scholarly journals Urinary Protein Biomarkers and Renal Angina Index for Detection of Renal Dysfunction in Sick Full-Term Neonates

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Balsam Fahmy ◽  
Manal Abdelmgeed ◽  
Rasha Galal ◽  
Ahmed Galal
Keyword(s):  
Renal Dysfunction ◽  
Full Term ◽  
Urinary Protein ◽  
Protein Biomarkers ◽  
Term Neonates ◽  
Renal Angina Index ◽  
Renal Angina

scholarly journals DIAGNOSTIC VALUE OF MALONIC ALDEHYDE IN URINE AS A MARKER OF RENAL DYSFUNCTION IN FULL-TERM NEONATES WITH PERINATAL PATHOLOGY

2021 ◽  
Vol 11 (4(42)) ◽  
pp. 21-27
Author(s):  
A. Babintseva ◽  
Y. Hodovanets ◽  
O. Makarova ◽  
O. Makarova
Keyword(s):  
Positive Result ◽  
Renal Dysfunction ◽  
General Condition ◽  
Threshold Value ◽  
Diagnostic Value ◽  
Full Term ◽  
Kidney Damage ◽  
Term Neonates ◽  
Perinatal Pathology

Introduction. One of the mechanisms of pathologic oxidative stress in neonates is intensification of membrane lipid peroxide oxidation. Malonic aldehyde (MA) is a secondary product used as an indicator of lipid peroxidation processes and therefore a marker of cellular membrane damage. Meanwhile, nowadays the mechanisms determining organ peculiarities of lipid and protein peroxidation as well as resistance to ischemic kidney damage are not studied completely and require further development.   Objective: to determine diagnostic value of MA in urine as a marker of renal dysfunction in full-term neonates with perinatal pathology of various degrees of severity.   Material and methods. One-centered cohort prospective study was carried out including 41 full-term children with disorders of general condition of a moderate degree of severity (І group); 36 full-term children with disorders of general condition of a severe degree without acute kidney damage (ІІА group); 30 full-term children with disorders of general condition of a severe degree with acute kidney damage (ІІB group) and 40 healthy children (ІІІ group). МА level in urine was determined by means of reaction with thiobarbituric acid at the end of the 3rd day of life. Results. The lack of a negative test diagnostic value with determination of MA in urine was determined when renal dysfunction had been found in full-term neonates with signs of perinatal pathology of a moderate severity. It was evidenced by AUROC 0,53 (95% CІ 0,50; 0,65, р>0,05) with a threshold value of the parameter ≤9,57 mcmol/L. A perfect discriminating ability to determine MA level in urine was demonstrated in diagnostics of disorders of the functional kidney state in children who had signs of severe postnatal adaptation disorders. It was evidenced by AUROC 0,81 (95% CІ 0,71; 0,91, р<0,001) with a threshold value of the parameter ≥ 9,58 mcmol/L; specificity  97,6% (95% CІ 87,1%; 99,9%), prognostic value of a positive result 95,7% (95% CІ 75,7%; 99,4%) and likelihood ratio of a positive result 25,1 (95% CІ 3,55; 76,7). Diagnostics of acute kidney injury in critically sick term neonates found a proper quality of the diagnostic pattern with determination of MA level in urine.  It was evidenced by AUROC 0,80 (95% CІ 0,66; 0,89, р<0,05) with a threshold value of the parameter ≥12,9 mcmol/L; specificity 91,4% (95% CІ 76,9%; 98,2%), %), prognostic value of a positive result 85,7% (95% CІ 66,2; 94,9%) and likelihood ratio of a positive result 7,0 (95% CІ 2,28; 21,5). Conclusions. Considering the value of reactions of pathologic oxidative stress in the formation of maladjustment syndromes, determination of MA in urine is suggested to be used as one of the possible markers of renal dysfunction in neonates which reflects the state of lipid peroxidation processes in the kidney structures and degree of their damage. 

Assessment of serum levels of vitamin B12 in full term neonates with indirect hyperbilirubinemia

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Gamal Mohamed ◽  
Reem Abdel-Salam ◽  
Rabie Mortada
Keyword(s):  
Vitamin B12 ◽  
Serum Levels ◽  
Full Term ◽  
Term Neonates

Cord Blood Alkaline Phosphatase as a predictor of Neonatal Jaundice in full term neonates

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Samah Esmail ◽  
Ali Abdo ◽  
Sherief Elgebaly ◽  
Marwa Mostafa
Keyword(s):  
Alkaline Phosphatase ◽  
Cord Blood ◽  
Neonatal Jaundice ◽  
Full Term ◽  
Term Neonates

scholarly journals Sufentanil Disposition and Pharmacokinetic Model-Based Dosage Regimen for Sufentanil in Ventilated Full-Term Neonates

Pharmacology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Pavla Pokorná ◽  
Martin Šíma ◽  
Birgit Koch ◽  
Dick Tibboel ◽  
Ondřej Slanař
Keyword(s):  
Linear Regression ◽  
Dosage Regimen ◽  
Regression Models ◽  
Drug Disposition ◽  
Prospective Trial ◽  
Full Term ◽  
Pharmacokinetic Parameters ◽  
Therapeutic Drug ◽  
Linear Regression Models ◽  
Term Neonates

<b><i>Introduction:</i></b> Sufentanil is a potent synthetic opioid used for analgesia in neonates; however, data concerning drug disposition of sufentanil and dosage regimen are sparse in this population. Therefore, the aim of the study was to explore sufentanil disposition and to propose optimal loading and maintenance doses of sufentanil in ventilated full-term neonates. <b><i>Methods:</i></b> Individual sufentanil pharmacokinetic parameters were calculated based on therapeutic drug monitoring data using a 2-compartmental model. Linear regression models were used to explore the covariates. <b><i>Results:</i></b> The median (IQR) central volume of distribution (Vd<sub>c</sub>) and clearance (CL) for sufentanil were 4.7 (4.1–5.4) L/kg and 0.651 (0.433–0.751) L/h/kg, respectively. Linear regression models showed relationship between Vd<sub>c</sub> (L) and GA (<i>r</i><sup>2</sup> = 0.3436; <i>p</i> = 0.0452) as well as BW (<i>r</i><sup>2</sup> = 0.4019; <i>p</i> = 0.0268). Median optimal sufentanil LD and MD were 2.13 (95% CI: 1.78–2.48) μg/kg and 0.29 (95% CI: 0.22–0.37) μg/kg/h, respectively. Median daily COMFORT-B (IQR) scores ranged from 6 to 23 while no significant relationship between pharmacokinetic parameters and COMFORT-B scores was found. <b><i>Discussion/Conclusion:</i></b> Body weight and gestational age were found as weak covariates for sufentanil distribution, and the dosage regimen was developed for a prospective trial.

The Hemodynamically Significant Ductus Arteriosus in Critically Ill Full-Term Neonates

Neonatology ◽  
2006 ◽  
Vol 91 (4) ◽  
pp. 260-265 ◽  
Author(s):  
Linh G. Ly ◽  
Judith Hawes ◽  
Hilary E. Whyte ◽  
Lilian S. Teixeira ◽  
Patrick J. McNamara
Keyword(s):  
Critically Ill ◽  
Ductus Arteriosus ◽  
Full Term ◽  
Term Neonates

Bifidobacterium longum and Bifidobacterium breve isolates from preterm and full term neonates: Comparison of cell surface properties

Anaerobe ◽  
2014 ◽  
Vol 28 ◽  
pp. 212-215 ◽  
Author(s):  
Valérie Andriantsoanirina ◽  
Anne-Claire Teolis ◽  
Liu Xin Xin ◽  
Marie Jose Butel ◽  
Julio Aires
Keyword(s):  
Cell Surface ◽  
Surface Properties ◽  
Bifidobacterium Longum ◽  
Full Term ◽  
Term Neonates ◽  
Bifidobacterium Breve ◽  
Cell Surface Properties

Magnetic Resonance Imaging Evaluation of Neonates With Retinal Hemorrhages

PEDIATRICS ◽  
1992 ◽  
Vol 89 (2) ◽  
pp. 332-333
Author(s):  
WILBUR L. SMITH ◽  
RANDELL C. ALEXANDER ◽  
G. FRANK JUDISCH ◽  
YUTAKA SATO ◽  
SIMON C. S. KAO
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Abusive Head Trauma ◽  
Full Term ◽  
Resonance Imaging ◽  
Retinal Hemorrhages ◽  
Imaging Evaluation ◽  
Term Neonates ◽  
Magnetic Resonance Imaging Evaluation ◽  
A Prospective Study

Retinal hemorrhages occur frequently in association with abusive head trauma.1 The injuries are venous [See table in the PDF] in origin and, as such, are similar to the retinal hemorrhages which frequently occur in full-term neonates after vaginal delivery. Because retinal hemorrhages in child abuse frequently are associated with intracranial bleeding, we questioned the possibility of a relationship between parturitional retinal hemorrhages and concurrent intracranial injuries. To answer this question we designed a prospective study in which we performed magnetic resonance imaging on 10 randomly selected full-term neonates in whom the presence of retinal hemorrhages was confirmed on fundascopic examination by a pediatric ophthalmologist.

Genetic polymorphisms of IL-6-174 and IL-10-1082 in full term neonates with late onset blood stream infections

2015 ◽  
Vol 04 (04) ◽  
pp. 357-365 ◽  
Author(s):  
Mohamed El-Naggar ◽  
Ghada El-Nady ◽  
Rawia Badr ◽  
Medhat El-Daker ◽  
Hesham Abdel-Hady
Keyword(s):  
Genetic Polymorphisms ◽  
Late Onset ◽  
Blood Stream ◽  
Full Term ◽  
Blood Stream Infections ◽  
Term Neonates
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