scholarly journals Ameliorative Effect of Jojoba Oil on Monosodium Glutamate Induced Cardiotoxicity and Neurotoxicity: Molecular, Metabolic and Histopathological study

Author(s):  
Sahar Abo El Wafa ◽  
Rania Mohamady ◽  
Sania Elwia
2012 ◽  
Vol 92 (15) ◽  
pp. 3002-3006 ◽  
Author(s):  
Sauganth Paul ◽  
Abhilash Mohanan ◽  
Mathews V Varghese ◽  
Manju Alex ◽  
Harikumaran Nair

2017 ◽  
Vol 2017 ◽  
pp. 1-8
Author(s):  
Anouar ben Saad ◽  
Ilhem Rjeibi ◽  
Sana Ncib ◽  
Nacim Zouari ◽  
Lazhar Zourgui

Opuntia ficus indica(family Cactaceae) is used in the treatment of a variety of conditions including metal-induced toxicity. The study reports the protective effects ofOpuntia ficus indica(CCE) against lithium carbonate-induced toxicity in rats. Nephrocardiotoxicity was induced in male Wistar rats by single dose of lithium carbonate (25 mg/kg b.w twice daily for 30 days). Aqueous extract ofOpuntia ficus indicawas administered at the dose of 100 mg/kg of b.w by gavage for 60 days. Obtained results revealed that administration of lithium carbonate caused a significant increase in serum creatinine, uric acid, and urea levels. Additionally, a significant decrease in the level of renal and cardiac SOD, CAT, and GPx activities was associated with a significant increase of MDA levels in lithium carbonate group more than those of the control. However, the treatment of experimental rats with CCE prevented these alterations and maintained the antioxidant status. The histopathological observations supported the biochemical evidences of nephrocardioprotection. CCE supplementation could protect against lithium carbonate-induced renal and cardiac injuries in rats, plausibly by the upregulation of antioxidant enzymes and inhibition of MDA to confer the protective effect.


2016 ◽  
Vol 50 (3s) ◽  
pp. S200-S208 ◽  
Author(s):  
Alexander Victor Anand David ◽  
Namani Satyanarayana ◽  
Subramani Parasuraman ◽  
Sengodan Bharathi ◽  
Radhakrishnan Arulmoli

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