scholarly journals Effect of Crude Ethanolic Leaf Extract of Rauwolfia Vomitoria on the Fetal Lungs of Wistar Rats

2014 ◽  
Vol 5 (1) ◽  
pp. 1-7
Author(s):  
Mokutima Eluwa ◽  
Kenneth Osim ◽  
Moses Ekong ◽  
Theresa Ekanem ◽  
Amabe Akpantah ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Fetal Lungs ◽  
Ethanolic Leaf Extract ◽  
Rauwolfia Vomitoria

scholarly journals Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Alian Désiré Afagnigni ◽  
Maximilienne Ascension Nyegue ◽  
Chantal Florentine Ndoye Foe ◽  
Youchahou Njankouo Ndam ◽  
Frédéric Nico Njayou ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Shigella Flexneri ◽  
Female Rats ◽  
Male Rats ◽  
Dependent Manner ◽  
Subacute Toxicity ◽  
Antidiarrheal Activity ◽  
Dose Dependent ◽  
Ethanolic Leaf Extract

The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity. S. flexneri stool load decreased significantly in dose-dependent manner. The level of ALT increased (p<0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses. In female rats, a significant decrease (p<0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D. multiflora. Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg. This finding suggests that D. multiflora leaf extract is efficient against diarrhea caused by S. flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.

scholarly journals Free Radical Scavenging and Antioxidant Potential of Ethanolic Leaf Extract of Diodia sarmentosa on High Fat Fed Wistar Rats

2020 ◽  
pp. 54-63
Author(s):  
Ezejiofor Tobias I. Ndubuisi ◽  
Korie Stephen Chinedumije ◽  
Peter Chukwudi
Keyword(s):  
Nitric Oxide ◽  
Antioxidant Enzymes ◽  
Free Radicals ◽  
Free Radical ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
High Fat ◽  
Ethanolic Leaf Extract

Diodia sarmentosa (Sw) commonly known as Zimbabwe flora or Tropical button weed is a straggling or procumbent perennial herb which grows in evergreen forest, riverine vegetation and bush land. It has been used traditionally for the treatment of ulcer, diabetes and other ailments. This study investigated the Free radical scavenging and antioxidant potential of ethanolic leaf extract of Diodia sarmentosa on high fat fed wistar rats. Thirty (30) male wistar rats (150 g-200 g) were divided into five (5) groups: Negative control rats, Positive control rats, Low dose extract rats treated with 250 mg/kg, High dose extract rats treated with 500mg/kg of the extract, and Standard antihyperlipidaemic drug rats treated with 5 mg/kg of Simvastatin. High fat diet was fed to the rats with Ghee and Coconut oil in the ratio of 3:1 for six (6) weeks, and administration of the treatments started from the 3rd week till the 6th week. The free radical scavenging and antioxidant potentials of Diodia sarmentosa was determined by assessing parameters like nitric oxide radical, hydroxyl radical, malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx) and Glutathione S-transferase (GST) in the serum of the test rats. Diodia sarmentosa scavenged free radicals In vitro by inhibiting Nitric oxide and Hydroxyl radicals in a concentration-dependent manner, showing an inhibitory concentration at 50% (IC50) of 907.17 µg/ml ± 45.36 and 2173.44 µg/ml ± 100.11 respectively. Results obtained showed antioxidant enzymes like SOD, GPx and CAT in the serum of the test rats were significantly increased (p<0.05) by both doses of the extract when compared to the PC group and was similar to the standard drug used. GST activity was decreased in the serum by both doses of the extract, this decrease was not significant (p>0.05), while Malondialdehyde level was significantly decreased (p<0.05) by both doses of the extract in the serum of the tests rats. Diodia sarmentosa has antioxidants potentials because of its ability to scavenge free radicals, replenish antioxidant enzymes and reduce lipid peroxidation.

scholarly journals ANNONA MURICATA LINN. ETHANOLIC LEAF EXTRACT AMELIORATES REPRODUCTIVE COMPLICATIONS IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

2020 ◽  
Vol 18 (1) ◽  
pp. 166-175
Author(s):  
O. E. ADELEYE ◽  
N. A. ABOAJAH ◽  
A. I. ADELEYE ◽  
E. A.O. SOGEBI ◽  
F. M. MSHELBWALA ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Sperm Count ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Male Rats ◽  
Annona Muricata ◽  
Major Health Problem ◽  
Ethanolic Leaf Extract

Diabetes mellitus is an endocrine and metabolic disorder of humans and animals characterized by hyperglycemia and low blood insulin levels or insensitivity of target organs to insulin and it’s a major health problem affecting patient’s quality of life due to its many complications. Infertility is one of the major secondary complications in diabetes. Although numerous drugs have been used for intervention studies on diabetes-induced infertility worldwide, there are currently no treatments for diabetes associated infertility in humans. This study was performed to investigate the effects of Annona muricata ethanolic leaf extract (AMELE) on fertility of male diabetic rats and levels of blood glucose. Twenty male Wistar rats (150-200g) were randomly distributed into 4 groups (n=5) treated thus: CTRL (control), DNT, DT1 and DT2 (diabetic, single intraperitoneal injection, streptozotocin, 60 mg/kg). Group DT1 and DT2 received AMELE orally at 100 mg/kg and 200 mg/kg respectively daily for fourteen days. Data were analysed using ANOVA at α0.05. The animals were sacrificed after 2 weeks via thiopental injection and testicular weights were recorded. Fasting blood glucose was determined using a digital glucometer. Sperm count, motility, viability and morphology were assessed microscopically. Testes were histologically evaluated. The results showed that oral administration of AMELE at 100 mg/kg and 200 mg/kg to diabetic male rats for fourteen days significantly decreased blood glucose level and also ameliorated diabetes-induced decreases in sperm functions in streptozotocin-induced diabetic male rats.    

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