scholarly journals Possible Ameliorative Role of Ethanolic Ginger Extract (Zingiber officinale) against Testicular Toxicity Induced By Monosodium Glutamate In Albino Rats

2021 ◽  
Vol 13 (2) ◽  
pp. 285-300
Author(s):  
Heba Mohamed ◽  
Mona Mohamed ◽  
Afaf Kamel.
Keyword(s):  
Monosodium Glutamate ◽  
Zingiber Officinale ◽  
Albino Rats ◽  
Testicular Toxicity ◽  
Ginger Extract

scholarly journals Possiple Protective Role of Ascorbic Acid on Ethanol Induced Testicular Toxicity in Male Albino Rats

2019 ◽  
Vol 19 (4) ◽  
pp. 49-63
Author(s):  
Sally Ahmed ◽  
Marcelle Haroun ◽  
Nermeen Hassan ◽  
Abeer Sharf El Din ◽  
Sahar Abo El Wafa ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Protective Role ◽  
Albino Rats ◽  
Testicular Toxicity

scholarly journals Effect of Aqueous Extract of Zingiber officinale (Ginger) on Some Biochemical Parameters in Streptozotocin-induced Diabetes Rats

2019 ◽  
pp. 1-8
Author(s):  
M. K. Jiyil ◽  
C. D. Luka ◽  
C. E. Mafuyai ◽  
N. Pamela
Keyword(s):  
Body Weight ◽  
Biochemical Parameters ◽  
Zingiber Officinale ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
The Body ◽  
Albino Rats ◽  
Ginger Extract ◽  
Hematological Analysis ◽  
Treatment Of Diabetes

Background: Appreciable number of medicinal plants are used for the treatment of diabetes in Nigeria. Aim of the Study: The present study aimed to investigate the antidiabetic activity of Zingiber officinale extracts and its potential mechanisms in streptozotocin-induced diabetic rats. Study Duration: The period of the study was done on 30th September, 2018 at the Department of Biochemistry, Faculty of Basic Medical Sciences, university of Jos, Nigeria. Methodology: Albino rats of Wistar strain weighing between 130 g to 160 g were induced with single freshly prepared streptozotocin (55 mg/kg body weight). Diabetes was confirmed after forty eight hours in streptozotocin -induced rats showing fasting blood glucose levels > 10 mmol/l. The rats were randomly divided into four (4) experimental groups (n = 4). A (Control diabetic group fed with normal feed), Group B (Normal control fed with normal feed), Group Group C (Diabetic rats treated with 400 mg/Kg body weight extract of ginger and Group D, (Diabetic rats are treated with 400 mg/Kg body weight of metformin). After 8 days the animals were sacrificed and blood samples were collected for biochemical and hematological analysis. Changes in the animal body weights were also measured within the period. Results: From the results, it was observed that treatment of rats with extract of ginger compensates for the reduction of body weight, and caused an increase in the body weight of the treated rats (+11.5%) in contrast to 24.8% reduction observed in diabetic control. In the same order, serum glucose significantly decreased (p<0.05) after the 8-day treatment compared to diabetic control. The extent of reversal of hyperglycemia in the ginger extract treated animals compared well with the metformin treated group. The results, therefore, showed that ginger extract has a significant (p<0.05) hypoglycemic effect in diabetic rats and moreover, elevations in the measured biochemical parameters were significantly (p<0.05) attenuated in rats treated with ginger extract. Conclusion: Zingiber officinale extracts has a significant effect on some biochemical parameters and hematological assays. These provide scientific evidence to confirm the traditional use of Z. officinale in the treatment of diabetes mellitus.

Effect of monosodium glutamate on the ovaries of adult female albino rats and the possible protective role of green tea

2014 ◽  
Vol 27 (4) ◽  
pp. 793 ◽  
Author(s):  
MonaAbd El Mawla Mohammed Soliman ◽  
AhmedAbozaid Ali ◽  
GhadaHassan El-Seify ◽  
HalaMohammed El Haroun
Keyword(s):  
Green Tea ◽  
Adult Female ◽  
Monosodium Glutamate ◽  
Protective Role ◽  
Albino Rats

Attenuating Role of Vitamin C on Sperm Toxicity Induced by Monosodium Glutamate in Albino Rats

2013 ◽  
Vol 13 (4) ◽  
pp. 298-301 ◽  
Author(s):  
U.B. Ekaluo ◽  
E.V. Ikpeme ◽  
Y.B. Ibiang ◽  
O.S. Amaechina
Keyword(s):  
Vitamin C ◽  
Monosodium Glutamate ◽  
Albino Rats

scholarly journals Protective Role of Rockect Seed (Eruca sativa) Extract against Monosodium Glutamate-induced Hepato-renal Toxicity in Male Rats

2020 ◽  
pp. 1-10
Author(s):  
Ehab Tousson ◽  
Afaf El-Atrash ◽  
Yosra Karson
Keyword(s):  
Renal Damage ◽  
Renal Toxicity ◽  
Monosodium Glutamate ◽  
Chloride Ions ◽  
Male Rats ◽  
Male Rat ◽  
Albino Rats ◽  
Male Adult ◽  
Liver And Kidney

Background and Objective: Monosodium glutamate (MSG) is identified as an Accent that is used in the food industry as a flavour enhancer with an umami taste that intensifies the meaty, savoury flavour of food. The present study aimed at evaluating the protective and ameliorative role of rocket seeds extract against monosodium glutamate-induced hepatic renal toxicity and oxidative stress in the male rat. Materials and Methods: A total of 60 male adult albino rats were equally divided into six groups (G1, Control; G2, rocket seeds (RS); G3, ACCENT or MSG; G4, Co- treated (RS+MSG); G5, Post- treated (MSG+RS); G6, Self-treated MSG).  Results: Current results revealed that; a significant increase in serum ALT, AST, ALP, AFP, Urea, Creatinine, potassium ions, chloride ions, cholesterol, triglyceride, HDL, and LDL levels in MSG as compared to control and RS groups. In contrast; a significant decrease in serum albumin, total proteins, catalase, GSH and SOD in liver and kidney homogenates in MSG as compared to control and RS groups. Co- or post-treatment of MSG with rocket seeds improved this change in liver and kidney functions, with best results for co-treatment than post and self-treatment. Conclusion: These findings suggested that the misuse of monosodium glutamate may contribute to continuous hepatic and renal damage. This shows that the desired dose of monosodium glutamate can safely be used with grapes seed in improving hepatic and renal damage in monosodium glutamate in young rats.

scholarly journals Anti-inflammatory and analgesic activity of ointment based on dense ginger extract (Zingiber officinale)

2019 ◽  
Vol 8 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Iryna Kravchenko ◽  
Lidiya Eberle ◽  
Mariia Nesterkina ◽  
Alona Kobernik
Keyword(s):  
Analgesic Activity ◽  
Transdermal Delivery ◽  
Allyl Isothiocyanate ◽  
Zingiber Officinale ◽  
Vital Role ◽  
Ginger Extract ◽  
Effective Inhibition ◽  
Anti Inflammatory ◽  
Subplantar Injection

Introduction: Zingiber officinale (Zingiberaceae family) is traditionally used in alternative medicine to reduce pain from rheumatoid arthritis and osteoarthritis. Ginger is also often applied for stomach and chest pain, toothaches and as anti-inflammatory agent. The aim of this study is to investigate analgesic and anti-inflammatory activities of Z. officinale dense extract after its transdermal delivery using allyl isothiocyanate (AITC) induced model with further discussion of possible action mechanism of ginger phytoconstituents. Methods: Inflammation was induced by subplantar injection to the plantar fasciitis (aponeurosis) of the hind limb of rats using 30 µL AITC solution (100 µg/limb) in 1,2-propyleneglycol. The dynamics of changes of inflammatory process was evaluated before addition of the inflammation inducer and after 1, 2, 3, 4, 6 and 24 hours of its injection for measuring the volume and the thickness of affected limb. Analgesic activity of ointments with ginger extract was examined using the model of AITC-induced pain. Results: The most effective inhibition of the development of inflammation process was 0.025% ointment with ginger extract, and the highest anti-nociceptive effect was observed at the application of 0.05% ointment 10 minutes before pain inducer agent. Conclusion: Zingiber officinale dense extract was revealed to possess significant antinociceptive and anti-inflammatory actions after its transdermal delivery. Since the pharmacological effects of ginger extract have been investigated on AITC-induced model, we may suggest the vital role of phytoconstituents binding to TRPA1 and TRPV1 ion channels as possible mechanism of action.

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