analysis were used. The reliability of the difference between the indicators is estimated by the Student-Fisher criterion. Results. The method of prophylaxis of «Great Obstetrical Syndromes» by sequential administration from the early stages of pregnancy of micronized progesterone with the following appointment – from the second trimester of pregnancy – showed a high efficacy of the phleboprotector, which is manifested in a significantly lower number of cases of preeclampsia in the main group of 3.5% (2) versus 50% (15) in the control group, placental insufficiency was 13.8% (8) versus 100% (30); fetal growth retardation was 5.2% (3) versus 56.7% (17); fetal distress was 3.5% (2) versus 43 , 3% (13), preterm labor 1.7% (1) versus 13.3% (4) and in the absence of premature detachment normal but located on the placenta, severe forms of preeclampsia and placental insufficiency. Conclusions. Pregnant of «Great Obstetrical Syndromes» risk groups need timely prophylactic measures to reduce the likelihood of a pathological pregnancy and improve perinatal outcomes. The proposed prophylaxis scheme significantly lowered the incidence of large obstetric syndromes and improved neonatal outcomes. Key words: great obstetrical syndromes, pathological pregnancy, placental dysfunction, phleboprotector.

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Stress-protective effects of micronized progesterone in treatment of anxiety disorders in pregnant women after in vitro fertilisation

GYNECOLOGY ◽

10.26442/20795696.2021.4.201091 ◽

2021 ◽

Vol 23 (4) ◽

pp. 346-353

Author(s):

Natalya I. Tapilskaya ◽

Mikhail S. Nekrasov ◽

Inna O. Krikheli ◽

Ksenia V. Ob'edkova ◽

Alexander M. Gzgzyan ◽

...

Keyword(s):

Anxiety Disorders ◽

Pregnant Women ◽

Rating Scale ◽

Depression Scale ◽

Anxiety And Depression ◽

In Vitro Fertilisation ◽

Group 3 ◽

The Mean ◽

Micronized Progesterone

Aim. To study a stress-protective efficacy of micronized progesterone (MP) in pregnant women with anxiety disorders after in vitro fertilisation (IVF). Materials and methods. We conducted a prospective, comparative open-label randomized trial in two IVF-clinics. A total of 98 pregnant women after IVF with anxiety disorders were recruited at the 9th week of pregnancy. Progesterone supplementation after IVF for luteal phase support was administered out until 9 weeks gestation. Then, after randomization, group 1 (n=35) received 400 mg per day of MP vaginally, group 2 (n=33) received 400 mg of MP orally, group 3 (n=30) was comparative for the other groups. The duration of progesterone treatment was 12 weeks. The Spielberger State Trait Anxiety Inventory (STAI), the Montgomerysberg depression rating scale (MADRS), Hospital Anxiety and Depression Scale (HADS), and the Epworth Sleepiness Questionnaires (ESQ) were used to compare maternal mood at 9 weeks (day of randomization) after delivery and at 283, 565, 847 days after randomization. Results. The mean STAI sumscore in MP-groups was significantly lower than in group 3 starting from day 565 and continued until the end of the study. There were no significant differences between vaginal and oral administration of progesterone. There were no significant differences between the mean sumscores when questioning on the HADS, MADRS and ESQ. Conclusion. Prolonged use of MP in pregnant women with anxiety disorders led to the prevention of manifestations of an increase in anxiety and depression. The stress-protective and neuromodulating properties of MP can determine additional indications for its prolonged administration in women with anxiety disorders and/or premorbid history.

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Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Missed Abortion

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0040-1709693 ◽

2020 ◽

Vol 42 (05) ◽

pp. 235-239

Author(s):

Ismail Biyik ◽

Mustafa Albayrak ◽

Fatih Keskin

Keyword(s):

Pregnant Women ◽

Medical Records ◽

Complete Blood Count ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Missed Abortion ◽

Distribution Width ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Inflammatory Parameters

Abstract Objective Missed abortion occurs in ∼ 15% of all clinical pregnancies. The pathogenesis is not clearly known. However, defective placentation resulting in maternal systemic inflammatory response is considered responsible for missed abortion. Platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) are increasingly cited parameters of inflammation in the literature. However, no study evaluated the PLR and NLR rates in missed abortions so far. The aim of the present study is to investigate whether complete blood count (CBC) inflammatory parameters such as NLR and PLR are increased in patients with missed abortion. Methods Medical records of 40 pregnant women whose gestation ended in missed abortion at between 6 and14 weeks of gestation and of 40 healthy pregnant women were collected and compared retrospectively. The groups were compared regarding hemoglobin, hematocrit, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), PLR and NLR. Results Platelet distribution width, NLR and PLR values were higher in the missed abortion group compared with the healthy pregnant women group (rates are p = 0.043; p = 0.038; and p = 0.010, respectively). Hematocrit, MPV, and lymphocyte values were found to be lower in the missed abortion group compared with the healthy pregnant women group (p = 0.027, p = 0.044 and p = 0.025, respectively). Conclusion The PDW, NLR and PLR values of the missed abortion group were reported high; and MPV values were reported low in the present study. These findings may help to speculate a defective placentation in the pathogenesis of missed abortion.

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Therapy of bacterial vaginosis

Medical Council ◽

10.21518/2079-701x-2019-7-104-109 ◽

2019 ◽

pp. 104-109

Author(s):

O. I. Marushkina

Keyword(s):

Bacterial Vaginosis ◽

Pregnant Women ◽

Clinical Laboratory ◽

Reproductive Age ◽

Laboratory Methods ◽

Anaerobic Microorganisms ◽

Second Stage ◽

Complex Therapy ◽

Ph Level ◽

Effective Remedy

Aim:evaluation of efficacy of Multi-Gyn® Actigel application in the complex therapy of bacterial vaginosis (BV) and prevention of its recurrence in pregnant women.Patients and methods:87 patients of reproductive age were examined and treated with the diagnosis of «bacterial vaginosis, chronic recurrent course». 41 of them from the main group were given Multi-Gyn® Actigel at the 1st stage of treatment, while 46 women of the comparison group were given 2% clindamycin cream In order to restore vaginal microbiocenosis, a probiotic containing Lactobacillus casei rhamnosus spp. LCR35 was used in both groups at the second stage Clinical laboratory methods were used.Results:efficacy of Multi-Gyn® Actigel application in complex therapy of BV and prevention of its recurrences in non-pregnant women was proved. As a result of Multi-Gyn® Actigel prescription there were no complaints, pH level was normalized, almost complete absence of BV-associated microorganisms was achieved and lactobacillus pool preservation even in the distant period after treatment.Conclusion:Multi-Gyn® Actigel is an effective remedy for treatment of BV and prevention of its recurrence in non-pregnant patients, especially in the chronic recurrent course of the disease. This effect is achieved not only by eliminating anaerobic microorganisms, but also due to the persistent preservation of the lactobacillus pool.

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