Evaluation of CD44 Expression in Malignant Salivary Gland Tumors

2021 ◽  
Vol 8 (4) ◽  
pp. 641-648
Author(s):  
Nermen Mohammed ◽  
Amany Taha ◽  
Nadia Radi ◽  
Eman AboHager
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumors ◽  
Cd44 Expression ◽  
Malignant Salivary Gland Tumors

DNA base excision repair and nucleotide excision repair proteins in malignant salivary gland tumors

2021 ◽  
Vol 121 ◽  
pp. 104987
Author(s):  
Fernanda Aragão Felix ◽  
Leorik Pereira da Silva ◽  
Maria Luiza Diniz de Sousa Lopes ◽  
Ana Paula Veras Sobral ◽  
Roseana de Almeida Freitas ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Salivary Gland Tumors ◽  
Dna Base Excision Repair ◽  
Dna Base ◽  
Nucleotide Excision ◽  
Base Excision ◽  
Malignant Salivary Gland Tumors

scholarly journals Immunohistochemical Detection of Proliferative Marker Ki-67 in Benign and Malignant Salivary Gland Tumors

2018 ◽  
Vol 19 (4) ◽  
pp. 375-383
Author(s):  
Smita Bussari ◽  
Sindhu M Ganvir ◽  
Manish Sarode ◽  
Prabhakar A Jeergal ◽  
Anjum Deshmukh ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumors ◽  
Immunohistochemical Detection ◽  
Ki 67 ◽  
Proliferative Marker ◽  
Malignant Salivary Gland Tumors

The Myoepithelial Immunophenotype in 135 Benign and Malignant Salivary Gland Tumors Other Than Pleomorphic Adenoma

1999 ◽  
Vol 123 (9) ◽  
pp. 801-806 ◽  
Author(s):  
Anil R. Prasad ◽  
Adnan T. Savera ◽  
Allen M. Gown ◽  
Richard J. Zarbo
Keyword(s):  
Smooth Muscle ◽  
Salivary Gland ◽  
Salivary Gland Tumors ◽  
Low Grade ◽  
Salivary Duct ◽  
Not Otherwise Specified ◽  
Adenoid Cystic ◽  
Myoepithelial Differentiation ◽  
Specific Proteins ◽  
Malignant Salivary Gland Tumors

Abstract Background.—We have previously studied the immunoreactivity of 3 novel smooth muscle–specific proteins, α-smooth muscle actin, smooth muscle myosin heavy chains, and calponin, to assess myoepithelial differentiation in pleomorphic adenomas. Objective.—To further expand our knowledge of myoepithelial differentiation in other benign and malignant salivary gland tumors. Design.—Formalin-fixed paraffin sections of 135 salivary gland tumors with associated normal glands were stained with monoclonal antibodies using the avidin-biotin complex immunoperoxidase method and enzymatic and microwave heat–induced epitope retrieval. Results.—In adenoid cystic carcinomas and epithelial-myoepithelial carcinomas, all 3 markers exclusively highlighted the myoepithelial cell components and the epithelial cells were entirely negative. No immunostaining was detected in canalicular adenomas, oncocytomas, Warthin tumors, acinic cell carcinomas, mucoepidermoid carcinomas, squamous cell carcinomas, and polymorphous low-grade adenocarcinomas. Salivary duct carcinomas and adenocarcinomas, not otherwise specified had a distinctive pattern of uniform periductal staining of reactive myofibroblastic cells, and in salivary duct carcinomas some ducts retained a peripheral immunoreactive myoepithelial cell layer. Conclusion.—Immunoreactivity for these 3 smooth muscle–specific proteins confirms the known neoplastic myoepithelial component of adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. The consistently positive staining pattern in adenoid cystic carcinomas may be diagnostically useful in discriminating histologically similar but consistently negative polymorphous low-grade adenocarcinomas. Periductal linear staining in adenocarcinoma, not otherwise specified and salivary duct carcinomas is distinctive and appears to represent a tight cuff of myofibroblasts associated with the infiltrating glands.

scholarly journals Prognostic factors and overall survival in a 15-year followup of patients with malignant salivary gland tumors: a retrospective analysis of 193 patients

2020 ◽  
Author(s):  
Osias Vieira de Oliveira Filho ◽  
Talita Jordânia Rocha do Rêgo ◽  
Felipe Herbert de Oliveira Mendes ◽  
Thinali Sousa Dantas ◽  
Maria do Perpétuo Socorro Saldanha Cunha ◽  
...  
Keyword(s):  
Overall Survival ◽  
Salivary Gland ◽  
Prognostic Factors ◽  
Retrospective Analysis ◽  
Salivary Gland Tumors ◽  
Malignant Salivary Gland Tumors

scholarly journals Pattern of distribution of different salivary gland tumors; a retrospective study in NICRH, Dhaka

2016 ◽  
Vol 15 (1) ◽  
pp. 95-98
Author(s):  
Afroza Khanam ◽  
Gulshan Akhter ◽  
Md. Abdur Rahman
Keyword(s):  
Salivary Gland ◽  
Retrospective Study ◽  
Parotid Gland ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Major Salivary Gland ◽  
Gland Tumor ◽  
Minor Salivary Gland Tumors ◽  
Malignant Salivary Gland Tumors

Background: Salivary gland tumors are rare, generally benign and affect both major and minor salivary glands.Objective: To find out the pattern of distribution of different benign and malignant salivary gland epithelial tumors and their relation to age and sex in a tertiary care center in Bangladesh.Methodology: This is a retrospective study. Details of epithelial salivary gland tumors were obtained from department of ENT, National institute of cancer & research hospital (NICRH), Dhaka, Bangladesh from the period January 2009 to December 2012 (3 years).Result: A total number of 261 cases presenting with both benign and malignant salivary gland tumors were analyzed according to gender, age and histopathological findings. There were 130 (49.84%) males and 131 (50.19%) females with the male female ration of 1: 0.99. Age of study population ranged from 10 to 70 years with the mean age 40.78. Percentage of benign salivary gland tumors was 73.94% and malignant salivary gland tumor 26.05%. Among major salivary gland tumors, no sublingual tumors were found and parotid gland tumors were the commonest. Whereas, among minor salivary gland tumors palatal minor salivary tumors were common.Conclusion: Parotid gland was the most common site of origin of both benign and malignant salivary gland tumors. Histopathologically, pleomorphic adenoma was the most common benign salivary gland tumor and mucoepidermoid carcinoma was the most frequent malignant neoplasm. Adenoid cystic carcinoma was common minor salivary gland tumor.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.90-94

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