Potential Clinical and Laboratory Prognostic Factors for Prediction of Need for ICU admission in Acute Aluminum Phosphide Poisoning

Background: Aluminum phosphide is a highly toxic fungicide. It causes such severe adverse effects as cardiac arrhythmias, metabolic acidosis, acute renal failure, shock, and even death. Therefore, this study investigated the prognostic factors of aluminum phosphide poisoning. Methods: In this cross-sectional study, all hospitalized patients due to aluminum phosphide poisoning admitted to the poisoning center at Taleghani Hospital, Urmia City, Iran, from 2015 to 2019 were evaluated. The demographics characteristics, clinical findings, and laboratory profiles were retrospectively studied by an investigator-made checklist and evaluated concerning the explored patients’ treatment outcomes. Then, the obtained data were analyzed by descriptive and analytical statistics using SPSS V. 16. Results: The present study investigated 134 patients (96 males & 38 females). The mortality rate was equal to 29.8% (22.4% males & 7.4% females) in the study patients. The research patients’ Mean±SD age was 28.6±11.5) years. The Mean±SD ingestion amount of aluminum phosphide was 1.48±1.06 g (min=0.2 g, max=15 g). Nausea and vomiting with 119 (88.8%), hypotension: 89 (66.4%), vertigo: 80 (59.7%), and sinus tachycardia: 74 (55.2%) were the most signs and symptoms in the study patients, respectively. Statistically significant relationships (P<0.05) were found between the patients’ treatment outcomes and white blood cells, direct bilirubin, Hco3, base excess, magnesium, Aspartate Aminotransferase, Alanine Aminotransferase, Blood Urea Nitrogen, creatinine, blood glucose, pH, prothrombin time, and the international normalized ratio. Furthermore, significant relationships were detected between the patients’ treatment outcomes and leukocytosis, hypokalemia, hyperglycemia, and hypoglycemia (P<0.05). Conclusion: Such prognostic factors as demographics characteristics, clinical findings, laboratory profiles, and electrolytes could be used as good indices of the severity of toxicity in patients; accordingly, such data are beneficial for the proper management of patients by healthcare providers. Therefore, prognostic factors should be considered in the diagnosis, treatment, and follow-up stages for these patients.

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Supportive Measures in Treatment of Aluminum Phosphide Poisoning

Case Medical Research ◽

10.31525/ct1-nct03879356 ◽

2019 ◽

Author(s):

Keyword(s):

Aluminum Phosphide ◽

Aluminum Phosphide Poisoning

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Rice tablet (Aluminum Phosphide) poisoning

International Journal of Bioassays ◽

10.21746/ijbio.2016.11.008 ◽

2016 ◽

Vol 5 (11) ◽

pp. 5041

Author(s):

Farkhondeh Jamshidi ◽

Ahmad Ghorbani ◽

Sina Darvishi*

Keyword(s):

Medical Records ◽

Statistical Tests ◽

Patient Records ◽

Demographic Information ◽

Aluminum Phosphide ◽

Men And Women ◽

Significant Difference ◽

The Mean ◽

Aluminum Phosphide Poisoning ◽

Commit Suicide

The abuse of some pesticides especially to suicide is one of the current problems of pesticides. Aluminum phosphide induced poisoning usually happens to suicide and sometimes it is due to accidental occupational exposure and in a few cases it has some criminal intensions. This study is conducted to evaluate patients poisoned with aluminum phosphide. In the present study the medical records of cases of poisoning with rice tablets (aluminum phosphide) hospitalized in Ahvaz Razi hospital is studied. Accordingly, a checklist is prepared that included demographic information of patients (age, gender) and information on patient records (information on poisoning) are completed using the patients’ medical records. The analysis of data is done by SPSS V22. 18 patients poisoned with rice tablet (aluminum phosphide) are studied. Results of the study show that 11 patients are male and seven are female. The mean patient age is 27.06 ±8.04 years that is 28 ±9 and 25 ±6.02 in men and women respectively. Statistical tests show no statistically significant difference in mean age in both genders (P> 0.05). Among patients, 11 subjects took aluminum phosphide to attempt suicide and 3 cases took it unintentionally and of course the reason is not mentioned in four cases. Among the patients who tried to commit suicide by taking aluminum phosphide, 6 cases are male and 5 cases are female that no statistically significant difference is observed between the genders in this respect (P> 0.05). In addition to the study of the complications caused by this poisoning and its mortality, it is recommended to responsible authorities to provide the necessary educations and treatments to prevent this type of poisoning.

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Acute Aluminum Phosphide Poisoning: The menace of phosphine exposure

Clinica Chimica Acta ◽

10.1016/j.cca.2021.05.026 ◽

2021 ◽

Author(s):

Deepak Yadav ◽

Rajasri Bhattacharyya ◽

Dibyajyoti Banerjee

Keyword(s):

Aluminum Phosphide ◽

Aluminum Phosphide Poisoning

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Therapeutic effects of oral liothyronine on aluminum phosphide poisoning as an adjuvant therapy

Human & Experimental Toxicology ◽

10.1177/0960327117694074 ◽

2017 ◽

Vol 37 (2) ◽

pp. 107-117 ◽

Cited By ~ 4

Author(s):

MH Goharbari ◽

F Taghaddosinejad ◽

M Arefi ◽

M Sharifzadeh ◽

M Mojtahedzadeh ◽

...

Keyword(s):

Gastric Lavage ◽

Case Group ◽

Therapeutic Effects ◽

Aluminum Phosphide ◽

Cardiovascular Failure ◽

Arterial Blood ◽

Total Antioxidant ◽

Cardioprotective Effects ◽

Aluminum Phosphide Poisoning ◽

Decrease Lipid Peroxidation

Background: In aluminum phosphide (AlP) poisoning, death is mainly due to cardiovascular failure and refractory acute heart failure. There is a lot of evidence showing thyroid hormones have cardioprotective effects. Objective: The purpose of this study was to evaluate the effect of oral liothyronine in the treatment of AlP poisoning. Methods: Twenty-four patients from intensive care unit of Baharloo Hospital, Tehran, Iran, were included based on the inclusion and exclusion criteria. They were randomly divided into two parallel groups of 12 cases and 12 controls. Intervention in the case group was administration of 50 µg liothyronine via nasogastric tube after gastric lavage, in the first 6 h of poisoning. In both groups, the routine treatment of AlP poisoning was performed. Blood samples were prepared at the beginning of the study and after 12 h. Patients were followed up till discharge from the hospital or death. Results: The findings demonstrated that oral liothyronine was able to significantly improve systolic blood pressure, arterial blood pH, and total thiol molecules and also could decrease lipid peroxidation, increase catalase activity, and prevent further decline in total antioxidant capacity. Conclusion: Liothyronine administration is effective in controlling AlP poisoning and can improve patients’ outcome.

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