IMPACT OF NON-SURGICAL PERIODONTAL THERAPY ON VISFATIN LEVEL IN GINGIVAL CREVICULAR FLUID OF TYPE II DIABETIC PATIENTS WITH PERIODONTITIS

ABSTRACTObjective: Periodontitis, a chronic inflammatory disease characterized by destruction of the periodontal ligament and alveolar bone is the sixthcomplication of diabetes mellitus. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Therefore, thepresent study was designed to determine the effect of treating chronic periodontitis with oral antibiotics azithromycin and metronidazole on the levelof serum glycated hemoglobin in type-II diabetic patients.Methods: This prospective observational study was carried out in the dental department of a tertiary care hospital for 9 months. Clinical andbiochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Packagefor Social Sciences 17 and Graph Pad Prism 7.0.Results: Significant reduction in all the clinical and dental parameters was comparatively higher in patients who received azithromycin than inpatients who received metronidazole and scaling and root planning alone.Conclusion: Periodontal therapy with oral azithromycin can be employed as a supportive strategy for the management of diabetes mellitus.Henceforth, prevention and control of periodontal disease along with antibiotics must be considered an integral part of glycemic control. However,due to the lesser sample size in this study, further investigations are required to confirm the effect of periodontal therapy on systemic diseases.Keywords: Periodontitis, Azithromycin, Metronidazole, Glycemic control, Diabetes mellitus.

Download Full-text

Effect of nonsurgical periodontal therapy on plasma-reactive oxygen metabolite and gingival crevicular fluid resistin and serum resistin levels in obese and normal weight individuals with chronic periodontitis

Journal of Indian Society of Periodontology ◽

10.4103/jisp.jisp_108_18 ◽

2018 ◽

Vol 22 (4) ◽

pp. 310 ◽

Cited By ~ 3

Author(s):

Jaideep Mahendra ◽

Snophia Suresh ◽

Gurdeep Singh ◽

AngambakkamRajasekaran Pradeep Kumar ◽

Sivasankari Thilagar ◽

...

Keyword(s):

Chronic Periodontitis ◽

Gingival Crevicular Fluid ◽

Reactive Oxygen ◽

Normal Weight ◽

Periodontal Therapy ◽

Reactive Oxygen Metabolite ◽

Nonsurgical Periodontal Therapy ◽

Crevicular Fluid

Download Full-text

A COMPARATIVE EVALUATION OF C-REACTIVE PROTEIN GCF LEVEL IN PERIODONTITIS PATIENTS AFTER SCALING AND ROOT PLANING WITH AND WITHOUT DIODE LASER

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i1.1618 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Sangeeta Roy ◽

C.S. Joshi ◽

Pradeep Shukla ◽

Gaurav Malhotra ◽

Prerna Kataria ◽

...

Keyword(s):

Diode Laser ◽

Chronic Periodontitis ◽

Gingival Crevicular Fluid ◽

Periodontal Therapy ◽

Type I ◽

Scaling And Root Planing ◽

C Reactive Protein ◽

Reactive Protein ◽

Root Planing ◽

Crevicular Fluid

Background and Objectives: C?reactive protein (CRP) is a type I acute phase reactant. A number of studies have reported elevated gingival crevicular fluid (GCF) CRP levels in periodontitis subjects, which decrease following periodontal therapy. Effect of diode laser as an adjuct to Scaling & Root planing is also well stablished. The aim of the present study was to evaluate the effect of periodontal treatment SRP with diode laser, on CRP levels in GCF in patients with chronic periodontitis. Materials and Methods: A total of 40 subjects with moderate periodontitis based on community periodontal index scores, were included in the study. Periodontal therapy was performed dividing each side of jaw as a group (Split mouth); one side SRP alone & another Diode laser with SRP. GCF was collected from each subject at Baseline (prior to treatment) and 1 month after periodontal therapy. The collected sample was subjected to biochemical analysis to detect CRP levels by using a commercially available highly sensitive kit. Results: The present study demonstrated that the mean CRP values at baseline were found to be 0.11043mg/l in side-I (side treated with SRP alone); 0.11042mg/l in side-II (side treated with SRP & laser) of the patient, which reduced to 0.4148 mg/L in side I and 0.3985mg/L in side II after treatment, which are highly significant according to statistical analysis but the changes between two sides were non- significant statistically. Interpretation and Conclusion: Within the limitations of this study, it can be concluded that periodontal therapy is able to reduce the GCF C reactive protein level significantly, but there was no statistically significant result in CRP level, between sides treated with SRP & SRP with laser. Key words: Chronic periodontitis, C?reactive protein, gingival crevicular fluid, Scaling and root planing, Diode laser

Download Full-text

Proinflammatory Cytokines in the Saliva, Gingival Crevicular Fluid and Serum of Diabetic Patients with Periodontal Disease

Journal of Research and Practice in Dentistry ◽

10.5171/2013.956990 ◽

2013 ◽

pp. 1-10

Author(s):

Fawad Javed ◽

Asma Ahmed

Keyword(s):

Periodontal Disease ◽

Proinflammatory Cytokines ◽

Gingival Crevicular Fluid ◽

Diabetic Patients ◽

Crevicular Fluid

Download Full-text

Possible interaction between visfatin, periodontal infection, and other systemic diseases: A brief review of literature

European Journal of Dentistry ◽

10.4103/ejd.ejd_284_16 ◽

2017 ◽

Vol 11 (03) ◽

pp. 407-410 ◽

Cited By ~ 13

Author(s):

Mojtaba Bayani ◽

Mohammad Pourali ◽

Mohammad Keivan

Keyword(s):

Periodontal Disease ◽

Bacterial Infections ◽

Alveolar Bone ◽

Gingival Crevicular Fluid ◽

Systemic Diseases ◽

Hand Search ◽

Periodontal Infection ◽

Etiologic Agents ◽

Visfatin Level ◽

Crevicular Fluid

ABSTRACTGingivitis and periodontitis are common bacterial infections caused by a variety of microorganisms. Despite the microorganisms' roles as etiologic agents, inflammation-induced substances also have crucial parts in the loss of connective tissue and the supporting alveolar bone. Visfatin is a pleiotropic mediator, which acts as growth factor, cytokine, and pre-B-cell colony-enhancing factor. A positive correlation was detected between the serum/plasma levels of visfatin and inflammatory disorders such as diabetes mellitus and cardiovascular disease. In addition, the visfatin level was higher in saliva and the gingival crevicular fluid (GCF) of subjects with periodontal disease. This review defined current, predictable patterns of possible interaction of visfatin with periodontal infection and other systemic diseases, using PubMed and Medline databases searching for articles written in English. Peer-reviewed articles were targeted using the following keywords: “visfatin,” “periodontal disease,” “inflammatory mediator,” and “biomarker.” Available full-text articles were read, and related articles were also scrutinized, while a hand search was also performed. Search was confined to human studies, and articles written in English and published between 1985 and 2016 were selected. It was concluded that periodontal infection and other systemic diseases could be related to the levels of visfatin in GCF, saliva, and serum as a biomarker of these diseases.

Download Full-text