scholarly journals REVIEW ON THE SIGNIFICANCE OF QUINAZOLINE DERIVATIVES AS BROAD SPECTRUM ANTI-CANCER AGENTS.

2021 ◽  
Vol 64 (2) ◽  
pp. 21-40
Author(s):  
Mohamed El-Zahabi
Keyword(s):  
Broad Spectrum ◽  
Anti Cancer ◽  
Quinazoline Derivatives

Anti-cancer activity of camptothecin nanocrystals decorated by silver nanoparticles

2017 ◽  
Vol 5 (14) ◽  
pp. 2692-2701 ◽  
Author(s):  
Honglei Zhan ◽  
Xiaqing Zhou ◽  
Yang Cao ◽  
Tina Jagtiani ◽  
Tzu-Lan Chang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Broad Spectrum ◽  
High Selectivity ◽  
Anti Cancer ◽  
Cancer Activity

CPT/Ag nanocrystals display extreme and broad-spectrum anti-cancer activity and high selectivity through a cooperation effect between CPT and AgNPs.

scholarly journals Inhibitors of anti-apoptotic Bcl-2 family proteins exhibit potent and broad-spectrum anti-mammarenavirus activity via cell cycle arrest at G0/G1 phase

2021 ◽  
Author(s):  
Yu-Jin Kim ◽  
Haydar Witwit ◽  
Beatrice Cubitt ◽  
Juan C. de la Torre
Keyword(s):  
Cell Cycle ◽  
Antiviral Activity ◽  
Cell Cycle Arrest ◽  
Broad Spectrum ◽  
Cancer Therapeutics ◽  
Cyclin B1 ◽  
G1 Phase ◽  
Cycle Arrest ◽  
Anti Cancer ◽  
Antiviral Activities

Targeting host factors is a promising strategy to develop broad-spectrum antiviral drugs. Drugs targeting anti-apoptotic Bcl-2 family proteins that were originally developed as tumor suppressors have been reported to inhibit multiplication of different types of viruses. However, the mechanisms whereby Bcl-2 inhibitors exert their antiviral activity remain poorly understood. In this study, we have investigated the mechanisms by which obatoclax (OLX) and ABT-737 Bcl-2 inhibitors exhibited a potent antiviral activity against the mammarenavirus lymphocytic choriomeningitis virus (LCMV). OLX and ABT-737 potent anti-LCMV activity was not associated with their pro-apoptotic properties, but rather their ability of inducing cell arrest at G0/G1 phase. OLX and ABT-737 mediated inhibition of Bcl-2 correlated with reduced expression levels of thymidine kinase 1 (TK1), cyclin A2 (CCNA2), and cyclin B1 (CCNB1) cell cycle regulators. In addition, siRNA-mediated knock down of TK1, CCNA2, and CCNB1 resulted in reduced levels of LCMV multiplication. The antiviral activity exerted by Bcl-2 inhibitors correlated with reduced levels of viral RNA synthesis at early times of infection. Importantly, ABT-737 exhibited moderate efficacy in a mouse model of LCMV infection, and Bcl-2 inhibitors displayed broad-spectrum antiviral activities against different mammarenaviruses and SARS-CoV-2. Our results suggest that Bcl-2 inhibitors, actively being explored as anti-cancer therapeutics, might be repositioned as broad-spectrum antivirals. IMPORTANCE Anti-apoptotic Bcl-2 inhibitors have been shown to exert potent antiviral activities against various types of viruses via mechanisms that are currently poorly understood. This study has revealed that Bcl-2 inhibitors mediated cell cycle arrest at the G0/G1 phase, rather than their pro-apoptotic activity, plays a critical role in blocking mammarenavirus multiplication in cultured cells. In addition, we show that Bcl-2 inhibitor ABT-737 exhibited moderate anti-mammarenavirus activity in vivo , and that Bcl-2 inhibitors displayed broad-spectrum antiviral activities against different mammarenaviruses and SARS-CoV-2. Our results suggest that Bcl-2 inhibitors, actively being explored as anti-cancer therapeutics, might be repositioned as broad-spectrum antivirals.

scholarly journals Characteristic and use of spilanthol in cosmetology

2021 ◽  
Vol 10 (3) ◽  
pp. 101-108
Author(s):  
Mirosława Grymel ◽  
Keyword(s):  
Biological Activity ◽  
Broad Spectrum ◽  
Plant Material ◽  
Specific Activity ◽  
Facial Muscles ◽  
Aesthetic Dermatology ◽  
Anti Cancer ◽  
Bioactive Substance ◽  
Anti Inflammatory ◽  
Natural Component

Acmella oleracea is an interesting plant with a high spilanthol content, which due to its specific activity is considered as a valuable bioactive substance. Spilanthol displays a broad spectrum of biological activity, including analgesic, anti-inflammatory, antifungal, antioxidant, anti-cancer and bacteriostatic effects. In addition, it inhibits contractions of the facial muscles, and thanks to it was called a natural herbal botox. The interest in spilanthol by the cosmetics industry, leads that effective methods of its isolation from plant material are still being sought. The aim of the study was to present the possibility of using spilanthol in cosmetology and aesthetic dermatology. In this work, application studies presented, confirm the possibility of its use as a natural component of anti-wrinkle cosmetics.

Human Arginase I (Arg I)—A Potential Broad-spectrum Anti-cancer Agent: Perspectives and the Road Ahead

2020 ◽  
Author(s):  
Sayantap Datta ◽  
Priyanka Kawathe ◽  
Snehal Sainath Jawalekar ◽  
Abhay H Pande
Keyword(s):  
Broad Spectrum ◽  
The Road ◽  
Anti Cancer ◽  
Cancer Agent ◽  
Arginase I
Sign in / Sign up

Export Citation Format

Share Document