scholarly journals Monosodium glutamate induced testicular toxicity and the possible ameliorative role of vitamin E or selenium in male rats

2014 ◽  
Vol 1 ◽  
pp. 1037-1045 ◽  
Author(s):  
Reham Z. Hamza ◽  
Mohammad S. AL-Harbi
Keyword(s):  
Vitamin E ◽  
Monosodium Glutamate ◽  
Male Rats ◽  
Testicular Toxicity

Physiological and Histological Study to the Effects of Monosodium Glutamate in Laboratory male Rats and the protective role of vitamin E

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Genan Musheer Ghaib AL-Khatawi ◽  
Mohammed R S AL-Attabi ◽  
Ali Fayadh Bargooth
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Low Density Lipoprotein ◽  
Monosodium Glutamate ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Liver And Kidney

The current study was conducted at the Department of Biology, College of Science, Wasit University to investigate physiological and histological effect monosodium glutamate in laboratory male rats, preventive role of vitamin E. This study was carried out in Laboratories of College of Science, Wasit University, AL- Shaheed Dr. Fairooz Hospitals, from November 2017 to April 2018.The study included twenty-four and divided into four groups (six rats per group). the first group severe as a control group orally dosed with distilled water, and treated the second group (100 mg/kg b.w. Monosodium glutamate for 30 days, and the third group were dosed orally 200 mg/kg of b.w. for 30 days, either The fourth group were dosed with a mixture of Monosodium glutamate 200mg/kg and vitamin E 100 mg/kg of body weight for 30 days. after the trial period has been sacrificing animals for testing and chemical standards physiological and histological. As are result of by exposure to Monosodium glutamate in blood serum are negatively biochemical whole height of the level of serum cholesterol, triglycerides, Low-density lipoprotein, very- low density lipoprotein, liver enzymes, AST, ALT, ALP, creatinine level, urea serum, further more we noticed a decrease in high density lipoprotein. The preventive treatment resulted in vitamin E 100mg/kg b.w. with Monosodium glutamate 200 mg/kg b.w. (p≤ 0.05) in body weight and relative weights of organs (liver and kidney). We noticed a higher moral when treatment with vitamin E with Monosodium glutamate 100 mg/kg in high- density lipoprotein, while serum cholesterol level decrease, triglycerides, Low-density lipoprotein, very- low density lipoprotein. And liver and kidney functions have improved by low Enzyme AST, ALT, ALP, creatinine and urea serum level. Histological examination revealed that the liver and kidneys, of rats exposed 100, 200 mg/kg of Monosodium glutamate has been adversely affected by exposure to Monosodium glutamate. Whereas, the histological of the liver of animals treated with vitamin E with Monosodium glutamate natural pictures showed improvement. These results demonstrate that MSG toxic effects on the liver and kidney tissue. The more toxic than salt rate too. The study recommends to avoid using MSG as food additives and food for animals because of the toxic effects of this salt.

scholarly journals Effect of Flavonoids Extracted from Black Cumin (Nigella sativa) and Vitamin E in Ameliorating Hepatic Damage Induced by Sodium Nitrate in adult male rats

2012 ◽  
Vol 36 (0E) ◽  
pp. 172-181
Author(s):  
Baraa N. AL-Okaily
Keyword(s):  
Vitamin E ◽  
Adult Male ◽  
Sodium Nitrate ◽  
Nigella Sativa ◽  
Hemoglobin Concentration ◽  
Protective Role ◽  
Hepatic Damage ◽  
Male Rats ◽  
Bilirubin Concentration

This study was designed to investigate the effect of sodium nitrate as oxidant agent on hepatic function of adult male rats, as well as the possible protective role of vitamin E and flavonoid extracted from Nigella Sativa seeds against the deleterious effects of sodium nitrate. Forty adult male rats were randomly divided in to 4 equal groups and treated daily for 84 days as follows: Animals in the first group were received normal saline, serving as control (group C), rats of the second group (T1) were intubated orally sodium nitrate 30mg/kg. B.W.; animals in T2 group were intubated orally vit. E 40mg/Kg B.W. in addition to sodium nitrate, while rats in the fourth group (T3) were intubated orally 50mg/kg B.W of flavonoids was extracted from Nigella Sativa seeds with sodium nitrate. Blood samples were collected at 0, 21, 42, 63 and 84 days of experiment to study the following parameters: Serum alanine aminotransferase (ALT) and alkaline phosphtase activity (ALP), serum billirubin, as well as hemoglobin concentration. The result revealed that oral intubation of 30mg/kg. B.W of sodium nitrate (T1 group) for 84 days caused hepatic damage manifested by significant increase (p<0.05) in serum ALT and ALP activities, bilirubin concentration and depression in hemoglobin concentration. On other hand, the protective role of vitamin E and flavonoids extracted from Nigella Sativa was clarified in groupsT2 and T3, including correction of hepatic damage manifested by significant (p<0.05) depression in ALT and ALP activities and bilirubin concentration as well as significant (p<0.05) elevation in hemoglobin concentration. In conclusion, the results of this study confirm the protective role of vitamin E and flavonoids of Nigella sativa seed against hepatic dysfunction caused by sodium nitrate manifested by structural and functional changes.

scholarly journals The Role of Vitamin D on Fluoxetine Induced Testicular Toxicity in Adult Male Rats.

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yasmeen El Sayed ◽  
Nagah Ali ◽  
Amal Elshazly ◽  
Rabab Salim ◽  
Bodour Baioumy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adult Male ◽  
Male Rats ◽  
Testicular Toxicity

Vitamin E Stimulates Luteinizing Hormone-Releasing Hormone and Ascorbic Acid Release from Medial Basal Hypothalami of Adult Male Rats

2003 ◽  
Vol 228 (7) ◽  
pp. 779-785 ◽  
Author(s):  
S. Karanth ◽  
W.H. Yu ◽  
C.A. Mastronardi ◽  
S.M. McCann
Keyword(s):  
Ascorbic Acid ◽  
Vitamin E ◽  
Luteinizing Hormone ◽  
Adult Male ◽  
Male Rats ◽  
Soluble Form ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Lhrh Release

Vitamin E, a dietary factor, is essential for reproduction in animals. It is an antioxidant present in all mammalian cells. Previously, we showed that ascorbic acid (AA) acted as an inhibitory neurotransmitter in the hypothalamus by scavenging nitric oxide (NO). Earlier studies have shown the antioxidant synergism between vitamin E and ascorbic acid (AA). Therefore, it was of interest to evaluate the effect of vitamin E on luteinizing hormone-releasing hormone (LHRH) and AA release. Medial basal hypothalami from adult male rats of the Sprague Dawley strain were incubated with Krebs-Ringer bicarbonate buffer or graded concentrations of a water soluble form of vitamin E, tocopheryl succinate polyethylene glycol 1000 (TPGS, 22–176 μM) for 1 hr. Subsequently, the tissues were incubated with vitamin E or combinations of vitamin. E + N-methyl-D-aspartic acid (NMDA), an excitatory amino acid for 30 min to study the effect of prior and continued exposure to vitamin E on NMDA-induced LHRH release. AA and LHRH released into the incubation media were determined by high-performance liquid chromatography and radioimmunoassay, respectively. Vitamin E stimulated both LHRH and AA release. The minimal effective concentrations were 22 and 88 μM, respectively. NMDA stimulated LHRH release as previously shown and this effect was not altered in the combined presence of vitamin E plus NMDA. However, AA release was significantly reduced in the combined presence of vitamin E plus NMDA. To evaluate the role of NO in vitamin E-induced LHRH and AA release, the tissues were incubated with vitamin E or combinations of vitamin E + NG-monomethyl-L-arginine (NMMA), a competitive inhibitor of NO synthase. NMMA significantly suppressed vitamin E-induced LHRH and AA release indicating a role of NO in the release of both LHRH and AA. The data suggest that vitamin E plays a role in the hypothalamic control of LHRH and AA release and that the release is mediated by NO.

scholarly journals Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

2016 ◽  
Vol 103 (2) ◽  
pp. 157-168 ◽  
Author(s):  
AA El-Faras ◽  
IA Sadek ◽  
YE Ali ◽  
MIM Khalil ◽  
EB Mussa
Keyword(s):  
Vitamin E ◽  
Male Rats ◽  
Testicular Toxicity ◽  
Protective Effects

scholarly journals Protective Role of Rockect Seed (Eruca sativa) Extract against Monosodium Glutamate-induced Hepato-renal Toxicity in Male Rats

2020 ◽  
pp. 1-10
Author(s):  
Ehab Tousson ◽  
Afaf El-Atrash ◽  
Yosra Karson
Keyword(s):  
Renal Damage ◽  
Renal Toxicity ◽  
Monosodium Glutamate ◽  
Chloride Ions ◽  
Male Rats ◽  
Male Rat ◽  
Albino Rats ◽  
Male Adult ◽  
Liver And Kidney

Background and Objective: Monosodium glutamate (MSG) is identified as an Accent that is used in the food industry as a flavour enhancer with an umami taste that intensifies the meaty, savoury flavour of food. The present study aimed at evaluating the protective and ameliorative role of rocket seeds extract against monosodium glutamate-induced hepatic renal toxicity and oxidative stress in the male rat. Materials and Methods: A total of 60 male adult albino rats were equally divided into six groups (G1, Control; G2, rocket seeds (RS); G3, ACCENT or MSG; G4, Co- treated (RS+MSG); G5, Post- treated (MSG+RS); G6, Self-treated MSG).  Results: Current results revealed that; a significant increase in serum ALT, AST, ALP, AFP, Urea, Creatinine, potassium ions, chloride ions, cholesterol, triglyceride, HDL, and LDL levels in MSG as compared to control and RS groups. In contrast; a significant decrease in serum albumin, total proteins, catalase, GSH and SOD in liver and kidney homogenates in MSG as compared to control and RS groups. Co- or post-treatment of MSG with rocket seeds improved this change in liver and kidney functions, with best results for co-treatment than post and self-treatment. Conclusion: These findings suggested that the misuse of monosodium glutamate may contribute to continuous hepatic and renal damage. This shows that the desired dose of monosodium glutamate can safely be used with grapes seed in improving hepatic and renal damage in monosodium glutamate in young rats.

scholarly journals Role of Vitamin E on Antispermatogenic Effects of Indomethacin on Number of Sperm Containing Seminiferous Tubules of Testes in Long Evans Rats

1970 ◽  
Vol 7 (1) ◽  
pp. 5-9
Author(s):  
Md Jahangir Alam ◽  
Monira Khatun ◽  
Manowara Begum ◽  
Muazzem Hossain ◽  
Jesmin Akhter ◽  
...  
Keyword(s):  
Vitamin E ◽  
The Other ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Testicular Damage ◽  
Other Hand ◽  
Group I ◽  
Long Evans ◽  
Different Doses

Context: Indomethacin is the most commonly and widely used nonsteroidal antiinflammatory analgesic and antipyretic drug. Despite its effectiveness as an antiinflammatory use, indomethacin causes inhibition of spermatogenesis leading to infertility. On the other hand, vitamin E enhances spermatogenesis. Therefore, the present study was designed to observe the protective role of vitamin E on indomethacin induced testicular damage. Objective: To observe the effects of vitamin E on indomethacin induced testicular damage in Long Evans rats. Study design: An experimental study. Place and period of study: The study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka. Materials and methods: Eightyfour mature Long Evans male rats were divided into four groups (I, II, III and IV). The rats of group I, II and III were treated with indomethacin at different doses and duration. Group IV rats were treated with indomethacin and vitamin E at different doses for 49 days. Histologically the number of sperm containing and nonsperm containing seminiferous tubules were counted. Results: There was significant reduction (P<0.001) in number of sperm containing seminiferous tubules when the rats were treated with indomethacin at low (2 mg/kg body wt/day) and high dose (10 mg/kg body wt/day) for 7, 14 and 42 days, respectively. On the other hand, rats treated with indomethacin and vitamin E for 49 days showed increase in number of sperm containing seminiferous tubules compared to the other groups (P<0.001). Conclusion: It can be concluded from this study that vitamin E has potential role in the prevention of the antispermatogenic effects of indomethacin. Key words: Seminiferous tubules, Indomethacin, Vitamin E    doi: 10.3329/bja.v7i1.3009 Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 5-9

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