The effect of non- surgical periodontal therapy on periostin level in the gingival crevicular fluid of type II diabetic patients with periodontitis

ABSTRACTObjective: Periodontitis, a chronic inflammatory disease characterized by destruction of the periodontal ligament and alveolar bone is the sixthcomplication of diabetes mellitus. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Therefore, thepresent study was designed to determine the effect of treating chronic periodontitis with oral antibiotics azithromycin and metronidazole on the levelof serum glycated hemoglobin in type-II diabetic patients.Methods: This prospective observational study was carried out in the dental department of a tertiary care hospital for 9 months. Clinical andbiochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Packagefor Social Sciences 17 and Graph Pad Prism 7.0.Results: Significant reduction in all the clinical and dental parameters was comparatively higher in patients who received azithromycin than inpatients who received metronidazole and scaling and root planning alone.Conclusion: Periodontal therapy with oral azithromycin can be employed as a supportive strategy for the management of diabetes mellitus.Henceforth, prevention and control of periodontal disease along with antibiotics must be considered an integral part of glycemic control. However,due to the lesser sample size in this study, further investigations are required to confirm the effect of periodontal therapy on systemic diseases.Keywords: Periodontitis, Azithromycin, Metronidazole, Glycemic control, Diabetes mellitus.

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Effect of nonsurgical periodontal therapy on plasma-reactive oxygen metabolite and gingival crevicular fluid resistin and serum resistin levels in obese and normal weight individuals with chronic periodontitis

Journal of Indian Society of Periodontology ◽

10.4103/jisp.jisp_108_18 ◽

2018 ◽

Vol 22 (4) ◽

pp. 310 ◽

Cited By ~ 3

Author(s):

Jaideep Mahendra ◽

Snophia Suresh ◽

Gurdeep Singh ◽

AngambakkamRajasekaran Pradeep Kumar ◽

Sivasankari Thilagar ◽

...

Keyword(s):

Chronic Periodontitis ◽

Gingival Crevicular Fluid ◽

Reactive Oxygen ◽

Normal Weight ◽

Periodontal Therapy ◽

Reactive Oxygen Metabolite ◽

Nonsurgical Periodontal Therapy ◽

Crevicular Fluid

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A COMPARATIVE EVALUATION OF C-REACTIVE PROTEIN GCF LEVEL IN PERIODONTITIS PATIENTS AFTER SCALING AND ROOT PLANING WITH AND WITHOUT DIODE LASER

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i1.1618 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Sangeeta Roy ◽

C.S. Joshi ◽

Pradeep Shukla ◽

Gaurav Malhotra ◽

Prerna Kataria ◽

...

Keyword(s):

Diode Laser ◽

Chronic Periodontitis ◽

Gingival Crevicular Fluid ◽

Periodontal Therapy ◽

Type I ◽

Scaling And Root Planing ◽

C Reactive Protein ◽

Reactive Protein ◽

Root Planing ◽

Crevicular Fluid

Background and Objectives: C?reactive protein (CRP) is a type I acute phase reactant. A number of studies have reported elevated gingival crevicular fluid (GCF) CRP levels in periodontitis subjects, which decrease following periodontal therapy. Effect of diode laser as an adjuct to Scaling & Root planing is also well stablished. The aim of the present study was to evaluate the effect of periodontal treatment SRP with diode laser, on CRP levels in GCF in patients with chronic periodontitis. Materials and Methods: A total of 40 subjects with moderate periodontitis based on community periodontal index scores, were included in the study. Periodontal therapy was performed dividing each side of jaw as a group (Split mouth); one side SRP alone & another Diode laser with SRP. GCF was collected from each subject at Baseline (prior to treatment) and 1 month after periodontal therapy. The collected sample was subjected to biochemical analysis to detect CRP levels by using a commercially available highly sensitive kit. Results: The present study demonstrated that the mean CRP values at baseline were found to be 0.11043mg/l in side-I (side treated with SRP alone); 0.11042mg/l in side-II (side treated with SRP & laser) of the patient, which reduced to 0.4148 mg/L in side I and 0.3985mg/L in side II after treatment, which are highly significant according to statistical analysis but the changes between two sides were non- significant statistically. Interpretation and Conclusion: Within the limitations of this study, it can be concluded that periodontal therapy is able to reduce the GCF C reactive protein level significantly, but there was no statistically significant result in CRP level, between sides treated with SRP & SRP with laser. Key words: Chronic periodontitis, C?reactive protein, gingival crevicular fluid, Scaling and root planing, Diode laser

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Proinflammatory Cytokines in the Saliva, Gingival Crevicular Fluid and Serum of Diabetic Patients with Periodontal Disease

Journal of Research and Practice in Dentistry ◽

10.5171/2013.956990 ◽

2013 ◽

pp. 1-10

Author(s):

Fawad Javed ◽

Asma Ahmed

Keyword(s):

Periodontal Disease ◽

Proinflammatory Cytokines ◽

Gingival Crevicular Fluid ◽

Diabetic Patients ◽

Crevicular Fluid

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Effects of Initial Periodontal Therapy on Heat Shock Protein 70 Levels in Gingival Crevicular Fluid from Periodontitis Patients

Journal of Clinical Medicine ◽

10.3390/jcm9103072 ◽

2020 ◽

Vol 9 (10) ◽

pp. 3072

Author(s):

Nobuhisa Furuse ◽

Hideki Takai ◽

Yorimasa Ogata

Keyword(s):

Heat Shock ◽

Gingival Crevicular Fluid ◽

Periodontal Therapy ◽

Enzyme Linked Immunosorbent Assay ◽

Microbial Infection ◽

Pocket Depth ◽

Probing Pocket Depth ◽

Factor Α ◽

Crevicular Fluid ◽

Shock Proteins

Periodontitis is an inflammatory disease of periodontium which is caused by periodontopathic bacteria. Moreover, various cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and IL-6 are expressed in the inflamed periodontium. Heat shock proteins (HSPs) protect cells from abnormal conditions including inflammation, microbial infection and diseases. The 70-kDa HSPs (HSP70s) are major HSPs that express in the inflamed tissues. In this study, an enzyme-linked immunosorbent assay was applied to measure the levels of HSP70 in gingival crevicular fluid (GCF) from two periodontal pockets in each of 10 patients with Stage III, Grade B periodontitis. Sites with probing pocket depth (PPD) of ≤3 mm were named the healthy control (HC) sites, and sites with PPD of ≥5 mm were named the diseased sites. HSP70 levels in GCF were expressed higher at diseased sites than at HC sites, and decreased after initial periodontal therapy at diseased sites. These results suggest the association of HSP70 with the stage of periodontitis.

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