Today, the different speeds of regional development and the preservation of unresolved structural contradictions, which have a pronounced regional dimension, have become one of the main foundations of political reconstruction in the growth of changes to ensure national security. Favorable regional institutional environment creates opportunities for optimal use of resources of the territory, which is the basis for ensuring the proper quality of life of the population of the region, eliminating all possible dangers at all levels. The strategic objectives of regional policy are to increase the competitiveness of regions and strengthen their resource potential, ensure human resources development, development of interregional cooperation, it is clear that under conditions of stable functioning of the security system at the regional level and thus the national system. In addition, the regional policy of the state - targeted actions of the state aimed at balancing the conditions of regions and their results, improving the use of aggregate regional resources and opportunities that can be implemented against the background of comprehensive security actions in all areas, including local levels. The mechanism of implementation of state regional policy, which can be defined as a system of specific state levers and organizational and economic means by which state influence on the spatial organization of society, provides socio-economic development of regions, improves the structure of their economic complex. That recently, due to the crisis situation in the country and military action, the system of state regional policy has paid considerable attention to the system of ensuring the security of the region from possible threats and challenges that may cause national dangers. The main components of the integrated mechanism of state regional policy of Ukraine, as defined by current regulations, are: the relevant legal framework, budget and financial regulation of regional development, forecasting and programming, development of various forms of territorial organization of productive forces. Legislative regulation at the international level of regulatory relations creates favorable conditions for a single legal activity related to national security, which, in turn, includes organizational and communicative tasks in the implementation of domestic and foreign policy at all levels.