Role of Pregnancy-Associated Plasma Protein-A and Uterine Artery Doppler in Early Detection of Preeclampsia

2020 ◽  
Vol 5 (1) ◽  
pp. 1-8
Author(s):  
W.N. Mohamed ◽  
M.A. Mohamed ◽  
A.A. Sharf Eldin
Keyword(s):  
Early Detection ◽  
Plasma Protein ◽  
Uterine Artery ◽  
Protein A ◽  
Uterine Artery Doppler

scholarly journals Role of pregnancy associated plasma protein-A and doppler velocimetry in the assessment of fetomaternal outcome in high risk pregnancy

2019 ◽  
Vol 8 (5) ◽  
pp. 1981
Author(s):  
Asmita Kaundal ◽  
Usha Gupta ◽  
Jayashree Bhattcharjee
Keyword(s):  
High Risk ◽  
Pregnancy Outcome ◽  
Plasma Protein ◽  
Uterine Artery ◽  
Protein A ◽  
High Risk Population ◽  
Risk Population ◽  
Uterine Artery Doppler ◽  
Adverse Pregnancy

Background: The study aimed at defining the role of Pregnancy associated plasma protein-A (PAPP-A) and uterine artery doppler (Ut.A.PI) in the development of adverse pregnancy outcome (APO) in high risk pregnancies.Methods: This was an observational study where 100 singleton pregnancies at high risk of development of APO, between 11 to 13 + 6 weeks POG were enrolled. PAPP-A levels were measured at 11 to 13 + 6 weeks POG and uterine artery doppler PI was measured at 20 weeks. Women were followed till delivery. Pregnancy outcome were seen and a cut off at which APO developed was derived.Results: In this study women with lower mean PAPP-A (0.75±0.19 MOM versus 1.23±0.31MOM) (p<0.001) values and higher Ut.A.PI (1.43±0.35MOM versus 0.99±0.25MOM) (p<0.001) developed APO. Cut off value for PAPP-A and Ut.A.PI was determined and was found to be ≤11.65 µg/ml (≤0.79MoM) and   >1.42 (>1.19MoM) respectively which was higher than what is determined in other studies done on low risks populations thereby suggesting for an intervention or more meticulous observations at a higher cut offs.Conclusions: PAPP-A and uterine artery doppler are already being used for the screening of preeclampsia in most of the countries but not for other adverse pregnancy outcomes. PAPP-A levels along with the uterine artery PI in predicting APO in high risk women has high negative predictive value. Hence can be uses as a screening method in high risk population whether they should be used for low risk population also needs further evaluation.

First-Trimester Uterine Artery Doppler and Serum Pregnancy-Associated Plasma Protein-A in Preeclampsia and Chromosomal Defects

2009 ◽  
Vol 25 (3) ◽  
pp. 336-339 ◽  
Author(s):  
Ismini Staboulidou ◽  
Alberto Galindo ◽  
Nerea Maiz ◽  
George Karagiannis ◽  
Kypros H. Nicolaides
Keyword(s):  
Plasma Protein ◽  
Uterine Artery ◽  
Protein A ◽  
First Trimester ◽  
Uterine Artery Doppler ◽  
Chromosomal Defects

Role of Uterine Artery Doppler Flow in Fibroid Embolization

2002 ◽  
Vol 21 (2) ◽  
pp. 113-120 ◽  
Author(s):  
Bruce McLucas ◽  
Rita Perrella ◽  
Scott Goodwin ◽  
Louis Adler ◽  
Jerry Dalrymple
Keyword(s):  
Uterine Artery ◽  
Uterine Artery Doppler ◽  
Doppler Flow

scholarly journals Macroglobulin signaling system

2012 ◽  
Vol 58 (4) ◽  
pp. 400-410
Author(s):  
N.A. Zorin ◽  
V.N. Zorina
Keyword(s):  
Significant Role ◽  
Plasma Protein ◽  
Protein A ◽  
Transcriptional Factors ◽  
Signaling System

This review will focus on the systematization of knowledge about structure of macroglobulin signaling system, which includes macroglobulin family proteins (alpha-2-macroglobulin, alpha-2-glycoprotein, pregnancy associated plasma protein A), their receptors (LRP, grp78), ligands (proteinases, cytokines, hormones, lipids, et al.) transforming and transcriptional factors for regulation of macroglobulins synthesis. After reviewing the functions of macroglobulin signaling system, and mechanisms of their realization, we discuss the complex and significant role of this system in different physiological and pathological processes.

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